aTAG 4531 is a selective MTH1 degrader that exerts its action through the formation of a ternary complex with MTH1, CRBN E3 ligase, and the degrader itself. It displays a DC50 value of 0.28 nM and a Ki value of 1.8 nM, highlighting its potent degradation capability. This compound is valuable for research focused on MTH1 inhibition and subsequent cellular effects, offering insights into its role in cancer biology and related therapeutic applications.
aTAG 4531 is a selective MTH1 degrader that exerts its action through the formation of a ternary complex with MTH1, CRBN E3 ligase, and the degrader itself. It displays a DC50 value of 0.28 nM and a Ki value of 1.8 nM, highlighting its potent degradation capability. This compound is valuable for research focused on MTH1 inhibition and subsequent cellular effects, offering insights into its role in cancer biology and related therapeutic applications.
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