Catalog No.
Product Name
Application
Product Information
Citations
-
iNOS Inhibitor
GW274150 dihydrochloride is a selective and potent inhibitor of inducible nitric oxide synthase (iNOS), demonstrating an IC50 of 2.19 μM and a Kd of 40 nM, alongside an ED50 of 1.15 μM for rat iNOS. This compound exhibits reduced activity against endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS). Research applications include studying inflammatory responses and evaluating protective effects in models of acute lung injury. -
NOS Inhibitor
Iromycin A is a potent inhibitor of nitric oxide synthases (NOS), derived from Streptomyces sp. It effectively modulates nitric oxide production, making it valuable for research on vascular biology and inflammatory processes. This compound serves as a critical tool in studying the physiological and pathological roles of nitric oxide in various biological systems. -
NO Synthase Inhibitor
Trichaspside F is a sesquiterpene aminoglycoside that serves as a selective inhibitor of nitric oxide synthase. This compound effectively reduces nitric oxide production, exhibiting an IC50 value of 54.8 µM in RAW 264.7 macrophage cells. Its potential applications include studies related to anti-inflammatory mechanisms and the modulation of nitric oxide-related pathways in various biological contexts. -
NO Synthase Antagonist
L-NMMA citrate is a competitive antagonist of L-arginine and effectively inhibits nitric oxide (NO) production by targeting nitric oxide synthase. This reagent is commonly used in research to study the role of NO in various physiological processes and to explore potential therapeutic interventions in conditions associated with dysregulated NO signaling. -
Adrenal Steroid Derivative
α-Epibromide, also known as 16α-Bromoepiandrosterone, is an adrenal steroid derivative that functions primarily by decreasing nitric oxide production. This compound is notable for its ability to restore T helper cell type 1 activity and enhance bacterial clearance in chemotherapy-induced progressive pulmonary tuberculosis models. Additionally, α-Epibromide has been shown to reduce mortality associated with excessive inflammation and opportunistic lung infections, making it significant for research in immunology and infectious diseases. -
NO Donor Agent
SP/W-5186 is a nitric oxide (NO) donor agent featuring a cysteine structure. It exhibits protective effects on cardiac function, reduces myocardial damage, and enhances vascular endothelial integrity while also inhibiting inflammation and oxidative stress. SP/W-5186 is particularly relevant in studies of myocardial ischemia-reperfusion injury due to its capacity to mitigate oxidative damage caused by peroxynitrite (ONOO⁻). -
Amucolitic aAent
Telmesteine is an effective mucolytic agent that exhibits anti-protease activity. It has been shown to inhibit LPS-induced nitric oxide production in RAW264.7 cells, making it a valuable tool for studying inflammatory processes. This compound is particularly relevant for research on conditions such as acute and chronic bronchitis and obstructive airway diseases. -
NO Inhibitor
Staphylionoside D is a nitric oxide (NO) inhibitor derived from Annona squamosa L. It demonstrates significant anti-inflammatory activity by effectively reducing NO production. This compound is of interest for research applications focused on inflammation-related pathways and the modulation of nitric oxide signaling in various biological contexts. -
NO Synthase Inhibitor
Harzianol J is a harziane-type diterpene identified as a nitric oxide synthase inhibitor. Exhibiting significant anti-inflammatory properties, it achieves an 81.8% inhibition of nitric oxide production at a concentration of 100 µM, with an IC50 value of 66.7 µM. This compound is suitable for research applications focused on investigating anti-inflammatory mechanisms and potential therapeutic interventions. -
Isoflavone Glycoside
Achyranthoside A is an isoflavone glycoside derived from the roots of Achyranthes bidentata. It effectively inhibits nitric oxide (NO) production in macrophages stimulated with lipopolysaccharide (LPS), indicating its potential role in modulating inflammatory responses. This compound is relevant for research focused on inflammatory diseases, providing insights into anti-inflammatory mechanisms and therapeutic potential. -
Neuroprotective Agent
SCR-4026 is a neuroprotective agent that effectively penetrates the blood-brain barrier. It exerts its protective effects by disrupting the interaction between neuronal nitric oxide synthase (nNOS) and PSD9, with an IC50 of 6.3 μM. SCR-4026 has been shown to mitigate excitotoxic damage induced by N-methyl-D-aspartate (NMDA) in primary cortical neurons and offers protection in oxygen-glucose deprivation (OGD) models. Additionally, it reduces cerebral infarct volume in the rat middle cerebral artery occlusion (MCAO) reperfusion model, making it a valuable tool for stroke research. -
iNOS Inhibitor
ATV399 is an allosteric inhibitor of inducible nitric oxide synthase (iNOS) that effectively reduces nitric oxide (NO) production by preventing iNOS dimerization. This compound offers protective effects on rat pancreatic islet β-cells by mitigating cytokine-induced mitochondrial stress, endoplasmic reticulum stress, and apoptosis. ATV399 is suitable for research applications focused on type 1 diabetes and related metabolic disorders. -
nNOS Inhibitor
hnNOS-IN-3 is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki value of 0.32 μM, demonstrating competitive binding with L-arginine. This compound exhibits remarkable selectivity, with 115-fold increased affinity for nNOS over inducible nitric oxide synthase (iNOS, Ki=37 μM) and 29-fold greater affinity over endothelial nitric oxide synthase (eNOS, Ki=9.4 μM). hnNOS-IN-3 serves as a valuable tool for studying nNOS-related biological processes and potential therapeutic interventions in neurological disorders. -
NO Synthase Inhibitor
Cycloneroside A is a sesquiterpene aminoglycoside that functions as an inhibitor of nitric oxide synthase. It exhibits significant activity in reducing nitric oxide production, with an IC50 value of approximately 100 µM observed in RAW 264.7 macrophage cells. This compound is valuable for investigating anti-inflammatory mechanisms and the modulation of nitric oxide in various biological contexts. -
NO Synthase Inhibitor
Oxyphyllenone A is a selective inhibitor of nitric oxide synthase (NOS), effectively reducing nitric oxide production in lipopolysaccharide-activated macrophages. With an IC50 value of 28 μM, it serves as a valuable tool in investigating the roles of nitric oxide in inflammatory responses and related biological processes. Oxyphyllenone A is useful for research applications focused on immunology and cellular signaling pathways. -
NOS Inhibitor
7-Nitroindazole sodium is a selective inhibitor of nitric oxide synthase (NOS) that effectively penetrates the blood-brain barrier. It demonstrates significant inhibitory activity towards central NOS, with an IC50 of 0.47 μM measured in murine cerebellar tissue. This compound exhibits neuroprotective and anti-injurious properties, making it a valuable tool for research into neurodegenerative diseases and neuropharmacology. -
NO Synthase Inhibitor
Inflexuside A is a potent inhibitor of nitric oxide synthase. Isolated from the aerial parts of Isodon inflexus, this abietane diterpenoid effectively suppresses lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 macrophage cells. Its significant biological activity makes Inflexuside A a valuable reagent for research into inflammatory responses and nitric oxide signaling pathways. -
Sesquiterpene
(4S)-10-Nor-calamenen-10-one, a eudesmane sesquiterpene, primarily enhances lipopolysaccharide (LPS)-induced nitric oxide (NO) production in microglial cells. This compound, isolated from Alpinia oxyphylla, serves as a valuable tool for investigating neuroinflammatory responses and exploring the roles of microglia in various neurodegenerative diseases. Its ability to modulate inflammatory pathways makes it useful for biological research focused on neuroinflammation and related therapeutic strategies. -
iNOS Inhibitor
MEG hemisulfate is a selective and potent inducible nitric oxide synthase (iNOS) inhibitor, exhibiting EC50 values of 11.5 μM for iNOS, alongside higher values for endothelial and brain nitric oxide synthases. In addition to its role as an iNOS inhibitor, MEG hemisulfate functions as a robust scavenger of peroxynitrite, mitigating peroxynitrite-induced oxidative damage. This compound demonstrates protective effects in various inflammation-related models, including ischemia/reperfusion injury, periodontitis, and inflammatory bowel disease, making it a valuable tool for research in inflammatory processes and oxidative stress responses. -
Sesquiterpene Lactone Dimer
Ainsliadimer A is a sesquiterpene lactone dimer derived from Ainsliaea macrocephala, characterized by its unique carbon skeleton. It functions as an inhibitor of nitric oxide production in cells stimulated by lipopolysaccharides (LPS). This compound is valuable for research applications involving inflammation and immune response modulation. -
NO Synthase Inhibitor
Cycloneroside B is a novel sesquiterpene aminoglycoside that functions as an inhibitor of nitric oxide synthase, effectively reducing nitric oxide production with an IC50 value of 50.7 µM. This compound is significant for research in the anti-inflammatory domain, providing valuable insight into pathways and mechanisms associated with inflammation. Its unique structure and activity make it a relevant tool for investigators exploring nitric oxide's role in various biological processes. -
NO Production Inhibitor
Idesin is a nitric oxide production inhibitor derived from the fruits of Idesia polycarpa. It effectively inhibits lipopolysaccharide (LPS)-induced nitric oxide synthesis while exhibiting minimal cytotoxic effects. This compound is valuable in research applications focused on inflammation, immune response modulation, and studies exploring the roles of nitric oxide in various biological processes. -
Steroidal Compound
Cyathisterol is a steroidal compound that functions by inhibiting lipopolysaccharide (LPS)-induced nitric oxide production. This compound demonstrates significant anti-inflammatory properties, making it valuable for research focused on inflammatory diseases. Its ability to modulate nitric oxide levels provides a potential therapeutic avenue for understanding and treating related pathologies. -
NO Synthase Inhibitor
KLYP961 is a selective, orally active dual inhibitor of inducible and neuronal nitric oxide synthase (IC50 = 50-400 nM). This compound effectively reduces endotoxin-induced increases in plasma nitrates and alleviates pain behaviors in a mouse formalin model. KLYP961 is also shown to mitigate carrageenan-induced edema and inflammatory hyperalgesia, as well as the writhing response provoked by phenylbenzoquinone. It is suitable for research focused on neurological diseases and related inflammatory conditions. -
iNOS Inhibitor
iNOs-IN-3 is a selective inhibitor of inducible nitric oxide synthase (iNOS) with an IC50 of 3.342 µM. This compound exhibits significant anti-inflammatory effects and is applicable in research related to LPS-induced acute lung injury (ALI). Its ability to modulate nitric oxide production makes it a valuable tool for exploring inflammatory pathways and potential therapeutic interventions. -
NO Production Inhibitor
iNOS-IN-2 is a potent inhibitor of inducible nitric oxide synthase (iNOS), effectively reducing nitric oxide (NO) production with an IC50 of 6.4 μM. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research into chronic inflammatory conditions. Its ability to modulate NO levels positions iNOS-IN-2 as an important reagent for studying the roles of iNOS in various biological processes and potential therapeutic interventions. -
NOS Inhibitor
L-ENIPO hydrochloride is a selective inhibitor of nitric oxide synthases (NOS), specifically targeting inducible NOS (iNOS), neuronal NOS (nNOS), and endothelial NOS (eNOS) with Ki values of 17, 10.3, and 58.2 μM, respectively. It demonstrates reversible, tight-binding inhibition with a preference for iNOS, particularly at extended incubation periods. This compound is valuable in research applications focused on inflammation, neurodegenerative diseases, and vascular biology, providing insight into the role of nitric oxide in various physiological and pathological processes. -
Active Compound
Paneolilludinic acid is an active compound derived from the endolichenic fungus Cryptomarasmius aucubae. It is known to significantly inhibit the production of nitric oxide (NO), making it a valuable reagent for studies focused on inflammatory responses. This compound can be utilized in research applications exploring pathways involving nitric oxide and its role in various biological processes. -
iNOS Inhibitor
Cindunistat (hydrochloride) maleate is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS). This compound demonstrates significant anti-inflammatory activity, making it valuable for research into inflammatory diseases and associated pathways. Its oral bioavailability facilitates its use in in vivo studies, enabling deeper exploration of iNOS's role in various biological contexts. -
NO Synthase Inhibitor
Cycloneroside E is a sesquiterpene aminoglycoside that functions as a nitric oxide synthase inhibitor. It demonstrates significant inhibitory activity on nitric oxide production, with an IC50 value of 48.0 µM in RAW 264.7 macrophage cells. This compound is valuable for research in the field of anti-inflammatory therapeutics, providing insights into the modulation of nitric oxide levels in inflammatory responses. -
NO Synthase Inhibitor
(-)-10,11-Dihydroxyfarnesol is a potent nitric oxide synthase inhibitor derived from the endolichenic fungus Cryptomarasmius aucubae. This compound demonstrates significant inhibition of nitric oxide production, making it a valuable tool for studying NO-related biological pathways and mechanisms. Its applications include research into vascular biology, neurobiology, and inflammation where modulation of nitric oxide signaling is critical. -
iNOS Inhibitor
Juncutol is a potent inhibitor of inducible nitric oxide synthase (iNOS), effectively reducing iNOS protein expression stimulated by lipopolysaccharide (LPS). This compound plays a significant role in studies targeting inflammatory pathways, making it valuable for research in conditions characterized by excessive nitric oxide production, such as sepsis and neurodegenerative diseases. Its ability to modulate iNOS activity positions Juncutol as a crucial tool in understanding the regulation of nitric oxide in various biological contexts. -
NO Synthase Inhibitor
Isophysalin A is a potent inhibitor of inducible nitric oxide synthase (iNOS), targeting multiple cysteine residues on IKKβ and effectively diminishing nitric oxide (NO) production. Its mechanism involves binding to glutathione (GSH), which contributes to its anti-inflammatory properties. This compound is valuable for research applications focused on inflammation and related signaling pathways. -
NO Inhibitor
8A8 is a potent inhibitor of nitric oxide (NO) with an IC50 value of 4.7 μM. This compound effectively suppresses lipopolysaccharide (LPS)-induced proliferation of HaCat cells, demonstrating significant anti-inflammatory effects. 8A8 is useful for research applications focused on understanding NO's role in inflammatory processes and related cellular responses. -
NO Donor
BNN3 is a caged nitric oxide (NO) donor that is membrane-permeant and integrates into lipid membranes. This compound facilitates the controlled release of nitric oxide, allowing for precise modulation of NO-dependent signaling pathways. BNN3 is valuable for research applications focused on studying NO's role in various biological processes, including vascular biology and neurobiology. -
Anti-heart Failure Agent
Anti-Heart Failure Agent 2 targets inflammatory mechanisms associated with heart failure. Derived from processed Cornus officinalis, this compound exhibits significant anti-inflammatory activity by inhibiting nitric oxide release in LPS-induced RAW264.7 macrophages. It demonstrates protective effects against myocardial ischemia-reperfusion injury, reduces myocardial infarction size, and improves histopathological changes in cardiac tissues. This agent is a valuable tool for research focused on heart failure mechanisms and therapeutic interventions. -
NO Synthase Inhibitor
Harzianol M is a potent nitric oxide synthase inhibitor derived from Trichoderma sp. SCSIOW21. This compound effectively reduces nitric oxide production, demonstrating significant anti-inflammatory properties. Harzianol M is useful in research applications focused on inflammation-related pathways and nitric oxide modulation. -
Stilbenoid Compound
Isoarundinin I is a stilbenoid compound known for its biological activity against various cellular targets. This compound exhibits antioxidant properties and has potential applications in research related to cancer biology and neuroprotection. Isoarundinin I can be isolated from Arundinaria bambusifolia, making it a valuable reagent for studies investigating the therapeutic potential of stilbenoids in disease models. -
NOS Inhibitor
S-Isopropylisothiourea hydrobromide is a potent nitric oxide synthase (NOS) inhibitor that effectively penetrates the blood-brain barrier. With IC50 values of 0.66, 0.75, and 0.29 μM against mouse spinal cord, cerebellar, bovine aortic, and porcine endothelial cell NOS, it demonstrates a significant blood pressure-raising effect while preserving vital organ perfusion. This compound is utilized in research focused on hemorrhagic shock and the modulation of pain responses, particularly in models utilizing formalin-induced late-phase pain. -
NO Production Inhibitor
Lethedoside A is a natural flavonoid identified as an inhibitor of nitric oxide (NO) production, specifically targeting lipopolysaccharide (LPS)-induced pathways in RAW 264.7 cells. Its primary biological activity involves the modulation of inflammatory responses, making it a valuable tool for research into nitric oxide signaling and inflammatory diseases. This compound is applicable in studies exploring mechanisms of immune regulation and the development of anti-inflammatory strategies. -
NO and H₂S Dynamic Alternating Probe
BOD-NH-SC is a dual-response fluorescent reporter molecule designed for the simultaneous detection of nitric oxide (NO) and hydrogen sulfide (H₂S) in living cells through activatable near-infrared (NIR) II fluorescence, with a primary absorption peak at 664 nm. This reagent enables dynamic monitoring of NO and H₂S fluctuations, providing valuable insights into cellular signaling pathways. It is particularly suitable for applications in biochemistry, cell biology, and physiology related to redox biology and gasotransmitter research. -
Nitric Oxide Synthase Inhibitor
ONO-1714 is an orally active inhibitor of nitric oxide synthase, which plays a crucial role in nitric oxide production. This compound demonstrates significant biological activities, including the attenuation of endotoxin-induced acute lung injury, reduction of intestinal ischemia-reperfusion injury, and repression of biliary carcinogenesis. It is a valuable reagent for research applications focusing on inflammatory responses and tissue protection mechanisms. -
NO Synthase Inhibitor
S-MTC is a selective inhibitor of type I nitric oxide synthase (NOS), primarily targeting the enzymatic production of nitric oxide. This compound has been shown to effectively modulate nitric oxide levels in various biological systems and is valuable for studies investigating vascular function, neurobiology, and inflammation. S-MTC serves as a crucial tool in research aimed at understanding the role of nitric oxide in physiological and pathological processes. -
NO Inhibitor
(-)-Cryptamide C is a potent inhibitor of nitric oxide (NO) production. Derived from the Periostracum cicadae, this dopamine enantiomer trimer demonstrates significant anti-inflammatory activity. It serves as a valuable tool for studying inflammatory diseases and their underlying mechanisms. -
NO Synthase Inhibitor
nNOS-IN-5 is a potent inhibitor of human neuronal nitric oxide synthase (nNOS) with a Ki value of 22 nM. This compound demonstrates remarkable selectivity, exhibiting a 900-fold preference for nNOS over human endothelial nitric oxide synthase (eNOS). nNOS-IN-5 is suitable for research applications related to neurodegenerative diseases, including Alzheimer's and Parkinson's disease, providing valuable insights into nNOS's role in neurobiology and associated pathologies. -
iNOS Inhibitor
2-Iminopiperidine hydrochloride is a potent inhibitor of inducible nitric oxide synthase (iNOS). This compound is utilized in research to explore nitric oxide-mediated processes in various conditions, including arthritis, inflammatory bowel disease, diabetes, allodynia, and cerebral ischemia, as well as other central nervous system disorders. Its role in modulating nitric oxide production makes it a valuable tool for investigating the underlying mechanisms of inflammation and neuroprotection. -
NOS Inhibitor
L-NIO is a potent, non-selective nitric oxide synthase (NOS) inhibitor that acts by inhibiting the NADPH-dependent activity of the enzyme. It displays inhibition constants (Kis) of 1.7, 3.9, and 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) isoforms, respectively. L-NIO has been shown to induce focal ischemic infarcts in rat models, making it a valuable tool for studying the role of nitric oxide in various physiological and pathological processes. Its ability to effectively modulate NOS activity positions it as a significant reagent in cardiovascular and neurobiological research applications. -
NO Releasing Agent
FR144420 is an orally active nitric oxide (NO)-releasing agent that primarily induces vasodilation and inhibits platelet aggregation through cGMP-mediated mechanisms. This compound demonstrates notable vasodilatory and antiplatelet effects, making it a valuable tool in cardiovascular research. Its potential applications include studies related to angina pectoris and coronary artery spasm, contributing to a better understanding of cardiovascular diseases. -
NO Production Inhibitor
Bisacurone is a natural terpenoid that acts as a nitric oxide production inhibitor. It demonstrates potent inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production, with an IC50 value of 29.8 μM. Bisacurone is useful in research settings focused on inflammation and related pathways. -
SPSB2-iNOS Inhibitor
SPSB2-iNOS inhibitory cyclic peptide-2 is a selective inhibitor of the interaction between SPSB2 and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity with a KD of 21 nM. This cyclic peptide is both reduction-resistant and oxidatively stable, making it suitable for various biological assays. Its ability to inhibit SPSB2-iNOS interactions positions it as a valuable tool in research focused on nitric oxide signaling and related pathophysiological processes.
