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CUDC-907 (Fimepinostat)

Catalog No.: A11153

PI3K/HDAC inhibitor

CUDC-907 (Fimepinostat)

CUDC-907 (Fimepinostat) Chemical Structure

CAS NO. 1339928-25-4

CUDC-907 (Fimepinostat) is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
50 mg
$350.00
100 mg
$600.00
10mM * 1mL in DMSO
$150.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Chie Ishikawa, .et al. The role of CUDC-907, a dual phosphoinositide-3 kinase and histone deacetylase inhibitor, in inhibiting proliferation of adult T-cell leukemia, Eur J Haematol, 2020, Eur J Haematol PMID: 32780889

Biological Activity

CUDC-907 (Fimepinostat) is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses.
Targets
Target Value
HDAC1IC50: 1.7nM
HDAC3IC50: 1.8nM
HDAC10IC50: 2.8nM
HDAC2IC50: 5.0nM
HDAC11IC50: 5.4nM
PI3KαIC50: 19nM
HDAC6IC50: 27nM
PI3KδIC50: 39nM
PI3KβIC50: 54nM
HDAC8IC50: 191nM
PI3KγIC50: 311nM
HDAC4IC50: 409nM
HDAC7IC50: 426nM
HDAC9IC50: 554nM
HDAC5IC50: 674nM
In vitro DMSO 87 mg/mL (171.07 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.66 mL 98.31 mL 196.62 mL
0.5 mM 3.93 mL 19.66 mL 39.32 mL
1 mM 1.97 mL 9.83 mL 19.66 mL
5 mM 0.39 mL 1.97 mL 3.93 mL

*The above data is based on the productmolecular weight 508.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11153
Actions Inhibitor
CAS No. 1339928-25-4
Formula C23H24N8O4S
M. Wt 508.6
Purity >98%
Synonyms CUDC907
SMILES CN(CC1=CC2=C(S1)C(=NC(=N2)C3=CN=C(C=C3)OC)N4CCOCC4)C5=NC=C(C=N5)C(=O)NO
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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