Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Itraconazole-d3 is a deuterium-labeled derivative of Itraconazole, a triazole antifungal that targets lanosterol 14α-demethylase, a cytochrome P450 enzyme, with an IC50 of approximately 800 nM. This compound acts as a potent antagonist of the Hedgehog (Hh) signaling pathway, and exhibits notable anticancer and antiangiogenic properties. Additionally, Itraconazole-d3 functions as an oxysterol-binding protein (OSBP) inhibitor, making it a valuable tool for studying fungal infections, cancer biology, and metabolic pathways in research settings. -
Stable Isotope
Pentamidine-d4 dihydrochloride is a deuterium-labeled derivative of Pentamidine dihydrochloride, known for its role as an antimicrobial agent. This compound targets DNA biosynthesis and exhibits inhibitory effects on Leishmania infantum with an IC50 of 2.5 μM. Additionally, it acts as a potent and selective inhibitor of protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL). Pentamidine-d4 dihydrochloride holds therapeutic potential for conditions such as Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia, while also demonstrating antitumor and antibacterial activities. -
Stable Isotope
Undecanoic acid-d21 is a deuterium-labeled derivative of undecanoic acid, serving as a stable isotope for research applications. This monocarboxylic acid exhibits antifungal properties by inhibiting the production of extracellular keratinase and lipase, as well as interfering with the biosynthesis of phospholipids in Trichophyton rubrum. It is valuable for studies in metabolic pathways and for tracking the bioactivity of undecanoic acid in various biological systems. -
Stable Isotope
Terbinafine-d3 hydrochloride is a deuterium-labeled analog of Terbinafine hydrochloride, primarily used as a stable isotope in analytical research. This compound acts as a potent non-competitive inhibitor of squalene epoxidase, exhibiting a Ki of 30 nM, and is indicated for the treatment of fungal infections. In addition to its antifungal properties, Terbinafine hydrochloride demonstrates antibacterial activity against specific Gram-positive and Gram-negative bacteria, making it a valuable tool in microbiological studies. -
Stable Isotope
Quinapril-d5 hydrochloride is a deuterium-labeled derivative of Quinapril hydrochloride, which acts as a prodrug targeting the angiotensin-converting enzyme (ACE). This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace drug behavior in biological systems. Its application is crucial for understanding the dynamics of ACE inhibition and evaluating therapeutic efficacy in cardiovascular diseases. -
Stable Isotope
Enalapril-d3 is a deuterium-labeled derivative of Enalapril, an angiotensin-converting enzyme (ACE) inhibitor. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research related to hypertensive diseases. Enalapril-d3 serves as a valuable tool for tracing drug metabolism and dynamics in various biological contexts. -
Stable Isotope
(S)-Lisinopril-d5 sodium is a stable isotope-labeled form of the angiotensin-converting enzyme (ACE) inhibitor, Lisinopril. This deuterium-labeled compound retains the biological activity of Lisinopril, which is utilized primarily in the management of hypertension, congestive heart failure, and post-myocardial infarction. Its application in research includes pharmacokinetic studies, metabolic profiling, and investigations into the mechanisms of ACE inhibition. -
Stable Isotope
Imidapril-d3 hydrochloride is a stable isotope-labeled form of Imidapril hydrochloride, a selective angiotensin-converting enzyme (ACE) inhibitor. This compound exhibits significant antihypertensive activity and is used to investigate the pharmacokinetics and pharmacodynamics of ACE inhibitors in biological systems. Its deuterium labeling facilitates advanced research applications, including mass spectrometry and metabolic studies. -
Stable Isotope
Temocapril-d5 is a deuterated form of Temocapril, an angiotensin-converting enzyme (ACE) inhibitor. This stable isotope can be employed in research focusing on hypertension and related cardiovascular conditions, such as congestive heart failure and acute myocardial infarction. Additionally, Temocapril-d5 is relevant for studies investigating insulin resistance and renal diseases, providing a valuable tool for understanding the pharmacokinetics and dynamics of ACE inhibition in various biological contexts. -
Stable Isotope
Quinaprilat-d5 is a deuterium-labeled derivative of Quinaprilat, a nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. Quinaprilat serves as the active diacid metabolite of Quinapril, effectively blocking the conversion of angiotensin I to angiotensin II and inhibiting the degradation of bradykinin. This compound primarily functions as a vasodilator, leading to decreased total peripheral and renal vascular resistance, making it valuable in cardiovascular research and studies on blood pressure regulation. -
Stable Isotope
Perindopril-d4 erbumine is a stable isotope of Perindopril, functioning as a long-acting angiotensin-converting enzyme (ACE) inhibitor. This reagent is primarily used in pharmacokinetic studies and metabolic profiling of Perindopril for conditions such as hypertension, heart failure, and stable coronary artery disease. Its deuterium labeling allows for enhanced tracking and quantification in research applications, facilitating investigations into drug metabolism and therapeutic efficacy. -
Stable Isotope
Imidaprilat-d3 is a deuterium-labeled form of Imidaprilate, a potent angiotensin-converting enzyme (ACE) inhibitor known for its IC50 of 2.6 nM. This stable isotope is utilized in research related to hypertensive diseases, enabling precise studies of ACE inhibition and its effects on blood pressure regulation. Imidaprilat's active metabolite properties make it a valuable tool for exploring cardiovascular pharmacology and related therapeutic applications. -
Stable Isotope
Methyl Paraben-13C6 is a stable isotope-labeled derivative of Methyl Paraben, specifically designed for use in various analytical and biological research applications. As a well-characterized antimicrobial preservative derived from p-hydroxybenzoic acid, Methyl Paraben exhibits significant biological activity, primarily by enhancing histamine release and influencing cell-mediated immune responses. This compound is particularly useful in studies investigating chemical allergenicity, antimicrobial effectiveness, and metabolic pathways in food and cosmetic formulations. -
Stable Isotope
Sudan I-d5 is a deuterated form of Sudan I, a diazo-conjugate red dye. This compound exhibits antimicrobial properties, notably inhibiting the growth of bacterial strains such as Clostridium perfringens and Lactobacillus rhamnosus. Sudan I-d5 serves as a stable isotope for applications in chemical research, including studies related to dye behavior and microbiological interaction in various formulation products. -
Stable Isotope
Physcion-d3 is a deuterated derivative of Physcion, functioning as a stable isotope and serving as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 of 38.5 μM and a Kd of 26.0 μM. This compound displays a range of biological activities including laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative, and anti-tumor effects. Its distinctive properties make Physcion-d3 suitable for research applications focusing on metabolic pathways, disease modeling, and drug development studies. -
Stable Isotope
Lansoprazole-d4 is a deuterium-labeled derivative of Lansoprazole, a proton pump inhibitor that inhibits gastric acid secretion by targeting the H+/K+ ATPase in the gastric parietal cells. The incorporation of deuterium enhances the stability and can facilitate metabolic studies and pharmacokinetic research applications. This stable isotope-labeled compound is valuable for tracing studies, improving analysis of drug metabolism, and understanding the pharmacodynamics of proton pump inhibitors. -
Stable Isotope
p-Anisic acid-d4 is a deuterium-labeled derivative of p-Anisic acid (4-Methoxybenzoic acid). This stable isotope is utilized in various research applications, particularly in pharmacokinetic studies and metabolic tracing. p-Anisic acid displays notable antibacterial and antiseptic properties, making it relevant for studies focused on microbial inhibition and therapeutic effects. Its isotopic labeling aids in elucidating metabolic pathways and quantitative analysis in biological systems. -
Stable Isotope
Tridecanoic acid-d2 is a deuterium-labeled derivative of Tridecanoic acid, a 13-carbon medium-chain saturated fatty acid. It exhibits significant biological activity as an antipersister and antibiofilm agent, specifically inhibiting the persistence and biofilm formation of Escherichia coli. This stable isotope is valuable for research applications focused on bacterial infections and biofilm-related studies, providing insights into metabolic processes and the behavior of microbial communities. -
Stable Isotope
Rimonabant-d10 is a deuterium-labeled analog of Rimonabant, a highly potent and selective antagonist of the central cannabinoid receptor (CB1) with a Ki of 1.8 nM. This compound not only exhibits strong brain penetration but also inhibits Mycobacterial membrane protein Large 3 (MMPL3). Rimonabant-d10 serves as a valuable tool for studying cannabinoid receptor signaling and the role of CB1 in various biological processes, as well as for applications in mycobacterial research. -
Stable Isotope
Sapienic acid-d19 is a deuterated derivative of sapienic acid, which is a fatty acid present in skin and mucosal tissues. This compound exhibits notable antimicrobial properties against both Gram-positive and Gram-negative bacteria, including Streptococcus sanguinis, Streptococcus mitis, and Fusobacterium nucleatum, with minimum bactericidal concentrations (MBC) of 31.3 μg/mL, 375.0 μg/mL, and 93.8 μg/mL, respectively. Sapienic acid-d19 is valuable for research applications involving microbial interactions and fatty acid metabolism. -
Stable Isotope
Triclosan-methyl-d3 is a deuterium-labeled derivative of Triclosan-methyl and serves as a stable isotope for research applications. Triclosan-methyl is a transformation product of triclosan, a widely used bactericide in personal care products, including toothpaste, shampoos, and soaps. This compound is also utilized as a stabilizing agent in various detergents and cosmetic formulations, making it valuable for studying environmental and biological interactions of triclosan-related compounds. -
Stable Isotope
Butylparaben-13C6 is a stable isotope-labeled form of Butylparaben, a widely used antimicrobial preservative in cosmetics and personal care products. Additionally, it serves as a component in medication suspensions and as a flavoring additive in food products. This compound is essential for research applications involving metabolic studies, environmental tracking, and quantitative analysis of paraben compounds in various matrices. -
Stable Isotope
N-Hexanoyl-L-homoserine lactone-d3 is a deuterium-labeled variant of N-Hexanoyl-L-homoserine lactone, a short-chain N-acyl homoserine lactone. This stable isotope serves as a valuable tracer in studies investigating cell-to-cell communication among Proteobacteria in aquatic environments, where these bacteria utilize AHLs to coordinate behavior. Its application in chemical research facilitates enhanced understanding of interspecies signaling mechanisms and the dynamics of microbial communities. -
Stable Isotope
N4-Acetylsulfamethoxazole-d4 is a deuterium-labeled derivative of N4-Acetylsulfamethoxazole. This compound serves as a stable isotope used in pharmacokinetic studies and metabolic research related to sulfamethoxazole, a sulfonamide antibiotic known for its bacteriostatic properties. Its application in isotopic tracing facilitates the analysis of drug metabolism and bioavailability, making it valuable in pharmacological investigations and related fields. -
Stable Isotope
Mandelic Acid-13C8 is a stable isotope-labeled variant of the alpha-hydroxycarboxylic acid, mandelic acid, featuring eight carbon-13 atoms. It serves as a key intermediate for pharmaceutical applications and the synthesis of fine chemicals. Mandelic acid possesses notable antimicrobial properties, making it relevant in the study of urinary tract infections and vaginal trichomoniasis. Additionally, it demonstrates significant sperm-immobilizing activity with minimal vaginal irritation, supporting its use in reproductive health research. -
Stable Isotope
Monooctyl phthalate-d4 is a deuterium-labeled derivative of Monooctyl phthalate, serving as a stable isotope for analytical applications. This compound exhibits antimycobacterial activity, with a minimum inhibitory concentration (MIC) of 20 μg/mL. It is primarily used in research focusing on the study of mycobacterial infections and their treatment. -
Stable Isotope
4-Hydroxybenzoic acid-13C is a stable isotope-labeled derivative of 4-Hydroxybenzoic acid, a phenolic compound closely related to benzoic acid. It exhibits antibacterial activity, effectively inhibiting a range of gram-positive and select gram-negative bacteria with an IC50 of 160 μg/mL. This reagent is valuable for applications in metabolic studies, isotopic tracing, and antimicrobial research, providing insights into bacterial response and compound bioavailability. -
Stable Isotope
Ethyl acetoacetate-d5 is a stable isotope-labeled variant of ethyl acetoacetate, an ester commonly employed as an intermediate in the synthesis of diverse chemical compounds. This reagent demonstrates significant biological activity as an inhibitor of bacterial biofilm formation, making it valuable for studies related to microbial growth and biofilm development. Researchers utilize ethyl acetoacetate-d5 in metabolic tracing and kinetic studies, leveraging its isotopic labeling for enhanced analytical applications in synthetic and biological research. -
Stable Isotope
Tenuazonic acid-d13 is a deuterium-labeled derivative of Tenuazonic acid, a nonhost-selective mycotoxin from the tetramic acid family. This compound primarily functions as a protein biosynthesis inhibitor by interfering with ribosomal activity, thus suppressing protein release. Tenuazonic acid-d13 exhibits significant biological activities, including photosystem II inhibition via the D1 protein, and demonstrates antiviral effects against various viruses such as measles and respiratory viruses. Furthermore, this reagent is utilized in research exploring the compound’s potential inhibitory effects on skin cancer. -
Stable Isotope
Probenecid-d14 is a deuterated form of Probenecid, which serves as a selective agonist of the transient receptor potential vanilloid 2 (TRPV2) channels. This stable isotope enables precise tracking and quantification in metabolic studies. Additionally, Probenecid-d14 is recognized for its inhibitory effects on pannexin 1 channels, making it a valuable tool for investigating cellular signaling pathways and receptor interactions in various biological research applications. -
Stable Isotope
Syringic acid-d6 is a deuterated form of syringic acid, serving as a stable isotope for analytical applications. This compound exhibits significant antioxidant properties and has been shown to inhibit the oxidation of low-density lipoproteins (LDL). It is useful in biochemical research for studying the metabolic pathways of antioxidants and their potential protective effects in cardiovascular health. -
Isotope-Labeled Compound
Isothipendyl-d6 is a deuterium-labeled compound utilized in various chemical research applications. This isotope-labeled version of (7E,9E)-β-Ionylideneacetaldehyde serves as a valuable tool for studying metabolic pathways and reaction mechanisms. Its unique isotopic properties facilitate enhanced analytical detection and quantification in mass spectrometry and nuclear magnetic resonance (NMR) experiments, making it essential for researchers focusing on organic synthesis and molecular interactions. -
Stable Isotope
Oxyphenbutazone-d9 is a deuterated derivative of Oxyphenbutazone, a non-selective cyclooxygenase (COX) inhibitor. This compound exhibits notable anti-inflammatory properties and serves as a key metabolite of Phenylbutazone. In addition to its COX inhibition, Oxyphenbutazone has been shown to selectively target and eliminate non-replicating Mycobacterium tuberculosis, making it valuable in tuberculosis research and anti-infective studies. -
Stable Isotope
(R)-Propranolol-d7 is a deuterated derivative of (R)-Propranolol, serving as a stable isotope-labeled compound. This reagent is invaluable for pharmacokinetic studies and metabolic pathway analysis, enabling the tracking of drug metabolism and distribution in biological systems. Researchers can utilize (R)-Propranolol-d7 in studies focused on cardiovascular research, anxiety treatments, and the mechanisms of action associated with beta-adrenergic receptors. -
Stable Isotope
Hydroxymetronidazole-d4 is a deuterium-labeled derivative of Hydroxymetronidazole, a nitroimidazole metabolite of Metronidazole. This stable isotope serves as a valuable tool in pharmacokinetic studies and metabolic pathway investigations. It is applicable in research related to bacterial and protozoal infections, particularly in poultry, as well as in the study of swine dysentery and genital trichomoniasis in cattle. -
Stable Isotope
Tinidazole-d5 is a deuterium-labeled analog of Tinidazole, a 5-nitroimidazole antibiotic. This stable isotope compound is primarily utilized in pharmacokinetic studies and metabolic research. Tinidazole exhibits selective antibacterial activity against anaerobic bacteria and protozoa, making it valuable for investigations into infectious diseases and microbiome interactions. -
Stable Isotope
Chloroxylenol-d6 is a deuterium-labeled form of chloroxylenol, a broad-spectrum antimicrobial agent. This compound exerts activity against bacteria, algae, fungi, and viruses, making it valuable in various microbiological applications. Chloroxylenol-d6 is particularly useful for research involving stable isotope methods, allowing for enhanced analytical studies in pharmacology and environmental science. -
Stable Isotope
Brodimoprim-d6 is a deuterium-labeled derivative of Brodimoprim, a potent dihydrofolate reductase inhibitor. This compound exhibits strong antimicrobial activity against a wide range of both gram-negative and gram-positive bacteria, making it a valuable tool in microbiological research. The stable isotope labeling allows for enhanced tracking and analysis in pharmacokinetic studies and metabolic profiling. -
Stable Isotope
Ethylenediaminetetraacetic acid-13C4 (EDTA-13C4) is a stable isotope-labeled form of Ethylenediaminetetraacetic acid (EDTA), a potent metal chelating agent that binds to bivalent and trivalent metal cations, particularly calcium. EDTA exhibits a range of biological activities, including antibacterial, anti-inflammatory, antioxidant, and anticoagulant properties. It plays a critical role in mitigating metal ion-catalyzed oxidative damage to proteins and maintaining a reducing environment during protein purification processes. EDTA has potential therapeutic applications in liver fibrosis and is also relevant for research involving coronary artery disease and neurological disorders. -
Stable Isotope
Pentyl 4-hydroxybenzoate-d11 is a deuterated analog of Pentyl 4-hydroxybenzoate, which serves as a stable isotope used in various research applications. This compound exhibits antibacterial properties and has been shown to inhibit induced oxygen consumption, making it relevant in studies investigating metabolic processes and preservative efficacy. Its isotopic labeling enhances tracking and quantification in biochemical assays and environmental studies. -
Stable Isotope
Lauric acid-d5 is a stable isotope-labeled derivative of lauric acid, a medium-chain fatty acid known for its potent bactericidal activity. This compound has demonstrated effective antimicrobial properties, with EC50 values against Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis measured at 2, 6, and 4 µg/mL, respectively. Lauric acid-d5 is applicable in research focused on lipid metabolism, antimicrobial studies, and metabolic tracing in biological systems. -
Stable Isotope
Sulfanitran-13C6 is a stable isotope-labeled form of the antibacterial and anticoccidial agent Sulfanitran. This compound functions as a stimulator of the multidrug resistance protein 2 (MRP2), enhancing its affinity for estradiol-17-β-D-glucuronide (E217βG). Sulfanitran-13C6 is useful for research applications such as studying drug transport and metabolism, particularly in the context of poultry health and pharmacology. -
Stable Isotope
3-Pentanol-d5 is a deuterium-labeled variant of 3-Pentanol, a volatile organic compound with significant biological relevance. This stable isotope serves as a tool for tracing studies in organic synthesis and metabolic research. 3-Pentanol is known to induce plant immune responses against microbial pathogens and insect pests, making it valuable for studies on plant defense mechanisms and insect behavior in agricultural contexts. -
Stable Isotope
Rabeprazole sulfide-d3 is a deuterium-labeled analog of Rabeprazole Sulfide, which serves as a metabolite of the proton pump inhibitor Rabeprazole. This compound effectively inhibits the motility of Helicobacter pylori, making it a valuable tool for studying H. pylori infections. Rabeprazole sulfide-d3 can facilitate research on antibiotic resistance and the mechanisms underlying H. pylori pathogenesis. -
Stable Isotope
16β-Hydroxy-17β-estradiol-2,4-d2 is a stable isotope-labeled derivative of 16β-Hydroxy-17β-estradiol, providing a crucial tool for metabolic studies. This compound retains the biological activity of its non-labeled counterpart while enabling more precise quantification in biological assays. It is particularly useful in pharmacokinetic studies and isotopic labeling experiments, facilitating a deeper understanding of estrogen metabolism and signaling pathways. -
Stable Isotope
3,4,5-Trimethoxybenzoic acid-d3, a deuterated form of 3,4,5-Trimethoxybenzoic acid, acts as a stable isotope for various analytical applications. This benzoic acid derivative serves as a critical building block in medicinal chemistry and organic synthesis. It has demonstrated antibacterial activity against Staphylococcus aureus, with a minimum inhibitory concentration of 0.97 μg/mL, making it useful for microbial studies and drug development research. -
Stable Isotope
Veratraldehyde-13C (3,4-Dimethoxy[7-13C]-benzaldehyde) is a stable isotope-labeled derivative of Veratraldehyde, targeting the PilY1 protein. This compound exhibits significant antibacterial activity against Pseudomonas aeruginosa and demonstrates a repellent effect against mosquitoes and ticks. Veratraldehyde-13C is useful in research applications involving metabolic studies, flavoring agent assessments, and investigations into the interactions of aromatic compounds with biological targets. -
Stable Isotope
Ronidazole-d3 is a deuterium-labeled derivative of Ronidazole, primarily functioning as a stable isotope for analytical applications. This compound exhibits potent antiprotozoal and antimicrobial properties, and is particularly effective against Tritrichomonas foetus in feline models. Ronidazole-d3 is suitable for research related to histomoniasis and swine dysentery, facilitating studies on these significant veterinary diseases. -
Stable Isotope
Methyl paraben-d4 is the deuterium-labeled form of Methyl Paraben, a well-characterized chemical allergen derived from Tsuga dumosa. As a stable, non-volatile compound, it functions as an antimicrobial preservative in food, pharmaceuticals, and cosmetics. Methyl paraben has been shown to increase histamine release, potentially influencing cell-mediated immunity, making it valuable for research applications in allergenicity and immunological studies. -
Stable Isotope
Saccharin-13C6 is a stable isotope-labeled variant of saccharin, a non-caloric artificial sweetener. It exhibits bacteriostatic properties and can modulate microbiome activities, making it valuable in metabolic and nutritional research. The use of Saccharin-13C6 in studies allows for precise tracking of metabolic pathways and interactions with gut microbiota, contributing to a deeper understanding of its biological effects.
