(2E)-TCO-PNB ester functions as a Click Amino Acid and serves as a versatile linker for the synthesis of PROTAC molecules. Its unique TCO group can participate in an inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-containing compounds, facilitating efficient conjugation in bioconjugation strategies. This reagent is suitable for applications in chemical biology, enabling the development of targeted therapeutics and advanced biomolecular constructs.
(2E)-TCO-PNB ester functions as a Click Amino Acid and serves as a versatile linker for the synthesis of PROTAC molecules. Its unique TCO group can participate in an inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-containing compounds, facilitating efficient conjugation in bioconjugation strategies. This reagent is suitable for applications in chemical biology, enabling the development of targeted therapeutics and advanced biomolecular constructs.
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