Fig. 1 · Structure
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endo-BCN-PEG2-NH2
PROTAC Linker
endo-BCN-PEG2-NH2 is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTAC molecules. It features a bicyclo[6.1.0]nonyne (BCN) group, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-bearing compounds. This linker is pivotal for advancing research in targeted protein degradation and optimizing the pharmacological profiles of novel therapeutic agents. Its utility in PROTAC development makes it an essential tool for scientists exploring innovative approaches in drug discovery and cellular regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1263166-93-3 |
| Applications | PROTAC Linker |
| Formula | C17H28N2O4 |
| Molecular Weight | 324.42 |
| SMILES | NCCOCCOCCNC(OC[C@H]1[C@@]2([H])CCC#CCC[C@@]12[H])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.