Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Albendazole-d7 is a deuterium-labeled derivative of Albendazole, a broad-spectrum parasiticide primarily targeting parasitic infections. This stable isotope variant is utilized in pharmacokinetic studies and metabolic research to track the disposition of Albendazole in biological systems. Its application extends to investigating gastrointestinal parasites affecting both humans and animals, aiding in the development of effective therapeutic strategies. -
Stable Isotope
Norfloxacin-d8 is a deuterium-labeled form of Norfloxacin, a broad-spectrum antibiotic that targets DNA gyrase to disrupt bacterial DNA replication. This compound demonstrates significant antibacterial activity against a range of both Gram-positive and Gram-negative bacteria. Norfloxacin-d8 is primarily utilized in pharmacokinetic studies and isotopic labeling applications in biochemical research. -
Stable Isotope
Atovaquone-d5 is a deuterium-labeled derivative of Atovaquone, a selective and orally active inhibitor targeting the mitochondrial cytochrome bc1 complex in parasites. It exhibits significant inhibitory activity against human cytochrome bc1 with an IC50 of 460 nM and against Plasmodium falciparum with an IC50 of 2.0 nM. This reagent is essential for studying the mechanisms of action in antimalarial therapies and has applications in investigating conditions such as pneumocystis pneumonia, toxoplasmosis, malaria, and babesia. -
Stable Isotope
Baquiloprim-d6 is a deuterium-labeled analogue of Baquiloprim, which selectively targets bacterial dihydrofolate reductases. This compound exhibits bacteriostatic activity against a range of both Gram-negative and Gram-positive bacteria in vitro. It serves as a valuable tool for studying microbial response and dynamics in antibiotic research. -
Stable Isotope
Sulfachloropyridazine-13C6 is a stable isotope-labeled form of Sulfachloropyridazine, a broad-spectrum sulfonamide antibiotic. It exhibits inhibitory activity against both Gram-positive and Gram-negative aerobic bacteria, making it valuable for microbiological research. This compound is particularly useful in studies involving pharmacokinetics, metabolic pathways, and antibiotic resistance mechanisms. The isotopic labeling facilitates precise tracking and quantification in various biological assays. -
Stable Isotope
(S)-Ofloxacin-d3 is a deuterium-labeled derivative of Levofloxacin, a synthetic fluoroquinolone antibiotic. It primarily targets bacterial DNA gyrase, inhibiting its supercoiling function and thereby disrupting DNA replication. This stable isotope is essential for pharmacokinetic studies and can be utilized in metabolic research to track drug metabolism and behavior in biological systems. -
Stable Isotope
Sulfaquinoxaline-d4 is a deuterium-labeled derivative of Sulfaquinoxaline, an antimicrobial agent primarily used in veterinary medicine. This compound exhibits broad-spectrum activity against both Gram-negative and Gram-positive bacteria, making it effective in the prevention of coccidiosis and other bacterial infections. Sulfaquinoxaline-d4 is valuable for research involving pharmacokinetics, metabolic studies, and the investigation of antimicrobial mechanisms. -
Stable Isotope
Carbadox-d3 is a deuterium-labeled derivative of Carbadox, a quinoxaline-di-N-oxide antibiotic. This reagent is primarily used as a stable isotope for metabolic studies and animal health research. It is known for its effectiveness in controlling enteric diseases in nursery-age pigs and enhancing feed efficiency, making it valuable in veterinary and pharmacological investigations. -
Stable Isotope
Desmethyl Levofloxacin-d8 hydrochloride is a deuterium-labeled derivative of Desmethyl Levofloxacin, a metabolite of the antibacterial agent Levofloxacin. This compound primarily targets bacterial DNA gyrase, inhibiting its supercoiling activity and effectively halting DNA replication. It is useful in biochemical studies that require stable isotopes to trace metabolic pathways and investigate pharmacokinetics in research applications involving fluoroquinolone antibiotics. -
Stable Isotope
Djalonensone-d3 is a stable isotope-labeled derivative of Djalonensone, a compound isolated from the roots of Anthocleista djalonensis (Loganiaceae). This deuterium-labeled form serves as a valuable taxonomic marker for the characterization of plant species within the Loganiaceae family. It is suitable for applications in plant identification studies, metabolic tracing, and other research requiring precise isotopic labeling. -
Stable Isotope
Sulfamerazine-13C6 is a stable isotope-labeled derivative of sulfamerazine, a sulfonamide antibacterial compound. It functions by inhibiting bacterial dihydrofolic acid synthesis through competition with para-aminobenzoic acid (PABA) for dihydropteroate synthase binding. This reagent is used in biological and pharmacokinetic studies to trace metabolic pathways and assess drug interaction mechanisms in bacterial systems. -
Stable Isotope
Ertapenem-d4 disodium is a stable isotope-labeled variant of the antibiotic Ertapenem. This deuterium-labeled form is utilized in pharmacokinetic studies and metabolic research to trace the drug's behavior and interactions within biological systems. Researchers can employ Ertapenem-d4 disodium to enhance the sensitivity and accuracy of analytical methods, including mass spectrometry, in the study of drug metabolism and efficacy. -
Stable Isotope
(Rac)-Fosfomycin (benzylamine)-13C3 is a stable isotope-labeled form of Fosfomycin, a broad-spectrum antibiotic. It targets bacterial cell wall synthesis by irreversibly inhibiting the enzyme MurA, making it effective against various bacteria, including multidrug-resistant and pan-drug-resistant strains. This reagent is useful in pharmacokinetic studies, metabolic tracing, and understanding the mechanisms of antibiotic resistance. -
Stable Isotope
DL-Histidine-15N is a stable isotope-labeled derivative of histidine, specifically containing nitrogen-15. It is commonly utilized in various biological studies, particularly in NMR spectroscopy and metabolic labeling experiments. This reagent facilitates research in protein synthesis, metabolism, and the analysis of nitrogen dynamics in biological systems. -
Stable Isotope
Sulfamethizole-d4-1 is a deuterium-labeled derivative of Sulfamethizole, a sulfathiazole antibiotic. This compound inhibits the synthesis of folic acid and thymine, selectively reducing bioluminescence in Photobacterium phosphoreum. Sulfamethizole demonstrates antibacterial activity against Escherichia coli related to urinary tract infections, while exhibiting no effects on sulII gene-positive strains. It is primarily utilized in research focused on urinary tract infections and the mechanisms underlying Photobacterium phosphoreum bioluminescence. -
Stable Isotope
Nifursol-15N2,d2 is a deuterium and nitrogen-15 labeled derivative of the veterinary antibiotic Nifursol. It primarily targets Histomonas meleagridis, effectively preventing histomoniasis in turkeys. This labeled compound is valuable in research investigating Escherichia coli gastroenteritis, particularly within the context of Salmonella-infected poultry and aquatic animal studies. -
Stable Isotope
Ribavirin-13C2 is a stable isotope-labeled form of the antiviral agent Ribavirin, targeting a range of viral pathogens. This compound demonstrates significant antiviral activity against various viruses, including Hepatitis C virus (HCV), Human Immunodeficiency Virus (HIV), and Respiratory Syncytial Virus (RSV). Additionally, Ribavirin exhibits effectiveness against orthopoxviruses and variola, making Ribavirin-13C2 a valuable tool for research applications in virology and drug development studies. -
Stable Isotope
Enrofloxacin-d5 hydriodide is a deuterium-labeled derivative of the antibiotic Enrofloxacin (monohydrochloride). This stable isotope can be utilized in pharmacokinetic studies and metabolic research, particularly in tracing and quantifying Enrofloxacin metabolism in biological systems. Demonstrating high antibacterial activity with an MIC90 of 0.312 μg/mL against Mycoplasma bovis, Enrofloxacin-d5 hydriodide serves as an essential tool for investigating antibiotic resistance and microbial dynamics. -
Stable Isotope
Ethambutol-d8 is a stable isotope-labeled analog of Ethambutol, featuring deuterium substitution. This compound is essential for studies involving pharmacokinetics and metabolic tracing of Ethambutol in biological systems. It is utilized in research to investigate drug metabolism, distribution, and mechanisms of action in tuberculosis treatment. -
Stable Isotope
Ribavirin-13C5 is a stable isotope-labeled form of Ribavirin, distinguished by five carbon-13 isotopes. Ribavirin exhibits antiviral activity against a range of viruses, including hepatitis C virus (HCV), human immunodeficiency virus (HIV), and respiratory syncytial virus (RSV). This compound is particularly valuable for metabolic studies and tracer experiments in virology research, providing insights into viral replication and drug metabolism. -
Stable Isotope
2-Phenylethanol-d9 is the deuterium-labeled derivative of 2-Phenylethanol, a stable isotope used in various analytical applications. It exhibits a pleasant floral scent and serves as an autoantibiotic produced by the fungus Candida albicans. This compound is utilized as a flavoring agent and preservative in personal care products and has relevance in studies involving metabolic pathways and fragrance analysis. The stable isotopic label allows for enhanced sensitivity and specificity in mass spectrometry and other analytical techniques. -
Stable Isotope
Ethambutol-d10 is a deuterium-labeled derivative of Ethambutol, a bacteriostatic antimycobacterial agent. It primarily targets arabinosyl transferases, disrupting cell wall synthesis in Mycobacterium tuberculosis. Ethambutol-d10 is utilized in research for studies involving drug metabolism, metabolic tracking, and the investigation of mycobacterial resistance mechanisms. -
Stable Isotope
Metronidazole-d4 hydrochloride is a stable isotope-labeled form of Metronidazole hydrochloride, featuring deuterium substitution. This compound is utilized in metabolic and pharmacokinetic studies to accurately trace drug absorption, distribution, metabolism, and excretion. Its application in isotope labeling enhances the analytical precision of various biochemical research methodologies. -
Stable Isotope
Quinoxaline-d4 is a deuterium-labeled variant of Quinoxaline, serving as a stable isotope for analytical applications. Quinoxaline functions as an intermediate in the synthesis of the anti-tuberculosis agent Pyrazinamide and exhibits structural similarities to quinolone antibiotics. This reagent is essential for studies involving metabolism, pharmacokinetics, and drug interactions in pharmaceutical research. -
Stable Isotope
Cefuroxime-d3 is a deuterium-labeled derivative of the second-generation cephalosporin antibiotic, cefuroxime sodium. This compound demonstrates enhanced stability to β-lactamase, allowing it to maintain its efficacy against a broad spectrum of both Gram-positive and Gram-negative bacteria. Cefuroxime-d3 is primarily utilized in pharmacokinetic studies and metabolic research to trace the absorption and distribution of cefuroxime in biological systems. -
Stable Isotope
Danofloxacin-d3 mesylate is a deuterated derivative of Danofloxacin mesylate, a fluoroquinolone antibiotic primarily utilized in veterinary medicine. This stable isotope serves as an important tool for pharmacokinetic studies, metabolic profiling, and further research into the mechanisms of action of fluoroquinolones. It enables the investigation of drug dynamics and interactions with bacterial targets, thereby facilitating advancements in veterinary pharmacotherapy and antibiotic efficacy assessments. -
Stable Isotope
Ochratoxin A-D4 is a deuterium-labeled derivative of Ochratoxin A, a mycotoxin produced by various fungal species. This compound serves as a stable isotope standard, facilitating the study of Ochratoxin A's nephrotoxicity and its role in renal tumor development across multiple animal models. It is essential for researchers investigating the metabolic pathways and toxicological effects of this mycotoxin. -
Stable Isotope
2-Phenylethanol-d5 is a deuterium-labeled analogue of 2-Phenylethanol, a stable isotope used in various scientific applications. This colorless liquid, characterized by its pleasant floral aroma, is commonly derived from natural sources such as rose, carnation, and orange blossom. As an essential compound in research, it serves as a tracer in metabolic studies and can aid in the investigation of flavor and fragrance interactions in various chemical environments. Additionally, its presence as a natural autoantibiotic compound provides further interest in microbiological research contexts. -
Stable Isotope
Sulbactam-d2 sodium is a deuterium-labeled derivative of Sulbactam sodium, a competitive and irreversible inhibitor of beta-lactamases. This compound exhibits antimicrobial activity against multidrug-resistant strains of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex. It serves as a valuable tool in chemical research to study beta-lactamase enzymology and the mechanisms of antibiotic resistance. -
Stable Isotope
Sulfameter-d4 is a deuterium-labeled derivative of Sulfameter, which serves as a long-acting sulfonamide antibiotic that targets bacterial infections. This compound demonstrates efficacy against a range of both Gram-positive and Gram-negative bacteria, making it valuable for studies involving respiratory and urinary tract infections. Sulfameter-d4 is particularly useful in pharmacokinetic and metabolic research applications where stable isotopes are required for tracer studies. -
Stable Isotope
2-Phenylethanol-d4 is a deuterated stable isotope of 2-Phenylethanol, which functions as a fragrance and flavor compound. Known for its pleasant floral aroma, it possesses various biological activities, including serving as an autoantibiotic in Candida albicans. This compound is commonly utilized in research applications related to organic synthesis, fragrance studies, and as a tracer in metabolic studies, allowing for precise tracking in biological systems. Additionally, its stability makes it suitable for use in various formulations and analytical methods. -
Stable Isotope
Olaquindox-d4 is a deuterium-labeled derivative of Olaquindox, functioning as a stable isotope. This quinoxalin antibiotic exhibits oral bioactivity and has been shown to enhance growth while reducing intestinal mucosal immunity in piglets. Research applications include studies on antibiotic effects in veterinary science and investigations into growth promotion mechanisms in livestock. -
Stable Isotope
Sulfadimethoxine-13C6 is a stable isotope-labeled derivative of Sulfadimethoxine, a sulfonamide antibiotic. This compound is utilized in various metabolic and pharmacokinetic studies, allowing for precise tracing of the antibiotic's distribution and metabolism in biological systems. Researchers can use Sulfadimethoxine-13C6 to investigate its efficacy and bioavailability in clinical and preclinical settings. -
Stable Isotope
Cefpodoxime-d3 is a deuterium-labeled form of the antibiotic cefpodoxime, which primarily targets bacterial cell wall synthesis. This stable isotope is useful in pharmacokinetic studies and metabolic profiling, allowing researchers to trace the pharmacological pathways and tissue distribution of cefpodoxime. Its application in isotope labeling facilitates advanced research in microbiology and drug metabolism. -
Stable Isotope
Serotonin-d4 is a deuterated form of serotonin that serves as a stable isotope for research applications. As a monoamine neurotransmitter in the central nervous system, serotonin is an endogenous agonist of 5-HT receptors. It also exhibits inhibitory activity against catechol O-methyltransferase (COMT) with a Ki of 44 μM. This compound is valuable for studies in neurobiology, pharmacology, and metabolic pathway analysis. -
Stable Isotope
Serotonin-d4 hydrochloride is a stable isotope of the monoamine neurotransmitter serotonin (5-Hydroxytryptamine). It acts as an endogenous agonist at 5-HT receptors, playing a crucial role in CNS signaling. Additionally, serotonin-d4 hydrochloride serves as a catechol O-methyltransferase (COMT) inhibitor, exhibiting a Ki value of 44 μM. This reagent is valuable for studies investigating neurotransmitter dynamics, receptor interactions, and metabolic pathways in pharmacological and neurobiological research. -
Stable Isotope
Clozapine-d4 is a deuterated derivative of Clozapine, an atypical antipsychotic primarily utilized in schizophrenia research. This stable isotope allows for advanced pharmacokinetic studies and the evaluation of metabolic pathways. Clozapine exhibits a high affinity for multiple neuroreceptors, making Clozapine-d4 valuable for investigating receptor interactions and drug metabolism in preclinical studies. -
Stable Isotope
Chlorpromazine-d6 hydrochloride is a deuterated derivative of Chlorpromazine, primarily functioning as a dopamine receptor antagonist. This stable isotope is utilized in biochemical and pharmacological research to explore the interactions and mechanisms of action of antipsychotic agents. Its ability to inhibit serotonin receptors, potassium channels, and sodium channels makes it valuable for studying neuropharmacology and drug metabolism. -
Stable Isotope
Brexpiprazole-d8 is a deuterium-labeled derivative of Brexpiprazole, an atypical antipsychotic agent. Acting primarily as a partial agonist at the human 5-HT1A and dopamine D2L receptors, it exhibits Ki values of 0.12 nM and 0.3 nM, respectively. Additionally, Brexpiprazole functions as a 5-HT2A receptor antagonist with a Ki of 0.47 nM and exhibits significant antagonistic activity at noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM). This reagent is suitable for various research applications including pharmacological studies and mechanism of action investigations. -
Stable Isotope
Ondansetron-d5 is a deuterium-labeled analog of Ondansetron, a highly selective antagonist of the 5-HT3 receptor with an IC50 value of 103 pM. It functions by blocking 5-HT3 receptors in neurons within both the peripheral and central nervous systems, thereby effectively reducing nausea and vomiting associated with chemotherapy and radiotherapy. Ondansetron-d5 is valuable for research involving pharmacokinetic studies and metabolic profiling of Ondansetron. -
Stable Isotope
Brexpiprazole-d8-1 is a stable isotope-labeled form of Brexpiprazole, an atypical antipsychotic agent. It functions as a partial agonist at the human 5-HT1A and dopamine D2L receptors, exhibiting affinities (Ki values) of 0.12 nM and 0.3 nM, respectively. Additionally, it acts as an antagonist at the 5-HT2A receptor with a Ki of 0.47 nM, and demonstrates potent antagonistic activity at noradrenergic α1B and α2C receptors with Ki values of 0.17 nM and 0.59 nM, respectively. This compound is suited for studies involving neuropharmacology and receptor interaction analysis. -
Stable Isotope
Trazodone-d6 hydrochloride is a deuterated form of Trazodone hydrochloride, serving as a stable isotope reagent. This compound is utilized in pharmacokinetic studies, particularly for the quantification of Trazodone in biological samples through mass spectrometry. It aids in understanding the metabolic pathways and pharmacological profiles of Trazodone in clinical research settings. -
Stable Isotope
Risperidone-d4 is a deuterated analog of Risperidone, functioning primarily as a serotonin 5-HT2 receptor antagonist and dopamine D2 receptor antagonist. It is characterized by its inhibitory effects on P-Glycoprotein, with binding affinities (Kis) of 4.8 nM for the 5-HT2A receptor and 5.9 nM for the dopamine D2 receptor. This stable isotope is valuable for pharmacokinetic studies, metabolic profiling, and tracing mechanisms in neurological research applications. -
Stable Isotope
Brexpiprazole S-oxide-d8 is a deuterium-labeled analog of Brexpiprazole S-oxide, the primary metabolite of the atypical antipsychotic Brexpiprazole. This compound acts as a partial agonist at human 5-HT1A and dopamine receptors, with inhibition constants (Kis) of 0.12 nM and 0.3 nM, respectively. Additionally, it functions as an antagonist at the 5-HT2A receptor, exhibiting a Ki of 0.47 nM. Brexpiprazole S-oxide-d8 is valuable for pharmacokinetic studies and metabolic profiling in research applications focused on psychiatric disorders. -
Stable Isotope
Ondansetron-d3 hydrochloride is a deuterium-labeled analog of Ondansetron hydrochloride, a potent antagonist of the serotonin 5-HT3 receptor. This stable isotope is primarily utilized in research applications involving pharmacokinetics and metabolic studies of Ondansetron. Its unique labeling enables precise tracking in biological systems, facilitating the investigation of its antiemetic properties, particularly in the context of chemotherapy-induced nausea and vomiting. -
Stable Isotope
Volinanserin-d4 hydrochloride is a deuterated analog of Volinanserin, a potent and selective antagonist of the 5-HT2 receptor, exhibiting a Ki value of 0.36 nM. This compound demonstrates significant selectivity, being 300-fold more potent at the 5-HT2 receptor compared to 5-HT1c, alpha-1, and DA D2 receptors. Volinanserin is primarily utilized in research focused on antipsychotic activity and the modulation of serotonergic signaling pathways. -
Stable Isotope
Clozapine-d8 is a stable isotope-labeled analog of Clozapine, an antipsychotic agent primarily utilized in schizophrenia research. This compound exhibits a high affinity for various neuroreceptors, making it valuable for studies investigating the pharmacodynamics and pharmacokinetics of antipsychotic therapies. Its deuterium labeling enables more precise analytical techniques in metabolic and binding studies. -
Stable Isotope
Aripiprazole-d8 is the deuterium-labeled variant of Aripiprazole, primarily known for its activity as a partial agonist at the human 5-HT1A receptor with a Ki of 4.2 nM. This stable isotope is utilized in research applications requiring precise quantification and tracing of Aripiprazole in biological systems. It facilitates studies on the pharmacokinetics, metabolism, and biological interactions of the compound. -
Stable Isotope
Norfluoxetine-d5 hydrochloride is a deuterated derivative of 3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine. This stable isotope-labeled compound serves as a valuable tool for pharmacokinetic studies and metabolic research, enabling precise tracking and analysis of drug interactions and dynamics. Its incorporation in experimental designs aids in the elucidation of the mechanisms underlying fluoxetine metabolism and pharmacology. -
Stable Isotope
Urapidil-d3 is a deuterium-labeled derivative of Urapidil, functioning primarily as an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist. This stable isotope is valuable in studying drug metabolism, distribution, and pharmacokinetics, providing insights into the bioactivity of Urapidil in various biological systems. Researchers can utilize Urapidil-d3 to enhance the understanding of cardiovascular and neuropharmacological effects associated with this compound.
