Fig. 1 · Structure
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5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
Nucleic Acid Analog
5'-ODMT cEt N-Bzm5 C Phosphoramidite is a modified nucleic acid analog that effectively enhances antisense oligonucleotide performance. Through the incorporation of a cEt modification, this reagent promotes the formation of a specific conformation of the furanose ring, which significantly improves hybridization to complementary RNA. Its primary applications include research into gene expression regulation associated with metabolic disorders, cardiovascular diseases, and cancer, as well as the advancement of antisense therapeutic compounds.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1197033-17-2 |
| Applications | Nucleic Acid Analog |
| Formula | C49H56N5O9P |
| Molecular Weight | 889.97 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H]([C@](O[C@H]1C)([H])[C@H](N2C(N=C(C(C)=C2)NC(C3=CC=CC=C3)=O)=O)O4)[C@@]41COC(C5=CC=C(C=C5)OC)(C6=CC=CC=C6)C7=CC=C(C=C7)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.