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Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas) .Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells.
Targets
| DNA polymerase α | DNA polymerase δ | |||
| 1.1 μM(Ki ) | 1.3 μM(Ki) |
| In vitro (25°C) | DMSO | 66 mg/mL (180.71 mM) | |
| Water | Warmed: 2 mg/mL (5.47 mM) | ||
| Ethanol | Insoluble | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.38 mL | 136.91 mL | 273.82 mL |
| 0.5 mM | 5.48 mL | 27.38 mL | 54.76 mL |
| 1 mM | 2.74 mL | 13.69 mL | 27.38 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.48 mL |
*The above data is based on the productmolecular weight 365.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10395 |
|---|---|
| CAS No. | 75607-67-9 |
| Formula | C10H13FN5O7P |
| M. Wt | 365.2 |
| Purity | >98% |
| SMILES | O[[email protected]]1[[email protected]](O)[[email protected]](O[[email protected]]1n1cnc2c1nc(F)nc2N)COP(=O)(O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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