Catalog No.
Product Name
Application
Product Information
Citations
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Purine Nucleoside Analog
2'-O-Methylinosine, a purine nucleoside analog, exhibits significant antitumor activity primarily against indolent lymphoid malignancies. Its mechanism of action includes the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focused on cancer biology and the development of therapeutic strategies targeting nucleoside metabolism. -
Purine Nucleoside Analog
5-Azidomethyl-2'-deoxyuridine (5-AmdU) is a purine nucleoside analog that functions as a radiosensitizer, particularly effective in EMT6 tumor cell lines. This compound serves as a valuable reagent in click chemistry, possessing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds that possess DBCO or BCN reactive groups, making it a versatile tool for biochemical research and molecular labeling applications. -
Intermediate
N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine functions as an essential intermediate in the synthesis of oligonucleotides. This compound facilitates the production of modified nucleic acids for various research applications, including gene expression studies and the development of therapeutic oligonucleotides. Its protective groups and chemical stability render it suitable for complex synthetic routes in nucleic acid chemistry. -
Uridine Analog
5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyluridine is a modified uridine analog featuring a 5'-O-(4,4'-dimethoxytrityl) protecting group and a 2'-O-methyl modification. This compound is primarily utilized as a precursor for the synthesis of conformationally rigid cyclic uridylic acid derivatives, which are valuable in various biochemical research applications. Its structural modifications enhance the stability and binding properties of oligonucleotides, making it an important tool for studies in nucleic acid chemistry and drug development. -
Purine Nucleoside Analog
4,10-Dioxatri cyclo[5.2.1.02.6]dec-8-ene-3,5-dione is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is useful in studies aimed at understanding and targeting specific cancer pathways. -
Nucleic Acid Analog
5'-ODMT cEt N-Bzm5 C Phosphoramidite is a modified nucleic acid analog that effectively enhances antisense oligonucleotide performance. Through the incorporation of a cEt modification, this reagent promotes the formation of a specific conformation of the furanose ring, which significantly improves hybridization to complementary RNA. Its primary applications include research into gene expression regulation associated with metabolic disorders, cardiovascular diseases, and cancer, as well as the advancement of antisense therapeutic compounds. -
Purine Nucleoside Analog
N1-Methyl-2'-deoxyadenosine is a purine nucleoside analog that serves as a DNA adduct. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological effects are attributed to mechanisms such as inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic applications. -
Adenosine Analog
8-Bromoadenosine is an adenosine analog known for its vasodilatory effects on smooth muscle and its potential to inhibit cancer progression. This compound can effectively quench the intrinsic fluorescence of human serum albumin through a static quenching mechanism. 8-Bromoadenosine serves as a precursor for synthesizing various adenosine phosphates, such as Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine, making it valuable for biochemical research and therapeutic applications. -
Nucleoside Analogue
2'-O,4'-C-Methylenecytidine is a bicyclic nucleoside analogue known for its fixed N-type conformation. This compound serves as a key building block for the synthesis of oligonucleotides, allowing for the formation of stable duplexes with complementary DNA and RNA strands. Its unique structural properties make it valuable for various applications in nucleic acid research and therapeutic development. -
Cytidine Analog
DMT-2'-OMe-Bz-C is a cytidine analog that primarily inhibits DNA methyltransferases. This compound exhibits significant anti-metabolic and anti-tumor activities, making it valuable in cancer research. It is utilized in studies exploring epigenetic modulation and the role of DNA methylation in gene regulation and tumorigenesis. -
Purine Nucleoside Analog
1,N6-Ethenoadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications focused on cancer biology and therapeutic development. -
Nucleoside Antimetabolite/Analog
Isocytosine is a synthetic nucleoside analog and structural isomer of cytosine. This compound serves as a nucleobase in the study of unnatural nucleic acid analogs, particularly when used in combination with Isoguanine. Isocytosine facilitates research into hachimoji RNA systems, contributing to advancements in genetic coding and nucleic acid chemistry. -
Purine Nucleoside Analog
4-Thio-2’-deoxyuridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, which subsequently induces apoptotic pathways in malignant cells. This compound is valuable in cancer research and may serve as a tool for studying DNA synthesis inhibition and apoptosis in oncological studies. -
LNA Analogue
5'-ODMT cEt m5U Phosphoramidite is a locked nucleic acid (LNA) analog that enhances oligonucleotide stability and binding affinity. This reagent demonstrates significant antisense activity, making it suitable for applications in gene regulation and therapeutic research. Its favorable safety profile in murine models further supports its use in various molecular biology studies. -
Intermediate
5'-O-DMT-Bz-rA is an important intermediate in the synthesis of cyclic di-nucleotide compounds. This reagent facilitates various biochemical applications, particularly in the development of nucleic acid-based therapeutics and diagnostic tools. Its utility in research makes it a valuable component in the study of nucleotide signaling pathways. -
Purine Nucleoside
8-Bromoguanosine is a brominated derivative of guanosine that targets purine nucleosides. It has been shown to significantly reduce the conformational heterogeneity of RNA, thereby enhancing its functional capabilities. This compound is useful in various molecular biology applications, particularly in studies focused on RNA stability and function. -
Nucleoside Analog
2'-F-Bz-A (N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine) is a nucleoside analog designed for the synthesis of oligoribonucleotides. Its structural modification enhances thermal stability and can influence hybridization properties. This reagent is valuable in nucleic acid research, particularly in studies involving RNA synthesis and modification. -
Nucleoside Analogue
2',3'-O-Isopropylideneadenosine is a nucleoside analogue that functions as a Golgi-targeting moiety. Exhibiting cyclization at the O (2') and O (3') atoms, it features a furanose ribose group, enabling its incorporation into fluorescent probes. As a key element of the fluorescent probe TPE-Ade, this compound facilitates specific Golgi localization for fluorescence imaging applications. Additionally, 2',3'-O-Isopropylideneadenosine plays a role in the development of aggregation-induced emission (AIE) fluorescent probes, contributing to advancements in biochemical research and imaging technologies. -
Adenosine Analog
2-Iodoadenosine is an adenosine analog known for its vasodilatory properties, primarily acting through smooth muscle relaxation. In addition to promoting vascular function, it exhibits potential in inhibiting cancer progression, making it a valuable tool for various research applications in oncology and cardiovascular studies. Its unique structural modifications enable investigations into adenosine's receptor interactions and biological effects, supporting its use in exploring therapeutic avenues. -
Adenosine Analog
N-Propargyladenosine is an adenosine analogue that primarily acts as a vasodilator by targeting adenosine receptors. This compound exhibits significant biological activity, demonstrating potential in inhibiting cancer progression. Additionally, N-Propargyladenosine functions as a click chemistry reagent, containing an alkyne group that allows it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it valuable for various chemical biology applications. -
Purine Nucleotide Analogue
Bredinin aglycone (5-Hydroxy-1H-imidazole-4-carboxamide) is a purine nucleotide analogue that serves as a valuable tool in biochemical research. This compound is utilized to investigate the efficiency of catalytic processes in the synthesis of purine nucleotide analogues, thereby enhancing the understanding of nucleic acid metabolism and associated pathways. Its applications extend to studies in pharmacology and biochemistry, particularly involving nucleotide synthesis and modification. -
Purine Nucleoside Analog
2-Methylthioadenosine is a purine nucleoside analog with significant antitumor activity, primarily targeting indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is used to explore therapeutic strategies for lymphoid malignancies and understand the underlying biochemical pathways involved in tumor development and progression. -
Nucleoside
iBu-rG (N-Isobutyrylguanosine) is a nucleoside compound that serves as a valuable precursor for the synthesis of oligoribonucleotides. It provides enhanced stability and handling properties for RNA research applications. This compound is essential for studies involving RNA processing, transcriptional regulation, and the development of RNA-based therapeutics. -
Purine Nucleoside Analog
2',3'-Dideoxyuridine is a purine nucleoside analog that primarily targets nucleic acid synthesis. It exhibits significant anticancer activity, particularly against indolent lymphoid malignancies, through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. This compound is utilized in research to explore therapeutic strategies for cancer treatment. -
Purine Nucleoside Analog
3'-Deoxyinosine is a purine nucleoside analog that exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound serves as a valuable tool for researchers investigating cancer biology and therapeutic strategies. -
Purine Nucleoside Analog
8-Bromo-2'-deoxyadenosine is a purine nucleoside analog that exerts anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. This compound has demonstrated broad antitumor activity, particularly against indolent lymphoid malignancies. It serves as a valuable tool for research applications related to cancer biology and therapeutic development. -
Adenosine Analog
2-Aminoadenosine is an adenosine analog and a modified adenine base that enhances the stability of RNA duplexes. By forming three hydrogen bonds with uracil, 2-Aminoadenosine increases the melting temperature of hybrid strands, making it a valuable tool for stabilizing uracil-containing RNA structures. This compound is widely utilized in biochemical research, particularly in studies involving RNA structure and function, template-directed nucleotide condensation reactions, and nucleic acid hybridization. -
Modified Uridine
2',3'-O-Isopropylideneuridine is a modified uridine that serves as a valuable tool in virology research. It exhibits antiviral activity, particularly against cytomegalovirus and varicella-zoster virus. This compound is primarily utilized to investigate the mechanisms of viral replication and to develop therapeutic strategies targeting viral infections. -
Purine Nucleoside Analog
3’-Azido-3’-deoxyuridine is a purine nucleoside analog that exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound acts as a click chemistry reagent, featuring an azide functional group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. This versatility makes it valuable for various applications in chemical biology and medicinal chemistry. -
Guanosine Analog
3’-O-(2-Methoxyethyl)guanosine is a guanosine analog that primarily targets Toll-like receptor 7 (TLR7). This compound exhibits immunostimulatory activity and has been shown to induce type I interferons, leading to antiviral effects in various animal models. Its unique biological activity makes it a valuable reagent for research applications related to innate immunity and antiviral response. -
Adenosine Analog
2-Methyladenosine is an adenosine analog that primarily functions as a smooth muscle vasodilator. This compound exhibits significant biological activity, including the potential to inhibit cancer progression. Its applications in research include studies focused on vasodilation, cancer biology, and the broader field of nucleotide signaling pathways. -
Adenosine Analog
3′-O-Methyladenosine is an adenosine analogue that primarily targets adenosine receptors. This compound exhibits significant biological activity as a smooth muscle vasodilator and has also demonstrated potential in inhibiting cancer progression. Its applications extend to various research fields, including cardiovascular studies and oncology, making it a valuable tool for investigating adenosine-related pathways and therapeutic targets. -
Purine Nucleoside Analog
Nebularine is a purine nucleoside analog that exerts its effects primarily through the inhibition of DNA synthesis. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the induction of apoptosis and disruption of cellular replication, making it a valuable tool for cancer research and therapeutic applications. -
Purine Nucleoside Analog
2'-Deoxy-N1-methylguanosine is a purine nucleoside analog that primarily interferes with DNA synthesis. This compound exhibits significant antitumor activity, particularly in indolent lymphoid malignancies, through mechanisms such as apoptosis induction. Its properties make it a valuable tool for research in cancer biology and therapeutic development. -
Derivative Of Guanosine
3′-Deoxyguanosine is a derivative of guanosine that primarily targets human purine nucleoside phosphorylase. This compound interacts through hydrogen bonding with key residues, including Glu201 and Asn243, and exhibits moderate displacement activity for [3H]-guanosine in rat meninges. 3′-Deoxyguanosine is valuable for research focused on the mechanisms of guanosine receptors and the pathways of purine metabolism. -
Purine Nucleoside Analog
3'-Deoxy-3'-fluoroadenosine is a purine nucleoside analogue that targets DNA synthesis in cells. This compound exhibits broad antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting cellular proliferation and inducing apoptosis. Its role in cancer research makes it a valuable tool for studying mechanisms of tumorigenesis and therapeutic response. -
Intermediate
2,2'-Anhydrouridine is a nucleoside analog that serves as a crucial intermediate in the synthesis of various nucleoside-related compounds. Its unique structural properties facilitate the development of novel therapeutic agents in research applications, particularly in the fields of biochemistry and molecular biology. Researchers utilize 2,2'-Anhydrouridine to enhance understanding of nucleoside metabolism and to explore potential drug development pathways. -
Purine Nucleoside Analog
5-Iodo-cytidine is a purine nucleoside analog that exhibits notable antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is essential for studies focused on understanding cancer biology and developing novel therapeutic strategies. -
Purine Nucleoside Analog
5-Hydroxyuridine (OHUrd) is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications aimed at exploring therapeutic strategies in cancer treatment and understanding the molecular mechanisms underlying tumor growth and proliferation. -
Purine Nucleoside Analog
6-O-Methyldeoxyguanosine is a purine nucleoside analog that functions as a DNA adduct. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in cancer biology and therapeutic development. -
Purine Nucleoside Analog
N-Acetyl-2′-deoxycytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to subsequent induction of apoptosis in cancer cells. This compound is valuable for research applications focused on cancer biology and therapeutic development in oncology. -
Purine Nucleoside Analog
2'-Chloro-2'-deoxyadenosine is a purine nucleoside analog that exerts significant antitumor activity, particularly against indolent lymphoid malignancies. This compound mainly functions by inhibiting DNA synthesis and inducing apoptosis in cancer cells, making it a valuable tool for cancer research and therapeutic studies. It is commonly utilized in investigations focused on the mechanisms of tumor growth and the development of novel treatment strategies. -
LNA Analogue
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer utilized for the synthesis of locked nucleic acid (LNA) analog oligonucleotides. This compound enhances hybridization affinity and mismatch discrimination with RNA due to its 2',4'-constrained ethyl modification, which locks the furanose ring in an N-type conformation. Its properties significantly improve resistance to exonuclease digestion and facilitate the formation of stable RNA hybrids that can mediate RNase H-dependent mRNA degradation or inhibit translation. Applications include the development of antisense oligonucleotides for gene expression regulation, gene function research, and the synthesis of oligonucleotides for therapeutic interventions. -
Thymidine Analog
5-Methoxycarbonylmethyl-2'-O-methyluridine is a thymidine analog primarily targeting DNA synthesis. This compound exhibits insertional activity towards replicated DNA, making it an effective tool for cellular labeling and tracking of DNA synthesis. Its unique properties facilitate its application in various molecular biology research contexts, particularly in studies related to nucleic acid metabolism and cell proliferation. -
Purine Nucleoside Analog
5-Methyl-2-thiouridine is a purine nucleoside analogue known for its significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focusing on cancer biology and the development of therapeutic strategies targeting nucleic acid metabolism. -
Nucleic Acid Analog
5'-ODMT cEt G Phosphoramidite is a potent nucleic acid analog that serves as a key reagent for the synthesis of modified oligonucleotides. This compound exhibits effective antisense activity, making it valuable for research applications in gene regulation and therapeutic development. Its structural properties allow for enhanced stability and specificity in nucleic acid interactions. -
Oligonucleotide
DMT-2'-F-iBu-G is a chemically modified oligonucleotide that features a 2'-deoxy-2'-fluoro modification. This structure enhances nuclease resistance while maintaining strong binding affinity to RNA targets. It is valuable for applications in molecular biology research, including RNA interference and antisense oligonucleotide studies. -
Adenosine
Bz-rA (N6-Benzoyladenosine) targets adenosine and serves as a nucleoside derivative featuring an N6 protecting group. This compound is primarily utilized as a synthetic intermediate in photocatalytic oxidative cyclization reactions, facilitating the synthesis of oligoribonucleotides. Bz-rA is effective in constructing heterocyclic skeletons through photochemical conversions and offers protection to the ribose moiety, thereby regulating the cyclization pathway in research applications. -
Nucleoside Analog
N4-Benzoyl-2'-fluoro-2'-deoxycytidine is a nucleoside analog that serves as a building block for nucleic acid synthesis. It exhibits important structural modifications that enhance its utility in the development of nucleotide-based therapeutics and molecular probes. This compound is valuable for research in areas such as antiviral drug design and studies on DNA/RNA interactions. -
Purine Nucleoside Analog
1,3,5-Tri-O-benzoyl-a-D-ribofuranose serves as a purine nucleoside analog, exhibiting significant antitumor activity particularly against indolent lymphoid malignancies. Its primary mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research and therapeutic applications. This compound is crucial for studies aimed at understanding the molecular pathways involved in lymphoid malignancies and developing targeted treatments.
