Nucleoside Antimetabolite/Analog

Items 351-400 of 1704

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  1. Purine Nucleoside Analog

    4’,5’-Didehydro-2’-O-(2-methoxyethyl)uridine is a purine nucleoside analog known for its anticancer properties. It exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool for exploring cancer biology and test therapeutic approaches in research applications.
  2. Purine Nucleoside Analog

    3’-Deoxy-N6-methyladenosine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its molecular mechanism primarily involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research focused on cancer biology and therapeutic approaches targeting nucleoside metabolism.
  3. Purine Nucleoside Analog

    3'-Deoxy-3'-fluoro-beta-D-xylo-inosine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptotic pathways in cancer cells. This compound is valuable for research into cancer therapeutics and mechanisms of purine metabolism.
  4. Sulfur-containing Metabolite

    S-(Indolylmethylthiohydroximoyl)-L-cysteine is a secondary sulfur-containing metabolite associated with glucosinolates. It exhibits significant biological activity relevant to plant defense mechanisms and may play a role in the modulation of enzymatic processes. This compound is valuable for research applications related to metabolomics, phytochemistry, and the study of sulfur metabolism in various biological systems.
  5. Purine Nucleoside Analog

    3’-Azido-N6-benzoyl-3’-deoxyadenosine is a purine nucleoside analog that exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. This compound is also a versatile click chemistry reagent, containing an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules featuring alkyne, DBCO, or BCN groups. Its unique properties make it valuable for various biochemical and molecular biology applications.
  6. Purine Nucleoside Analog

    3’-Deoxy-3-deazauridine is a purine nucleoside analogue that effectively targets indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to the induction of apoptosis in cancer cells. This compound shows promise in various anticancer research applications, particularly in studying treatments for hematological malignancies.
  7. Uridine Analog

    2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite is a uridine analog that targets nucleotide synthesis pathways. This compound exhibits potential antiepileptic properties, making it a useful tool for investigating anticonvulsant and anxiolytic activities. Additionally, it may contribute to the development of novel antihypertensive agents in chemical research applications.
  8. Purine Nucleoside Analog

    N6-Benzoyl-7’-OH-N-trityl morpholino adenine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound can be utilized to study the therapeutic potential and cellular pathways associated with purine metabolism and tumorigenesis.
  9. Purine Nucleoside Analog

    5-Carboxymethyl-2-thiouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis. This compound is primarily utilized in cancer research and therapeutic studies focused on lymphoid malignancies.
  10. Thymidine Analog

    3’-beta-C-Methyl-5-methyluridine is a thymidine analogue that acts as a nucleotide substrate. This compound exhibits insertional activity towards replicated DNA, making it useful for labeling cells and investigating DNA synthesis dynamics. It has potential applications in molecular biology and cancer research, facilitating studies on nucleic acid behavior and cellular proliferation.
  11. Nucleoside Metabolite

    Docosanoyl-CoA is a nucleoside metabolite involved in lipid metabolism. This compound plays a crucial role in the biosynthesis of fatty acids and serves as an acyl donor in various metabolic reactions. It is useful for research applications focused on fatty acid synthesis and metabolic pathways in cellular biology.
  12. Purine Nucleoside Analog

    Uridine 5-oxyacetic acid methyl ester is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is useful for studies exploring novel therapeutic strategies and understanding the pathways involved in tumor cell proliferation and survival.
  13. Purine Nucleoside Analog

    3',5'-Di-O-acetyl-2'-O-methyl-6-chloro-2-aminopurine riboside is a purine nucleoside analog that exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. This compound functions by inhibiting DNA synthesis and inducing apoptosis, contributing to its efficacy in cancer research. Its utilization in studies targeting cancer cell proliferation makes it a valuable tool for investigating therapeutic strategies in oncology.
  14. Nucleoside Metabolite

    N2-Succinyl-L-ornithine is a nucleoside metabolite that serves as an intermediate in the urea cycle and plays a role in nitrogen metabolism. This compound is significant for studying metabolic pathways and can be utilized in research related to amino acid metabolism and enzyme regulation. Its biochemical properties make it valuable for investigations into cellular metabolism and potential therapeutic applications in metabolic disorders.
  15. Purine Nucleoside Analog

    N3-Ethyl pseudouridine is a purine nucleoside analogue that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research into cancer therapies targeting nucleoside metabolism and cellular proliferation.
  16. Purine Nucleoside Analog

    N2-iBu-5’-O-DMTr-2’-O-hexadecanyl guanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound functions by inhibiting DNA synthesis and inducing apoptosis, contributing to its effectiveness in cancer research. It serves as a valuable tool for studying the mechanisms of cancer biology and evaluating potential therapeutic strategies in oncology.
  17. Nucleoside Metabolite

    L-Selenocystathionine is a seleno amino acid metabolite that participates in the synthesis and regulation of various biological molecules. Its primary mechanism involves the involvement in sulfur metabolism, acting as a precursor in the generation of selenium-containing compounds. This compound is of interest in research applications related to oxidative stress and sulfur metabolism in cells.
  18. Purine Nucleoside Analog

    N6-(3-Trifluoromethylbenzyl)-3’-deoxyadenosine is a purine nucleoside analog known for its significant antitumor activity. This compound targets indolent lymphoid malignancies, employing mechanisms such as inhibition of DNA synthesis and induction of apoptosis. Its efficacy makes it a valuable tool for research in cancer biology and therapeutic development.
  19. Purine Nucleoside Analog

    2’,3’,5’-Tri-O-benzoyl-2’-β-C-methyl-5-fluorouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool in cancer research, providing insights into therapeutic strategies targeting nucleoside metabolism and cancer cell proliferation.
  20. Purine Nucleoside Analog

    2′,5′-Dideoxy-5′-iodouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is suitable for research applications focused on cancer treatment development and the exploration of nucleoside analogs in therapeutic strategies.
  21. Nucleoside Metabolite

    N-Methylethanolamine phosphate is a nucleoside metabolite that plays a crucial role in cellular signaling and metabolism. It is involved in various biochemical pathways, including those related to phospholipid synthesis and membrane dynamics. This compound can be utilized in research focused on metabolic studies, cell signaling, and the elucidation of nucleoside functions in physiological processes.
  22. Thymidine Analog

    5-Hydroxymethyl xylouridine is a thymidine analog that exhibits insertional activity towards replicated DNA. As a biolabeling agent, it enables the tracking of DNA synthesis in both cellular and molecular research applications. This compound is particularly useful for studies involving nucleic acid metabolism and cellular proliferation.
  23. Purine Nucleoside Analog

    3’-dC(Bz)-2’-phosphor amidite is a purine nucleoside analog that exhibits significant biological activity in anticancer research. This compound primarily functions by inhibiting DNA synthesis and inducing apoptosis, making it a valuable tool for targeting indolent lymphoid malignancies. Its role in cancer therapeutics underscores its potential for advancing research in oncology and related fields.
  24. Purine Nucleoside Analog

    3',5'-Di-O-benzoyl thymidine is a purine nucleoside analog that exerts its biological activity through the inhibition of DNA synthesis and the induction of apoptosis. This compound demonstrates broad anticancer potential, particularly in the treatment of indolent lymphoid malignancies. Its applications in chemical research make it a valuable tool for studying mechanisms of cancer cell proliferation and therapeutic resistance.
  25. Histidine Precursor

    Imidazole-4-pyruvic acid is a biologically relevant precursor of histidine, generated through the action of histidine transaminase. This compound serves as a valuable reagent for selective histidine labeling in proteins overexpressed in E. coli, facilitating the study of protein structure and function. Its application in research enables precise manipulation of proteins for various biochemical and biophysical analyses.
  26. Nucleoside Metabolite

    Haemulcholic acid is a nucleoside metabolite that plays an essential role in nucleotide metabolism. It has demonstrated potential biological activity in regulating cellular energy homeostasis and influencing metabolic pathways. This compound is useful in research applications focused on cellular metabolism, signaling pathways, and the pharmacological effects of nucleosides.
  27. Purine Nucleoside Analog

    3’-Deoxy-3’-fluoro-5-trifluoromethyluridine is a purine nucleoside analogue that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to the induction of apoptosis in cancer cells. This compound is valuable for research aimed at understanding the molecular mechanisms of cancer and developing novel therapeutic strategies.
  28. Purine Nucleoside Analog

    2'-Deoxy-2'-fluoro-N3-(4-nitrobenzyl)-beta-D-arabinouridine is a purine nucleoside analog that exerts significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound facilitates investigations into nucleoside metabolism and the efficacy of chemotherapeutic strategies.
  29. GTP Analog

    3'-O-Bn-GTP (3'-O-Benzyl-5'-O-guanosine triphosphate) is a GTP analog designed for enhanced stability against esterases. This compound is useful in biochemical research involving GTP-binding proteins and signal transduction pathways. Its resistance to hydrolysis makes it a valuable tool for studies that require prolonged activity and effective interactions in nucleotide-dependent processes.
  30. Purine Nucleoside Analog

    2'-Deoxy-6-O-methylinosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is suitable for studies exploring the therapeutic potential of nucleoside analogs in oncology.
  31. Purine Nucleoside Analog

    2-Chloro-N6-iso-pentenyladenosine is a purine nucleoside analog that serves as a potent inhibitor of DNA synthesis. Its primary biological activity includes the induction of apoptosis, making it effective in targeting indolent lymphoid malignancies. This compound is valuable for research applications focused on cancer therapeutics and the investigation of nucleoside analogs in oncological studies.
  32. Purine Nucleoside Analog

    4-Deoxy-xylo-uridine is a purine nucleoside analog that exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. This compound functions primarily by inhibiting DNA synthesis and inducing apoptosis in cancer cells. It is utilized in research applications focused on understanding cellular mechanisms of cancer and exploring potential therapeutic strategies.
  33. Purine Nucleoside Analog

    N6,N6-Dimethyl-4’-thio-adenosine is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its anticancer effects are primarily mediated through the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool for research applications in cancer biology and therapeutic development.
  34. Purine Nucleoside Analog

    4-Methoxy-1-β-D-ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidin-6-amine functions as a purine nucleoside analog. This compound exhibits significant antitumor activity, specifically targeting indolent lymphoid malignancies through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. Its application in cancer research makes it a valuable tool for investigating therapeutic strategies in oncology.
  35. Nucleoside Metabolite

    Allochenodeoxycholic acid is a nucleoside metabolite that plays a crucial role in lipid metabolism and signaling pathways. This compound participates in the modulation of bile acid homeostasis and has implications in hepatic function and gastrointestinal health. Its unique biological activity makes it a valuable reagent for research in metabolic disorders and liver-related studies.
  36. Cytidine Analog

    DMT-2'-F-Bz-dC is a cytidine analog that functions as an inhibitor of DNA methyltransferases, which are critical in the regulation of DNA methylation. This compound exhibits potential anti-metabolic and anti-tumor activities, making it valuable for research in epigenetics and cancer biology. Its unique structure allows for investigation into the dynamics of nucleic acid modifications and their implications in cellular processes.
  37. Purine Nucleoside Analog

    1-[6-Phosphono-2-O-methyl-β-D-ribo-hexofuranosyl]uracil is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound functions primarily by inhibiting DNA synthesis and inducing apoptosis in cancer cells. Its mechanisms of action make it a valuable tool for research in oncology and for investigating therapeutic strategies in hematological malignancies.
  38. Purine Nucleoside Analog

    7-(2,3-Anhydro-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its anticancer effects are primarily mediated through the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research into therapeutic strategies for hematological cancers and for understanding the mechanisms underlying nucleoside analog efficacy.
  39. Purine Nucleoside Analog

    1,9-Dihydro-9-β-D-xylofuranosyl-6H-purin-6-one is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its primary mechanism includes the inhibition of DNA synthesis, leading to the induction of apoptosis in cancer cells. This compound serves as a valuable tool for research focused on cancer therapeutics and the exploration of novel treatment strategies in oncology.
  40. Purine Nucleoside Analog

    5-Methoxy-2-thiouridine is a purine nucleoside analogue that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve inhibition of DNA synthesis and the induction of apoptosis. This compound serves as an important tool in cancer research, helping to elucidate the pathways associated with tumor growth and treatment resistance.
  41. Purine Nucleoside Analog

    N2-(Isopropylphenoxyacetyl)-2'-O-propargylguanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as a click chemistry reagent, featuring an alkyne moiety that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it a versatile tool for chemical biology applications.
  42. Purine Nucleoside Analog

    5’-O-TBDPS-5-methyl-2,2’-anhydrouridine is a purine nucleoside analog that exhibits significant antitumor activity. It primarily targets indolent lymphoid malignancies through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. This compound is a valuable tool in cancer research, aiding in the development of therapeutic strategies for treating specific malignancies.
  43. Oxidation Product of DHICA

    5,6-Indolequinone-2-carboxylic acid is an oxidation product of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and serves as a potential biomarker in melanogenesis research. It exhibits important biological activity related to oxidative stress and may influence melanin synthesis pathways. This compound can be utilized in studies exploring skin pigmentation mechanisms and the effects of oxidative agents on cellular processes.
  44. Purine Nucleoside Analog

    2’,3’,5’-Tri-O-benzoyl-5-methoxyuridine is a purine nucleoside analog that plays a pivotal role in cancer research. This compound exhibits significant antitumor activity, particularly in targeting indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for elucidating therapeutic pathways in cancer biology.
  45. Nucleoside Metabolite

    N-Acetyl-L-glutamate 5-phosphate is a nucleoside metabolite produced via the phosphorylation of N-acetyl-L-glutamate by the enzyme N-acetyl-L-glutamate kinase (NAGK). This compound plays a crucial role in amino acid metabolism and is involved in the regulation of nitrogen metabolism. It serves as a valuable tool for researchers studying metabolic pathways and enzyme functions in cellular processes.
  46. Thymidine Analog

    5-Azidomethyl-2'-beta-methyl-2',3',5'-tri-O-benzoyluridine is a thymidine analog that displays insertional activity towards replicated DNA, making it valuable for cell labeling and the tracking of DNA synthesis. This compound features an azide functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, facilitating its use in bioorthogonal labeling applications.
  47. Adenosine Analog

    5’-O-(4,4’-Dimethoxytrityl)-2’-beta-C-methyl adenosine is an adenosine analog that primarily acts as a smooth muscle vasodilator. This compound exhibits significant biological activities, including the inhibition of cancer progression. It serves as a valuable tool in research applications related to cardiovascular research, cancer therapies, and the study of adenosine receptor signaling pathways.
  48. Purine Nucleoside Analog

    2-Chloro-N6-isopropyladenosine is a purine nucleoside analog that functions by interfering with nucleic acid synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by promoting apoptosis and inhibiting DNA synthesis. It is a valuable reagent for research applications aimed at understanding cancer biology and developing novel therapeutic strategies.
  49. Purine Nucleoside Analog

    3’-O-Methyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research applications. This reagent is useful for studies focused on the therapeutic potential of purine analogs in oncology.
  50. Guanosine Analog

    8-(Methylthio)guanosine is a guanosine analog that acts primarily as an immunostimulatory agent. This compound has demonstrated the ability to induce type I interferons in various animal models, resulting in notable antiviral effects. The biological activity of 8-(Methylthio)guanosine is closely linked to the activation of Toll-like receptor 7 (TLR7), making it a valuable tool in research related to antiviral therapies and immune response modulation.

Items 351-400 of 1704

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