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TCO-PEG2-NHS ester

PROTAC linker

TCO-PEG2-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs. This reagent features a TCO group capable of participating in an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules, facilitating targeted protein degradation applications. Its unique properties make it an essential component for researchers investigating protein modulation through innovative PROTAC methodologies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2250217-33-3
Applications	PROTAC linker
Formula	C₂₀H₃₀N₂O₈
Molecular Weight	426.46
SMILES	O=C(NCCOCCOCCC(ON1C(CCC1=O)=O)=O)OC2CC/C=C\CCC2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.