Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Terconazole-d4 is a deuterated form of Terconazole, a broad-spectrum antifungal agent. This stable isotope can be utilized in pharmacokinetic studies and metabolic research to trace the pathways and concentration of Terconazole in biological systems. Its application is particularly relevant in understanding the pharmacodynamics of antifungal therapies and optimizing treatment regimens. -
Stable Isotope
Cyprodinil-13C6 is a stable isotope-labeled version of Cyprodinil, an anilinopyrimidine fungicide that primarily targets the aryl hydrocarbon receptor. This compound exhibits broad-spectrum antifungal activity by inhibiting methionine biosynthesis in plant-pathogenic fungi, thus providing protection to fruits and vegetables from various pathogens. It also displays anti-androgenic and androgenic activities, making it relevant for studies exploring hormonal interactions in biological systems. Cyprodinil-13C6 is particularly useful in trace analysis applications and metabolic studies involving Cyprodinil. -
Stable Isotope
Flucytosine-13C,15N2 is a stable isotope-labeled analog of Flucytosine, incorporating both carbon-13 and nitrogen-15 isotopes. This molecularly modified compound serves as a valuable tool for tracking metabolic pathways and understanding drug metabolism in microbiological and pharmacological studies. Its applications extend to isotope labeling experiments, allowing researchers to investigate the pharmacokinetics and pharmacodynamics of Flucytosine in various biological systems. -
Stable Isotope
Itraconazole-d9 is a deuterium-labeled derivative of itraconazole, a triazole antifungal agent known for its function as a potent inhibitor of the Hedgehog (Hh) signaling pathway, with an IC50 of approximately 800 nM. This compound effectively inhibits lanosterol 14α-demethylase, a cytochrome P450 enzyme, disrupting the conversion of lanosterol to ergosterol. Itraconazole-d9 exhibits notable anticancer and antiangiogenic properties, making it suitable for research in cancer biology and related therapeutic applications. Additionally, it serves as an oxysterol-binding protein (OSBP) inhibitor, highlighting its versatility in biochemical research. -
Stable Isotope
Climbazole-d4 is a deuterium-labeled derivative of Climbazole, a potent antifungal agent targeting fungal pathogens. This stable isotope provides a valuable tool for tracking metabolic pathways and studying the pharmacokinetics of Climbazole in biological systems. Climbazole-d4 is also effective in research focused on the induction of hepatic cytochrome P450 enzymes, enhancing understanding of drug metabolism and enzymatic activity. -
Stable Isotope
Thiophanate-methyl-d6 is a deuterium-labeled form of Thiophanate-methyl, a systemic fungicide that inhibits fungal growth. This stable isotope-labeled compound is crucial for studies involving metabolic pathways and biological distribution of fungicides in environmental and agricultural research. Its use in isotopic labeling enhances the accuracy of analytical techniques, facilitating in-depth exploration of thiophanate interactions within biological systems. -
Stable Isotope
Posaconazole-d5 is a deuterium-labeled analogue of Posaconazole, a broad-spectrum, second-generation triazole antifungal agent. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace the compound's metabolism and pharmacodynamics in biological systems. Its application aids in the investigation of the drug's behavior and efficacy in various fungal infections. -
Stable Isotope
Itraconazole-d5 is a deuterium-labeled form of Itraconazole, a triazole antifungal agent that functions primarily as a Hedgehog (Hh) signaling pathway antagonist with an IC50 of approximately 800 nM. This compound effectively inhibits lanosterol 14α-demethylase, a cytochrome P450 enzyme, blocking the conversion of lanosterol to ergosterol. Itraconazole-d5 is utilized in research applications investigating antifungal mechanisms, anticancer effects, and antiangiogenic properties. -
Stable Isotope
Efinaconazole-d4 is a deuterium-labeled derivative of Efinaconazole, a triazole antifungal agent targeting fungal pathogens. It demonstrates potent in vitro activity against Trichophyton mentagrophytes and Candida albicans, with minimal inhibitory concentrations (MICs) of 0.0039 μg/mL and 0.00098 μg/mL, respectively. This stable isotope compound is valuable for pharmacokinetic studies and mechanistic research involving fungal infections and dermatophyte activity. -
Stable Isotope
Ketoconazole-d4 is a deuterium-labeled derivative of the imidazole antifungal agent Ketoconazole. It primarily targets CYP3A4 and CYP24A1 enzymes, serving as a valuable tool for studying drug metabolism and pharmacokinetics. This stable isotope is particularly useful in quantitative mass spectrometry applications and investigations into the pharmacological behavior of Ketoconazole in biological systems. -
Stable Isotope
Cymoxanil-d3 is a deuterium-labeled variant of the fungicide Cymoxanil, which acts as a cyanooxime targeting plant diseases caused by fungi in the Perenosporales order. This compound inhibits fungal growth and impacts DNA and RNA synthesis in various Phytophthora species. It is primarily utilized in research applications to study the biochemical pathways involved in plant-fungal interactions and to analyze the environmental fate of Cymoxanil in agricultural settings. -
Stable Isotope
Ketoconazole-d8 is a deuterated analogue of the antifungal agent Ketoconazole, which primarily targets the cytochrome P450 enzymes CYP3A4 and CYP24A1. This stable isotope-labeled compound is valuable for metabolic and pharmacokinetic studies, providing insights into the drug's biochemical pathways. Its unique labeling enables precise tracking in various biological assays, facilitating advanced research in pharmacology and toxicology. -
Stable Isotope
Benzoic acid-13C6 is a stable carbon-13 isotope-labeled form of benzoic acid. This compound serves as a key metabolic tracer in various biochemical studies and is widely utilized in environmental and food safety research. Its primary biological activity includes the inhibition of bacterial and fungal growth, which positions it as an important agent for studying preservation mechanisms in food and cosmetic formulations. -
Stable Isotope
Thiram-d12 is a deuterium-labeled derivative of Thiram, a well-known fungicide used extensively on seeds and as a foliar treatment for various crops, including turf, vegetables, and fruits. Thiram primarily functions as a vulcanization accelerator in the rubber industry. In biological research, Thiram is recognized for its dual role, inducing antioxidant defenses while also acting as a prooxidant that promotes the formation of reactive oxygen species (ROS). Thiram-d12 serves as a valuable tool for studies involving oxidative stress and the monitoring of antioxidant responses in agricultural and environmental research. -
Stable Isotope
Clotrimazole-d5 is a deuterated form of the antifungal agent Clotrimazole, which is classified as an imidazole derivative and functions primarily as a CYP (cytochrome P450) inhibitor. This stable isotope allows for accurate tracking and quantification in various biological studies. Clotrimazole-d5 is utilized in research focusing on antifungal mechanisms, metabolic studies, and investigations into drug interactions related to cytochrome P450 enzymes. -
Stable Isotope
Itraconazole-d3 is a deuterium-labeled derivative of Itraconazole, a triazole antifungal that targets lanosterol 14α-demethylase, a cytochrome P450 enzyme, with an IC50 of approximately 800 nM. This compound acts as a potent antagonist of the Hedgehog (Hh) signaling pathway, and exhibits notable anticancer and antiangiogenic properties. Additionally, Itraconazole-d3 functions as an oxysterol-binding protein (OSBP) inhibitor, making it a valuable tool for studying fungal infections, cancer biology, and metabolic pathways in research settings. -
Stable Isotope
Pentamidine-d4 dihydrochloride is a deuterium-labeled derivative of Pentamidine dihydrochloride, known for its role as an antimicrobial agent. This compound targets DNA biosynthesis and exhibits inhibitory effects on Leishmania infantum with an IC50 of 2.5 μM. Additionally, it acts as a potent and selective inhibitor of protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL). Pentamidine-d4 dihydrochloride holds therapeutic potential for conditions such as Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia, while also demonstrating antitumor and antibacterial activities. -
Stable Isotope
Undecanoic acid-d21 is a deuterium-labeled derivative of undecanoic acid, serving as a stable isotope for research applications. This monocarboxylic acid exhibits antifungal properties by inhibiting the production of extracellular keratinase and lipase, as well as interfering with the biosynthesis of phospholipids in Trichophyton rubrum. It is valuable for studies in metabolic pathways and for tracking the bioactivity of undecanoic acid in various biological systems. -
Stable Isotope
Terbinafine-d3 hydrochloride is a deuterium-labeled analog of Terbinafine hydrochloride, primarily used as a stable isotope in analytical research. This compound acts as a potent non-competitive inhibitor of squalene epoxidase, exhibiting a Ki of 30 nM, and is indicated for the treatment of fungal infections. In addition to its antifungal properties, Terbinafine hydrochloride demonstrates antibacterial activity against specific Gram-positive and Gram-negative bacteria, making it a valuable tool in microbiological studies. -
Stable Isotope
Melitracen-d6 hydrochloride is a deuterium-labeled form of Melitracen hydrochloride, a biphasic antidepressant and anxiolytic. It primarily acts by inhibiting the reuptake of norepinephrine and serotonin at the presynaptic membrane, leading to increased levels of monoamine neurotransmitters in the synaptic cleft. This stable isotope form is useful in pharmacokinetic studies and metabolic tracing in biochemical research. -
Stable Isotope
Zimeldine-d6 is a deuterium-labeled analog of Zimeldine, primarily used as a stable isotope in chemical research. This compound allows for enhanced tracking and analysis in metabolic studies and pharmacokinetic investigations. Its incorporation into experimental designs facilitates detailed studies of Zimeldine's biological activity and interactions, aiding in the understanding of its pharmacological properties. -
Stable Isotope
Eletriptan-d3 is a deuterated form of Eletriptan hydrobromide, acting as a selective agonist for the 5-HT1B and 5-HT1D receptors, with Ki values of 0.92 nM and 3.14 nM, respectively. This stable isotope is valuable for pharmacokinetic studies, allowing researchers to investigate the distribution and metabolism of Eletriptan in biological systems. Its use in isotopic labeling enhances the sensitivity and specificity of analytical techniques in neurological research. -
Stable Isotope
Setiptiline-d3 is a deuterium-labeled analog of Setiptiline, a tetracyclic antidepressant functioning primarily as a noradrenergic and specific serotonergic antidepressant. Its mechanism involves norepinephrine reuptake inhibition and antagonism of α2-adrenergic and various serotonin receptors, including 5-HT2A, 5-HT2C, and 5-HT3 subtypes, in addition to H1 receptor inverse agonism. This stable isotope variant is valuable for tracing studies in pharmacokinetics and elucidating the pharmacodynamics of Setiptiline in clinical research. -
Stable Isotope
Cisapride-d6 is a deuterium-labeled analogue of Cisapride, primarily functioning as a stable isotope for analytical applications. As a 5-HT4 receptor agonist with an EC50 of 140 nM, Cisapride enhances gastrointestinal motility, making it a valuable gastroprokinetic agent. Additionally, it acts as a hERG blocker with an IC50 value of 9.4 nM, facilitating research into cardiac safety profiles. This reagent is ideal for studying pharmacokinetics and metabolic pathways in preclinical models. -
Stable Isotope
Lumateperone-d4 is a deuterium-labeled analog of Lumateperone, primarily targeting the 5-HT2A receptor as an antagonist (Ki = 0.54 nM). It exhibits dual action as a partial agonist at presynaptic D2 receptors and an antagonist at postsynaptic D2 receptors (Ki = 32 nM), along with modulation of dopamine D1 receptors. This compound is valuable for investigating schizophrenia, bipolar depression, and has demonstrated anticancer properties, making it a versatile tool in chemical research. -
Stable Isotope
Pindolol-d7 is a deuterated form of Pindolol, primarily targeting the 5-HT 1A (Ki=33 nM) and 5-HT 1B receptors, as well as β1/β2-adrenergic receptors. This stable isotope is utilized in research to investigate the pharmacokinetics and metabolic pathways of Pindolol. The compound demonstrates significant anti-anxiety and antidepressant activities, making it valuable for studies related to psychiatric disorders and neuropharmacology. -
Stable Isotope
Dehydroaripiprazole-d8 is a deuterated form of Dehydroaripiprazole, a key active metabolite of the antipsychotic Aripiprazole. This stable isotope serves as a valuable analytical tool in pharmacokinetic studies and metabolic pathway investigations. Dehydroaripiprazole exhibits comparable antipsychotic activity to its parent compound, allowing researchers to explore its efficacy and safety profiles in various clinical settings. It is particularly useful for studies involving isotopic labeling techniques and drug metabolism enzyme interactions. -
Stable Isotope
Trimipramine-d3 maleate is a deuterium-labeled analog of Trimipramine maleate, functioning primarily as a selective antagonist of 5-HT receptors. It exhibits pKis of 6.39 for 5-HT1C, 8.10 for 5-HT2, and 4.66 for 5-HT1A, highlighting its specificity towards serotonin signaling pathways. This stable isotope is valuable for pharmacokinetic studies and metabolic tracing in biological research, providing insights into the pharmacodynamics of serotonergic modulation. -
Stable Isotope
Loxapine-d8 hydrochloride is a deuterated derivative of Loxapine, primarily acting as a D2 and D4 dopamine receptor inhibitor. This stable isotope is utilized in research to study pharmacokinetics and metabolic pathways of Loxapine. Its serotonergic receptor antagonism further facilitates investigations into the neuropharmacological effects associated with dibenzoxazepine anti-psychotic agents. -
Stable Isotope
Granisetron-d3 is a deuterium-labeled derivative of Granisetron, which acts as a selective antagonist of the serotonin 5-HT3 receptor. This compound is primarily utilized in research related to antiemetic effects and mechanisms of nausea and vomiting, particularly in the context of chemotherapy treatments. Its stable isotope labeling enables advanced analytical studies and metabolism investigations in preclinical settings. -
Stable Isotope
Bopindolol-d9 is the deuterium-labeled form of Bopindolol, a non-selective antagonist of β-adrenoceptors (ARs) with partial agonist activity. This compound exhibits low affinity for the β3-AR subtype and possesses intrinsic sympathomimetic properties, alongside membrane stabilizing actions. Bopindolol-d9 is useful for research on essential and renovascular hypertension, as well as for studying renin secretion and interactions with 5-HT receptors. -
Stable Isotope
Quetiapine-d8 fumarate is a deuterated derivative of Quetiapine, primarily functioning as a stable isotope for enhanced analytical studies. This compound acts as a 5-HT receptor agonist, exhibiting a pEC50 of 4.77 for the human 5-HT1A receptor, while also serving as a dopamine receptor antagonist with a pIC50 of 6.33 for the human D2 receptor. Quetiapine-d8 fumarate demonstrates moderate to high affinity for multiple receptors, including human D2, 5-HT1A, 5-HT2A, and 5-HT2C, with respective pKis of 7.25, 5.74, 7.54, and 5.55, making it valuable for research into antidepressant and anxiolytic pharmacology. -
Stable Isotope
Blonanserin-d5 is a deuterated analog of Blonanserin, serving as a stable isotope for research applications. As a dopamine D2 and 5-HT2 receptor antagonist, Blonanserin is classified as an atypical antipsychotic. This reagent is useful for pharmacokinetic studies and can facilitate investigations into the pharmacodynamics and metabolism of antipsychotic compounds. -
Stable Isotope
Melperone-d4 hydrochloride is a deuterium-labeled derivative of Melperone hydrochloride, a butyrophenone with atypical antipsychotic properties. It acts as a multireceptor antagonist, exhibiting binding affinities (Kd values) of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, respectively. Additionally, Melperone-d4 displays weak interactions with several other receptors and inhibits CYP2D6. This reagent is particularly valuable for investigating schizophrenia and managing agitation in geriatric populations. -
Stable Isotope
GW-117 is a stable isotope characterized as a 5-HT2C receptor antagonist and a melatonin (MT1/MT2) receptor agonist. This compound exhibits significant antidepressant-like and anxiolytic-like effects, making it valuable for research in mood disorders and anxiety. It serves as a crucial tool for studies investigating the interplay between serotonin and melatonergic systems in neuropharmacology. -
Stable Isotope
Clozapine-d3 is a deuterium-labeled derivative of Clozapine, primarily targeting neuroreceptors involved in psychiatric disorders. This compound exhibits high affinity as a dopamine D2 receptor antagonist with a Ki of 75 nM, while also inhibiting the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Additionally, Clozapine-d3 acts as a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM), making it valuable for investigations into schizophrenia and related neurochemical pathways. -
Stable Isotope
Rizatriptan-d6 benzoate is a deuterium-labeled derivative of Rizatriptan benzoate, which acts as an agonist for the serotonin receptors 5-HT1B and 5-HT1D. This compound exhibits peripheral vasoconstrictive properties and effectively crosses the blood-brain barrier, thereby inhibiting pain neurotransmission within the central nervous system. It is commonly utilized in research applications focused on migraine pathophysiology, pharmacokinetics, and receptor signaling studies. -
Stable Isotope
Urapidil-d4 is a deuterium-labeled derivative of Urapidil, which functions primarily as an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist. This stable isotope-labeled compound is valuable for tracing studies and in-depth biochemical research, allowing for precise pharmacokinetic assessments and potential insights into receptor interactions and mechanisms of action. Its unique isotopic labeling enhances the ability to study the metabolism and distribution of Urapidil in various biological contexts. -
Stable Isotope
Metoclopramide-d3 is a deuterium-labeled derivative of Metoclopramide. This compound functions as a potent antagonist of the 5-HT3 and dopamine D2 receptors, exhibiting IC50 values of 308 nM and 483 nM, respectively. Metoclopramide-d3 is utilized in research focusing on nausea, vomiting, gastroesophageal reflux disease, and gastroparesis, providing a valuable tool for studying the pharmacokinetics and dynamics of this important therapeutic agent. -
Stable Isotope
Cyclobenzaprine-d6 hydrochloride is a deuterium-labeled analogue of Cyclobenzaprine, serving as a stable isotope compound. This reagent is primarily utilized in pharmacokinetic studies and mass spectrometry applications for the quantification of Cyclobenzaprine and its metabolites. Its unique isotopic labeling allows for enhanced sensitivity and specificity in analytical assays, facilitating research in drug metabolism and pharmacodynamics. -
Stable Isotope
Zolmitriptan-d6 is a deuterium-labeled derivative of Zolmitriptan, a selective partial agonist of the 5-HT1B and 5-HT1D receptors, exhibiting inhibitory constants (Kis) of 5.01 nM, 0.63 nM, and 63.09 nM for the 5-HT1B, 5-HT1D, and 5-HT1F receptors, respectively. This stable isotope is primarily utilized in analytical research for understanding the pharmacokinetics and metabolism of Zolmitriptan in migraine studies, facilitating more accurate mechanism-of-action investigations. -
Isotope-Labeled Compounds
Cyclobenzaprine-d3-1 hydrochloride is a deuterium-labeled analog of Cyclobenzaprine hydrochloride, functioning primarily as a 5-HT2 receptor antagonist. This compound exhibits significant skeletal muscle relaxant properties, effectively alleviating muscle spasms and associated pain. Furthermore, it possesses antiprotozoal and antiparasitic activities, making it a valuable tool for research in acute musculoskeletal disorders as well as infectious diseases. Its isotope-labeled nature enables advanced studies in pharmacokinetics and mechanism of action. -
Stable Isotope
Deulumateperone is a deuterated derivative of Lumateperone, serving as a stable isotope for research applications. Lumateperone acts as a selective antagonist of the 5-HT2A receptor (Ki = 0.54 nM) and modulates dopamine receptors, demonstrating significant antipsychotic and antineoplastic properties. This reagent is valuable for studies involving receptor interactions, pharmacokinetics, and metabolic profiling in various biological systems. -
Stable Isotope
Paliperidone palmitate-d4 is a deuterium-labeled derivative of paliperidone palmitate, serving as a stable isotope for research applications. This compound functions as a competitive antagonist of dopamine D2 and 5-hydroxytryptamine 2A (5-HT2A) receptors, effectively modulating neurotransmitter systems and demonstrating antipsychotic activity. Its ability to cross the blood-brain barrier makes it particularly valuable for studies focused on schizophrenia and related psychiatric disorders. -
Stable Isotope
Cisapride-13C,d3 is a stable isotope-labeled form of Cisapride, which primarily acts as a 5-HT4 receptor agonist, exhibiting an EC50 of 140 nM. Additionally, Cisapride functions as a hERG channel inhibitor with an IC50 of 9.4 nM. This compound serves as a gastroprokinetic agent, promoting gastrointestinal motility, making it valuable for research involving gastrointestinal disorders and pharmacokinetic studies. -
Stable Isotope
Quetiapine-d4-1 fumarate is a deuterated analogue of Quetiapine, specifically designed to enhance analytical precision in research applications. As a serotonin (5-HT) receptor agonist, it exhibits a pEC50 of 4.77 at the human 5-HT1A receptor and acts as a dopamine receptor antagonist with a pIC50 of 6.33 for the human D2 receptor. Quetiapine-d4-1 fumarate demonstrates moderate to high affinity for several key receptors, including D2, 5-HT1A, 5-HT2A, and 5-HT2C, making it suitable for studies in neuropharmacology, particularly in exploring antidepressant and anxiolytic effects. -
Stable Isotope
Ondansetron-13C,d3 is a stable isotope-labeled variant of Ondansetron, a selective 5-HT3 receptor antagonist with an IC50 of 103 pM. This compound inhibits nausea and vomiting by blocking 5-HT receptors in both peripheral and central nervous systems. It is particularly valuable in research applications involving the effects of chemotherapy and radiotherapy on antiemetic responses. Used in pharmacokinetic studies and metabolic research, Ondansetron-13C,d3 aids in understanding the drug's behavior and efficacy in clinical settings. -
Stable Isotope
Sarpogrelate-d3 hydrochloride is a deuterium-labeled form of Sarpogrelate hydrochloride, serving as a selective antagonist for the 5-HT2 receptor family. With pKis of 8.52, 6.57, and 7.43 for the 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively, it demonstrates notable selectivity over 5-HT1, 5-HT3, 5-HT4, and various adrenergic and histamine receptors. This reagent is valuable for studying vascular diseases related to thrombosis, enabling researchers to investigate the pharmacodynamics and metabolism of Sarpogrelate in biological systems. -
Stable Isotope
Azasetron Hydrochloride-13C,d3 is a deuterium and carbon-13 isotope-labeled form of Azasetron, a potent 5-HT3 receptor antagonist. This antiemetic agent is widely utilized in the research of postoperative nausea and vomiting, as well as nausea induced by chemotherapy. Importantly, Azasetron maintains neutrophil chemotaxis and phagocytosis without reacting with superoxide or hydrogen peroxide in cell-free systems, making it suitable for various biological studies. -
Stable Isotope
Eletriptan-d5 is a deuterium-labeled analog of Eletriptan, a highly selective and orally active agonist for the serotonin 5-HT1B and 5-HT1D receptors, exhibiting pKi values of 8.0 and 8.9, respectively. This compound demonstrates inhibitory effects on neurogenic inflammation markers in preclinical models, particularly in rats. Eletriptan-d5 is valuable for research applications focused on migraine pathophysiology and the pharmacological profiling of serotonin receptor interactions.
