Catalog No.
Product Name
Application
Product Information
Citations
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Nitric Qxide Production Inhibitor
Mudanpioside F is a monoterpene glycoside that serves as an inhibitor of nitric oxide production, specifically targeting LPS-induced pathways. It displays potent activity with an IC50 of 18.65 ± 2.1 μM, making it a valuable tool for investigating nitric oxide modulation. This compound is particularly relevant in studies related to inflammation and immune response, providing insights into the signaling mechanisms involving nitric oxide. -
Carcinogen
Retrorsine N-oxide is a pyrrolizidine alkaloid N-oxide recognized for its carcinogenic properties. This compound generates DNA adducts that serve as significant toxicological biomarkers in studies of pyrrolizidine alkaloid N-oxides. Retrorsine N-oxide is utilized in research investigating the mechanisms of carcinogenesis and the effects of alkaloid exposure on cellular DNA integrity. -
nNOS Inhibitor
Nω-allyl-L-arginine is a competitive and reversible inhibitor of neuronal nitric oxide synthase (nNOS). This compound effectively inactivates nNOS in a time-dependent manner while serving as a substrate that generates L-arginine, acrolein, and water. Its role in nitric oxide signaling pathways makes it valuable for research into neurovascular functions and related pathophysiological conditions. -
NO Synthase Inhibitor
L-NAME is a nitric oxide synthase (NOS) inhibitor with an IC50 of 70 μM. This compound acts as a precursor to the more potent NOS inhibitor L-NOARG, which has an IC50 of 1.4 μM. L-NAME requires hydrolysis by cellular esterases to achieve its full inhibitory activity. It is commonly utilized in research to induce hypertension and preeclampsia models, facilitating studies on cardiovascular health and nitric oxide signaling pathways. -
Neuroinflammation Inhibitors
Stephalonine P is a hasubanan-type alkaloid that serves as a neuroinflammation inhibitor. It exhibits significant anti-inflammatory properties by inhibiting nitric oxide production in lipopolysaccharide-activated BV2 microglia, with an IC50 value of 34.01 μM. By reducing microglial activation, Stephalonine P provides neuroprotective effects, which are particularly relevant in the context of stroke and other neuroinflammation-related diseases. This compound can be isolated from the plant Stephania japonica and is valuable for research into neuroinflammatory mechanisms and therapeutic interventions. -
Glucose Pyranoside
6-Hydroxygenistein-7-O-β-D-glucopyranoside targets glucose pyranoside pathways. Isolated from the flower of Pueraria lobata, this compound exhibits potential anti-inflammatory properties, particularly in microglial cells. Its ability to inhibit nitric oxide production makes it a valuable tool for research in neuroinflammation and related biological studies. -
NO Synthesis Inhibitor
Kadsulignan H is a lignan that functions as a nitric oxide (NO) synthesis inhibitor. It effectively inhibits NO production in BV-2 cells, demonstrating an IC50 value of 14.1 μM. This compound is valuable for research applications focused on inflammatory processes and neurological studies where modulation of nitric oxide levels is relevant. -
NO Synthase Inhibitor
Harzianol A is a potent inhibitor of nitric oxide (NO) synthase. Isolated from Trichoderma sp. SCSIOW21, this compound demonstrates significant anti-inflammatory activity by effectively reducing NO production. Harzianol A is suitable for research applications focused on nitrosative stress and inflammatory pathways. -
NO Synthase Inhibitor
L-NABE is a selective inhibitor of nitric oxide (NO) synthase, effectively modulating the production of nitric oxide in biological systems. This compound exhibits significant vasoconstrictive properties, contributing to endothelium-dependent vasoconstriction and inhibiting relaxation responses. L-NABE is primarily utilized in research to study vascular physiology and the role of nitric oxide in cardiovascular conditions. -
Lipid-lowering Agent
NCX-6560 is an orally active nitric oxide-releasing derivative of atorvastatin, primarily designed as a lipid-lowering agent. It effectively inhibits cholesterol biosynthesis while exhibiting notable anti-inflammatory and antithrombotic properties. This compound has potential applications in cardiovascular research and the study of metabolic disorders. -
NO Synthase Inhibitor
Harzianoside A is a diterpene aminoglycoside that acts as a nitric oxide synthase inhibitor. It effectively reduces the production of nitric oxide, making it a valuable tool for investigating anti-inflammatory mechanisms. This compound is useful in research focused on inflammation and related pathophysiological conditions. -
NO Inhibitor
Geranyl ferulate, a derivative of ferulic acid isolated from Zingiber officinale, serves as a nitric oxide (NO) inhibitor. This compound demonstrates a significant inhibitory effect on NO production, making it valuable for research related to nitric oxide signaling pathways. Its potential applications extend to studies focused on inflammatory processes, vascular biology, and related therapeutic interventions. -
NO Inhibitor
Thunalbene is a stilbene derivative that acts as a nitric oxide (NO) inhibitor. It demonstrates a moderate inhibitory effect on nitric oxide production, making it a valuable tool for studies examining NO-related pathways. Additionally, Thunalbene has been shown to be non-cytotoxic, enabling its use in various biological assays without compromising cell viability. -
iNOS/ICAM-1 Inhibitor
Aloenin aglycone is an inhibitor of iNOS and ICAM-1, derived from aloe exudate. It effectively suppresses TNFα-induced NF-κB transcriptional activity with an IC50 of 18.7 μM. Additionally, at a concentration of 10 μM, it significantly reduces the expression of both inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) in HepG2 cells following TNFα stimulation. This compound serves as a valuable tool for investigating inflammatory pathways and potential therapeutic interventions in related conditions. -
Sesquiterpene
Alismol is a natural sesquiterpene that exhibits significant inhibitory effects on interferon-gamma (INF-γ)-induced nitric oxide production in murine macrophage RAW264.7 cells. This molecule serves as a valuable tool for studying inflammation and immune responses, particularly in the context of macrophage activation. Its potential applications extend to research in immunology and pharmacology, focusing on therapeutic strategies for inflammatory diseases. -
Fatty Acid Derivative
Echinochlorin A is a fatty acid derivative primarily derived from Echinochloa utilis. This compound exhibits notable biological activity, contributing to various metabolic processes. It serves as a valuable reagent for research in fatty acid metabolism and other biochemical pathways involving lipid-derived compounds. -
Antihypertensive Agent
Cicletanine hydrochloride is an orally active furopyridine derivative that functions as an antihypertensive agent primarily by stimulating nitric oxide (NO) release. This compound promotes effective pulmonary vasodilation, making it useful in the study of cardiovascular health and hypertension-related research. Its mechanisms may offer insights into potential therapeutic strategies for managing elevated blood pressure and related vascular conditions. -
NO Production Inhibitor
6-Methoxynaringenin is a natural flavonoid that functions as an inhibitor of nitric oxide (NO) production, exhibiting an IC50 of 25.8 μM. This compound is valuable for research focused on cardiovascular health and inflammation, where NO plays a critical role. Its ability to modulate NO levels makes it an important tool for studying various biochemical pathways and therapeutic interventions. -
NO Synthase Inhibitor
Ronopterin is a nitric oxide synthase (NOS) inhibitor, primarily utilized in research investigating the pathophysiology of urogenital and neurological disorders. By inhibiting NO production, Ronopterin modulates crucial signaling pathways, making it a valuable tool for studying conditions linked to dysregulated nitric oxide signaling. Applications include exploring the role of NO in various diseases and assessing therapeutic strategies targeting NOS pathways. -
Furanocoumarin
(Rac)-Isogosferol is a furanocoumarin derived from the fruits of Cnidium monnieri. It exhibits significant biological activity, including potential anti-inflammatory and antimicrobial properties. This compound is primarily utilized in research applications aimed at understanding its therapeutic effects and mechanisms of action within various biological systems. -
SPSB2-iNOS Inhibitor
SPSB2-iNOS inhibitory cyclic peptide-3 is a selective inhibitor targeting the interaction between SPSB2 and inducible nitric oxide synthase (iNOS). This compound binds to the SPSB2 site on iNOS with a dissociation constant (KD) of 7 nM. It demonstrates significant biological activity in modulating nitric oxide production and has potential applications in studies related to inflammation and oxidative stress. -
NOS Inhibitor
NOS-IN-2 is a selective inhibitor of nitric oxide synthase (NOS), primarily targeting inducible nitric oxide synthase (iNOS) with an IC50 of 20 µM, while sparing endothelial nitric oxide synthase (eNOS). Its low toxicity profile makes it suitable for research in inflammatory disorders and related pathways. NOS-IN-2 is an important tool for investigating the role of nitric oxide in various biological processes and for developing therapeutic strategies for conditions associated with elevated iNOS activity. -
NO Synthase Inhibitor
GW 273629 is a selective nitric oxide synthase inhibitor that effectively modulates nitric oxide production. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research investigating inflammation-related pathways and conditions. Its specificity for nitric oxide synthase positions it as a suitable reagent for studies aimed at understanding the role of nitric oxide in various biological processes. -
NO Synthase Inhibitor
Cycloneroside C is a sesquiterpene aminoglycoside that functions as a nitric oxide synthase inhibitor. In studies utilizing RAW 264.7 macrophage cells, it demonstrated an IC50 value of 57.1 μM for the inhibition of nitric oxide production. This compound is primarily applied in research focused on anti-inflammatory mechanisms and potential therapeutic interventions. -
NO Synthase Inhibitor
Harzianoside B is a diterpene aminoglycoside known for its role as a nitric oxide (NO) synthase inhibitor. It effectively reduces NO production, demonstrating an IC50 value near the maximum tested concentration of 100 µM in RAW 264.7 macrophage cells. This compound is valuable for research into anti-inflammatory mechanisms and therapeutic applications. -
NO Synthesis Inhibitor
Schiarisanrin A is a lignan that acts as an inhibitor of nitric oxide (NO) synthesis. It demonstrates a significant inhibitory effect on NO production in BV-2 cells, with an IC50 value of 9.6 μM. This compound may serve as a valuable tool in research focused on inflammatory pathways and neuroprotection. -
iNOS Inhibitor
Myricananin A is a selective inhibitor of inducible nitric oxide synthase (iNOS), effectively modulating nitric oxide production. This compound demonstrates significant anti-inflammatory properties, making it valuable for research in inflammation-related pathways and conditions. Myricananin A serves as a critical tool for elucidating the role of iNOS in various biological processes and may aid in the development of therapeutic strategies targeting iNOS-related diseases. -
Vasodilator
L-Arginine is a substrate for endothelial nitric oxide synthase (eNOS), facilitating the production of nitric oxide (NO). This compound acts as a potent vasodilator, influencing vascular tone and blood flow. It is commonly utilized in research applications related to cardiovascular studies and may also be employed to induce experimental acute pancreatitis. -
NO Synthase Inhibitor
Chloranthalactone E is a labdane diterpene that acts as an inhibitor of nitric oxide synthase (NOS). It effectively reduces nitric oxide production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages, making it a valuable tool for studying inflammatory pathways. This compound is useful in research focused on immune responses and the modulation of macrophage activity. -
NO donor
LA-419 is an orally active nitric oxide (NO) donor that effectively reduces fecal worm egg excretion and shortens the duration of egg shedding in mice infected with S. venezuelensis. Additionally, it decreases the larval load in the lungs and the count of parasitic females in the intestines. LA-419 also demonstrates protective effects against atherosclerosis in apolipoprotein E-deficient mice, making it valuable for studies in infection and cardiovascular diseases. -
NO Synthase Inhibitor
Mercaptoethylguanidine (MEG) dihydrobromide is a selective inhibitor of inducible nitric oxide synthase, acting as a peroxynitrite scavenger. This compound exhibits significant anti-inflammatory properties, making it a valuable tool for research into inflammatory bowel diseases and related conditions. Its ability to modulate nitric oxide production makes MEG an important reagent for studies focusing on nitric oxide-related pathologies. -
NO Production Inhibitor
Dimeric coniferyl acetate is an inhibitor of nitric oxide (NO) production, exhibiting an IC50 value of 7.9 μM in BV-2 microglial cells. This compound is valuable for research applications aimed at understanding the regulation of NO synthesis and its implications in neuroinflammatory processes. Its specificity and potency make it a useful tool for studying the role of NO in cellular signaling and neurobiology. -
Cardiac Protectant
RC-552 is a novel synthetic glycolipid that acts as a cardiac protectant through an inducible nitric oxide synthase (iNOS)-dependent mechanism. This compound has demonstrated the ability to attenuate myocardial stunning, providing delayed cardioprotective effects. It is valuable in research focused on cardiac ischemia and myocardial injury, offering insights into potential therapeutic strategies for heart-related conditions. -
Nitric Oxide Inhibitor
(+)-Hannokinol is a nitric oxide inhibitor derived from the fruit of AMOMUM TSAO-KO, a member of the ginger family. This compound effectively inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia, making it a valuable tool for studies related to neuroinflammation and oxidative stress. Its biological activity contributes to research in various fields, including neurobiology and immunology. -
NOS Inhibitor
Guanidino ethyl disulfide is a selective nitric oxide synthase (NOS) inhibitor, showing EC50 values of 110 μM for iNOS, 630 μM for eNOS, and 180 μM for bNOS. This compound effectively inhibits nitrite production in J774.2 macrophages, making it a valuable tool for studying mechanisms of nitric oxide modulation. Guanidino ethyl disulfide can be utilized in research related to circulatory shock, inflammation, and neurological disorders. -
Nitric Oxide Inhibitor
Kansuinine E is a jatrophane-type diterpenoid that acts as a nitric oxide inhibitor with an IC50 of 6.3 μM. Isolated from the roots of Euphorbia kansui, this compound demonstrates significant biological activity by modulating nitric oxide levels. Kansuinine E is primarily utilized in research applications focusing on vascular biology and the study of nitric oxide-related pathways. -
Triterpene
11-Deoxyalisol B is a triterpene known for its potent inhibitory effect on lipopolysaccharide (LPS)-induced nitric oxide (NO) production. This compound has significant implications for research into inflammatory responses and immune modulation. Its ability to modulate nitric oxide levels makes it a valuable reagent for studying mechanisms underlying various inflammatory diseases. -
NO Inhibitor
Isolupalbigenin is a nitric oxide (NO) inhibitor that exhibits significant anti-proliferative activity against HL-60 human leukemia cells, with an IC50 value of 5.1 μM. This compound is useful in research applications focused on the modulation of nitric oxide signaling pathways and the exploration of therapeutic strategies for leukemia and related disorders. -
NO Production Inhibitor
O-Acetylschisantherin L is a natural lignan that serves as an inhibitor of nitric oxide (NO) production. It effectively suppresses LPS-induced NO production in BV-2 cells, demonstrating an IC50 value of 23.1 μM. This compound is useful in research focused on neuroinflammation and associated signaling pathways. -
NOS Inhibitor
NOS-IN-3 is a selective inhibitor of nitric oxide synthase (NOS) with a notable affinity for inducible nitric oxide synthase (iNOS), exhibiting an IC50 of 4.6 μM, while sparing endothelial nitric oxide synthase (eNOS). This compound demonstrates minimal toxicity, making it suitable for investigations into diseases associated with the inducible isoform, such as septic shock. NOS-IN-3 is a valuable tool for elucidating the role of iNOS in various pathological conditions. -
NO Production Inhibitor
Valeriandoid F is an iridoid compound that acts as a potent inhibitor of nitric oxide (NO) production, exhibiting an IC50 value of 0.88 μM. This reagent possesses anti-inflammatory and antiproliferative properties, making it beneficial for studies related to inflammation and cancer research. Its ability to modulate NO levels may also provide insights into various pathological conditions associated with dysregulated nitric oxide signaling. -
Antitumor Agent
Antitumor Agent-49 is a harmine derivative-furoxan hybrid that acts as an antitumor agent. This compound exhibits significant cytotoxic activity against HepG2 cells, with an IC50 of 1.79 µM, indicating its potential effectiveness in cancer research. Additionally, Antitumor Agent-49 generates elevated levels of nitric oxide (NO) in vitro, making it a valuable tool for investigating antitumor mechanisms and therapeutic strategies. -
NO Inhibitor
Britannilactone diacetate is a notable nitric oxide (NO) inhibitor, demonstrating significant efficacy in reducing NO production induced by lipopolysaccharide (LPS) in BV-2 microglial cells, with an effective concentration (EC50) of 6.3 μM. This compound is characterized by its favorable penetration across the blood-brain barrier, along with promising absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles, making it a valuable tool for investigating NO-related neuroinflammatory processes. Its unique mechanisms and properties position it for various research applications in neurobiology and pharmacology. -
Chalcone Derivative
2′-Hydroxy-2,3-dimethoxychalcone is a chalcone derivative that exhibits anti-inflammatory properties. It effectively inhibits the production of nitric oxide through the inhibition of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. This compound is valuable for research applications focused on the modulation of inflammatory responses and the investigation of nitric oxide pathways in various biological systems. -
Plant Growth Regulator
N-Isobutyl decanamide is a plant growth regulator that enhances the development of adventitious and lateral roots in Arabidopsis thaliana hypocotyl and taproot explants, respectively. It promotes root formation by inducing the accumulation of nitric oxide (NO) in the areas of active adventitious root generation. This compound is valuable for research applications focused on root development and plant physiology. -
iNOS Inhibitor
BYK 191023 is a selective inhibitor of inducible nitric-oxide synthase (iNOS) that functions as an L-arginine competitive antagonist, exhibiting an IC50 value of 86 nM for iNOS, while displaying significantly higher IC50 values of 17 µM and 162 µM for neuronal (nNOS) and endothelial (eNOS) nitric-oxide synthases, respectively. This compound is vital for studying the role of iNOS in various pathological conditions and demonstrates potential applications in inflammation research and related disease models. -
NO Production Inhibitor
9-Hydroxy-α-lapachone is a natural phenolic compound that serves as an effective nitric oxide (NO) production inhibitor. It demonstrates significant inhibitory activity, with an IC50 value of 4.64 µM, against LPS-induced NO production in RAW 264.7 macrophage cells. This compound is utilized in research applications focused on understanding inflammatory responses and nitric oxide signaling pathways. -
NO Synthase Inhibitor
1,3-PBIT dihydrobromide is a selective inhibitor of inducible nitric oxide synthase (iNOS), demonstrating a Ki value of 47 nM. In contrast, it shows reduced inhibition for endothelial (eNOS) and neuronal nitric oxide synthase (nNOS), with Ki values of 9 µM and 0.25 µM, respectively, for purified human enzymes. While it effectively inhibits iNOS in vitro, its cellular activity may be limited by membrane permeability, making it primarily useful for biochemical studies on nitric oxide pathways and their related regulatory mechanisms. -
Cancer Biomarker
8-Nitroguanine is a product of nitrative DNA damage resulting from reactive nitrogen species and serves as a potential biomarker for cancer progression. This compound is particularly relevant in the study of malignant fibrous histiocytoma, providing insights into tumor development and response to treatment. Its role in oxidative stress pathways makes it a valuable tool for researchers investigating mechanisms of DNA damage and repair in cancer biology. -
Analgesic Agent
Dipyrocetyl is an analgesic agent that exhibits anti-inflammatory properties. This compound is utilized in research applications focused on pain management and inflammation pathways, providing valuable insights into potential therapeutic interventions for various inflammatory disorders. Its mechanism of action makes it a significant candidate for studies aimed at understanding pain relief mechanisms.
