Catalog No.
Product Name
Application
Product Information
Citations
-
Anti-inflammatory Agent
11-Keto-beta-boswellic acid is a pentacyclic triterpenic acid derived from the oleogum resin of the Boswellia serrata tree, commonly known as Indian Frankincense. This compound exhibits significant anti-inflammatory activity through the inhibition of 5-lipoxygenase (5-LOX), which subsequently reduces leukotriene synthesis and attenuates nuclear factor-kappa B (NF-κB) activation, along with the production of tumor necrosis factor alpha. Due to its mechanism of action, 11-Keto-beta-boswellic acid is of interest in studies focused on inflammation-related conditions. -
Anti-inflammatory Agent
Mulberrofuran H is a 2-arylbenzofuran derived from the mulberry tree (Morus lhou (ser.) Koidz.), exhibiting significant anti-inflammatory properties. It effectively inhibits the enzymatic activity of L-tyrosine with an IC50 of 4.45 µM and L-DOPA with an IC50 of 19.70 µM. This compound is of interest in research applications focused on inflammation and oxidative stress, where it demonstrates potent antioxidative activity. -
Anti-Inflammatory Agent
Damascenone is a complex of E-isomer and Z-isomer variants, derived from Epipremnum pinnatum, known for its anti-inflammatory properties. This compound exhibits significant biological activity, making it a valuable candidate for research focused on inflammatory pathways and mechanisms. Its potential applications include investigations into new anti-inflammatory therapies and understanding the underlying biology of inflammation-related conditions. -
Anti-Inflammatory Agent
5-PAHSA is an anti-inflammatory agent that enhances insulin sensitivity and exhibits neuroprotective effects. In studies involving high-fat diet-induced diabetic mice, 5-PAHSA demonstrated significant oral activity in reducing inflammation and preserving neuronal function. This compound is suitable for research focused on neurological dysfunction associated with diabetes. -
Anti-Inflammatory Agent
7β-Hydroxy-epi-androsterone primarily targets estrogen receptor beta (ERβ) and exhibits notable anti-inflammatory and neuroprotective activities. As an endogenous androgenic derivative of dehydroepiandrosterone, it is utilized in research to explore its potential therapeutic effects in inflammation-related conditions and neurodegenerative diseases. This compound facilitates investigations into the mechanisms of action involving steroid hormones and their roles in immune and neural functions. -
Anti-inflammatory Agent
Fenclofenac is an orally active anti-inflammatory agent primarily targeting inflammation pathways with a low ulcerogenic effect. This compound also demonstrates antipyretic and analgesic properties, making it valuable in research involving pain and fever. Its safety profile includes an oral LD50 of 2280 mg/kg in rats, supporting its potential for use in inflammation research. -
Anti-inflammatory Agent
BI-L-45 XX is an orally active anti-inflammatory agent that targets and inhibits the release of neutrophil enzymes as well as chemotaxis. This compound is particularly useful for investigating mechanisms underlying adjuvant-induced arthritis and other inflammatory conditions. Its ability to modulate neutrophil activity makes it a valuable tool in the study of inflammatory pathways. -
Anti-inflammatory agents
2-Hydroxy-4-methoxybenzoic acid potassium primarily functions as an anti-inflammatory agent. As a significant phytoconstituent derived from Decalepis arayalpathra, it exhibits a range of biological activities, including anti-inflammatory, antipyretic, antioxidant, and anti-diabetic effects. This compound is valuable for researchers investigating mechanisms of inflammation and related metabolic disorders. Its diverse pharmacological potential makes it a useful tool in therapeutic studies and drug development. -
Anti-inflammatory Compound
2′-Hydroxydaidzein is an anti-inflammatory compound that acts as a metabolite. It effectively inhibits the release of chemical mediators from inflammatory cells and significantly reduces the secretion of lysozyme and β-glucuronidase from rat neutrophils stimulated with fMLP/CB. This reagent is valuable for research applications related to inflammation and immune response modulation. -
Anti-inflammatory compound
β-Amyrin is a natural triterpenoid compound that exhibits anti-inflammatory properties. It effectively mitigates amyloid β (Aβ)-induced impairments in long-term potentiation (LTP), making it a promising candidate for Alzheimer's disease research. Additionally, β-Amyrin demonstrates protective activity against pulmonary fibrosis and possesses notable antibacterial capabilities, supporting its potential applications in various areas of biological and medicinal research. -
Anti-inflammatory Agent
Fendosal is a potent, orally active non-steroidal anti-inflammatory agent that primarily targets and inhibits Plasminogen activator inhibitor-1 (PAI-1). It demonstrates significant anti-inflammatory activity, making it a valuable tool for research in inflammatory disease models and therapeutic applications. Its dual action offers insights into conditions mediated by PAI-1, enhancing the understanding of inflammatory pathways and potential treatments. -
Non-steroidal Antiinflammatory Agent
Protizinic acid is a non-steroidal anti-inflammatory agent that exerts its effects primarily through the inhibition of phospholipase A2 (PLA2) activity, with an IC50 value of 210 μM. This compound exhibits notable anti-inflammatory and antipyretic properties, making it a valuable tool in research focused on inflammatory processes and pain relief mechanisms. It is suitable for studies involving the modulation of inflammatory pathways. -
Anti-inflammatory Agent
BMS-188184 is a type II secretory phospholipase A2 (s-PLA2) inhibitor with an IC50 value of 17 µM. This compound exhibits significant anti-inflammatory activity, making it a valuable tool for studying various inflammatory conditions. It is particularly useful in research aimed at understanding the role of s-PLA2 in mediating inflammatory processes and potential therapeutic interventions. -
Anti-inflammatory Drug
Sanggenon A is an anti-inflammatory compound that modulates the NF-κB and HO-1/Nrf2 signaling pathways, demonstrating significant effects in BV2 and RAW264.7 cells. This reagent effectively inhibits the lipopolysaccharide (LPS)-induced production of nitric oxide, making it a valuable tool for research into inflammatory processes and potential therapeutic applications in inflammation-related diseases. -
Anti-inflammatory agent
N,N-Dimethylacetamide (DMAc) is an anti-inflammatory agent that primarily inhibits the NF-κB signaling pathway. Its ability to traverse the blood-brain barrier and function as an FDA-approved drug excipient enhances its utility in various research contexts. DMAc is particularly relevant for investigating the mechanisms of weight gain related to high-fat diets and exploring neuroinflammation associated with Alzheimer's disease. -
Anti-Oxidative/Inflammatory Agent
Sulfuretin is a potent anti-oxidative and anti-inflammatory agent that inhibits the NF-κB signaling pathway. It demonstrates efficacy in reducing oxidative stress, platelet aggregation, and mutagenesis, making it relevant for research in allergic airway inflammation. Sulfuretin acts as a competitive inhibitor of monophenolase and diphenolase activities, with an IC50 of 13.64 μM, underscoring its significance in exploring inflammatory responses and oxidative damage in biochemical studies. -
Anti-inflammatory Agent
Anti-inflammatory Agent 51 is an amide/sulfonamide derivative that functions primarily as an anti-inflammatory agent. This compound effectively inhibits the activation of NF-κB, making it a valuable tool for research into conditions such as acute lung injury and ulcerative colitis. Its ability to modulate inflammatory pathways positions it as a significant reagent for studying inflammatory diseases and therapeutic interventions. -
Anti-inflammatory Agent
Ageconyflavone B is a flavonoid that functions as an anti-inflammatory agent. It effectively reduces inflammation through the inhibition of IκBα phosphorylation, thereby modulating the NF-κB signaling pathway. This compound is relevant for research applications focused on inflammatory diseases and the underlying molecular mechanisms of inflammation. -
Anti-inflammatory Agent
BS-153 is a synthetic oxazolidinone compound that functions as an anti-inflammatory agent by inhibiting the activation of the NF-κB/PKCθ signaling pathway. It effectively reduces the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6, in LPS-stimulated RAW264.7 macrophage cells. This reagent is suitable for research applications focused on inflammation and immune response modulation. -
Anti-Inflammatory Agent
8α-Hydroxyhirsutinolide is a sesquiterpene lactone that acts as an anti-inflammatory agent by inhibiting TNF-α-induced NF-κB activity with an IC50 of 1.9 μM. Additionally, it reduces nitric oxide production, indicating a potential role in modulating inflammatory pathways. This compound can be isolated from the plant Vernonia cinerea and is useful for research in inflammation and related cellular signaling mechanisms. -
Anti-Inflammatory Agent
Goshonoside F5 is an anti-inflammatory agent derived from the unripe fruits of Rubus chingii. It demonstrates significant anti-inflammatory activity by inhibiting the NF-κB and MAPK signaling pathways. This compound is relevant for research applications focusing on inflammation-related conditions and the underlying molecular mechanisms. -
Anti-inflammatory Agent
Catalposide is an iridoid glycoside derived from Catalpa ovata G. Don (Bignoniaceae) that acts as an anti-inflammatory agent. It effectively inhibits the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, as well as the activation of NF-κB (p65) in lipopolysaccharide-stimulated RAW 264.7 macrophages. This compound is valuable for research in inflammatory pathways and potential therapeutic interventions in inflammatory diseases. -
Anti-Inflammatory Agent
Catalpalactone is an anti-inflammatory agent that functions by inhibiting LPS-induced nitric oxide production and the expression of inducible nitric oxide synthase (iNOS) in RAW264.7 macrophage cells. Additionally, it suppresses the activation of key signaling pathways, including IRF3, NF-κB, and IFN-β/STAT-1. Furthermore, Catalpalactone demonstrates the ability to reduce dopamine biosynthesis through the inhibition of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities, making it valuable for investigations into inflammatory processes and neurochemical pathways. -
Anti-inflammatory Agent
Se-Aspirin is a hybrid compound combining selenium with aspirin, primarily functioning as an anti-inflammatory agent. It exhibits significant biological activity by reducing the viability of various cancer cell lines, with notable efficacy against colorectal cancer cells. This compound is valuable for research applications targeting inflammation-related pathways and cancer therapeutics. -
Anti-neuroinflammatory Agent
Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent that targets MAO-B with an IC50 value of 10.30 μM. It demonstrates significant inhibition of Aβ1-42 aggregation, achieving 96.33% reduction at a concentration of 25 μM. Additionally, Neuroinflammatory-IN-2 provides neuroprotective effects in H2O2-induced PC-12 cell injury and exhibits biometal chelating and antioxidant properties. With favorable blood-brain barrier permeability, this compound is suitable for research applications related to Alzheimer’s disease and neuroinflammatory conditions. -
Anti-inflammatory Agent
Manghaslin is a flavonoid glycoside that serves as an anti-inflammatory agent. It exhibits inhibitory activity against acetylcholinesterase (AChE), with an IC50 value of 94.92 μM. This compound is relevant for research into the modulation of inflammation and potential neuroprotective effects. -
Anti-inflammatory Compound
Cuminaldehyde, a primary component of Cuminum cyminum, is recognized for its anti-inflammatory properties. This compound exhibits various biological activities, including inhibition of aldose reductase (IC50 = 0.00085 mg/mL), α-glucosidase (IC50 = 0.5 mg/mL), and lipoxygenase (IC50 = 1370 μM). Additionally, cuminaldehyde inhibits the fibrillation and aggregation of α-synuclein, indicating its potential application in the study of neurodegenerative diseases, cancer, diabetes, and neuropathic pain disorders. -
Antioxidant/Anti-Inflammatory Agent
PQM-164 is an antioxidant agent that targets oxidative stress by exhibiting potent radical scavenging activity (IC50: 0.93 μM for DPPH radical). It demonstrates anti-inflammatory effects by mitigating neuronal damage induced by 6-OHDA in activated microglial cells, and it reduces α-synuclein accumulation. Additionally, PQM-164 promotes the nuclear translocation and transcriptional activity of Nrf2. This compound serves as a valuable tool for research into neurodegenerative conditions such as Parkinson’s disease. -
Anticancer/Anti-inflammatory Agent
Antroquinonol, a ubiquinone derivative derived from the mushroom Antrodia camphorata, demonstrates notable anticancer and anti-inflammatory properties. This compound is primarily studied for its potential in colon cancer research due to its ability to reduce oxidative stress by activating the Nrf2 signaling pathway. Additionally, Antroquinonol has shown efficacy in inhibiting inflammation and sclerosis in models of focal segmental glomerulosclerosis. -
Anti-inflammatory Agent
Chitoheptaose, a chitosan oligosaccharide, is recognized for its anti-inflammatory properties. It exhibits antioxidant, anti-inflammatory, and anti-apoptotic activities, making it a valuable tool in the investigation of myocarditis and related cardiovascular conditions. Research indicates that Chitoheptaose offers cardioprotective effects by improving critical cardiac parameters and modulating inflammatory cytokines such as IL-1β in various models. -
Anti-inflammatory Agent
Tesimide is an aryl/heteroarylidene pyridinedione that acts as an anti-inflammatory agent. It exhibits potent inhibition of pro-inflammatory cytokines and promotes the modulation of inflammatory pathways. Tesimide is valuable for research in inflammation-related conditions and may aid in the development of therapeutic interventions for various inflammatory diseases. -
Anti-inflammatory Agent
Zierin is a compound derived from Xeranthemum annuum L. that functions as an anti-inflammatory agent. It exhibits significant anti-inflammatory and antioxidant activities, making it a valuable tool for research into inflammatory diseases and oxidative stress. Its application in studies may enhance understanding of various biological pathways related to inflammation. -
Anti-inflammatory Agent
Anti-inflammatory agent 43 is a 6-methoxyflavonol glycoside that exhibits significant anti-inflammatory activity. This compound can be isolated from the aerial parts of Tetragonia tetragonoides. Its properties make it suitable for research applications focused on the modulation of inflammatory processes and the investigation of potential therapeutic options for inflammatory diseases. -
Anti-inflammatory Agent
Se-DMC is an anti-inflammatory agent that effectively attenuates the inflammatory response induced by complete Freund’s adjuvant (CFA) in murine models. It has demonstrated significant effects in reducing nociception and alleviating neurobehavioral deficits. This compound is valuable for research applications focused on understanding inflammation mechanisms and evaluating potential therapeutic interventions for inflammatory disorders. -
Anti-inflammatory
L-Leucinamide hydrochloride is an amino acid derivative that exhibits anti-inflammatory activity. It is utilized in research to investigate mechanisms of inflammation and may provide insights into therapeutic strategies for inflammatory diseases. Its role in modulating immune responses makes it a valuable tool for studying inflammatory pathways. -
Anti-inflammatory Agent
Anti-inflammatory agent 44 is a 6-methoxyflavonol glycoside that exhibits significant anti-inflammatory activity. This compound, isolated from the aerial parts of Tetragonia tetragonoides, is instrumental in research focused on inflammation pathways and therapeutic interventions. Its properties make it a valuable reagent for studies aimed at understanding inflammatory responses and developing new anti-inflammatory treatments. -
Anti-Inflammatory Agent
Proxazole is an anti-inflammatory agent that exhibits protective effects against Indomethacin-induced ulcers without inducing anti-secretory activity. Additionally, Proxazole functions as a spasmolytic agent, displaying properties similar to those of papaverine. It is primarily utilized in research exploring gastrointestinal protection and inflammation modulation. -
Tyrosinase Inhibitor, Glutathione Reductase Inhibitor, Dopachrome Tautomerase Cofactor, Melanocortin Receptor 1 and 4 Modulator, Eumelanogenesis Inhibitor, Hair Hypopigmentation Inducer, Hair Cycle Modulator, Antioxidant, Healing Accelerator, Tensile Strength Enhancer, Anti-inflammatory Agent
Zinc sulphate functions primarily as an inhibitor of tyrosinase and glutathione reductase, exhibiting significant modulation of melanocortin receptors 1 and 4. Its biological activities include inducing hair hypopigmentation, enhancing wound healing, and exhibiting antioxidant and anti-inflammatory properties. This compound is valuable for research applications focused on eumelanogenesis, hair follicle cycling, and the investigation of conditions such as benign gastric ulcers and rheumatoid arthritis. -
Anti-inflammatory agent
SerBut is a serine-conjugated butyrate prodrug designed to exert anti-inflammatory effects. It demonstrates potential therapeutic activity in modulating inflammation, making it suitable for research applications targeting inflammatory pathways and related diseases. Its oral bioactivity enhances its utility in in vivo studies. -
Nonsteroidal Anti-inflammatory Drug
Azapropazone is a nonsteroidal anti-inflammatory drug (NSAID) primarily targeting the inhibition of cyclooxygenase enzymes. This compound exhibits significant anti-inflammatory and analgesic properties, making it valuable in the study of rheumatoid arthritis and related inflammatory disorders. Researchers can utilize Azapropazone to investigate its effects on pain management and the underlying mechanisms of inflammatory conditions. -
Anti-inflammatory Agent
Fenclozic acid is an orally active anti-inflammatory agent that exerts its effects by inhibiting prostaglandin synthesis. It demonstrates significant analgesic and antipyretic properties, making it useful in the study of pain and fever management. Researchers commonly utilize fenclozic acid to explore pathways underlying inflammation and to develop therapeutic strategies for related conditions. -
Anti-inflammatory Substance
Kebuzone is a non-steroidal anti-inflammatory compound that targets inflammatory pathways. It exhibits significant anti-inflammatory activity and may be useful in research related to inflammatory diseases, including thrombophlebitis and rheumatoid arthritis. This reagent provides a valuable tool for studying mechanisms of inflammation and exploring potential therapeutic strategies. -
Non-steroidal Anti-inflammatory Agent
Difenpiramide is a non-steroidal anti-inflammatory agent that exhibits pronounced anti-inflammatory, analgesic, antipyretic, and uricosuric properties. This compound also demonstrates platelet anti-aggregation activity, making it valuable for research applications in inflammation, pain management, and cardiovascular studies. Its multifaceted biological activities contribute to its potential use in various therapeutic contexts. -
Anti-inflammatory Agent
Furobufen is an anti-inflammatory agent that exerts antiarthritic and antipyretic effects, providing significant relief in conditions characterized by inflammation. Its analgesic properties are particularly pronounced in inflamed tissues, making it a valuable compound for research applications focused on pain management and inflammatory diseases. This compound can be utilized in exploring therapeutic strategies for various inflammatory conditions. -
Antiinflammatory Agent
D228 is an orally active anti-inflammatory agent that targets T and B lymphocytes. It effectively reduces ConA-induced T cell proliferation with an IC50 of 42.85 μM and LPS-induced B cell proliferation with an IC50 of 3.15 μM. D228 demonstrates efficacy in the treatment of inflammatory bowel disease (IBD) by alleviating inflammation in the DSS-induced IBD model, primarily through the downregulation of the MyD88/TRAF6/p38 signaling pathway. -
Anti-Inflammatory Agent
Anti-inflammatory agent 32 (compound C3) functions as an anti-inflammatory agent, exhibiting notable antioxidative properties. This compound is ideal for research focused on anti-inflammatory mechanisms and skin care product development, contributing valuable insights into inflammatory pathways and therapeutic interventions. -
Anti-inflammatory Agent
Nicotredole is an orally active anti-inflammatory agent that primarily targets inflammatory pathways. It demonstrates significant anti-inflammatory and analgesic effects, exhibiting potency comparable to that of Phenylbutazone while presenting only minimal ulcerogenic activity. Nicotredole is suitable for research applications focused on inflammation and pain management studies. -
Anti-inflammatory Agent
Tetridamine is a non-steroidal anti-inflammatory agent that primarily targets inflammatory pathways. It has been demonstrated to significantly reduce paw swelling and alleviate pain sensitivity in various models of inflammation. This compound is valuable for research into inflammation-related conditions and the development of novel anti-inflammatory therapies. -
Anti-inflammatory Agent
Cedrol methyl ether is an anti-inflammatory agent derived from ginger. It exhibits significant anti-inflammatory activity, making it a valuable compound for research applications related to hyperhidrosis and abnormal vaginal discharge. Its potential uses in studying inflammatory conditions highlight its importance in biochemical and therapeutic investigations. -
Anti-Inflammatory Agent
Mosedipimod is a monoacetyldiaglyceride that functions as a Toll-Like Receptor (TLR) signaling inhibitor. It exhibits significant anti-inflammatory activity by reducing myeloperoxidase expression in lung tissue, thereby attenuating airway inflammation. This compound is primarily utilized in research related to chronic obstructive pulmonary disease (COPD), contributing to the understanding of inflammatory pathways and potential therapeutic interventions.
