Fig. 1 · Structure
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5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
LNA Analogue
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer utilized for the synthesis of locked nucleic acid (LNA) analog oligonucleotides. This compound enhances hybridization affinity and mismatch discrimination with RNA due to its 2',4'-constrained ethyl modification, which locks the furanose ring in an N-type conformation. Its properties significantly improve resistance to exonuclease digestion and facilitate the formation of stable RNA hybrids that can mediate RNase H-dependent mRNA degradation or inhibit translation. Applications include the development of antisense oligonucleotides for gene expression regulation, gene function research, and the synthesis of oligonucleotides for therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1197033-19-4 |
| Applications | LNA Analogue |
| Formula | C49H54N7O8P |
| Molecular Weight | 899.97 |
| SMILES | COC(C=C1)=CC=C1C(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)OC[C@]45[C@H]([C@](O[C@H]5C)([H])[C@H](N6C7=NC=NC(NC(C8=CC=CC=C8)=O)=C7N=C6)O4)OP(OCCC#N)N(C(C)C)C(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.