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Gefitinib (Iressa)

Catalog No.: A10422

EGFR Inhibitor

Gefitinib (Iressa)

Gefitinib (Iressa) Chemical Structure

CAS NO. 184475-35-2

Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.

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100 mg
250 mg
500 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
  • Mansi Srivastava, .et al. Inhibition of the TIRAP-c-Jun interaction as a therapeutic strategy for AP1-mediated inflammatory responses, Int Immunopharmacol, 2019, 71: 188-197 PMID: 30909134

Biological Activity

Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.
Tyr1173 (NR6W cells) Tyr1173 (NR6wtEGFR cells) Tyr992 (NR6wtEGFR cells) Tyr992 (NR6W cells)
26 nM37 nM37 nM57 nM
In vitro (25°C) DMSO 80 mg/mL (179 mM)
Water Insoluble
Ethanol 4 mg/mL (8.95 mM)
In vivo 1% CMC Na 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.38 mL 111.88 mL 223.76 mL
0.5 mM 4.48 mL 22.38 mL 44.75 mL
1 mM 2.24 mL 11.19 mL 22.38 mL
5 mM 0.45 mL 2.24 mL 4.48 mL

*The above data is based on the productmolecular weight 446.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10422
Actions Inhibitor
CAS No. 184475-35-2
Formula C22H24ClFN4O3
M. Wt 446.9
Purity >98%
Synonyms ZD-1839

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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