5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer utilized for the synthesis of locked nucleic acid (LNA) analog oligonucleotides. This compound enhances hybridization affinity and mismatch discrimination with RNA due to its 2',4'-constrained ethyl modification, which locks the furanose ring in an N-type conformation. Its properties significantly improve resistance to exonuclease digestion and facilitate the formation of stable RNA hybrids that can mediate RNase H-dependent mRNA degradation or inhibit translation. Applications include the development of antisense oligonucleotides for gene expression regulation, gene function research, and the synthesis of oligonucleotides for therapeutic interventions.
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer utilized for the synthesis of locked nucleic acid (LNA) analog oligonucleotides. This compound enhances hybridization affinity and mismatch discrimination with RNA due to its 2',4'-constrained ethyl modification, which locks the furanose ring in an N-type conformation. Its properties significantly improve resistance to exonuclease digestion and facilitate the formation of stable RNA hybrids that can mediate RNase H-dependent mRNA degradation or inhibit translation. Applications include the development of antisense oligonucleotides for gene expression regulation, gene function research, and the synthesis of oligonucleotides for therapeutic interventions.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
