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Biological Activity
Gefitinib hydrochloride is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells. Therefore, it is only effective in cancers with mutated and overactive EGFR.
| In vitro | DMSO | 7 mg/mL (14.48 mM) | |
| Water | 1 mg/mL (2.06 mM) | ||
| Ethanol | 1 mg/mL (2.06 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.69 mL | 103.44 mL | 206.89 mL |
| 0.5 mM | 4.14 mL | 20.69 mL | 41.38 mL |
| 1 mM | 2.07 mL | 10.34 mL | 20.69 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.14 mL |
*The above data is based on the productmolecular weight 483.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15093 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 184475-55-6 |
| Formula | C22H25Cl2FN4O3 |
| M. Wt | 483.36 |
| Purity | >98% |
| Synonyms | Iressa hydrochloride, ZD 1839 hydrochloride, ZD-1839 hydrochloride, ZD1839 hydrochloride |
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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