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- Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
- Mansi Srivastava, .et al. Inhibition of the TIRAP-c-Jun interaction as a therapeutic strategy for AP1-mediated inflammatory responses, Int Immunopharmacol, 2019, 71: 188-197 PMID: 30909134
Biological Activity
Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.
Targets
Tyr1173 (NR6W cells) | Tyr1173 (NR6wtEGFR cells) | Tyr992 (NR6wtEGFR cells) | Tyr992 (NR6W cells) | |
26 nM | 37 nM | 37 nM | 57 nM |
In vitro (25°C) | DMSO | 80 mg/mL (179 mM) | |
Water | Insoluble | ||
Ethanol | 4 mg/mL (8.95 mM) | ||
In vivo | 1% CMC Na | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.38 mL | 111.88 mL | 223.76 mL |
0.5 mM | 4.48 mL | 22.38 mL | 44.75 mL |
1 mM | 2.24 mL | 11.19 mL | 22.38 mL |
5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
*The above data is based on the productmolecular weight 446.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10422 |
---|---|
Actions | Inhibitor |
CAS No. | 184475-35-2 |
Formula | C22H24ClFN4O3 |
M. Wt | 446.9 |
Purity | >98% |
Synonyms | ZD-1839 |
SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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