TCO

Tco-PEG2-Tco is a bifunctional reagent featuring TCO groups at both termini, which engage in selective and efficient reactions with tetrazine. The inclusion of a hydrophilic PEG linker enhances the solubility of the compound in aqueous environments, making it suitable for various biochemical assays. This reagent is ideal for applications requiring bioconjugation or labeling of biomolecules in research studies.

(2E)-TCO-PNB ester functions as a Click Amino Acid and serves as a versatile linker for the synthesis of PROTAC molecules. Its unique TCO group can participate in an inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-containing compounds, facilitating efficient conjugation in bioconjugation strategies. This reagent is suitable for applications in chemical biology, enabling the development of targeted therapeutics and advanced biomolecular constructs.

TCO-PNB ester is an amine-reactive building block designed for the modification of amine-containing molecules. It features a strained trans-cyclooctene (TCO) group that participates in an inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-containing compounds. This reagent is valuable for applications in bioconjugation, enabling precise labeling and modification of biomolecules for use in various biochemical studies and therapeutic developments.

TCO-PEG8-TCO is a PEG-based PROTAC linker designed for the synthesis of protein-targeting chimeras. This linker facilitates the conjugation of E3 ligase recruiters and protein-targeting moieties, enhancing the stability and efficacy of PROTAC compounds. It is instrumental in advancing research in targeted protein degradation and drug discovery applications.

TCO-PEG4-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound serves as a versatile building block to facilitate the recruitment of E3 ligases for targeted protein degradation, enabling the modulation of protein levels in biological systems. Its application in the development of PROTACs supports research into therapeutic strategies for various diseases by allowing precise control over protein function and turnover.

TCO-PEG2-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs. This reagent features a TCO group capable of participating in an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules, facilitating targeted protein degradation applications. Its unique properties make it an essential component for researchers investigating protein modulation through innovative PROTAC methodologies.

TCO-amine is an alkyl chain-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). As a click chemistry reagent, TCO-amine features a TCO group that participates in inverse electron demand Diels-Alder (iEDDA) reactions with Tetrazine-containing molecules. This allows for precise conjugation in the development of targeted protein degradation strategies, facilitating studies in cellular biology and therapeutic applications.

TCO-C3-PEG3-C3-amine is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of PROTACs by enhancing their solubility and stability. It plays a crucial role in targeted protein degradation research, allowing researchers to explore novel therapeutic strategies in various disease models.

TCO-PEG5-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a TCO group, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules. Its versatile functionality makes TCO-PEG5-NHS ester a valuable tool for developing targeted protein degradation strategies in cellular studies.

TCO-PEG4-TCO is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound plays a crucial role in facilitating the targeted degradation of specific proteins, enabling the development of novel therapeutic strategies. Its application in research underscores its importance in the fields of protein modulation and targeted therapy.

Z-CITCO is the cis isomer of CITCO and acts as an agonist for the constitutive androstane receptor (CAR), with an EC50 value of 3.9 µM. This compound is significant in the study of hepatic gene expression and plays a role in drug metabolism research. Z-CITCO is also useful for investigating the modulation of xenobiotic metabolism and its implications in pharmacology and toxicology.

CITCO, an imidazothiazole derivative, is a selective Constitutive androstane receptor (CAR) agonist.

TCO-PEG3-Glu-Val-Cit-PABC-MMAF is a drug-linker conjugate designed for targeted delivery in antibody-drug conjugate (ADC) applications. It incorporates a trans-cyclooctene (TCO) moiety for efficient click chemistry attachment, a polyethylene glycol (PEG) spacer for solubility enhancement, and a cleavable linker (Glu-Val-Cit) that releases the potent cytotoxic agent MMAF upon internalization. This reagent is ideal for advancing research in targeted cancer therapeutics and ADC development.

TCO-PEG2-acid is a click chemistry linker that features a trans-cyclooctene (TCO) moiety and a terminal carboxylic acid, enabling efficient interaction with primary amine groups when activated by agents such as EDC. This reagent exhibits high reactivity with tetrazine through an inverse electron demand Diels-Alder (IEDDA) reaction, facilitating the formation of stable conjugates. The inclusion of a hydrophilic polyethylene glycol (PEG) spacer enhances solubility in aqueous environments, making it suitable for biochemical assays and various bioconjugation applications.

TCO-PEG4-TFP Ester is an amine-reactive labeling reagent, primarily targeting amine-containing biopolymers such as proteins and antibodies. The inclusion of 2,3,5,6-tetrafluorophenol (TFP) provides enhanced hydrolytic stability in aqueous environments, leading to more efficient and reproducible labeling processes. TFP esters react with primary amines to form covalent amide bonds at rates comparable to NHS esters, making this reagent valuable for biochemical assays and various protein modification applications.

N-(TCO)-N-bis(PEG4-acid) is a versatile click chemistry reagent featuring a terminal trans-cyclooctene (TCO) group and two terminal carboxylic acid moieties. This compound facilitates the formation of stable covalent bonds through inverse-electron demand Diels-Alder cycloaddition with tetrazine-containing molecules, representing one of the fastest and most selective bioorthogonal reactions. The carboxylic acids can also efficiently react with primary amino groups in the presence of common coupling activators, such as EDC or HATU, making this reagent suitable for various biochemical assays and labeling applications in research settings.

TCO-PEG5-C2-Mal is a heterobifunctional linker designed for use in tetrazine ligation and sulfhydryl conjugation. This reagent facilitates the efficient coupling of biomolecules by enabling selective labeling and conjugation strategies. It is particularly useful in bioconjugation applications, including targeted drug delivery and the development of novel therapeutics.