Catalog No.
Product Name
Application
Product Information
Citations
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Antiinflammatory Agent
Aristololactam IIIa functions as an anti-inflammatory agent by effectively inhibiting superoxide anion generation and elastase release, demonstrating IC50 values of 0.12 and 0.20 μg/mL, respectively. This compound is valuable in research applications focused on oxidative stress and inflammatory responses, making it suitable for studying various inflammatory diseases. -
Anti-inflammatory Agent
Sutherlandin trans-p-coumarate is a selective γ-hydroxynitrile glycoside that acts as an anti-inflammatory agent by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, demonstrating 56.9% inhibition at a concentration of 25 μg/mL. This compound can be naturally extracted from the dried aerial parts of Sorbaria sorbifolia, a member of the Rosaceae family. Due to its biological activity, it is of interest in research focused on inflammation and immune response modulation. -
Anti-inflammatory Drug
Regaloside A is a phenylpropanoid with notable anti-inflammatory properties. It demonstrates significant DPPH radical scavenging activity, with a measured efficacy of 58.0% at a concentration of 160 ppm. This compound is useful in investigating anti-inflammatory mechanisms and for potential therapeutic applications in inflammatory diseases. -
Anti-inflammatory Agent
Ciwujianoside C3 is an orally active compound that functions as an anti-inflammatory agent. Isolated from the leaves of Acanthopanax henryi Harms, this reagent demonstrates significant anti-inflammatory properties while also enhancing object recognition memory. Its biological activity supports research in neuroprotection and cognitive enhancement studies. -
Anti-inflammatory Drug
Ikarisoside A is a natural flavonol glycoside known for its anti-inflammatory properties. This compound exhibits significant activity in reducing inflammation, making it valuable for research focused on inflammatory diseases and related therapeutic applications. Its mechanism of action may involve the modulation of inflammatory pathways, providing insights for the development of new anti-inflammatory treatments. -
Anti-inflammatory Agent
Damnacanthol is a natural product derived from Damnacanthus major, acting primarily as an anti-inflammatory agent. It exhibits potent anti-15-lipoxygenase activity and effectively inhibits nitric oxide production in LPS-activated RAW 264.7 macrophage cells. This compound is suited for research applications focused on inflammation and related pathways. -
Anti-inflammatory Agent
Cauloside D is a triterpene glycoside derived from Caulophyllum robustum Max, known for its potent anti-inflammatory properties. It modulates inflammatory responses by inhibiting the expression of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines. This compound serves as a valuable tool for research into inflammatory diseases and therapeutic interventions targeting inflammatory pathways. -
Anti-inflammatory Agent
5,7,8-Trimethoxyflavone is a flavonoid compound known for its anti-inflammatory properties. Isolated from Andrographis echioides, this compound effectively inhibits nitric oxide (NO) production with an IC50 of 39.1 μM. It is utilized in research applications focused on understanding the mechanisms of inflammation and exploring potential therapeutic avenues for inflammatory diseases. -
Anti-Inflammatory Agent
Amaroswerin is a bioactive secoiridoid glucoside derived from Swertia mussotii, acting primarily as an anti-inflammatory agent. It exhibits multiple biological activities, including anti-inflammatory, antidiabetic, antiviral, anticholinergic, and immunomodulatory effects. Amaroswerin effectively inhibits nitric oxide (NO) release in RAW264.7 cells, demonstrating an IC50 value of 5.42 μg/mL, making it a valuable tool for research in inflammation and related health conditions. -
Anti-inflammatory Agent
(+)-Rhododendrol is an anti-inflammatory compound primarily known for its ability to inhibit nitric oxide (NO) production. This property makes it a valuable reagent in research focused on inflammatory processes and related pathways. Its use is particularly relevant in studies investigating the mechanisms of inflammation and potential therapeutic interventions. -
Anti-inflammatory Agent
Anti-inflammatory agent 18, an established anti-inflammatory agent, demonstrates inhibitory activity with an IC50 of 15.94 μM against HMGB1-induced later inflammation. This compound is valuable in research applications focused on later inflammatory diseases, including coronavirus-related conditions such as COVID-19 and sepsis. Its mechanism of action supports investigations into potential therapeutic strategies for managing chronic inflammatory responses. -
Anti-inflammatory Agent
2α-Acetoxy-14,15-cyclopimara-7β,16-diol is an anti-inflammatory agent that demonstrates a unique mechanism by inhibiting nitric oxide (NO) production in LPS-induced RAW264.7 macrophages. This compound exhibits a modest inhibition rate of 28.1%, indicating potential for further investigation in inflammation-related research. Naturally sourced from the ethanol extract of Caesalpinia minax Hance seeds, it offers a promising avenue for studying anti-inflammatory pathways and therapeutic applications. -
Anti-inflammatory Agent
Abiesadine I is a diterpenoid with anti-inflammatory properties, primarily acting as an inhibitor of lipopolysaccharide (LPS)-induced nitric oxide (NO) production. With an IC50 value greater than 100 μg/mL, Abiesadine I exhibits significant efficacy in RAW264.7 macrophages, making it a valuable tool for research applications focused on inflammation and immune response modulation. This compound is isolated from Abies georgei and is useful for investigating signaling pathways involved in inflammatory processes. -
Anti-inflammatory Agent
Isofouquierol is a selective inhibitor of nitric oxide (NO) production, primarily targeting the inducible nitric oxide synthase (iNOS) pathway. This compound demonstrates significant anti-inflammatory activity by effectively reducing NO overproduction. Isofouquierol is applicable in research focusing on inflammation-related diseases, including chronic inflammation and immune disorders. -
Anti-inflammatory Agent
Deltoin is a coumarin derivative that functions as an anti-inflammatory agent. It has demonstrated the ability to inhibit nitric oxide production, contributing to its anti-inflammatory effects. Research indicates that Deltoin significantly reduces paw edema, highlighting its potential applications in studying inflammatory processes and developing therapeutic strategies for inflammatory diseases. -
Anti-inflammatory Agent
Balanophonin B is a selective inhibitor of lipopolysaccharide (LPS)-induced nitric oxide (NO) production, exhibiting an IC50 of 1.46 μg/mL. Isolated from Lithocarpus pachylepis, this compound effectively reduces NO production in LPS-stimulated RAW264.7 macrophages, demonstrating significant anti-inflammatory activity. Balanophonin B is valuable for anti-inflammatory drug development and serves as a tool in the biological activity research of natural lignan compounds. -
Anti-inflammatory/Antitumor Agent
Rabdoternin E is an ent-kaurane-type diterpenoid known for its anti-inflammatory and antitumor properties. It effectively inhibits nitric oxide production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages with an IC50 of 2.3 μM. Additionally, Rabdoternin E demonstrates cytotoxicity against human tumor cell lines, HL-60 and SW-480, with IC50 values of 2.6 μM and 4.1 μM, respectively. This compound can be naturally sourced from the aerial parts of Isodon rosthornii, a member of the Lamiaceae family. -
Anti-inflammatory Agent
2-Oxostenine is a stenine-type alkaloid that exhibits anti-inflammatory properties. It has been shown to weakly inhibit lipopolysaccharide-induced nitric oxide production, thereby contributing to its potential role in managing inflammatory responses. This compound is suitable for research applications focused on understanding inflammation and evaluating novel anti-inflammatory agents. -
Anti-Inflammatory Agent
PPM-18 (NSC 73233) is a potent anti-inflammatory agent that inhibits nitric oxide synthase (iNOS) expression by preventing NF-κB from binding to its promoter. This compound has demonstrated the ability to induce autophagy and apoptosis in bladder cancer cells, mediated through reactive oxygen species (ROS) and AMP-activated protein kinase (AMPK) signaling pathways. PPM-18 is valuable for researchers studying inflammation and cancer therapeutics. -
Anti-inflammatory Agent
Anti-inflammatory agent 46, a potent nitric oxide (NO) inhibitor, targets inducible nitric oxide synthase (iNOS) to modulate inflammatory responses. This compound demonstrates significant anti-inflammatory activity, effectively reducing swelling in murine models at a dosage of 10 mg/kg. It is a valuable tool for researching the mechanisms of inflammation and potential therapeutic applications in inflammatory diseases. -
Anti-inflammatory Triterpenoid
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid is an anti-inflammatory triterpenoid that effectively inhibits nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in LPS-stimulated Raw264.7 macrophages. This compound is particularly relevant for research investigating the modulation of inflammatory pathways, making it a valuable tool for studies focused on inflammatory diseases and therapeutic development. Its mechanism of action supports exploration into potential anti-inflammatory therapies. -
Anti-inflammatory Agent
Anti-inflammatory agent 80 (Compound 2/2f) is an effective anti-inflammatory compound that also exhibits notable anti-tumor activity. Isolated from Cynanchum limprichtii Schltr., this agent is valuable for research in inflammation and cancer biology. Its ability to modulate inflammatory responses makes it a potential candidate for further studies in therapeutic applications related to inflammatory diseases and tumor progression. -
Anti-Inflammatory Agent
Randaiol is an anti-inflammatory agent derived from the stem bark of Magnolia officinalis, exhibiting significant antioxidant properties. This compound effectively inhibits lipopolysaccharide (LPS)-induced nitric oxide production, thereby mitigating inflammatory responses. Randaiol is valuable for research applications focused on inflammation pathways and oxidative stress regulation. -
Anti-inflammatory Agent
Scutebarbatine X is a neo-clerodane diterpenoid derived from Scutellaria barbatae, exhibiting significant anti-inflammatory activity. This compound has been shown to modulate inflammatory pathways, making it a valuable tool for investigating inflammatory diseases. Research applications include studying cellular responses in inflammation and evaluating potential therapeutic interventions for associated disorders. -
Inflammatory Pathway Inhibitor
(E)-Sinapoyl glucose is an inhibitor of inflammatory pathways, specifically targeting nitric oxide (NO) production. It demonstrates an IC50 value of 38.32 µM in RAW 264.7 macrophage cells, highlighting its potential in modulating inflammatory responses. This compound is valuable for research into inflammatory diseases and their underlying mechanisms. -
Anti-inflammatory Agent
Tetrandrine 2'-N-α-oxide is a bisbenzylisoquinoline alkaloid known for its anti-inflammatory properties. Isolated from the roots of Stephania tetrandra, this compound may be utilized in studies investigating inflammatory diseases and their underlying mechanisms. Its ability to modulate inflammatory pathways makes it a valuable tool for researchers in the field of inflammatory responses. -
Anti-Inflammatory Agent
Morachalcone A is a naturally occurring compound that functions as an aromatase inhibitor, exhibiting an IC50 value of 4.6 mM. It possesses significant anti-inflammatory and potential anticancer activities by inhibiting lipopolysaccharide-induced nitric oxide production. Morachalcone A is valuable for research focused on inflammation and cancer biology. -
Anti-inflammatory Agent
2,4-Dihydroxy-6-methoxy-3,5-diprenylacetophenone is an acetophenone derivative primarily functioning as an anti-inflammatory agent. It exhibits significant anti-inflammatory and antioxidant activities, including the inhibition of LPS-induced nitric oxide production with an IC50 of 34.5 μM, and a SC50 value of 0.15 mM for DPPH free radical scavenging. This compound is valuable for investigating mechanisms underlying inflammation and oxidative stress in various research settings. -
Anti-inflammatory Agent
12-Acetoxyganoderic acid D is a triterpenoid compound derived from Ganoderma sinense, primarily known for its anti-inflammatory properties. It effectively inhibits nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, demonstrating its potential as a therapeutic agent. This compound is valuable for research in inflammation and related biological pathways. -
Anti-inflammatory Agent
Anti-inflammatory agent 19 is a potent anti-inflammatory agent that targets HMGB1-induced inflammation. With an IC50 of 36.00 μM, it effectively inhibits the downstream inflammatory response, making it a valuable tool in the study of chronic inflammatory conditions. This compound is suitable for research applications related to inflammatory diseases, including COVID-19 and sepsis. -
Anti-inflammatory Agent
Apterin is a natural compound that functions as an anti-inflammatory agent by inhibiting nitric oxide (NO) production. In RAW264.7 cells, Apterin demonstrates significant inhibitory activity with an IC50 value of 41.8 μM. This compound is useful for research focused on inflammatory pathways and the modulation of immune responses. -
Anti-inflammatory Agent
Anti-inflammatory Agent 65 is a Hederagonic acid derivative that exhibits significant anti-inflammatory activity. This compound effectively inhibits the release of nitric oxide (NO) and prevents the nuclear translocation of IRF3 and p65. By disrupting the STING/IRF3/NF-κB signaling pathway, Anti-inflammatory Agent 65 significantly reduces the inflammatory response, making it a valuable tool for studying inflammation-related conditions and potential therapeutic interventions. -
Anti-inflammatory Agent
Anti-inflammatory agent 63 is an anti-inflammatory compound that specifically inhibits nitric oxide (NO) production in RAW264.7 cells induced by lipopolysaccharide (LPS), with an EC50 value of 5.33±0.57 μM. This reagent is valuable for research applications focused on inflammation mechanisms and the modulation of immune responses. Its potency makes it a useful tool for investigating potential therapeutic strategies against inflammatory diseases. -
Anti-inflammatory Agent
1-O-Caffeoylglycerol is an anti-inflammatory compound derived from Sorghum bicolor. It demonstrates significant inhibition of LPS-induced nitric oxide production, with an IC50 value of 18.5 μM, and effectively reduces iNOS protein expression in a dose-dependent manner. This reagent is suitable for studies focused on inflammatory conditions and the exploration of potential therapeutic applications in related research fields. -
Non-steroidal Anti-inflammatory Agent
Pirprofen is an orally active non-steroidal anti-inflammatory agent that functions as a reversible inhibitor of prostaglandin synthetase. Its key biological activities include anti-inflammatory, analgesic, and antipyretic effects, while also inhibiting leucocyte chemotaxis and the secondary phase of platelet aggregation triggered by collagen and arachidonic acid. This compound is of particular interest for research focused on inflammatory diseases and associated mechanisms. Note that pirprofen may also induce hepatotoxicity, warranting careful consideration in experimental applications. -
Anti-Inflammatory Agent
Apyramide is an anti-inflammatory agent that acts as a prodrug of indomethacin. It serves as a potent and nonselective inhibitor of cyclooxygenase enzymes COX-1 and COX-2, exhibiting significant blood-brain barrier permeability. Apyramide is primarily utilized in research applications focused on inflammation modulation and pain relief. -
Anti-inflammatory agent
Ketoprofen (lysinate) is a non-steroidal anti-inflammatory agent primarily targeting cyclooxygenase enzymes. It exhibits potent inhibitory activity with IC50 values of 2 nM for COX-1 and 26 nM for COX-2. This compound is valuable for research applications in inflammation, immunology, and metabolic diseases such as obesity, making it an essential tool for exploring pathways in these biological contexts. -
Anti-inflammatory Compound
Amfenac sodium is an orally active anti-inflammatory compound known for its potent analgesic and antipyretic properties. It acts by inhibiting the cyclooxygenase enzymes, thereby reducing inflammatory responses. This reagent is valuable for research applications related to both acute and chronic inflammation, facilitating a deeper understanding of inflammatory pathways and potential therapeutic interventions. -
Anti-inflammatory Agent
Daturaolone is a natural triterpenoid known for its anti-inflammatory properties. It primarily exerts its biological activity through inhibitory effects on COX-1, which plays a crucial role in inflammatory responses. This compound is of interest in research applications focused on understanding and developing therapies for pain management and various inflammatory conditions. -
Anti-inflammatory Agent
AHR-6293 is a potent anti-inflammatory agent that functions primarily through modulation of the aryl hydrocarbon receptor (AhR). This compound demonstrates superior anti-inflammatory effects compared to its predecessor AHR-5850, making it a valuable tool in the study of inflammatory pathways. AHR-6293 is not indicated for the inhibition of platelet aggregation, allowing for specific applications in inflammation research and therapeutic exploration. -
Anti-inflammatory Compound
Isoscoparin-7-O-glucoside is a flavonoid compound with a primary mechanism of COX-2 inhibition, demonstrating notable anti-inflammatory properties. This compound has a significant positive correlation with total phenolic content, suggesting its potential efficacy in reducing inflammation. Isoscoparin-7-O-glucoside is suitable for research applications focused on the mechanistic understanding of inflammatory processes. -
Anti-inflammatory Agent
COX-2/NO-IN-1 is an orally bioavailable inhibitor of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), demonstrating an IC50 of 3.52 μM. This compound exhibits significant anti-inflammatory activity, making it a valuable tool for research in inflammation-related pathways and therapeutic interventions for various inflammatory diseases. Its dual inhibition of iNOS and COX-2 positions COX-2/NO-IN-1 as a promising candidate for studies aimed at understanding and mitigating inflammatory responses. -
Anti-inflammatory Compound
Amfenac is a potent anti-inflammatory compound that exhibits antipyretic and analgesic properties. This orally active agent is primarily utilized in research related to acute and chronic inflammation, providing insights into inflammation-related mechanisms and potential therapeutic interventions. -
Anti-inflammatory Agent
Loxoprofenol-SRS tromethamine is an active metabolite of Loxoprofen that functions as a non-steroidal anti-inflammatory drug (NSAID). It exhibits potent anti-inflammatory and analgesic properties, making it suitable for various research applications in inflammation and pain management studies. This compound offers the advantages of intravenous administration, ensuring rapid action in therapeutic contexts. -
Anti-inflammatory Agent
Glucametacine is an anti-inflammatory agent that primarily targets cyclooxygenase enzymes. It exhibits significant anti-inflammatory activity, making it suitable for research involving the modulation of pain and inflammation pathways. This compound can be utilized in various biological studies focusing on chronic inflammatory conditions and related therapeutic approaches. -
Anti-Inflammatory Agent
COX-2-IN-32 is a potent inhibitor of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), primarily targeting inflammatory pathways. This compound demonstrates significant anti-inflammatory activity by reducing the production of nitric oxide in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, with an IC50 value of 11.2 μM. COX-2-IN-32 is useful for research applications focused on inflammation and related signaling pathways. -
Anti-Inflammatory Agent
Loxoprofen sodium (dihydrate) is a non-steroidal anti-inflammatory agent that functions primarily as a nonselective inhibitor of cyclooxygenase (COX) enzymes. It exhibits significant analgesic and antipyretic properties, with IC50 values of 6.5 μM for COX-1 and 13.5 μM for COX-2. Loxoprofen sodium has demonstrated the ability to reduce atherosclerosis and possesses antitumor activity, making it a valuable compound for research in inflammation, pain management, and cancer therapeutics. -
Non-Steroidal Anti-Inflammatory Agent
AHR-10037 is a non-steroidal anti-inflammatory agent that exhibits low gastric toxicity. As a prodrug, it is converted in vivo to a cyclooxygenase inhibitor, effectively reducing inflammation and pain. This compound is useful in the study of inflammatory conditions and related therapeutic applications. -
Anti-inflammatory Agent
Tiaprofenic acid-d3 is a deuterium-labeled derivative of Tiaprofenic acid, a nonsteroidal anti-inflammatory drug (NSAID) that primarily targets inflammatory pathways. It exhibits significant anti-inflammatory activity and is utilized in the treatment of various rheumatic diseases. Tiaprofenic acid-d3 is particularly useful in research applications involving metabolic studies and pharmacokinetic investigations of NSAIDs. -
Antioxidant/Anti-inflammatory/Antipyretic/Analgesic Agent
β-Selinene is a sesquiterpene that acts as a potent antioxidant, anti-inflammatory, antipyretic, and analgesic agent. It demonstrates significant antioxidant activity by scavenging free radicals and chelating pro-oxidative metal ions. Additionally, β-selinene inhibits cyclooxygenase (COX) activity and reduces the synthesis of pro-inflammatory prostaglandins, contributing to its anti-inflammatory properties. Furthermore, it regulates the thermoregulatory set point in the hypothalamus while inhibiting inflammatory mediators, providing antipyretic and analgesic effects. This compound is valuable for research applications focused on oxidative stress, inflammation, and pain management.
