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$0.00 - Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
- Mansi Srivastava, .et al. Inhibition of the TIRAP-c-Jun interaction as a therapeutic strategy for AP1-mediated inflammatory responses, Int Immunopharmacol, 2019, 71: 188-197 PMID: 30909134
Biological Activity
Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.
Targets
| Tyr1173 (NR6W cells) | Tyr1173 (NR6wtEGFR cells) | Tyr992 (NR6wtEGFR cells) | Tyr992 (NR6W cells) | |
| 26 nM | 37 nM | 37 nM | 57 nM |
| In vitro (25°C) | DMSO | 89 mg/mL (199.14 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 4 mg/mL (8.95 mM) | ||
| In vivo | 0.5% methylcellulose/0.2% Tween 80 | 12 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.38 mL | 111.88 mL | 223.76 mL |
| 0.5 mM | 4.48 mL | 22.38 mL | 44.75 mL |
| 1 mM | 2.24 mL | 11.19 mL | 22.38 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
*The above data is based on the productmolecular weight 446.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10422 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 446.9 |
| Formula | C22H24ClFN4O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 184475-35-2 |
| Synonyms | ZD-1839 |
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4 |
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