Catalog No.
Product Name
Application
Product Information
Citations
-
MAO Inhibitor
Phenoxypropazine is a potent monoamine oxidase (MAO) inhibitor that significantly modulates neurotransmitter levels in the central nervous system. This compound has demonstrated biological activity relevant to the study of depressive disorders and may aid in exploring the underlying mechanisms of mood regulation. Its role in MAO inhibition makes it a valuable tool for researchers investigating therapeutic strategies for depression and related mood disorders. -
MAO A Inhibitor
Salsolidine hydrochloride is a tetrahydroisoquinoline alkaloid that serves as a stereoselective competitive inhibitor of monoamine oxidase A (MAO A). It exhibits significant biological activity by modulating neurotransmitter levels, making it a valuable tool for research into neurodegenerative disorders and mood disorders. This compound is instrumental in exploring the therapeutic potential of MAO A inhibition in various preclinical studies. -
MAO-B Inhibitor
Monoamine Oxidase B Inhibitor 1 is a highly selective and reversible inhibitor of monoamine oxidase B (MAO-B), exhibiting an IC50 value of 0.02 nM. This compound demonstrates notable antioxidant and anti-neuroinflammatory properties. Its ability to cross the blood-brain barrier makes it a valuable tool for research applications related to neurodegenerative diseases, particularly Parkinson's disease. -
MAO-A/SERT Inhibitor
MAO-A/SERT-IN-1 is an inhibitor of monoamine oxidase A (MAO-A) and the serotonin transporter (SERT). This compound effectively reduces SERT-mediated reuptake of serotonin (5-HT), demonstrating notable neuroprotective properties in cell inhibition models. In preclinical studies, MAO-A/SERT-IN-1 has shown the ability to improve depressive behaviors in both zebrafish and murine models, making it a valuable tool for research in depression and related neuropsychiatric disorders. -
MAO A Inhibitor
Tetrindole hydrochloride is a selective inhibitor of monoamine oxidase A (MAO A) with competitive inhibitory properties, exhibiting a Ki value of 0.4 μM for rat brain mitochondrial MAO A and a Ki of 110 μM for MAO B. This compound demonstrates notable antidepressant activity, making it a valuable tool for neurological research. Its selective inhibition profile positions Tetrindole hydrochloride as a relevant reagent for investigating the biochemical pathways associated with mood disorders and the role of MAO A in neurotransmitter metabolism. -
MAO-B Inhibitor
Lazabemide hydrochloride is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 0.03 μM, demonstrating minimal activity against MAO-A (IC50 > 100 μM). At elevated concentrations, it inhibits monoamine uptake, with IC50 values of 86 μM for noradrenaline, 123 μM for serotonin, and >500 μM for dopamine. This compound is primarily used in research related to Parkinson's and Alzheimer's diseases, offering insights into the management of neurodegenerative disorders. -
MAO-A Inhibitor
MAO-A-IN-2 is a selective inhibitor of monoamine oxidase A (MAO-A) with an IC50 value of 0.4 μM. By inhibiting MAO-A, this compound effectively reduces the degradation of key monoamine neurotransmitters, including serotonin and norepinephrine. MAO-A-IN-2 is valuable for research into neurological diseases associated with monoamine neurotransmitter imbalances, such as depression and anxiety disorders. -
Monoamine Oxidase Inhibitor
Iproclozide is an irreversible and selective inhibitor of monoamine oxidase, exhibiting notable antidepressant properties. This compound is utilized in research focused on depressive disorders, facilitating the study of monoamine metabolism and potential therapeutic interventions in mood regulation. Its mechanism of action provides valuable insights into the biochemical pathways associated with depression. -
hMAO-B Inhibitor
hMAO-B-IN-12 is a selective inhibitor of human monoamine oxidase B (hMAO-B), exhibiting an IC50 of 17.7 nM. This compound effectively reduces oxidative stress and diminishes lipid metabolism-derived products, such as hydrogen peroxide. hMAO-B-IN-12 is a valuable tool for studying the mechanisms underlying atherosclerosis and related metabolic disorders. -
MAO-B Inhibitor
MAO-B-IN-12 is a potent inhibitor of monoamine oxidase B (MAO-B) with an IC50 value of 1.3 μM. This compound exhibits neuroprotective activity, making it a valuable tool for research into neurodegenerative diseases and related neurological disorders. Its selective inhibition of MAO-B may contribute to the modulation of neurotransmitter levels, and it is suitable for studies focused on neuroprotection and neuronal health. -
MAO-B Inhibitor
MAO-B-IN-53 is a selective inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 of 0.066 μM. This compound demonstrates mixed reversible inhibition and binding stability at the hMAO-B active site, while displaying a high selectivity for hMAO-B over hMAO-A. Due to its neuroprotective properties, MAO-B-IN-53 has been shown to mitigate 6-OHDA-induced cellular damage with minimal neurotoxicity in neuroblastoma cells, making it a valuable reagent for research into Parkinson's disease. -
Monoamine Oxidase Inhibitor
Fluoroclorgyline is a potent monoamine oxidase inhibitor that demonstrates an IC50 of 39 nM. This compound effectively modulates monoamine levels, making it a valuable tool for studying neurotransmitter dynamics and related disorders. Its application in neuropharmacology and mental health research provides insight into the biochemical pathways involved in mood regulation and neurodegenerative diseases. -
Monoamine Oxidase Inhibitor
Pimprinine is a potent monoamine oxidase inhibitor that has been isolated from fermented broths. This compound exhibits significant antioxidative properties and demonstrates anticonvulsant activity. Research indicates that Pimprinine effectively inhibits tremorine-induced tremors and produces analgesic effects in murine models, making it valuable for further investigation in neuropharmacological studies. -
MAO-B Inhibitor
PSB-1434 is a selective inhibitor of monoamine oxidase B (MAO-B), exhibiting an IC50 of 1.59 nM. This compound demonstrates greater than 6000-fold selectivity for MAO-B over MAO-A. PSB-1434 is primarily utilized in research applications focused on neurological disorders, making it a valuable reagent for studies involving dopaminergic signaling and neurodegenerative diseases. -
MAO-B inhibitor
Illudinine is a sesquiterpenoid alkaloid that acts as a selective inhibitor of monoamine oxidase B (MAO-B), exhibiting an IC50 value of 18.3 μM. This compound is valuable for investigating the biochemical pathways associated with neurological diseases, making it a potential tool for the study of neurodegenerative disorders and related therapeutic approaches. -
MAO-B Inhibitor
MAO-B-IN-42 is a selective and reversible inhibitor of monoamine oxidase-B (MAO-B), exhibiting an IC50 value of 0.184 μM. By inhibiting the oxidative deamination of monoamines, MAO-B-IN-42 helps preserve neurotransmitter levels. This compound is valuable for research in Parkinson's disease and related neurological conditions. -
hMAO-B Inhibitor
hMAO-B-IN-3 is a potent inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 value of 47.4 nM. This compound exhibits favorable agent-like properties and a broad safety margin, making it an excellent candidate for lead optimization. Its activity suggests potential applications in the development of multitarget-directed ligands for neurodegenerative diseases and related research areas. -
MAO-B Ligand
FCOB02 is a potent monoamine oxidase B (MAO-B) ligand designed for imaging applications. It exhibits high affinity for MAO-B, with an IC50 value of 10.68 nM, making it suitable for in vivo studies. When labeled as [18F]FCOB02, it serves as a valuable probe for specific MAO-B imaging and quantitative analysis, enabling researchers to investigate the role of MAO-B in various biological processes and diseases. -
Insecticides/Monoamine Oxidase Inhibitors
Insecticidal Agent 32 is a potent insecticide and monoamine oxidase inhibitor that targets the enzyme responsible for the degradation of neurotransmitters in insects. This compound exhibits significant biological activity by disrupting normal neurological functions, leading to increased toxicity in target insect species. It is valuable in research applications focusing on insect neurobiology and the development of innovative pest control strategies. -
MAO-A/B Inhibitor
WAY-620147 is an N-(2-morpholinoethyl)nicotinamide derivative that acts as a selective inhibitor of monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). Demonstrating inhibitory potency with IC50 values of 26 μM for MAO-A and 55 μM for MAO-B, this compound is valuable for exploring the roles of these enzymes in neurochemistry and the treatment of mood disorders. Research applications include studying monoamine metabolism and the potential development of antidepressant therapies. -
Monoamine Oxidase-A Inhibitor
BW1370U87 is a selective inhibitor of monoamine oxidase-A (MAO-A), a key enzyme involved in the catabolism of monoamines. This compound exhibits anti-depressant activity, making it a valuable tool for research focused on mood disorders and neuropharmacology. Its ability to modulate neurotransmitter levels positions BW1370U87 as a candidate for studying therapeutic strategies targeting depressive and anxiety-related conditions. -
MAO Inhibitor
6-Acetonyl-N-methyldihydrodecarine is a natural alkaloid recognized for its function as a monoamine oxidase (MAO) inhibitor. This compound exhibits significant biological activity by modulating the levels of monoamines, which are crucial neurotransmitters in various physiological processes. It serves as a valuable reagent in research applications targeting neuropharmacology and the study of mood disorders. -
MAO-B Inhibitor
NW-1172 free base is a selective inhibitor of monoamine oxidase B (MAO-B). It demonstrates significant biological activity by increasing levels of neurotransmitters, making it useful in research applications related to neurodegenerative disorders and mental health. Studies indicate that the (R) isomer is more effective than the (S) isomer, showing superior performance in cognitive tasks and enhanced affinity for the MAO-B target, thus providing insights into its potential therapeutic benefits. -
MAO-B Inhibitor
PSB-1410 is a selective and competitive inhibitor of monoamine oxidase B (MAO-B), exhibiting an IC50 value of 0.23 nM for human MAO-B and 1.01 nM for rat MAO-B. Its potent inhibition of MAO-B activity makes PSB-1410 valuable for research into neurodegenerative diseases, mood disorders, and other conditions associated with altered monoamine levels. This compound is suitable for studies focusing on the modulation of neurotransmitter metabolism and the role of MAO-B in various biological processes. -
MAO-B Inhibitor
SZV-558 is a selective inhibitor of monoamine oxidase B (MAO-B), demonstrating IC50 values of 50 nM for rat and 60 nM for human MAO-B. This compound has potential applications in the study of Parkinson's disease models, providing insights into neurochemical pathways and therapeutic strategies for this neurodegenerative disorder. Its potency makes it a valuable tool for research focused on MAO-B-related mechanisms in neurodegeneration. -
MAO-B Inhibitor
NW-1772 (methanesulfonate) is a selective inhibitor of monoamine oxidase B (MAO-B), demonstrating potent reversible inhibition. It is characterized by its ability to rapidly penetrate the blood-brain barrier, short-acting effects, and minimal toxicity in vitro. Additionally, NW-1772 shows limited inhibition of certain cytochrome P450 enzymes, making it a valuable tool for investigating neurodegenerative diseases and exploring the biochemical pathways related to neurotransmitter metabolism. -
Monoamine Oxidase Inhibitor
Lilly 51641 is a selective and orally active inhibitor of Type A monoamine oxidase, influencing neurotransmitter metabolism. This compound exhibits potential for investigation in neurological disorders, particularly depression and schizophrenia, by modulating levels of norepinephrine and serotonin. Its targeted mechanism makes it a valuable tool for research into the underlying biochemical pathways of these conditions. -
hMAO-A Inhibitor
hMAO-A-IN-1 is a selective inhibitor of human monoamine oxidase A (hMAO-A), exhibiting a potency with an IC50 of 90 nM. This compound is suitable for investigating the role of hMAO-A in neuropsychiatric disorders, particularly in the context of anxiety and depression research. Its inhibition of hMAO-A provides valuable insights into monoamine metabolism and its implications in mental health. -
MAO Inhibitor
5-(2-Aminopropyl)indole is a potent monoamine oxidase (MAO) inhibitor that exhibits psychoactive properties. This compound demonstrates long-lasting stimulatory effects, making it relevant for studies investigating neurotransmitter modulation and related behavioral outcomes. Its applications include research into mood disorders, neurodegeneration, and the pharmacological mechanisms underlying psychoactive substances. -
MAO-A Inhibitor
Brofaromine hydrochloride is a selective inhibitor of monoamine oxidase A (MAO-A), as well as a 5-hydroxytryptamine (5-HT) uptake inhibitor. This compound exhibits significant antidepressant-like effects, demonstrated in preclinical models, including the social conflict test in rodents. It is primarily used in research examining mood disorders and the pharmacological modulation of serotonin levels. -
MAO-B Inhibitor
Atibeprone is a selective inhibitor of monoamine oxidase B (MAO-B), a key enzyme involved in the metabolism of neurotransmitters. This compound exhibits notable antidepressant activity, making it relevant for research into mood disorders and neurodegenerative diseases. Its specificity for MAO-B allows for the potential exploration of therapeutic strategies with reduced side effects compared to non-selective MAO inhibitors. -
MAO-B Inhibitor
MD 780236 free base is a selective inhibitor of monoamine oxidase B (MAO-B), acting as a competitive antagonist with regard to substrates such as phenylethylamine and 5-hydroxytryptamine (5-HT). By inhibiting MAO-B, this compound plays a crucial role in the modulation of neurotransmitter levels, making it valuable in research focused on neurodegenerative diseases and mood disorders. Its specificity for MAO-B provides a useful tool for investigating the biochemical pathways involving monoamine metabolism. -
MAO Inhibitor
Methyl piperate is an effective inhibitor of monoamine oxidase (MAO), showing significant inhibitory activity with an IC50 of 3.6 µM against MAO. It exhibits a preferential inhibitory effect on MAO-A (IC50 27.1 µM) compared to MAO-B (IC50 1.6 µM), demonstrating a bidirectional action. This compound is valuable in research related to mental health disorders, providing insights into therapeutic strategies targeting monoamine regulation. -
MAO Inhibitor
Caroxazone is a reversible inhibitor of monoamine oxidase (MAO), which is involved in the catabolism of neurotransmitters such as serotonin, norepinephrine, and dopamine. This compound exhibits significant antidepressant activity, making it valuable in the study of mood disorders. Caroxazone is utilized in research to explore mechanisms of depression and to evaluate potential therapeutic interventions targeting MAO. -
MAO Inhibitor
Acacetin 7-O-(6-O-malonylglucoside) is a reversible monoamine oxidase inhibitor targeting both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) with IC50 values of 2.34 μM and 1.87 μM, respectively. This compound demonstrates significant inhibitory activity, making it a valuable tool in the research of neurodegenerative diseases and affective disorders. Its unique mechanism of action contributes to the understanding of monoamine neurotransmitter regulation in various neurological conditions. -
Monoamine Oxidase Inhibitor
Tranylcypromine is a potent monoamine oxidase (MAO) inhibitor that increases levels of neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain. This compound is primarily used in the research of mood disorders and depression therapies, offering insights into the biochemical pathways involved in these conditions. Its specific mechanism of action makes it valuable for studying the modulation of neurotransmitter systems and the pharmacological effects of MAO inhibition. -
MAO Inhibitor
6,7-Dimethylisatin is a selective inhibitor of monoamine oxidase (MAO), exhibiting IC50 values of 20.3 μM for MAO-A and 6.74 μM for MAO-B. This compound holds potential for exploration in neurodegenerative diseases such as depression, Alzheimer's disease, and Parkinson's disease. Its role as a MAO inhibitor may contribute to understanding underlying mechanisms and developing therapeutic strategies in neurobiological research. -
Monoamine Oxidase Inhibitor
MAO-B-IN-1 is a selective inhibitor of monoamine oxidase B, targeting the enzyme responsible for the catabolism of neurotransmitters such as dopamine. This compound demonstrates significant potential for studying the role of monoamine oxidase B in neurological disorders, including Parkinson's disease and depression. MAO-B-IN-1 is valuable for researchers investigating the modulation of oxidative stress and neuroprotection in various neurobiological contexts. -
MAO-B Inhibitor
MAO-B-IN-10 is a selective monoamine oxidase B (MAO-B) inhibitor with a potent IC50 of 5.3 μM. It effectively inhibits and disaggregates amyloid β (Aβ) aggregation, achieving 58.2% inhibition and 43.3% disaggregation of self-mediated Aβ. This compound is valuable for research related to Alzheimer's disease, offering insights into the modulation of Aβ aggregation in neurodegenerative processes. -
MAO-B Inhibitor
MAO-B-IN-50 is a selective inhibitor of monoamine oxidase B (MAO-B), demonstrating an IC50 value of 0.06 μM. This compound is effective in inhibiting the aggregation of amyloid-beta (Aβ40/42) and Tau proteins, with overall IC50 values near 1 μM. Additionally, MAO-B-IN-50 shows potent selective inhibition of acetylcholinesterase (AChE) with an IC50 of 1.78 μM. It is suitable for use in research related to Alzheimer's disease. -
AChE/MAO-B Inhibitor
AChE/MAO-B-IN-9 is a selective, reversible, non-competitive inhibitor of acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B), exhibiting an IC50 of 0.156 μM against electric eel AChE. This compound effectively inhibits the formation of Aβ40/42 fibrils, promotes the depolymerization of Aβ fibrils, and suppresses Tau protein fibril formation. Additionally, AChE/MAO-B-IN-9 demonstrates antioxidant and neuroprotective properties, while alleviating memory deficits induced by scopolamine in murine models. This reagent is valuable for research related to Alzheimer’s disease. -
Dual MAO/AChE Inhibitor
Ladostigil hemitartrate is a dual inhibitor of monoamine oxidase (MAO) and acetylcholinesterase (AChE), with established IC50 values of 37.1 μM for MAO-B and 31.8 μM for AChE. This compound is capable of crossing the blood-brain barrier and exhibits neuroprotective, antioxidant, and anti-inflammatory properties. Ladostigil hemitartrate is relevant for research into neurological disorders, including depression and Alzheimer's disease. Additionally, it functions as a click chemistry reagent, featuring an alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc). -
MAO/AChE Inhibitor
Ladostigil hydrochloride is a potent dual inhibitor of acetylcholinesterase (AChE) and monoamine oxidase-B (MAO-B), exhibiting IC50 values of 37.1 µM and 31.8 µM, respectively. This compound demonstrates neuroprotective, antioxidant, and anti-inflammatory properties, making it valuable for research related to depression and Alzheimer's disease. Additionally, Ladostigil hydrochloride functions as a click chemistry reagent, featuring an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating diverse chemical applications. -
Dual MAO and AChE Inhibitor
Ladostigil is a dual inhibitor of monoamine oxidase (MAO) and acetylcholinesterase (AChE), demonstrating IC50 values of 37.1 μM for MAO-B and 31.8 μM for AChE. This compound exhibits neuroprotective, antioxidant, and anti-inflammatory properties, making it valuable for research in conditions such as depression and Alzheimer's disease. Additionally, Ladostigil features an alkyne functional group, enabling it to serve as a click chemistry reagent through copper-catalyzed azide-alkyne cycloaddition (CuAAc). -
MAO Inhibitor
ASS234 is a potent monoamine oxidase (MAO) inhibitor, targeting MAO-A and MAO-B with IC50 values of 5.2 nM and 43 nM, respectively. In addition to its primary activity, ASS234 also exhibits inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC50 values of 350 nM and 460 nM, respectively. This compound can be utilized in research related to neurodegenerative diseases, mood disorders, and cholinergic signaling pathways. -
AChE-MAO B Inhibitor
Dual AChE-MAO B-IN-2 is a powerful inhibitor of both acetylcholinesterase (AChE) and monoamine oxidase B (MAO B), exhibiting IC50 values of 0.12 µM and 0.01 µM, respectively. This dual inhibition profile suggests its significant potential in the study and development of therapeutic strategies for Alzheimer's disease. Researchers can utilize Dual AChE-MAO B-IN-2 to explore mechanisms related to cholinergic dysfunction and oxidative stress in neurodegenerative conditions. -
ChEs/MAOs Inhibitor
ChEs/MAOs-IN-2 is a potent inhibitor of cholinesterases and monoamine oxidases, exhibiting IC50 values of 0.10 µM for MAO-A, 0.20 µM for MAO-B, 0.30 µM for acetylcholinesterase (AChE), and 0.40 µM for butyrylcholinesterase (BChE). This compound demonstrates significant biological activity relevant to neurodegenerative diseases, particularly Alzheimer's disease, and serves as a valuable tool for research into therapeutic strategies targeting these enzymes. -
ChE/MAO-A Inhibitor
Desoxypeganine is a potent alkaloid that serves as an inhibitor of cholinesterase (both BChE and AChE) as well as a selective inhibitor of monoamine oxidase A (MAO-A), exhibiting IC50 values of 2, 17, and 2 μM, respectively. This compound is primarily utilized in research related to alcohol abuse, offering valuable insights into the underlying mechanisms of addiction and potential therapeutic approaches. Its dual inhibitory action positions Desoxypeganine as a significant tool in the study of neurochemical pathways involved in substance use disorders. -
AChE/BChE/MAO-B Inhibitor
AChE/BChE/MAO-B-IN-5 is a multitarget inhibitor of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and monoamine oxidase B (MAO-B). With IC50 values of 0.24 µM, 6.29 µM, and 0.11 µM for AChE, BChE, and MAO-B, respectively, this compound demonstrates potent inhibition of key enzymes involved in cholinergic neurotransmission and monoamine metabolism. AChE/BChE/MAO-B-IN-5 is particularly relevant for research into neurodegenerative diseases, including Alzheimer's disease, due to its ability to penetrate the blood-brain barrier. -
AChE/BuChE/MAO-B Inhibitor
AChE/BuChE/MAO-B-IN-1 is a potent inhibitor of human acetylcholinesterase (hAChE), butyrylcholinesterase (hBuChE), and monoamine oxidase-B (hMAO-B), with IC50 values of 4.8 μM, 13.7 μM, and 1.11 μM, respectively. This compound also demonstrates a high affinity for σ1 and σ2 receptors, with Ki values of 42.8 nM and 191 nM, respectively. AChE/BuChE/MAO-B-IN-1 is potentially useful in research focused on Alzheimer's disease and related neurological disorders.
