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N2-(Isopropylphenoxyacetyl)-2’-O-propargylguanosine

Purine Nucleoside Analog

N2-(Isopropylphenoxyacetyl)-2'-O-propargylguanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as a click chemistry reagent, featuring an alkyne moiety that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it a versatile tool for chemical biology applications.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2095417-23-3
Applications	Purine Nucleoside Analog
Formula	C₂₄H₂₇N₅O₇
Molecular Weight	497.50
SMILES	OC[C@@H]1[C@@H](O)[C@@H](OCC#C)[C@H](N2C(NC(NC(COC3=CC=C(C(C)C)C=C3)=O)=NC4=O)=C4N=C2)O1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.