Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Agomelatine-d3 is a deuterium-labeled derivative of Agomelatine, which primarily targets MT1 and MT2 melatonin receptors, demonstrating high affinity with Ki values of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2 cells, respectively. Additionally, Agomelatine acts as a selective antagonist of the 5-HT2C receptor with pKi values of 6.4 and 6.2 for native porcine and cloned human receptors, respectively. This stable isotope compound is valuable for pharmacokinetic studies and metabolic research involving melatonergic modulation and serotonin receptor interactions. -
Stable Isotope
Sumatriptan-d6 succinate is a deuterated form of Sumatriptan succinate, functioning as an orally active agonist of the 5-HT1 receptor family. With inhibition constants (Kis) of 17 nM, 27 nM, and 100 nM for the 5-HT1D, 5-HT1B, and 5-HT1A receptors, respectively, this compound is primarily utilized in research focused on migraine headaches. Its stable isotope labeling enables advanced studies in pharmacokinetics and metabolism. -
Isotope-Labeled Compounds
5-Methoxytryptamine-d4 is a deuterium-labeled derivative of 5-Methoxytryptamine, functioning as a nonselective agonist of 5-HT receptors while showing no affinity for the 5-HT3 receptor. This compound exhibits significant antioxidant properties and offers radioprotective effects. It is valuable for research applications in neurotransmitter signaling, oxidative stress studies, and the exploration of melatonin metabolism. -
Stable Isotope
Quetiapine hemifumarate-d8 is a deuterated form of Quetiapine hemifumarate, primarily acting as an antagonist at dopamine D2 receptors and an agonist at 5-HT1A receptors. It exhibits moderate to high affinity for multiple serotonin receptors, including 5-HT2A and 5-HT2C, making it a valuable tool for studying neurochemical pathways involved in mood regulation. This stable isotope is useful in pharmacokinetic studies, aiding in the understanding of Quetiapine's pharmacodynamics and therapeutic effects related to its antidepressant and anxiolytic properties. -
Stable Isotope
Psychosine-d5 is a deuterium-labeled analog of Psychosine, a substrate for the galactocerebrosidase (GALC) enzyme. This stable isotope serves as a potential biomarker for Krabbe disease and is utilized in research to study the disease's pathophysiology. As a highly cytotoxic lipid, Psychosine can induce cell death across various cell types, making Psychosine-d5 valuable for investigations into cell toxicity and lipid metabolism. -
Stable Isotope
Ruboxistaurin-d6 hydrochloride is a deuterated form of Ruboxistaurin hydrochloride, a selective inhibitor of protein kinase C (PKC) beta. Exhibiting ATP-dependent competitive inhibition, it demonstrates significant potency with a Ki of 2 nM and an IC50 of 4.7 nM for PKC beta I and 5.9 nM for PKC beta II. This stable isotope is valuable for research applications involving metabolic tracing, pharmacokinetics, and the study of PKC-related cellular signaling pathways. -
Stable Isotope
1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol is a deuterium-labeled derivative of 1-Stearoyl-2-arachidonoyl-sn-glycerol, a diacylglycerol (DAG) that includes polyunsaturated fatty acids. This compound is known to activate protein kinase C (PKC) and enhance the activity of nonselective cation channels (NSCC). It serves as a valuable tool for studying lipid signaling pathways and the regulation of cellular processes in various research applications. -
Stable Isotope
Psychosine-d7 is a deuterium-labeled analog of psychosine, serving as a stable isotope for research applications. Psychosine acts as a substrate for the galactocerebrosidase (GALC) enzyme and is identified as a potential biomarker for Krabbe disease. This lipid is known for its high cytotoxicity, inducing apoptosis across various cell types, making it valuable for studies related to neurodegenerative disorders and cellular stress responses. -
Stable Isotope
Stearoyl-L-carnitine-d9 chloride is a deuterated analogue of Stearoyl-L-carnitine chloride, classified as a stable isotope. It serves as a valuable tool in metabolic studies, particularly in understanding lipid metabolism and energy deficiency in type 2 diabetes models. This compound is known to inhibit protein kinase C (PKC) and lecithin cholesterol acyltransferase (LCAT), while also acting as a metabolomic biomarker for Parkinson's disease. Additionally, it demonstrates reduced potency as an inhibitor of GlyT2, providing insights into neurotransmitter dynamics. -
Stable Isotope
Stearoyl-L-carnitine-d3 is a deuterated form of Stearoylcarnitine, functioning primarily as a stable isotope for research applications. This fatty ester lipid is an endogenous metabolite, known to inhibit protein kinase C (PKC) and accumulate in pancreatic β cells, resulting in impaired insulin synthesis and energy deficiency in type 2 diabetes models. Additionally, Stearoyl-L-carnitine-d3 inhibits lecithin cholesterol acyltransferase (LCAT) in animal plasma and serves as a potential metabolomics biomarker for Parkinson’s disease, further expanding its utility in metabolic research. -
Stable Isotope
(±)-1,2-Diolein-CC3 is a stable isotope-labeled derivative of (±)-1,2-Diolein, also known as 1,2-Dioleoyl-rac-glycerol-13C3. This compound acts as an activator of protein kinase C (PKC) and is known to enhance calcium ion influx in myotubes. It is particularly useful in research applications studying lipid signaling pathways, cell proliferation, and muscle physiology. -
Stable Isotope
2-Deoxyuridine-1,2,3,4,5-13C5 is a stable isotope-labeled form of 2'-Deoxyuridine, a naturally occurring pyrimidine nucleotide. This compound plays a crucial role in nucleotide metabolism and is linked to various neurological disorders. Notably, 2'-Deoxyuridine has been shown to enhance chromosome breakage and reduce thymidylate synthase activity. It also demonstrates neuroprotective effects by decreasing microglial activation and alleviating oxidative stress in models of Alzheimer's disease, making it a valuable tool for research in neurodegeneration and related fields. -
Stable Isotope
3,4,5-Trimethoxybenzoic acid-d3, a deuterated form of 3,4,5-Trimethoxybenzoic acid, acts as a stable isotope for various analytical applications. This benzoic acid derivative serves as a critical building block in medicinal chemistry and organic synthesis. It has demonstrated antibacterial activity against Staphylococcus aureus, with a minimum inhibitory concentration of 0.97 μg/mL, making it useful for microbial studies and drug development research. -
Stable Isotope
Veratraldehyde-13C (3,4-Dimethoxy[7-13C]-benzaldehyde) is a stable isotope-labeled derivative of Veratraldehyde, targeting the PilY1 protein. This compound exhibits significant antibacterial activity against Pseudomonas aeruginosa and demonstrates a repellent effect against mosquitoes and ticks. Veratraldehyde-13C is useful in research applications involving metabolic studies, flavoring agent assessments, and investigations into the interactions of aromatic compounds with biological targets. -
Stable Isotope
Ronidazole-d3 is a deuterium-labeled derivative of Ronidazole, primarily functioning as a stable isotope for analytical applications. This compound exhibits potent antiprotozoal and antimicrobial properties, and is particularly effective against Tritrichomonas foetus in feline models. Ronidazole-d3 is suitable for research related to histomoniasis and swine dysentery, facilitating studies on these significant veterinary diseases. -
Stable Isotope
Methyl paraben-d4 is the deuterium-labeled form of Methyl Paraben, a well-characterized chemical allergen derived from Tsuga dumosa. As a stable, non-volatile compound, it functions as an antimicrobial preservative in food, pharmaceuticals, and cosmetics. Methyl paraben has been shown to increase histamine release, potentially influencing cell-mediated immunity, making it valuable for research applications in allergenicity and immunological studies. -
Stable Isotope
Saccharin-13C6 is a stable isotope-labeled variant of saccharin, a non-caloric artificial sweetener. It exhibits bacteriostatic properties and can modulate microbiome activities, making it valuable in metabolic and nutritional research. The use of Saccharin-13C6 in studies allows for precise tracking of metabolic pathways and interactions with gut microbiota, contributing to a deeper understanding of its biological effects. -
Stable Isotope
trans-Cinnamic acid-d5 is a deuterium-labeled derivative of trans-Cinnamic acid, a naturally occurring compound known for its antimicrobial properties. This stable isotope can be utilized in various research applications, including pharmacokinetic studies and metabolic profiling. It exhibits a minimal inhibitory concentration (MIC) of 250 μg/mL against the fish pathogen Aeromonas sobria, SY-AS1, making it a valuable reagent for studies related to antimicrobial efficacy and resistance. -
Stable Isotope
1-Tetradecanol-d2 is a deuterium-labeled variant of 1-Tetradecanol, a straight-chain saturated fatty alcohol derived from Myristica fragrans. This compound exhibits notable antibacterial and anti-inflammatory properties, specifically in the context of periodontitis. It serves as a valuable stable isotope in research applications involving metabolic studies, lipid metabolism, and the investigation of fatty alcohols’ roles in biological systems. -
Stable Isotope
Valacyclovir-d4 hydrochloride is a deuterated form of the antiviral agent Valacyclovir hydrochloride, designed for use as a stable isotope in research applications. It effectively inhibits herpes simplex virus type 1 (HSV-1) with a half-maximal inhibitory concentration (IC50) of 2.9 μg/ml. This compound serves as a prodrug to Acyclovir, allowing for effective studies on antiviral mechanisms and pharmacokinetics in virology and medicinal chemistry research. -
Stable Isotope
Trimethoprim-13C3 is a stable isotope-labeled variant of Trimethoprim, a potent bacteriostatic antibiotic that acts primarily as a dihydrofolate reductase inhibitor. This compound exhibits significant activity against a variety of Gram-positive and Gram-negative aerobic bacteria and is employed in research focused on conditions such as urinary tract infections, Shigellosis, and Pneumocystis pneumonia. Additionally, Trimethoprim has been shown to inhibit Influenza A virus infection in chick embryos when used in conjunction with zinc, making it a valuable tool for studies related to antimicrobial and antiviral therapies. -
Stable Isotope
Iclaprim-d6 is a deuterium-labeled derivative of Iclaprim, a selective inhibitor of bacterial dihydrofolate reductase. This compound effectively inhibits the growth of methicillin-resistant Staphylococcus aureus (MRSA) with a minimal inhibitory concentration (MIC90) of 0.06 μg/mL. Iclaprim-d6 serves as a valuable tool for research applications involving antibiotic resistance and the mechanisms of bacterial growth inhibition. -
Stable Isotope
Tedizolid-13C,d3 is a stable isotope-labeled form of Tedizolid, which is an oxazolidinone antibiotic. Its primary mechanism involves the inhibition of bacterial protein synthesis by binding to the 23S ribosomal RNA component of the 50S ribosomal subunit. This compound is essential for research applications in studying antibiotic resistance, ribosomal function, and the pharmacokinetics of Tedizolid in various biological systems. -
Stable Isotope
Erythromycin-d6 is a deuterium-labeled analog of Erythromycin, a macrolide antibiotic derived from the actinomycete Streptomyces erythreus. This compound exhibits broad-spectrum antimicrobial activity by binding to the 50S ribosomal subunit of bacteria, thereby inhibiting RNA-dependent protein synthesis through the blockade of transpeptidation and translocation processes. Erythromycin-d6 is valuable for research applications in pharmacokinetics and metabolic studies, particularly in tracing and quantifying the pharmacological behavior of Erythromycin in various biological systems. -
Stable Isotope
Cefazolin-13C2,15N sodium is a stable isotope-labeled derivative of the first-generation cephalosporin antibiotic, Cefazolin. This reagent is designed for advanced research in bacterial infections, leveraging its antimicrobial properties. Additionally, Cefazolin has demonstrated anti-inflammatory effects, making it valuable for studies related to postoperative cognitive dysfunction (POCD) and other inflammatory conditions. -
Stable Isotope
Orbifloxacin-d4 is a deuterated derivative of Orbifloxacin, functioning as a stable isotope tracer in biological research. This compound is utilized for pharmacokinetic studies and metabolic tracing, providing insights into drug metabolism and pharmacodynamics. Its isotopic labeling allows for enhanced detection and quantification in various analytical assays. -
Stable Isotope
Gatifloxacin-d4 is a deuterium-labeled derivative of the fluoroquinolone antibiotic Gatifloxacin, which primarily targets bacterial topoisomerases II. It exhibits broad-spectrum antibacterial activity, with IC50 values of 13.8 μg/mL against S. aureus topoisomerase IV and 0.109 μg/mL for E. coli DNA gyrase. This stable isotope-labeled compound is suitable for investigative research into bacterial infections, particularly in studies related to bacterial conjunctivitis. -
Stable Isotope
trans-Cinnamic acid-d7 is a deuterium-labeled derivative of trans-Cinnamic acid, enabling enhanced tracking in metabolic studies. This compound exhibits natural antimicrobial properties, demonstrating a minimal inhibitory concentration (MIC) of 250 μg/mL against the fish pathogen Aeromonas sobria, strain SY-AS1. It is primarily utilized in biochemical research to study metabolic pathways and antimicrobial efficacy. -
Stable?Isotope
Lactate-d3 sodium (60% w/w in water) is a stable isotope of lactic acid sodium that acts as a hydroxycarboxylic acid receptor 1 (HCAR1) activator and serves as an epigenetic modulator through the lactylation of lysine residues. This compound is a key end-product of glycolysis, linking metabolic processes such as glycolysis and oxidative phosphorylation. Additionally, it plays a significant role in tumor metabolism and has been implicated in enhancing anti-tumor immunity. Lactate-d3 sodium also exhibits antimicrobial properties, making it suitable for use in food preservation. -
Stable Isotope
Lauric acid-d23 is a deuterium-labeled derivative of lauric acid, a medium-chain fatty acid known for its potent bactericidal properties. This compound exhibits strong antimicrobial activity, with effective concentration (EC50) values of 2 μg/mL against Propionibacterium acnes, 6 μg/mL against Staphylococcus aureus, and 4 μg/mL against Staphylococcus epidermidis. Lauric acid-d23 is valuable for use in biochemical research, particularly in studies exploring lipid metabolism and the antimicrobial mechanisms of fatty acids. -
Stable Isotope
Nonanoic acid-d17 is a deuterium-labeled derivative of nonanoic acid, a naturally occurring saturated fatty acid with nine carbon atoms. This compound serves as a stable isotope and is utilized in metabolic studies and tracer experiments. Nonanoic acid exhibits significant antibacterial activity, reduces bacterial translocation, and enhances the secretion of porcine β-defensins 1 (pBD-1) and pBD-2, making it valuable for research in antimicrobial mechanisms and gut health. -
Stable Isotope
Hexadecane-d34 is a deuterium-labeled stable isotope of hexadecane, a saturated hydrocarbon belonging to the alkane family. This compound serves as a valuable organic solvent and is a key component of petroleum. Hexadecane-d34 is primarily used in research applications focused on understanding the bacterial degradation of hydrophobic compounds, making it an important tool in environmental and biochemical studies. -
Stable Isotope
Lauric acid-d3 is a deuterium-labeled derivative of lauric acid, a medium-chain fatty acid noted for its potent bactericidal activity. It exhibits effective antimicrobial properties, with EC50 values of 2 μg/mL for Propionibacterium acnes, 6 μg/mL for Staphylococcus aureus, and 4 μg/mL for Staphylococcus epidermidis. Lauric acid-d3 is primarily utilized in tracer studies and metabolic research to investigate fatty acid metabolism and functions in various biochemical pathways. -
Stable?Isotope
Lactate-d4 sodium (60% w/w in water) is a deuterium-labeled derivative of lactic acid, targeting hydroxycarboxylic acid receptor 1 (HCAR1) for its biological activity. This compound serves as an epigenetic modulator, promoting lactylation of lysine residues and functioning as an important glycolytic end-product linking glycolysis and oxidative phosphorylation. As an oncometabolite, lactate-d4 sodium has demonstrated roles in anti-tumor immunity while also exhibiting antimicrobial properties that may be applied in food preservation. Its stable isotope labeling makes it a valuable tool for metabolic studies and tracer experiments. -
Stable Isotope
Lauric acid-13C is a stable isotope-labeled version of lauric acid, a medium-chain fatty acid recognized for its potent bactericidal activity. Its effectiveness is demonstrated by EC50 values of 2 μg/mL against Propionibacterium acnes, 6 μg/mL against Staphylococcus aureus, and 4 μg/mL against Staphylococcus epidermidis. This reagent is useful for metabolic tracing studies and examining fatty acid metabolism in various biological contexts. -
Stable Isotope
4-Hydroxybenzoic acid-d4 is a deuterium-labeled analog of 4-Hydroxybenzoic acid, a phenolic compound that serves as a potent antimicrobial agent. This compound demonstrates inhibitory activity against a variety of gram-positive bacteria as well as certain gram-negative strains, exhibiting an IC50 value of 160 μg/mL. It is primarily utilized in metabolic studies and as a stable isotope for biochemical applications. -
Stable Isotope
Omadacycline-d9 is a deuterium-labeled derivative of Omadacycline, designed for use as a stable isotope internal standard in analytical applications. This compound serves as a valuable tool for quantifying Omadacycline levels in biological samples, facilitating accurate pharmacokinetic studies and metabolic profiling. Researchers can leverage Omadacycline-d9 to enhance the reliability of their assays in drug development and therapeutic monitoring. -
Stable Isotope
Maleic acid-d2 is a deuterium-labeled derivative of maleic acid, which serves as a stable isotope for research applications. It functions primarily as an inhibitor of glutamate decarboxylase (GAD) in organisms such as E. coli and L. monocytogenes, making it useful for studies related to neurotransmitter regulation and bacterial metabolism. This compound is valuable in the fields of metabolic research and biochemical assays. -
Stable Isotope
L-Lactic acid-13C-1 sodium serves as a stable isotope-labeled precursor for various biochemical applications, including the study of metabolic pathways and biopolymer synthesis. This compound demonstrates key biological activity by exhibiting antiproliferative effects, making it valuable for research involving cancer metabolism and tissue engineering. Additionally, L-Lactic acid-13C-1 sodium is essential for the production of the biodegradable polymer poly-lactic acid, contributing to advancements in sustainable materials research. -
Stable Isotope
Vitamin D3-d3 is a deuterium-labeled form of Vitamin D3 (Cholecalciferol), a naturally occurring vitamin essential for various biological functions. This stable isotope is utilized in metabolic studies and tracer experiments to investigate Vitamin D3 metabolism, mechanisms of action, and its role in cellular differentiation and inhibition of cancer cell proliferation. Its applications extend to research in endocrinology, oncology, and nutrition. -
Stable Isotope
(±)-Leucine-d10 is a deuterium-labeled form of (±)-Leucine, which serves as a stable isotope. This compound exhibits significant growth inhibition of Escherichia coli HfrH by 92.08%, making it a valuable tool for studying metabolic pathways and protein synthesis. Its applications extend to various fields including biochemical research, nutrition studies, and chemosterilization processes. -
Stable Isotope
DL-3-Phenyllactic acid-d3 is a deuterated derivative of DL-3-Phenyllactic acid, functioning as a stable isotope. This compound exhibits broad-spectrum antimicrobial activity, making it valuable for research in microbiology and pharmacology. Its unique isotopic labeling enables precise tracking and quantification in metabolic studies and helps elucidate biochemical pathways involving phenyl lactate metabolism. -
Stable Isotope
D-Glucose-13C6,d7 is a stable isotope-labeled form of D-Glucose, incorporating both deuterium and carbon-13 isotopes. This compound serves as a valuable tracer in metabolic studies, aiding in the investigation of carbohydrate metabolism and metabolic flux analysis. Its unique isotopic composition allows for precise tracking of glucose utilization in various biological systems, making it a critical reagent for researchers studying energy metabolism and cellular processes. -
Stable Isotope
Sulfamethazine-d4 is a deuterium-labeled derivative of Sulfamethazine, a sulfonamide antibiotic. This stable isotope is primarily used for research applications, including pharmacokinetic studies and metabolic tracing in biological systems. Sulfamethazine itself is utilized for its antimicrobial properties, particularly in treating and preventing gastrointestinal and respiratory infections in animals. -
Stable Isotope
α-Terpineol-d3 is a deuterium-labeled derivative of α-Terpineol, a compound derived from Eucalyptus globulus. This stable isotope retains the strong antimicrobial properties of α-Terpineol, demonstrating significant activity against periodontopathic and cariogenic bacteria, as well as antifungal effects against Trichophyton mentagrophytes. Its unique labeling makes it valuable in research applications focused on microbial interactions and cellular disruption mechanisms. -
Stable Isotope
Nonanoic acid-d4 is a deuterium-labeled derivative of nonanoic acid, a naturally occurring saturated fatty acid with nine carbon atoms. This stable isotope is utilized in various research applications to study metabolic processes and fatty acid metabolism. Nonanoic acid has been shown to significantly reduce bacterial translocation, enhance antibacterial activity, and increase the secretion levels of porcine β-defensins 1 (pBD-1) and pBD-2, making it valuable for investigations into antimicrobial peptides and gut health. -
Stable Isotope
D-Sorbitol-13C6 is a stable isotope-labeled form of D-Sorbitol, a six-carbon sugar alcohol. This compound serves as a versatile stabilizing excipient and isotonicity agent, making it suitable for various formulations. It is often utilized in biological research to trace metabolic pathways and assess carbohydrate metabolism, providing valuable insights into biochemical processes. D-Sorbitol-13C6 is also employed extensively in dietary supplement research and food science applications. -
Stable Isotope
Urethane-d5 is a deuterium-labeled version of Urethane, which is the ethyl ester of carbamic acid. It is commonly utilized in studies involving fermentation and food products. Urethane is known to inhibit the growth of bacteria, protozoa, sea urchin eggs, and plant tissues in vitro, making it valuable for various research applications in microbiology and botany. -
Stable Isotope
Tridecanoic acid-d25 is a deuterated form of tridecanoic acid, a medium-chain saturated fatty acid consisting of 13 carbon atoms. This compound acts as an antipersister and antibiofilm agent, demonstrating significant inhibitory effects on the persistence and biofilm formation of Escherichia coli. Its unique properties make it a valuable tool in research focused on bacterial infections and the development of strategies to combat biofilm-related challenges. -
Stable Isotope
Saccharin-d4 is a deuterium-labeled form of saccharin, a widely used non-caloric artificial sweetener. As a stable isotope, Saccharin-d4 serves as a valuable tracer in metabolic studies and research involving dietary components. Its unique isotopic signature allows for enhanced tracking of saccharin's effects on microbiome modulation and bacteriostatic activity in various biological systems.
