FR260330 is a selective, orally active inhibitor of inducible nitric oxide synthase (iNOS), functioning by suppressing iNOS dimerization. This compound significantly reduces nitric oxide accumulation in rat splenocytes and human DLD-110 cells, with IC50 values of 27 nM and 10 nM, respectively. FR260330 has demonstrated efficacy in ameliorating lipopolysaccharide-induced inflammatory responses in rat models, making it a valuable tool for researchers investigating inflammatory diseases and related pathways.
FR260330 is a selective, orally active inhibitor of inducible nitric oxide synthase (iNOS), functioning by suppressing iNOS dimerization. This compound significantly reduces nitric oxide accumulation in rat splenocytes and human DLD-110 cells, with IC50 values of 27 nM and 10 nM, respectively. FR260330 has demonstrated efficacy in ameliorating lipopolysaccharide-induced inflammatory responses in rat models, making it a valuable tool for researchers investigating inflammatory diseases and related pathways.
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