Gefitinib (Iressa)

Name: Gefitinib (Iressa)
Brand: Adooq Bioscience
SKU: A10422
Rating: 100 (2 reviews)

Catalog No.: A10422

EGFR Inhibitor

Product Citations (2)

Gefitinib (Iressa) Chemical Structure

CAS NO. 184475-35-2

Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.

Availability: In stock

Package	Price	Qty
100 mg	$40.00
250 mg	$50.00
500 mg	$60.00
10mM * 1mL in DMSO	$50.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Gefitinib (Iressa)

Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
Mansi Srivastava, .et al. Inhibition of the TIRAP-c-Jun interaction as a therapeutic strategy for AP1-mediated inflammatory responses, Int Immunopharmacol, 2019, 71: 188-197 PMID: 30909134

Biological Activity

Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.

Targets

Tyr1173 (NR6W cells)	Tyr1173 (NR6wtEGFR cells)	Tyr992 (NR6wtEGFR cells)	Tyr992 (NR6W cells)
26 nM	37 nM	37 nM	57 nM

Solubility *

In vitro (25°C)	DMSO	80 mg/mL (179 mM)
	Water	Insoluble
	Ethanol	4 mg/mL (8.95 mM)
In vivo	1% CMC Na	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.38 mL	111.88 mL	223.76 mL
0.5 mM	4.48 mL	22.38 mL	44.75 mL
1 mM	2.24 mL	11.19 mL	22.38 mL
5 mM	0.45 mL	2.24 mL	4.48 mL

*The above data is based on the productmolecular weight 446.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10422
Actions	Inhibitor
CAS No.	184475-35-2
Formula	C22H24ClFN4O3
M. Wt	446.9
Purity	>98%
Synonyms	ZD-1839
SMILES	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.