Gefitinib-based PROTAC 3

Catalog No.: A19093

Gefitinib-based PROTAC 3

Gefitinib-based PROTAC 3 Chemical Structure

CAS NO. 2230821-27-7

Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.

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Package Price Qty
5 mg
$270.00
10 mg
$465.00
50 mg
$1,380.00
100 mg
$2,760.00
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Biological Activity

Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.7 mL 53.5 mL 107.01 mL
0.5 mM 2.14 mL 10.7 mL 21.4 mL
1 mM 1.07 mL 5.35 mL 10.7 mL
5 mM 0.21 mL 1.07 mL 2.14 mL

*The above data is based on the productmolecular weight 934.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A19093
M. Wt 934.51
Formula C47H57ClFN7O8S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2230821-27-7
SMILES O=C([[email protected]]1N(C([[email protected]@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC)=O)C(C)(C)C)=O)C[[email protected]](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

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