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- Chie Ishikawa, .et al. The role of CUDC-907, a dual phosphoinositide-3 kinase and histone deacetylase inhibitor, in inhibiting proliferation of adult T-cell leukemia, Eur J Haematol, 2020, Eur J Haematol PMID: 32780889
Biological Activity
CUDC-907 (Fimepinostat) is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses.
Targets
| Target | Value |
|---|---|
| HDAC1 | IC50: 1.7nM |
| HDAC3 | IC50: 1.8nM |
| HDAC10 | IC50: 2.8nM |
| HDAC2 | IC50: 5.0nM |
| HDAC11 | IC50: 5.4nM |
| PI3Kα | IC50: 19nM |
| HDAC6 | IC50: 27nM |
| PI3Kδ | IC50: 39nM |
| PI3Kβ | IC50: 54nM |
| HDAC8 | IC50: 191nM |
| PI3Kγ | IC50: 311nM |
| HDAC4 | IC50: 409nM |
| HDAC7 | IC50: 426nM |
| HDAC9 | IC50: 554nM |
| HDAC5 | IC50: 674nM |
| In vitro | DMSO | 87 mg/mL (171.07 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.66 mL | 98.31 mL | 196.62 mL |
| 0.5 mM | 3.93 mL | 19.66 mL | 39.32 mL |
| 1 mM | 1.97 mL | 9.83 mL | 19.66 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.93 mL |
*The above data is based on the productmolecular weight 508.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11153 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1339928-25-4 |
| Formula | C23H24N8O4S |
| M. Wt | 508.6 |
| Purity | >98% |
| Synonyms | CUDC907 |
| SMILES | CN(CC1=CC2=C(S1)C(=NC(=N2)C3=CN=C(C=C3)OC)N4CCOCC4)C5=NC=C(C=N5)C(=O)NO |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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