PQM-164 is an antioxidant agent that targets oxidative stress by exhibiting potent radical scavenging activity (IC50: 0.93 μM for DPPH radical). It demonstrates anti-inflammatory effects by mitigating neuronal damage induced by 6-OHDA in activated microglial cells, and it reduces α-synuclein accumulation. Additionally, PQM-164 promotes the nuclear translocation and transcriptional activity of Nrf2. This compound serves as a valuable tool for research into neurodegenerative conditions such as Parkinson’s disease.
PQM-164 is an antioxidant agent that targets oxidative stress by exhibiting potent radical scavenging activity (IC50: 0.93 μM for DPPH radical). It demonstrates anti-inflammatory effects by mitigating neuronal damage induced by 6-OHDA in activated microglial cells, and it reduces α-synuclein accumulation. Additionally, PQM-164 promotes the nuclear translocation and transcriptional activity of Nrf2. This compound serves as a valuable tool for research into neurodegenerative conditions such as Parkinson’s disease.
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