5-Azidomethyl-2'-beta-methyl-2',3',5'-tri-O-benzoyluridine is a thymidine analog that displays insertional activity towards replicated DNA, making it valuable for cell labeling and the tracking of DNA synthesis. This compound features an azide functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, facilitating its use in bioorthogonal labeling applications.
5-Azidomethyl-2'-beta-methyl-2',3',5'-tri-O-benzoyluridine is a thymidine analog that displays insertional activity towards replicated DNA, making it valuable for cell labeling and the tracking of DNA synthesis. This compound features an azide functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, facilitating its use in bioorthogonal labeling applications.
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