Rabdoternin E is an ent-kaurane-type diterpenoid known for its anti-inflammatory and antitumor properties. It effectively inhibits nitric oxide production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages with an IC50 of 2.3 μM. Additionally, Rabdoternin E demonstrates cytotoxicity against human tumor cell lines, HL-60 and SW-480, with IC50 values of 2.6 μM and 4.1 μM, respectively. This compound can be naturally sourced from the aerial parts of Isodon rosthornii, a member of the Lamiaceae family.
Rabdoternin E is an ent-kaurane-type diterpenoid known for its anti-inflammatory and antitumor properties. It effectively inhibits nitric oxide production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages with an IC50 of 2.3 μM. Additionally, Rabdoternin E demonstrates cytotoxicity against human tumor cell lines, HL-60 and SW-480, with IC50 values of 2.6 μM and 4.1 μM, respectively. This compound can be naturally sourced from the aerial parts of Isodon rosthornii, a member of the Lamiaceae family.
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