Catalog No.
Product Name
Application
Product Information
Citations
-
NO Production Inhibitor
Sinomenine N-oxide is a potent inhibitor of nitric oxide (NO) production, exhibiting an IC50 value of 23.04 μM. This compound demonstrates significant anti-angiogenic, anti-inflammatory, and anti-rheumatic properties, making it valuable for research in cardiovascular and inflammatory diseases. Its mechanisms may offer insights into therapeutic approaches for conditions characterized by excess NO production. -
NO Inhibitor
Diplacol is a geranylated flavanone that functions as a nitric oxide (NO) inhibitor. Isolated from Paulownia coreana UYEKI, Diplacol exhibits notable anti-inflammatory activity. It effectively reduces NO production in LPS-stimulated Raw264.7 macrophage cells, with an IC50 value of 4.53 μM, making it a valuable reagent for studies focusing on inflammation and related signaling pathways. -
NOS Inhibitor
L-NAPNA is a selective nitric oxide synthase (NOS) inhibitor, demonstrated to have an IC50 of 1.4 μM. It exhibits significant analgesic effects, as evidenced by its ability to reduce formalin-induced paw licking behavior in mice (ED50 of 57.2 mg/kg) and diminish acetic acid-induced abdominal writhing (ED50 of 25 mg/kg). This compound is valuable for exploring therapeutic approaches in research focused on central nervous system disorders. -
Guanidino Compound
α-Guanidinoglutaric acid is a guanidino compound that has been identified in cobalt-induced epileptogenic foci within the cerebral cortex of feline subjects. This compound is known to induce epileptic seizures in rodent models following intraventricular administration, making it a valuable tool for studying the mechanisms of epilepsy and related neurological disorders. Its application is particularly relevant in pharmacological studies aimed at elucidating seizure activity and potential therapeutic interventions. -
NO Synthase Inhibitor
Corydaldine is an alkaloid that acts as an inhibitor of nitric oxide synthase (NOS). It has been shown to effectively reduce nitric oxide production in BV2 microglial cells upon stimulation with lipopolysaccharide (LPS). This compound is relevant for research focusing on neuroinflammation and the roles of nitric oxide in various neurodegenerative diseases. -
iNOS Inhibitor
AR-C102222 is a spirocyclic fluoropiperidine quinazoline that selectively inhibits inducible nitric oxide synthase (iNOS). This compound demonstrates significant potential in mitigating neuropathic pain by reducing excessive nitric oxide production. Its specificity for iNOS makes it a valuable tool for researchers investigating the role of nitric oxide in pain pathology and related therapeutic interventions. -
iNOS Inhibitor
FR260330 is a selective, orally active inhibitor of inducible nitric oxide synthase (iNOS), functioning by suppressing iNOS dimerization. This compound significantly reduces nitric oxide accumulation in rat splenocytes and human DLD-110 cells, with IC50 values of 27 nM and 10 nM, respectively. FR260330 has demonstrated efficacy in ameliorating lipopolysaccharide-induced inflammatory responses in rat models, making it a valuable tool for researchers investigating inflammatory diseases and related pathways. -
NO Production Inhibitor
Anhydronotoptol is a potent inhibitor of nitric oxide (NO) production. It effectively inhibits NO generation in RAW 264.7 cells induced by lipopolysaccharide (LPS), with an IC50 value of 36.6 μM. This compound is valuable for research applications focused on inflammation and related signaling pathways. -
iNOS Inhibitor
1-Heptadecanoyl-rac-glycerol is an iNOS inhibitor that exhibits anti-inflammatory activity. By suppressing the expression of inducible nitric oxide synthase (iNOS), it effectively reduces inflammation. This compound is suitable for research applications focused on inflammatory diseases and related pathologies. -
NO Synthase Inhibitor
S-MTC acetate (S-Methyl-L-thiocitrulline acetate) is a potent inhibitor of inducible nitric oxide synthase (iNOS), selectively inhibiting iNOS while preserving the activity of constitutive nitric oxide synthase (nNOS). This compound is valuable for studying the roles of nitric oxide in various physiological and pathological processes, particularly in inflammation and neuroprotection research. Its specificity makes it an important tool for investigating the differential effects of nitric oxide in cellular signaling pathways. -
NO Release Inhibitor
Schisanchinin D is an NO release inhibitor derived from the fruits of Schisandra chinensis. It effectively inhibits the release of nitric oxide (NO) in lipopolysaccharide (LPS)-activated primary murine BV2 microglia cells. This compound holds potential for research in neurodegenerative diseases, particularly Alzheimer's disease (AD), due to its impact on microglial activation and neuroinflammatory processes. -
NO Synthase Inhibitor
Rubranol is a selective inhibitor of nitric oxide (NO) synthase, significantly reducing NO production in response to lipopolysaccharide (LPS) stimulation in activated macrophages, achieving a notable 74% inhibition. This compound is useful for researchers studying inflammatory responses and the role of NO in various pathological conditions. Its specific action on NO synthase makes it a valuable tool for investigating the modulation of nitric oxide pathways in cellular processes. -
NO Production Inhibitor
3β,15α-Dihydroxy-7,11,23-trioxo-lanost-8-dien-26-oic acid is a triterpene compound with a primary mechanism as a nitric oxide (NO) production inhibitor. It effectively suppresses NO production in BV-2 microglial cells stimulated by lipopolysaccharide (LPS), demonstrating an IC50 value of 6.50 μM. This compound serves as a valuable tool for anti-inflammatory research, potentially contributing to the development of therapeutic strategies targeting inflammatory pathways. -
Negative Control
Sulpho NONOate is a negative control compound that does not release nitric oxide (NO) at physiological pH. This reagent is utilized in experiments involving other NO-donor agents to effectively establish baseline comparisons and validate the biological activity of those compounds. Its role as a control is essential for clarifying the specific effects of NO-donors in various biochemical and physiological studies. -
NO Synthase Antagonist
L-NMMA hydrochloride is a competitive antagonist of L-arginine, effectively inhibiting nitric oxide (NO) production by targeting nitric oxide synthase. This compound is widely used in research to study the role of nitric oxide in various physiological and pathological processes, such as vascular regulation and immune response modulation. Its application extends to exploring potential therapeutic interventions in conditions associated with dysregulated NO signaling. -
iNOS Inhibitor
N-Benzylacetamidine hydrobromide is a selective inhibitor of inducible nitric oxide synthase (iNOS), exhibiting an IC50 of 0.20 μM. This compound is valuable for research focused on the modulation of nitric oxide production in inflammatory processes. Its selective action makes it a suitable tool for studying iNOS-related pathophysiology and potential therapeutic applications in related diseases. -
NO Synthesis Inhibitor
(2R)-6-Methoxynaringenin is a selective inhibitor of nitric oxide (NO) synthesis. This flavonoid exhibits significant biological activity, with an IC50 value of 25.8 μM for NO production inhibition. Its ability to modulate NO levels makes it a valuable tool for research applications focused on vascular biology, inflammation, and associated signaling pathways. -
iNOS Inhibitor
Cindunistat is a selective inhibitor of inducible nitric oxide synthase (iNOS), demonstrating potent oral bioactivity. This compound is valuable for investigating the role of iNOS in various inflammatory and pathological conditions. Research applications include studies on cytokine modulation, neuroinflammation, and cardiovascular diseases, making it a crucial tool for exploring therapeutic interventions in nitric oxide-mediated pathways. -
iNOS Inhibitor
Demethylregelin is a triterpene that functions as an inhibitor of inducible nitric oxide synthase (iNOS). It effectively decreases iNOS protein expression and subsequent nitric oxide production in RAW264.7 macrophages upon lipopolysaccharide stimulation. This compound exhibits notable anti-inflammatory properties and is useful in research focusing on inflammatory signaling pathways and modulation of nitric oxide levels in cellular models. -
NO Synthase Inhibitor
NG-Amino-L-arginine hydrochloride is a potent inhibitor of nitric oxide synthase (NOS), specifically targeting the nNOS, iNOS, and eNOS isoforms. It effectively induces inactivation of these enzymes, with Ki values of 0.3 μM, 3 μM, and 2.5 μM, respectively. This reagent is valuable for research applications focused on the modulation of nitric oxide pathways and their roles in various physiological and pathological processes. -
NO Production Inhibitor
N-cis-Feruloyl tyramine is a natural phenolic compound that acts as an inhibitor of nitric oxide (NO) production. It demonstrates moderate inhibitory effects on lipopolysaccharide (LPS)-activated NO production in RAW 264.7 macrophage cells. This compound can be utilized in research to explore inflammatory responses and the modulation of NO signaling pathways. -
NO Synthase Inhibitor
Anti-inflammatory agent 1 is a nitric oxide synthase inhibitor that modulates inflammatory processes by reducing nitric oxide production. This compound exhibits significant anti-inflammatory activity, making it a valuable tool for research focused on conditions characterized by excessive inflammation. Its applications extend to studying various inflammatory pathways and assessing the therapeutic potential of nitric oxide modulation in diverse biological contexts. -
iNOS/COX-2 Inhibitor
Longiferone B is a daucane sesquiterpene derived from the rhizomes of Boesenbergia longiflora, acting as an inhibitor of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). It exhibits significant anti-inflammatory properties, effectively reducing nitric oxide production with an IC50 value of 21.0 μM. Longiferone B also suppresses the mRNA expression of iNOS and COX-2, making it a valuable compound for research in inflammation-related studies. -
NO Synthase Inhibitor
DL-1′-Acetoxychavicol acetate is a potent inhibitor of nitric oxide synthase (NOS). This compound demonstrates significant anti-inflammatory and anticancer properties by suppressing the activity of NADPH oxidase (NOX), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) in inflammatory cells. It has been shown to exhibit preventive effects in various inflammation-related cancer models, making it a valuable tool for research into inflammatory diseases and cancer therapy. -
COX-2/iNOS Inhibitor
α-Chaconine is an inhibitor of COX-2 and iNOS, which demonstrates significant anti-inflammatory activity. It effectively reduces the transcriptional expression of COX-2, IL-1β, IL-6, and TNF-α. Additionally, α-Chaconine suppresses LPS-induced expression of iNOS and COX-2 at both the protein and mRNA levels, along with their promoter activities in RAW 264.7 macrophages. This makes α-Chaconine a valuable reagent for studies focused on inflammation and related signaling pathways. -
NO Donor Agent
RIG 200 is an S-nitrosothiol nitric oxide (NO) donor that releases NO through decomposition, activating guanylate cyclase (sGCM) in vascular smooth muscle cells. This process increases cGMP levels, resulting in vasodilation. Additionally, RIG 200 significantly inhibits collagen-induced platelet aggregation in platelet-rich plasma (PRP), making it a valuable tool for research focused on thrombus prevention and cardiovascular studies. -
NO Donor
SE 175 is an organic nitrate compound that functions as a nitric oxide (NO) donor through the reductive conversion of its nitrate group. Its primary mechanism involves the stimulation of endothelial soluble guanylate cyclase, resulting in pronounced aortic vasorelaxation, with an EC50 value of 0.20 µM. This compound is valuable for research investigating vascular biology and cardiovascular function, particularly in studies related to NO-mediated signaling pathways. -
NOS inhibitor
L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor. -
GPR3 agonist/NOS/ NADPH oxidases inhibitor
Diphenyleneiodonium chloride has been shown to be a potent irreversible inhibitor of NOS2 (iNOS) from macrophages and NOS3 (eNOS) from endothelial cells. -
GTP cyclohydrolase I inhibitor
2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production. -
INOS inhibitor
1400W Dihydrochloride is a slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). Selective over nNOS and eNOS (Ki values are 2 and 50 μM respectively). Cell-permeable and active in vivo. -
NOS cofactor
Biopterin is the oxidized form of tetrahydro-L-biopterin (BH4), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 uM after 48 hrs). -
Nitric oxide donor
Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin. Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model. It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range. Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris. - Tetrahydrobiopterin is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms.
-
Analog of curcumin
Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS. -
nNOS inhibitor
7-Nitroindazole, a heterocyclic compound, acts as a selective inhibitor for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS. -
nNOS inhibitor
3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). -
NO synthase inhibitor
Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. -
nitric oxide synthases inhibitor
2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5μM for murine iNOS and rat n-cNOS, respectively. -
iNOS Inhibitor
1400W is a selective inhibitor of inducible nitric-oxide synthase (iNOS) with a Kd value of ≤ 7 nM, demonstrating slow and tight binding characteristics. This compound effectively inhibits iNOS induction in microglial cells, leading to reduced nitric oxide production, which in turn helps alleviate oxidative stress and neuronal apoptosis in the rat cerebral cortex. 1400W's ability to ameliorate spatial memory dysfunction associated with acute hypobaric hypoxia-reoxygenation makes it a valuable tool for research in neuroprotection and neurodegenerative disease studies. -
iNOS Inhibitor
iNOS-IN-5 (Compound BN-4) is a potent inhibitor of inducible nitric oxide synthase (iNOS) with an IC50 of 0.1707 μM, effectively reducing nitric oxide levels in LPS-induced RAW264.7 cells. This compound demonstrates protective properties against hypoxic injury by decreasing reactive oxygen species (ROS) and lactate dehydrogenase expression, exhibiting significant anti-necrosis and anti-apoptosis effects. Additionally, iNOS-IN-5 has shown neuroprotective activity and protective effects against cerebral ischemia in SD rat models, while also being capable of penetrating the blood-brain barrier. -
iNOS Inhibitor
Glycylglycine hydrochloride hydrate is an iNOS inhibitor that acts as a non-selective dipeptidase substrate. This compound is capable of passive diffusion across cell membranes, where it is hydrolyzed to glycine, playing a role in energy metabolism and antioxidant activities. Glycylglycine hydrochloride hydrate promotes the proliferation of spermatogonial stem cells and mitigates astrocyte overactivation while decreasing nitric oxide release. Additionally, it upregulates the expression of neurotrophic factors, aiding in nerve myelin repair. This reagent is suitable for research into male reproductive biology and the neuroprotective mechanisms in neurodegenerative diseases. -
nNOS Inhibitor
2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS), exhibiting a Ki value of 20 μM. It effectively antagonizes BH4-induced nNOS dimerization, thereby modulating nitric oxide synthesis in neuronal tissues. In addition to its role as an nNOS inhibitor, 2-Thiouracil also has antithyroid properties and serves as a specific marker for melanoma detection. Furthermore, it promotes root growth in pea and corn, making it a valuable tool for various agricultural and biochemical research applications. -
iNOS Inhibitor
Glycylglycine, an iNOS inhibitor, is a dipeptide that serves as a non-selective glycylglycine dipeptidase substrate. It effectively crosses cell membranes through passive diffusion and is subsequently hydrolyzed to glycine, which participates in energy metabolism and antioxidant defense. This compound promotes the proliferation of spermatogonial stem cells (SSCs), mitigates astrocyte overactivation, and reduces nitric oxide (NO) release while enhancing the expression of neurotrophic factors such as PDGFA, FGF2, and CNTF, thereby supporting nerve myelin repair. Glycylglycine is valuable in research on male reproductive biology and neurodegenerative diseases, including the investigation of neuroprotective mechanisms in conditions like multiple sclerosis.
