Dactolisib Tosylate

Catalog No.: A11327

dual PI3K and mTOR kinase inhibitor

Dactolisib Tosylate

Dactolisib Tosylate Chemical Structure

CAS NO. 1028385-32-1

Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2.

Availability: In stock

Package Price Qty
50 mg
$63.00
100 mg
$109.00
500 mg
$322.00
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Biological Activity

Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.58 mL 77.91 mL 155.83 mL
0.5 mM 3.12 mL 15.58 mL 31.17 mL
1 mM 1.56 mL 7.79 mL 15.58 mL
5 mM 0.31 mL 1.56 mL 3.12 mL

*The above data is based on the productmolecular weight 641.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11327
Actions Inhibitor
M. Wt 641.74
Formula C37H31N5O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1028385-32-1
Synonyms BEZ235 (Tosylate); NVP-BEZ 235 (Tosylate)
SMILES CN(C1=C2C3=CC(C4=CC5=CC=CC=C5N=C4)=CC=C3N=C1)C(N2C6=CC=C(C=C6)C(C)(C#N)C)=O.CC7=CC=C(S(=O)(O)=O)C=C7

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