Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
3-Demethylcolchicine is an anti-inflammatory agent known for its potent tubulin-binding activity. This colchicine metabolite effectively inhibits carrageenan-induced edema in rat paw models, making it valuable for research into inflammatory responses. Additionally, the presence of a hydroxyl group on its carbocyclic ring enhances its ability to scavenge free radicals, contributing to its therapeutic potential. 3-Demethylcolchicine serves as a key reagent in studies focused on inflammation and oxidative stress. -
COX-2 Inhibitor
Hexahydrocurcumin is a selective, orally active inhibitor of cyclooxygenase-2 (COX-2), demonstrating significant potential in anti-inflammatory applications. As one of the primary metabolites of curcumin, it exhibits antioxidant and anticancer properties, making it relevant for research in various therapeutic areas. Its selectivity towards COX-2 over COX-1 highlights its potential for minimizing gastrointestinal side effects often associated with non-steroidal anti-inflammatory drugs (NSAIDs). -
Nrf2 Activator
Nrf2 activator-4 is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 µM. This compound effectively suppresses reactive oxygen species related to oxidative stress in microglial cells. Additionally, Nrf2 activator-4 demonstrates the ability to recover learning and memory impairments in a scopolamine-induced mouse model, making it a valuable tool for research focused on neuroprotection and cognitive function. -
KEAP1-NRF2 Inhibitor
Keap1-Nrf2-IN-14 is a potent inhibitor of the KEAP1-NRF2 interaction, exhibiting an IC50 value of 75 nM and a Kd of 24 nM for KEAP1. This compound promotes the expression of NRF2 target genes, resulting in enhanced antioxidant and anti-inflammatory responses. Keap1-Nrf2-IN-14 is valuable for investigating oxidative stress-related inflammation and exploring therapeutic strategies targeting the KEAP1-NRF2 signaling pathway. -
Anti-inflammatory compound
U-83836E is an anti-inflammatory compound that exhibits both anti-inflammatory and antioxidant activities. It effectively reduces lung inflammation by inhibiting oxidative stress and the production of reactive oxygen species (ROS). This compound is valuable for research applications focused on asthma and lung inflammation in various animal models. -
Anti-inflammatory Agent
Kumujian A (1-Ethoxycarbonyl-β-carboline) is an anti-inflammatory agent that effectively inhibits superoxide anion generation with an IC50 of 4.87 μg/mL and elastase release with an IC50 of 6.29 μg/mL. This compound is valuable for research applications focused on understanding inflammation pathways and developing potential therapeutic strategies for inflammatory diseases. -
Nonsteroidal Anti-inflammatory Agent
Feprazone is a nonsteroidal anti-inflammatory agent that targets cyclooxygenase-2 (COX-2), exhibiting significant analgesic and antipyretic properties. This compound has been shown to mitigate oxidative stress induced by free fatty acids by reducing mitochondrial reactive oxygen species (ROS) production. Additionally, Feprazone inhibits the expression of matrix metalloproteinases MMP-2 and MMP-9, while suppressing adipogenesis and promoting lipolysis in differentiating 3T3-L1 adipocytes. It is valuable for research applications focused on atherosclerosis and obesity. -
Anti-Inflammatory Compound
Dapsone hydroxylamine (DDS-NOH) is an anti-inflammatory compound that primarily targets catalase (CAT) activity. It inhibits CAT activity and reduces the generation of reactive oxygen species, contributing to its anti-inflammatory properties. Dapsone hydroxylamine is utilized in research applications focused on oxidative stress and inflammation modulation. -
Anti-Neuroinflammatory Agent
LZWL02003 is an anti-neuroinflammatory agent that targets neuroinflammatory pathways. It demonstrates protective effects against MPP+-induced neuronal damage and significantly reduces reactive oxygen species (ROS) levels. Additionally, LZWL02003 enhances cognitive functions such as memory, learning, and physical performance in a Rotenone-induced parkinsonism model in rats. This compound is valuable for research into neurodegenerative diseases and potential therapeutic interventions. -
Anti-inflammatory Agent
3′-Oxolutein is an anti-inflammatory agent and a metabolite of dietary lutein. It effectively reduces glutamate-induced reactive oxygen species (ROS) production and pro-inflammatory cytokine secretion in SH-SY5Y cells. Additionally, 3′-Oxolutein decreases glutamate-induced iron levels while enhancing thiol concentrations. This compound is suitable for research focused on inflammation and oxidative stress responses. -
Anti-inflammatory Agent
Pholidotol C is a stilbene compound that serves as an anti-inflammatory agent by inhibiting nitric oxide (NO) production. It demonstrates significant antioxidant properties, with IC50 values of 28.6 μM for NO production and 21.9 μM for DPPH free radical scavenging. Pholidotol C's mechanisms include the inhibition of NO production in activated macrophages and effective free radical scavenging. This compound is valuable for research in inflammation-related diseases and can be extracted from the dried whole plant of Pholidota chinensis. -
COX-2 Inhibitor
COX-2-IN-65 is a selective inhibitor of cyclooxygenase-2 (COX-2) with a reported IC50 of 10.24 μM. This compound exhibits antibacterial activity against Staphylococcus aureus and Escherichia coli, while also scavenging reactive oxygen species (ROS). COX-2-IN-65 is valuable for research applications focused on bacterial infections and inflammation pathways. -
Anti-inflammatory Agent
Anti-inflammatory agent 21 is an orally active compound that targets the inflammatory response through its inhibitory effects on nitric oxide production, demonstrating an IC50 value of 0.76 μM. This agent induces reactive oxygen species accumulation and effectively blocks the NF-κB/MAPK signaling pathway. Research applications include investigating its potential to mitigate cartilage destruction and reduce inflammatory cell infiltration in models of arthritis. -
CD47 Agonist Peptide
Cys-PKHB1 is a CD47 agonist peptide designed to mimic thrombospondin-1. This compound has demonstrated antitumor efficacy by inducing mitochondrial alterations, the generation of reactive oxygen species (ROS), and calcium-dependent cell death in breast cancer cells. Cys-PKHB1 also promotes immune activation through immunogenic cell death, making it a valuable tool for research in cancer immunotherapy and tumor biology. -
ROS Inhibitor
Picrasidine A is a potent reactive oxygen species (ROS) inhibitor derived from the natural product Picrasma quassioides. This compound demonstrates the ability to inhibit UVB-induced ROS generation, making it a valuable tool for research in oxidative stress and related cellular responses. Its applications extend to studies investigating the protective effects against UV radiation and the underlying mechanisms of antioxidative pathways. -
FKBP51-Hsp90 Interaction Inhibitor
FKBP51-Hsp90-IN-1 is a selective inhibitor targeting the FKBP51-Hsp90 protein-protein interaction, exhibiting an IC50 value of 0.1 μM against FKBP51. This compound is valuable for research into stress-related diseases, Alzheimer's disease, and various metabolic disorders, owing to its ability to modulate protein interactions critical for cellular stress responses and stability. Its specificity makes it a potent tool for elucidating the role of FKBP51 in disease mechanisms. -
FKBP51-Hsp90 Inhibitor
FKBP51-Hsp90-IN-2 is a selective inhibitor of the FKBP51-Hsp90 protein-protein interaction, demonstrating IC50 values of 0.4 µM for FKBP51 and 5 µM for FKBP52. This compound has been shown to enhance cellular energy metabolism and promote neurite growth. Its efficacy makes FKBP51-Hsp90-IN-2 a valuable tool in research focused on neurodegenerative diseases and cancer. -
Inflammatory Biomarker
8-Bromo-2'-deoxyguanosine is a halogenated DNA adduct associated with inflammation, serving as an early biomarker for oxidative tissue damage linked to inflammatory processes. Its formation precedes the generation of other oxidative and nitrative stress products and can be synthesized through the MPO-H2O2-Cl−-Br− system. This compound plays a critical role in detecting early DNA modifications using the monoclonal antibody mAb8B3, suitable for preclinical research. Additionally, its urinary levels are significantly elevated in various inflammatory disease models, making 8-Bromo-2'-deoxyguanosine valuable for investigations into inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin injuries. -
Anti-Inflammatory Agent
Vitisin A is a resveratrol tetramer with potent anti-inflammatory properties. It exerts its biological activity by inhibiting LPS-induced nitric oxide (NO) and inducible nitric oxide synthase (iNOS) production through the down-regulation of ERK1/2, p38, and NF-κB signaling pathways. Additionally, Vitisin A demonstrates antioxidative, anticancer, and neuroprotective effects while also inhibiting adipocyte differentiation. This compound is derived from the roots of Vitis vinifera and serves as a valuable reagent for research in inflammation and related diseases. -
Antagonist
Peptide E5 is an antagonist that targets the CXCR4/CXCL12 signaling axis. By blocking this interaction, Peptide E5 downregulates CXCR4 expression and inhibits the phosphorylation of key downstream proteins, Akt and Erk, leading to apoptosis in breast cancer cells. Additionally, Peptide E5 suppresses cellular migration and adhesion, as well as the recruitment of endothelial progenitor cells, thereby inhibiting tumor angiogenesis. This peptide is a valuable tool for research related to breast cancer and tumor microenvironment interactions. -
CXCR4 Antagonist
Peptide R analogue 10 is a potent CXCR4 antagonist, demonstrating enhanced antagonistic activity, specificity, and plasma stability compared to its predecessor, Peptide R. This compound effectively inhibits CXCL12-mediated cell migration, ERK phosphorylation, and CXCR4 internalization. Peptide R analogue 10 is valuable for research applications involving CXCR4 overexpression in models of leukemia and colon cancer. -
KRAS(Q61H) Inhibitor
RM-046 is a selective inhibitor targeting the KRAS(Q61H) mutant, functioning through the formation of a ternary complex with cyclophilin A. This compound non-covalently binds to activated KRASQ61H, obstructing effector binding and thereby inhibiting downstream signal transduction pathways. RM-046 has demonstrated efficacy in suppressing ERK phosphorylation, stalling cancer cell proliferation, and promoting anti-tumor activity, including tumor regression in preclinical xenograft studies. It serves as a valuable tool for investigating KRASQ61H-associated malignancies. -
Anti-inflammatory Agent
24-O-Acetyllycoclavanol is a triterpenoid compound that functions as an anti-inflammatory agent by selectively targeting the NF-κB and ERK1/2 signaling pathways. Its biological activity includes the inhibition of lipopolysaccharide (LPS)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to decreased production of inflammatory mediators like nitric oxide (NO), IL-1β, and IL-8. This compound is particularly relevant for research applications in the context of inflammatory bowel disease (IBD) and can be isolated from the ethyl acetate extract of Lycopodium clavatum. -
FAP Inhibitor
BR103354 is a selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 14 nM against human FAP. It effectively restores levels of phosphorylated ERK and Glut1, reduces non-fasting blood glucose concentrations, and enhances glucose tolerance, while also decreasing hepatic triglyceride content. This compound demonstrates potential in alleviating hepatic steatosis and fibrosis, making it a valuable tool for research into type 2 diabetes and non-alcoholic steatohepatitis. -
Anti-inflammatory Agent
Anti-inflammatory agent 31 is a derivative of andrographolide that functions primarily by inhibiting NF-κB activation through the upstream blockade of the PI3K/Akt and ERK1/2 MAPK signaling pathways. This compound exhibits notable anti-inflammatory activity, promoting the recovery of intracellular glutathione (GSH) levels. Additionally, anti-inflammatory agent 31 demonstrates a protective effect on liver cells, making it a valuable tool for research applications in inflammation and hepatoprotection. -
Antioxidant/Anti-inflammatory/Anticancer Agent
Licoflavanone, a flavanone with antioxidant, anti-inflammatory, and anticancer properties, is isolated from the leaf extract of Glycyrrhiza glabra. It exerts its anticancer effects by downregulating the mTOR/PI3K/AKT signaling pathway, leading to inhibition of cancer cell proliferation, migration, and invasion. Additionally, Licoflavanone activates pro-apoptotic factors such as Bax and Bad, along with multiple caspase enzymes. Its anti-inflammatory activity involves reducing NF-κB nuclear translocation and decreasing the phosphorylation of p38, JNK, and ERK1/2, ultimately inhibiting pro-inflammatory cytokines, COX-2, and iNOS expression. This compound is utilized in research on nasopharyngeal carcinoma and its underlying mechanisms. -
Anti-inflammatory Agent
Centaureidin is an orally active anti-inflammatory agent derived from Bidens pilosa, exhibiting an EC50 of 0.9 μg/mL as an IFN-promoter. This compound activates the Rho signaling pathway, resulting in actin and tubulin disassembly, which leads to dendritic retraction and the formation of stress fibers in melanocytes. Centaureidin demonstrates potent inhibitory effects on tumor cell growth and has been shown to significantly reduce paw edema in murine models, highlighting its potential utility in inflammatory and anticancer research. -
Multiple Target PROTAC
GT19630 is a multiple target PROTAC designed to degrade c-MYC, CK1α, GSPT1, and IKZF1/2/3 proteins. This compound effectively targets and reduces the levels of these proteins in various tumor cell lines, making it a valuable tool for studying diseases characterized by high c-MYC expression, including cancer, cardiovascular disorders, cerebrovascular diseases, and viral infections. Researchers can utilize GT19630 to further investigate the therapeutic potential of protein degradation in relevant biological contexts. -
IKZF2/CK1α Molecule Glue
DEG-35 is a CRBN-dependent dual degrader targeting IKZF2 and CK1α, exhibiting DC50 values of 1.4 nM and 4.4 nM, respectively. This compound activates the p53 apoptosis pathway, highlighting its potential in promoting cell death. DEG-35 serves as a valuable tool for research focused on Acute Myeloid Leukemia (AML), providing insights into targeted degradation strategies for therapeutic applications. -
IKZF1/3 And CSNK1A1 Molecular Glue Degrader
MI-2-80 is a molecular glue degrader that specifically targets IKZF1 and IKZF3, as well as CSNK1A1. This compound facilitates the binding of these proteins to the cereblon (CRBN) E3 ubiquitin ligase, promoting their subsequent ubiquitination and proteasomal degradation. MI-2-80 is valuable for research applications focused on understanding the functional roles of IKZF proteins and their involvement in various pathologies, including hematological malignancies. -
Anti-inflammatory Agent
(7'E,8S)-2',4,8-Trihydroxy-3-methoxy-2,4'-epoxy-8,5'-neolign-7'-en-7-one is an anti-inflammatory agent targeting hepatic stellate cells. With an IC50 of 25.2 μM against TGF-β-induced HSC-T6 cells, this compound is instrumental in studies related to liver fibrosis by inhibiting excessive cell proliferation. Isolated from the dried aerial parts of Penthorum chinense Pursh, it holds potential for research into liver fibrosis-related conditions. -
CTLA-4 Degrader
AN02 is a CTLA-4 degrader that demonstrates potent anti-cancer activity in ovarian cancer research. This compound inhibits cell proliferation, clonogenicity, migration, and invasion of ovarian cancer cells while upregulating the expression of antigen-presenting cells (APC). AN02 mediates CTLA-4 degradation through the SMAD4 pathway, significantly reducing tumor growth in small xenograft models and reversing the immune-suppressive tumor environment. Additionally, when used in combination with Ipilimumab, AN02 enhances therapeutic efficacy and inhibits epithelial-mesenchymal transition, making it a valuable tool for studying ovarian cancer. -
Bone Marrow Mesenchymal Stem Cell Inducer
Herpetin is an active lignan that functions as a bone marrow mesenchymal stem cell inducer. It activates the SDF-1/CXCR4 axis and the Wnt/β-catenin signaling pathway, promoting stem cell recruitment and differentiation. This compound is relevant for research applications focused on acute liver injury and related regenerative processes. -
Anti-IL-1β Antibody
Abdakibart is a humanized IgG4 monoclonal antibody that selectively targets IL-1β, a key cytokine involved in the inflammatory response. This reagent is particularly valuable for research applications related to inflammatory diseases, including type 2 diabetes. By inhibiting IL-1β, Abdakibart can help elucidate the pathways involved in inflammation and contribute to the development of novel therapeutic strategies. -
IL-17A Modulator
IL-17A modulator-3 is a selective modulator targeting IL-17A. This compound demonstrates effective inhibition of the IL-17A/A receptor complex with an IC50 value of less than 10 μM. It is suitable for research applications related to inflammation, cancer biology, and autoimmune disorders, providing valuable insights into these critical areas of study. -
Anti-IL-1β Antibody
SSGJ-613 is a fully human monoclonal antibody that targets interleukin-1 beta (IL-1β). This reagent is designed for the investigation of inflammatory conditions, particularly gouty arthritis, by inhibiting the activity of IL-1β, a key mediator in the inflammatory response. Its application extends to research focused on understanding the role of IL-1β in various diseases and therapeutic development. -
IL-17 modulator
IL-17 modulator 6 is a potent inhibitor of Interleukin 17 (IL-17) with a pIC50 of 9.1. This compound effectively modulates IL-17 signaling and is utilized in the study of inflammatory and autoimmune diseases. Researchers may employ IL-17 modulator 6 to explore therapeutic strategies targeting IL-17 pathways. -
STING Agonist
STING Agonist-50 is a potent oral STING agonist that activates the STING signaling pathway with an IC50 of 3.457 μM. It facilitates the phosphorylation of downstream proteins TBK1 and IRF3, leading to the enhanced expression of key cytokines such as IFN-β, CXCL10, and IL-6. This compound has demonstrated the ability to inhibit tumor growth in syngeneic mouse models, making it a valuable tool for research focused on colorectal cancer. -
Anti-inflammatory Agent
Anti-inflammatory Agent 58 is a potent inhibitor of IL-1β, demonstrating an IC50 of 1.08 μM. This compound effectively reduces pro-inflammatory gene expression, limits protein secretion, and inhibits NF-κB phosphorylation. It is suitable for research applications focused on inflammatory pathways and the modulation of immune responses. -
Anti-inflammatory Agent
Pseudoginsenoside RT4 is an orally active tetracyclic triterpenoid with notable anti-inflammatory properties. It effectively reduces the levels of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, while enhancing IL-10 levels. Additionally, Pseudoginsenoside RT4 modulates gut microbiota composition, making it a valuable reagent for research related to ulcerative colitis and other inflammatory conditions. Its multifaceted mechanism of action positions it as a significant tool in the study of anti-inflammatory pathways. -
Anti-inflammatory Agent
Anti-inflammatory agent 59 is a selective inhibitor of interleukin-1 beta (IL-1β) with an IC50 of 2.28 μM. This compound effectively reduces pro-inflammatory gene expression and protein secretion while inhibiting NF-κB phosphorylation. It serves as a valuable tool in the study of inflammatory pathways and may aid in the development of new therapeutic strategies for inflammatory diseases. -
Anti-inflammatory Agent
Acutissimalignan B is a bioactive compound recognized for its role as an anti-inflammatory agent. It effectively reduces the mRNA expression of key inflammatory cytokines, including inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6). Additionally, Acutissimalignan B inhibits the phosphorylation of IκBα and the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65, thereby demonstrating potential utility in neuroinflammation research and related disease models. -
Anti-inflammatory Agent
Linderaspirone A is a natural compound derived from the roots of Lindera aggregate that functions as an anti-inflammatory agent. It exhibits significant inhibitory effects on the production of pro-inflammatory mediators, including prostaglandin E2 (PGE2), TNF-α, and IL-6. This compound can be utilized in research applications focused on understanding the mechanisms of inflammation and developing therapeutic strategies for inflammatory diseases. -
PIKfyve Inhibitor
AS2677131 is a potent and orally active inhibitor of PIKfyve, targeting the PIKfyve-c-Rel signaling pathway. It effectively inhibits the production of pro-inflammatory cytokines, including IL-12p40, IL-6, and IL-1β, by selectively blocking the DNA-binding activity of c-Rel to their respective promoters. Additionally, AS2677131 reduces MHC class II expression on B cells. This compound is valuable for research in the fields of inflammation and immunology, particularly in studies related to arthritis. -
IL-2 Fusion Protein
Lecomkafusp alfa is an IL-2 fusion protein designed to enhance immunomodulatory activity. It consists of human IL-2 linked via a protease-cleavable peptide to a humanized single-domain VHH fragment that targets albumin. This compound demonstrates significant antineoplastic properties, making it a valuable tool in cancer immunotherapy research and the exploration of novel therapeutic strategies. -
Anti-IL-17A Antibody
HB-0017 is a humanized IgG1κ monoclonal antibody that specifically targets interleukin-17A (IL-17A). This antibody effectively inhibits IL-6 secretion induced by IL-17A with an IC50 value of 2.09 nM. HB-0017 has demonstrated significant efficacy in reducing ear thickness in a psoriasis-like mouse model induced by Imiquimod, as well as alleviating inflammation in models of IL-17A-induced arthritis and air pouch inflammation. -
Anti-IL-17A Antibody
Velvakiment is a humanized VHH nanobody that specifically targets interleukin-17A (IL-17A). This antibody is valuable for investigating autoimmune diseases, including multiple sclerosis and rheumatoid arthritis, by elucidating the role of IL-17A in inflammatory pathways. Its specificity and affinity facilitate advanced research on therapeutic interventions aimed at modulating IL-17A activity in various disease contexts. -
Anti-IL-17RB Antibody
Ponumkibart is a humanized IgG4κ antibody specifically designed to target the interleukin-17 receptor B (IL-17RB). This antibody serves as a critical tool for investigating the role of IL-17 signaling in various pathologies, including autoimmune diseases and inflammatory conditions. Its application in research includes the study of immune response modulation and the development of therapeutic strategies targeting IL-17 pathways. -
Anti-IL-13 Antibody
Zumilokibart is a humanized IgG1κ antibody that specifically targets interleukin-13 (IL-13). This antibody is designed to inhibit the biological activity of IL-13, a cytokine implicated in various allergic and inflammatory diseases. It is suitable for research applications focused on asthma, allergic rhinitis, and other conditions where IL-13 plays a pivotal role in pathophysiology. -
IL-17 Modulator
IL-17 Modulator 5 is a potent inhibitor targeting interleukin-17 (IL-17) with an IC50 of 1 nM. This compound exhibits significant inhibition of IL-17 associated pathways, playing a critical role in inflammatory responses. It is applicable in research on autoimmune diseases and inflammatory disorders, facilitating investigations into therapeutic avenues for conditions such as psoriasis and rheumatoid arthritis.
