Catalog No.
Product Name
Application
Product Information
Citations
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RNA Polymerases Inhibitor
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that serves as an inhibitor of DNA-dependent RNA polymerases I and II. It competitively inhibits the incorporation of UTP into RNA, demonstrating potent biological activity with a Ki value of 2.0 μM. This compound is valuable for research applications involving transcription regulation and the study of RNA synthesis mechanisms. -
DNA Polymerase
Pfu DNA Polymerase is a thermostable DNA polymerase sourced from Pyrococcus furiosus, known for its high fidelity during DNA amplification. This enzyme is essential for polymerase chain reaction (PCR) applications, particularly in generating accurate and reliable DNA products. Its robustness at elevated temperatures makes it ideal for amplifying complex templates and minimizing errors in nucleotide incorporation. -
Nucleoside Analogue
2′-O-(2-Methoxyethyl)guanosine is a nucleoside analogue that features a 2'-O-methoxyethyl modification, serving as a valuable intermediate in the synthesis of nucleic acid therapeutics. This compound is not significantly phosphorylated by cytosolic nucleoside kinases and is not incorporated into cellular DNA or RNA, making it crucial for studies involving nucleoside analogues and their applications in drug design and development. Its unique properties allow for exploration in various biochemical research areas, including antiviral and anticancer drug development. -
DNA Synthesis Inhibitor
Cytarabine triphosphate (Ara-CTP) is a competitive inhibitor of DNA synthesis, serving as an active metabolite of Cytarabine. This compound plays a crucial role in cellular mechanisms by disrupting normal DNA replication processes. Its intracellular levels are valuable for predicting the chemosensitivity of leukemic blasts to Cytarabine, making it a significant biomarker in the treatment of leukemia and related hematological disorders. -
DNA Synthesis Inhibitor
Cytembena is a potent inhibitor of DNA synthesis, primarily targeting replicative DNA processes, purine biosynthesis, and tetrahydrofolate formylase activity. Its biological activity demonstrates significant anti-cancer effects, particularly in the treatment of ovarian and breast cancer, as well as providing pain relief in cases of skeletal metastases. This compound is valuable in research applications focused on cancer therapeutics and the mechanisms of DNA replication and repair. -
MTH1 Degrader
aTAG 4531 is a selective MTH1 degrader that exerts its action through the formation of a ternary complex with MTH1, CRBN E3 ligase, and the degrader itself. It displays a DC50 value of 0.28 nM and a Ki value of 1.8 nM, highlighting its potent degradation capability. This compound is valuable for research focused on MTH1 inhibition and subsequent cellular effects, offering insights into its role in cancer biology and related therapeutic applications. -
DNA Alkylator
Methyl methanesulfonate is a potent DNA alkylator known for its ability to transfer methyl groups, leading to the induction of DNA damage. This chemical reagent is commonly employed in research focusing on mutagenesis, DNA repair mechanisms, and the study of cellular responses to genotoxic stress. Its applications extend to investigating the effects of alkylating agents on genetic stability and understanding the underlying processes of carcinogenesis. -
DNA Alkylator/Crosslinker
Phosphoramide mustard cyclohexanamine is a DNA alkylator and crosslinker that exerts its biological effects through the induction of DNA damage. As a biologically active metabolite of cyclophosphamide, it plays a crucial role in anticancer research by disrupting cellular replication processes. This compound is primarily utilized in studies focused on cancer treatment mechanisms and the exploration of targeted therapies. -
DNA Alkylator/Crosslinker
Fotemustine is a DNA alkylator and crosslinker that exhibits potent antitumor activity. By binding to DNA, it induces damage that triggers cellular apoptosis in cancer cells. This compound is primarily utilized in cancer research, particularly for studies focusing on DNA damage response mechanisms and therapeutic efficacy in various malignancies. -
DNA Alkylator/Crosslinker
Duocarmycin analog-1 is a potent DNA alkylator and crosslinker, functioning through the formation of covalent bonds with DNA, leading to cellular damage and apoptosis. It is a valuable tool in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. This compound is primarily utilized in research involving DNA interactions and cancer treatment modalities. -
DNA Alkylator/Crosslinker Chemical
Palifosfamide tromethamine is a synthetic alkylating agent that targets DNA, exhibiting potent antineoplastic activity. As the stabilized active metabolite of ifosfamide, it irreversibly alkylates and crosslinks DNA at GC base pairs, leading to inhibition of DNA replication and subsequent cell death. Palifosfamide tromethamine offers a reduced toxicity profile compared to its parent compound, making it a valuable tool for cancer research and therapeutic applications. -
DNA Alkylator/Crosslinker
Phosphoramide mustard is a potent DNA alkylator and crosslinker, functioning as a key metabolite of Cyclophosphamide. It exerts significant anticancer activity by inducing DNA damage, thereby interfering with cell proliferation. This compound is widely utilized in cancer research to study DNA repair mechanisms and the effectiveness of alkylating agents in therapeutic applications. -
DNA Alkylator/Crosslinker Inducer
Hepsulfam is a potent DNA alkylator and crosslinker inducer. It demonstrates significant antileukemic activity, with a median IC50 of 0.91 μg/mL across various tumor types. This compound is primarily utilized in cancer research to investigate mechanisms of DNA damage and repair, as well as to evaluate its potential in therapeutic applications against leukemia. -
DNA Alkylator/Crosslinker
Altretamine hydrochloride is an alkylating agent that primarily targets DNA by forming crosslinks. It exhibits significant antitumor activity, making it useful in the treatment of certain cancers, particularly ovarian cancer. This compound is often utilized in research settings to study its effects on tumor cell proliferation and apoptosis. -
DNA Alkylator/Crosslinker
NCI172112 is a bifunctional alkylating agent that acts as a DNA crosslinker. This compound demonstrates significant antitumor activity, particularly against central nervous system (CNS) tumors. It is utilized in research aimed at understanding the mechanisms of DNA damage and repair, as well as developing therapeutic strategies for cancer treatment. -
DNA Alkylator/Crosslinker
Seco-Duocarmycin TM is a potent DNA alkylator and crosslinker derived from the Duocarmycin family, known for its ability to inhibit DNA synthesis. This cytotoxic agent plays a crucial role as the active component in antibody-drug conjugates (ADCs), enabling targeted therapy in cancer research. Its unique mechanism of action is pivotal in understanding and developing novel therapeutic strategies against malignant tumors. -
DNA Alkylator/Crosslinker
DC10SMe is a potent DNA alkylator and crosslinker used primarily in the synthesis of antibody-drug conjugates (ADCs). It demonstrates significant cytotoxicity with IC50 values of 15 pM, 12 pM, and 12 pM against Ramos, Namalwa, and HL60/s cancer cell lines, respectively. This compound serves as a valuable tool in cancer research, particularly in the development of targeted therapies. -
DNA Alkylator/Crosslinker Inducer
Colibactin 742 is a potent DNA alkylator and crosslinker inducer that covalently targets DNA, exhibiting an IC50 of 5.2 μM in human cervical cancer cells (HeLa). This compound forms interstrand crosslinks, thereby activating the Fanconi anemia DNA repair pathway and promoting the formation of γH2AX and FANCD2 foci, which can lead to cell cycle arrest. Colibactin 742 serves as a valuable tool for investigations into colorectal cancer, microbial tumorigenesis, DNA damage repair mechanisms, and the study of mutation signatures, effectively mimicking the genotoxic effects of natural Colibactin while providing enhanced stability. -
DNA Alkylator/Crosslinker Control
Alagebrium bromide is a potent DNA alkylator and crosslinker control that plays a significant role in disrupting glucose cross-links. This compound has been shown to enhance ventricular and arterial compliance, showing promise in improving left ventricular diastolic filling. Alagebrium bromide is utilized in research to investigate its potential therapeutic effects on diastolic heart failure (DHF) and related cardiovascular conditions. -
SIRT3 Agonist
SKLB-11A is a selective, orally active allosteric agonist of SIRT3 (sirtuin 3), exhibiting a Kd value of 4.7 μM and demonstrating high selectivity for SIRT family members. This compound activates autophagy-related signaling pathways and plays a critical role in preventing mitochondrial dysfunction. SKLB-11A has shown efficacy in improving cardiac function in models of Doxorubicin-induced cardiotoxicity and myocardial ischemia/reperfusion, making it a valuable tool for research in cardiovascular protection and mitochondrial biology. -
Topoisomerase I Inhibitor
Irinotecan-d10 is a deuterated derivative of Irinotecan, a potent inhibitor of topoisomerase I. By binding to the topoisomerase I-DNA complex, it disrupts the religation of DNA strands, thereby inducing DNA damage and apoptosis in rapidly dividing cells. This reagent is useful in cancer research, particularly in studies aimed at understanding the mechanisms of action of topoisomerase inhibitors and their therapeutic potential in oncology. -
Topoisomerase I/II Inhibitor
SelB-1 is a dual inhibitor targeting Topoisomerase I and II, demonstrating significant anticancer activity. This compound is particularly useful in the study of prostate and colon cancers. Additionally, SelB-1 induces autophagy gene expression and lipid peroxidation, while effectively lowering glutathione (GSH) levels, providing insights into its mechanistic roles in cancer biology. -
PARP1 Inhibitor
Palacaparib is a potent inhibitor of PARP1, demonstrating over 8000-fold selectivity for PARP1 relative to PARP2, PARP3, PARP5a, and PARP6. It functions by selectively inhibiting PARP1 and trapping it at sites of single-strand breaks (SSBs), impeding DNA repair. This compound is investigated primarily for its anti-cancer properties, particularly in research related to HRD+ breast cancer and various advanced solid tumors. -
MTH1 Inhibitor
TH287 hydrochloride is a highly potent and selective inhibitor of MTH1, exhibiting an IC50 of 0.8 nM. It demonstrates significant selectivity for MTH1 over related enzymes, showing no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase, and ITPA at concentrations of 100 µM. This compound is valuable for cancer research, particularly in the exploration of novel chemotherapeutic strategies targeting MTH1's role in tumor metabolism. -
RNA Polymerase Inhibitor
MRL-436 is an RNA polymerase inhibitor that exhibits significant antibacterial activity against Rifampicin-resistant strains. Its mechanism of action involves targeting residue 622 of the RNA polymerase β' subunit and the RNAP ω subunit. This compound is particularly valuable for research involving antibiotic resistance and the study of bacterial transcription mechanisms. -
SIRT1/3 Inhibitor
SPC-180002 is a dual inhibitor of SIRT1 and SIRT3, exhibiting IC50 values of 1.13 μM and 5.41 μM, respectively. This compound disrupts redox homeostasis through reactive oxygen species (ROS) generation, resulting in enhanced stability of the p21 protein and consequential mitochondrial dysfunction. SPC-180002 effectively inhibits cell cycle progression and reduces cancer cell proliferation, while also activating the Nrf2 signaling pathway, making it a valuable tool for cancer research and studies on metabolic dysregulation. -
MTH1 Substrate
8-Oxo-dGTP (8-Oxo-Deoxyguanosine triphosphate) is a reactive oxidized guanine nucleotide that serves as a substrate for MTH1 and other pyrophosphohydrolases. This compound is known to act as a mutagen, integrating into DNA and leading to A:T to C:G transversions, which can contribute to genomic instability. Additionally, 8-Oxo-dGTP can provoke oxidative DNA modifications, strand breaks, and the promotion of apoptosis, particularly in mth1-deficient organisms. Its accumulation is linked to various biological processes and is extensively utilized in research on carcinogenesis, neurodegenerative diseases, and other pathologies. -
SIRT1 Activator
SRT 1720 dihydrochloride is a selective activator of SIRT1, exhibiting an EC50 of 0.10 μM. This compound demonstrates lower activity toward SIRT2 and SIRT3, making it an important tool for investigating SIRT1-related biological pathways. Its ability to modulate SIRT1 activity is particularly relevant in studies of metabolism, aging, and neuroprotection. -
Poly (ADP-ribose) Polymerase Inhibitor
8-NH2-ATP is an inhibitor of poly (ADP-ribose) polymerase (PARP), acting as a critical tool in research on cell apoptosis. This compound is derived from 8-NH2-Ado and exhibits potent effects by inducing apoptotic cleavage of PARP, making it useful for studying mechanisms of cell death, DNA repair, and cancer therapeutics. Its applications extend to exploring PARP's role in various biological pathways and assessing the therapeutic potential of PARP inhibition in disease models. -
T4 DNA Polymerase Inhibitor
3'-Fluorothymidine-5'-triphosphate tetrasodium is a competitive inhibitor of T4 DNA polymerase, functioning as an analog of dTTP. By inhibiting T4 DNA polymerases, including wild-type, L98, and CB121 variants, it effectively disrupts DNA synthesis processes. This compound is valuable for research applications involving DNA replication studies and exploration of polymerase inhibition mechanisms. -
DNA polymerase θ Inhibitor
RTx-303 is a selective inhibitor of DNA polymerase θ (Polθ), with an IC50 value of 5.1 nM. This compound demonstrates potent cellular activity and enhances the efficacy of PARP inhibitors in BRCA1/2 mutant cells and patient-derived xenograft models. RTx-303 is utilized in research focused on BRCA2-mutated breast cancer, providing valuable insights into therapeutic strategies targeting DNA repair mechanisms. -
HCV Polymerase Inhibitor
Dasabuvir sodium is a non-nucleoside inhibitor of hepatitis C virus (HCV) polymerase, specifically targeting the RNA-dependent RNA polymerase encoded by the HCV NS5B gene. It demonstrates potent antiviral activity against HCV genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC50 values of 7.7 nM and 1.8 nM, respectively. Dasabuvir sodium is primarily utilized in research focused on HCV replication and the development of antiviral therapies. -
DNA Gyrase/Topoisomerase Inhibitor
Levofloxacin sodium is a potent DNA gyrase and topoisomerase IV inhibitor that exhibits broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. Its primary applications include research on chronic periodontitis, airway inflammation, and BK viremia. Additionally, Levofloxacin sodium demonstrates anti-orthopoxvirus properties, making it a valuable reagent for studies involving viral infections. -
DNA/RNA Synthesis Chemical
5-Propargylamino-3'-azidomethyl-dUTP functions as a nucleoside analogue in DNA and RNA synthesis. This reagent is compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC), making it suitable for bioconjugation applications. Researchers can utilize this compound in diverse applications, including DNA synthesis and sequencing, owing to its azide and alkyne functionalities that facilitate modular addition of biomolecules. -
RNA Polymerase Activities Inhibitor
Thio-ITP (6-Thioinosine 5'-triphosphate) is a competitive inhibitor of RNA polymerase activities. It exhibits a high apparent affinity for RNA polymerases, with inhibition constants of 40.9 μM for RNA polymerase I and 38.0 μM for RNA polymerase II. Thio-ITP is useful in research applications aimed at understanding transcriptional regulation and dissection of RNA polymerase mechanisms. -
MTH1 Inhibitor
MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), a target implicated in cancer biology. This compound exhibits significant anti-tumor activity, making it a valuable tool for cancer research. MTH1-IN-2 can be utilized to investigate the mechanisms of tumorigenesis and to develop therapeutic strategies that exploit the MTH1 pathway. -
DNA/RNA Synthesis Inhibitor
Riddelline is a pyrrolizidine alkaloid that functions as a potent inhibitor of DNA and RNA synthesis. It exhibits significant genotoxic properties by inducing elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver models. This compound is utilized in research to study the mechanisms of genotoxicity and its implications in cellular processes and carcinogenesis. -
Topoisomerase I Inhibitor.
T-2513 hydrochloride is a selective inhibitor of topoisomerase I. By covalently binding to and stabilizing the topoisomerase I-DNA complex, it effectively inhibits DNA replication and RNA synthesis, resulting in cytotoxicity. This compound is utilized in research applications focused on cancer biology and the mechanisms of chemotherapeutic agents. -
RNA polymerase II Inhibitor
Dideoxy-amanitin is an allosteric inhibitor of RNA polymerase II, demonstrating potent selectivity with an IC50 of 74.2 nM. This compound is particularly valuable for research applications focused on transcriptional regulation and RNA synthesis inhibition. Its ability to selectively hinder RNA polymerase II makes it a crucial tool for investigating gene expression and related pathways in various biological contexts. -
DNA/RNA Synthesis Inhibitor
Bromochloroacetonitrile, a potent DNA/RNA synthesis inhibitor, exhibits direct mutagenic activity and can induce DNA strand breakage. This compound serves as a valuable tool in research focused on understanding DNA damage mechanisms and the effects of mutagens on genetic material. Its ability to disrupt nucleic acid synthesis makes it relevant for studies in genotoxicity and cancer research. -
DNA/RNA Synthesis
RNAP-σ interaction inhibitor-1 is a specific inhibitor of RNA polymerase-sigma factor interactions, playing a crucial role in DNA and RNA synthesis. This compound demonstrates significant antibacterial activity against Streptococci, with minimal inhibitory concentration (MIC) values ranging from 1 to 2 µg/mL. It is a valuable tool for research applications focused on bacterial transcription mechanisms and the development of novel antibacterial agents. -
Topoisomerase II Inhibitor
NK-611 is a topoisomerase II inhibitor that functions as an epipodophyllotoxin derivative. By inhibiting topoisomerase II with an IC50 of 56 μM, NK-611 induces DNA double-strand breaks, leading to effective antitumor activity. Unlike its parent compound Podofilox, NK-611 does not interfere with microtubule polymerization, thus minimizing associated side effects. This compound has shown potent efficacy in in vivo leukemia models and is valuable for cancer research applications. -
HBV DNA Synthesis Inhibitor
LB80317 is an active metabolite of LB80380 that functions as a potent inhibitor of HBV DNA synthesis, exhibiting an EC50 of 0.5 μM. This compound demonstrates antiviral activity, making it a promising candidate for the treatment of chronic hepatitis B. Its ability to inhibit viral replication supports its potential utility in HBV research and therapeutic applications. -
Topoisomerase I Inhibitor
T-2513 is a selective inhibitor of topoisomerase I, a critical enzyme involved in the relaxation of DNA supercoils during replication and transcription. By covalently binding to and stabilizing the topoisomerase I-DNA complex, T-2513 effectively inhibits DNA replication and RNA synthesis. This activity may induce cytotoxic effects, making it a valuable tool in cancer research and studies focused on cell proliferation and death. -
DNA Polymerase
Tth DNA polymerase is a thermostable DNA polymerase derived from Thermus thermophilus, primarily targeting DNA synthesis. It exhibits high fidelity and robust activity at elevated temperatures, making it ideal for applications such as PCR and DNA sequencing. This enzyme is essential for researchers requiring efficient amplification and accurate DNA replication in challenging experimental conditions. -
DNA Synthesis Inhibitor
Alldimycin A is an anthracycline compound that functions as a potent inhibitor of DNA and RNA synthesis. It demonstrates significant anti-proliferative activity against murine leukemic L1210 cells, exhibiting IC50 values of 0.05 μg/mL for growth inhibition, 0.92 μg/mL for RNA synthesis, and 0.47 μg/mL for DNA synthesis. Alldimycin A is valuable for research applications in cancer biology and the study of nucleic acid metabolism. -
DNA/RNA Synthesis Inhibitor
Ulicyclamide is a cytotoxic cyclic peptide that functions as a DNA and RNA synthesis inhibitor. Isolated from the tunicate Lissoclinum patella, Ulicyclamide effectively inhibits nucleic acid synthesis in leukemia cells. This compound is primarily utilized in research focused on leukemia and the underlying mechanisms of nucleic acid metabolism in cancer biology. -
DNA Synthesis Inhibitor
Teloxantrone is a potent DNA synthesis inhibitor with an IC50 of 0.33 μM. This compound exhibits significant antitumor activity and is particularly relevant in the study of colorectal cancer. Its ability to interfere with DNA replication makes it a valuable tool for cancer research and therapeutic investigations. -
RNA Polymerase Inhibitor
2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside that serves as a selective inhibitor of viral RNA polymerase. It effectively inhibits the replication of RNA viruses, making it a valuable tool for research focused on viral replication mechanisms and the development of antiviral therapies. This compound is instrumental for studies investigating RNA virus pathogenesis and potential therapeutic interventions. -
DNA/RNA Synthesis Inhibitor
Ledoxantrone is a potent inhibitor of DNA and RNA synthesis, specifically targeting DNA helicases with an IC50 of 0.17 μM. This compound demonstrates significant biological activity against cancer cells and is utilized in research focusing on prostate cancer. Its mechanism of action provides valuable insights into the role of DNA repair and replication in oncogenesis.
