Catalog No.
Product Name
Application
Product Information
Citations
-
Stable Isotope
Uridine-13C-3 is a stable isotope-labeled form of uridine, featuring three carbon atoms labeled with the carbon-13 isotope. This reagent is primarily used in metabolic studies and tracer experiments to investigate nucleoside metabolism and cellular processes. It facilitates research in areas such as RNA synthesis and nucleotide metabolism, providing insights into cellular dynamics and biochemical pathways. -
Stable Isotope
Cytidine-13C-1 is a stable isotope-labeled form of cytidine, a pyrimidine nucleoside integral to RNA structure. As a precursor to uridine, it plays a critical role in nucleic acid metabolism. This isotope-labeled reagent is utilized in metabolic studies to investigate neuronal and glial glutamate cycling and its impact on cerebral phospholipid metabolism and catecholamine biosynthesis. -
Stable Isotope
DL-Alanosine-15N2 is a stable isotope-labeled form of DL-Alanosine, an amino acid analogue known for its antitumor properties. This compound serves as a valuable tool in biological research, enabling the study of metabolic pathways and tumor biology through isotopic incorporation techniques. Its unique labeling provides insight into amino acid metabolism, making it suitable for applications in cancer research and biomolecular tracking. -
Stable Isotope
Cytidine-d2-1 is a deuterium-labeled pyrimidine nucleoside that serves as a stable isotope. This compound plays a crucial role as a building block of RNA and is a precursor to uridine. Its unique isotopic composition makes it valuable for tracing studies in metabolic pathways and investigating neuronal-glial glutamate cycling, impacting cerebral phospholipid metabolism and neurotransmitter dynamics in various research applications. -
Stable Isotope
Trifluralin-d14 is a deuterated form of the herbicide Trifluralin, which functions as a selective preemergence soil-applied herbicide. It effectively controls various annual grass and broadleaf weeds by inhibiting root development through disruption of mitosis, primarily targeting tubulin to hinder spindle apparatus and cell plate formation. This compound is useful in research applications focused on herbicidal mechanisms, plant development studies, and the assessment of neurotoxic and hematotoxic effects associated with Trifluralin. -
Stable Isotope
Orotic acid-13C,15N2 monohydrate is a stable isotope-labeled compound that serves as a precursor in the biosynthesis of pyrimidine nucleotides and RNA. As a key intermediate, it is released from mitochondrial dihydroorotate dehydrogenase (DHODH) and subsequently converted to UMP by cytoplasmic UMP synthase. This compound is utilized in research focusing on metabolic pathways, particularly in studies of urea cycle disorders and hepatic function, as it can induce hepatic steatosis and hepatomegaly in animal models. -
Stable Isotope
Uridine-13C is a stable isotope-labeled form of uridine, enriched with carbon-13. This reagent is utilized predominantly in metabolic studies and tracer experiments, helping to elucidate pathways in nucleic acid metabolism. Its unique isotopic labeling allows researchers to track uridine utilization and distribution in biological systems, facilitating insights into cellular processes and disease mechanisms. -
Stable Isotope
Uridine-13C9,15N2 is a stable isotope-labeled analog of uridine, featuring both 13C and 15N isotopes. As a glycosylated pyrimidine, it connects uracil to a ribose (arabinofuranose) structure through a β-N1-glycosidic bond. This compound is valuable for metabolic tracing studies and isotopic labeling applications in biochemical research, enabling insights into nucleic acid metabolism and cellular processes involving RNA and nucleotides. -
Stable Isotope
Uridine-15N2 is a stable isotope-labeled form of uridine, incorporating two nitrogen-15 isotopes. It serves as a valuable tool for metabolic studies and tracer experiments, allowing researchers to investigate nucleotide metabolism and cellular processes involving RNA synthesis. Its application extends to systems biology and pharmacokinetics, enabling precise analysis of metabolic pathways in various biological contexts. -
Stable Isotope
Uridine-d2-1 is a deuterium-labeled derivative of uridine, designed for use as a stable isotope in biochemical research. This compound serves as a valuable tracer in metabolic studies and can be utilized in nucleic acid research, allowing for enhanced detection and quantification of uridine-related metabolic pathways. Its stable nature makes it ideal for isotope labeling experiments and provides insights into biological processes in various cellular systems. -
Stable Isotope
Cytidine-d2 is a deuterium-labeled analog of cytidine, a pyrimidine nucleoside that serves as a fundamental component of RNA. It functions as a precursor to uridine and plays a critical role in neuronal-glial glutamate cycling, influencing cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function. Cytidine-d2 is primarily utilized in stable isotope labeling studies to investigate metabolic pathways and cellular processes in biochemical research. -
Stable Isotope
Cytidine-13C is a stable isotope-labeled form of cytidine, a pyrimidine nucleoside crucial for RNA synthesis. As a precursor to uridine, it plays a pivotal role in various cellular processes, including neuronal-glial glutamate cycling, which impacts cerebral phospholipid metabolism and catecholamine signaling. This reagent is valuable in metabolic tracing studies and isotopic labeling experiments in cellular and molecular biology research. -
Stable Isotope
Doxifluridine-d2 is a deuterium-labeled analog of Doxifluridine, which functions as a thymidine phosphorylase activator. It exhibits a significant biological activity with an IC50 value of 0.62 μM in PC9-DPE2 cells. This stable isotope can be utilized in research applications involving metabolic studies and pharmacokinetic assessments, providing insights into the interactions and mechanisms of nucleoside metabolism. -
Stable Isotope
Uridine-d is a deuterium-labeled analog of uridine, designed for use in stable isotope labeling studies. It is utilized primarily in metabolic and biochemical research to trace nucleoside metabolism and RNA synthesis pathways. This reagent is invaluable for elucidating cellular processes and improving the understanding of nucleic acid function in various biological systems. -
Stable Isotope
Uridine-13C-1 is a stable isotope-labeled analog of uridine, serving as a valuable tool in metabolic research. Its incorporation into RNA and nucleotides allows for tracing metabolic pathways and studying nucleoside metabolism in various biological systems. This reagent is particularly useful in isotopic labeling experiments and for exploring cellular pathways involving RNA synthesis, turnover, and degradation. -
Stable Isotope
Cytidine-d is a deuterium-labeled derivative of cytidine, a pyrimidine nucleoside essential for RNA synthesis. This stable isotope allows for detailed metabolic tracing in biological systems, particularly in studies of RNA metabolism and neuronal-glial interactions. Cytidine-d is valuable for investigating glutamate cycling and its impact on cerebral phospholipid metabolism and catecholamine levels, making it a useful tool in neurobiological research. -
Stable Isotope
Uridine 13C-4 is a stable isotope-labeled form of uridine, featuring four carbon atoms in the 13C configuration. It serves as a vital tool for metabolic studies, allowing researchers to trace metabolic pathways and analyze nucleoside metabolism. Its applications extend to various fields, including cell biology, biochemistry, and pharmacokinetics, providing essential insight into cellular processes and nucleotide dynamics. -
Stable Isotope
N-6-Methyl-2-deoxyadenosine-d3 is a deuterated analogue of N-6-Methyl-2-deoxyadenosine, featuring enhanced stability for research applications. This stable isotope is utilized for studies involving nucleotide metabolism and epigenetics, providing insights into cellular processes that involve adenine nucleosides. Its unique labeling allows for precise tracking and analysis in various biochemical experiments. -
Stable Isotope
Uridine-d2 is a deuterium-labeled derivative of uridine, functioning as a stable isotope. This reagent serves as a valuable tool in metabolic studies and tracer experiments, facilitating the investigation of nucleotide metabolism and RNA synthesis pathways. Researchers can utilize Uridine-d2 to enhance the sensitivity of detection methods, such as mass spectrometry, in diverse biological assays. -
Stable Isotope
Uridine-13C-2 is a stable isotope-labeled form of uridine, utilized for metabolic tracing and studies in cellular metabolism. Its incorporation into nucleic acids allows for precise tracking of nucleotide turnover and cellular uptake in various biological systems. This reagent is essential for applications in metabolic flux analysis, isotopic labeling experiments, and understanding nucleotide metabolism in research contexts. -
Stable Isotope
5,6-Dihydro-5-Fluorouracil-13C,15N2 is a stable isotope-labeled derivative of 5,6-Dihydro-5-Fluorouracil, which acts as a thymidylate synthase inhibitor through its active metabolite formation from the prodrug 5-fluorouracil via dihydropyrimidine dehydrogenase. This compound demonstrates cytotoxic effects on HaCaT keratinocytes with an IC50 of 13.5 μM. Research applications include investigating tumor growth inhibition, particularly in combination with 5-fluorouracil and dihydropyrimidine dehydrogenase inhibitors, in oncological studies such as rat colon cancer models. -
Stable Isotope
7-Methylguanosine 5'-Monophosphate-d3 is a deuterated form of 7-Methylguanosine 5'-monophosphate, serving as a stable isotope labeled nucleotide. This compound is an important building block for nucleic acids, aiding in the study of RNA synthesis and modification. Its unique isotopic labeling allows for advanced applications in metabolomics and isotopic tracing studies in biochemical research. -
Stable Isotope
N6-Threonylcarbamoyladenosine-13C4,15N is a stable isotope-labeled derivative of N6-Threonylcarbamoyladenosine. This compound acts as a nucleoside that plays a critical role in the modification of tRNA molecules. Its unique isotopic labeling makes it valuable for biological studies, particularly in metabolic tracking and analytical research involving nucleoside metabolism and modification processes. -
Stable Isotope
Uridine-13C,15N2 is a stable isotope-labeled form of uridine, incorporating both carbon-13 and nitrogen-15 isotopes. This compound is particularly valuable in metabolic studies, enabling researchers to trace nucleotide metabolism and investigate cellular processes involving RNA synthesis. Its application in stable isotope labeling techniques aids in elucidating metabolic pathways and biochemical interactions in various organisms. -
Stable Isotope
Cytidine-1',2',3',4',5'-13C5 is a stable isotope-labeled form of cytidine, a pyrimidine nucleoside integral to RNA structure. As a precursor of uridine, it plays a key role in various biological processes, including neuronal-glial glutamate cycling, cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function. This reagent is valuable for metabolic studies and isotopic tracing in cellular and molecular biology research. -
Stable Isotope
Phenylbutazone (diphenyl-d10) is a deuterium-labeled derivative of Phenylbutazone, functioning as an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). This compound exhibits notable anti-inflammatory properties and has been linked to hepatotoxicity. In addition to its role as a nonsteroidal anti-inflammatory drug (NSAID), Phenylbutazone (diphenyl-d10) is utilized in research focused on the modulation of muscle blind-like protein 1 (MBNL1) expression and may contribute to studies related to ankylosing spondylitis. -
Stable Isotope
γ-Tocopherol-d4 is a deuterium-labeled derivative of γ-Tocopherol, a naturally occurring form of Vitamin E found in various plant oils. As a potent cyclooxygenase (COX) inhibitor, γ-Tocopherol-d4 exhibits significant anti-inflammatory properties and has been studied for its anti-cancer activity. This stable isotope is valuable for metabolic research and tracing studies in biological systems. -
Stable Isotope
Celecoxib-d7 is a deuterium-labeled variant of Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID) known for its potent inhibition of cyclooxygenase-2 (COX-2) with an IC50 of 40 nM. This stable isotope is widely used in pharmacokinetic and metabolic studies, providing valuable insights into drug metabolism and efficacy. Its applications extend to the investigation of COX-2-related pathways in inflammatory diseases and cancer research. -
Stable Isotope
Nabumetone-d3 is a deuterium-labeled analogue of Nabumetone, primarily acting as a selective inhibitor of cyclooxygenase-2 (COX-2). This compound demonstrates significant anti-inflammatory properties and is known to suppress cancer cell proliferation while also providing protective effects against gastric ulcers. Nabumetone-d3 is valuable in research applications focused on elucidating the pharmacokinetics and mechanisms of action of COX-2 inhibitors in various biological contexts. -
Stable Isotope
(±)-Naproxen-d3 is a deuterium-labeled derivative of (±)-Naproxen, a widely used non-steroidal anti-inflammatory drug (NSAID). This stable isotope is employed in pharmacokinetic studies and metabolic research to trace the drug's behavior in biological systems. Its use allows for improved understanding of drug metabolism and efficacy without altering the biological activity of the parent compound. -
Stable Isotope
Celecoxib-d3 is a deuterium-labeled derivative of Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID) that specifically inhibits the COX-2 enzyme, exhibiting an IC50 value of 40 nM. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research to trace the kinetics and pathways of Celecoxib metabolism in biological systems. Celecoxib-d3 facilitates enhanced analytical sensitivity for investigating the drug’s biological effects and interactions. -
Stable Isotope
Piroxicam-d3 is a deuterium-labeled derivative of Piroxicam, a non-steroidal anti-inflammatory drug (NSAID) that primarily acts as a cyclooxygenase (COX) inhibitor. It exhibits inhibitory activity against human monocyte COX-1 and COX-2, with IC50 values of 47 μM and 25 μM, respectively. This stable isotope is essential for studies requiring precise tracking of Piroxicam in pharmacokinetic and metabolic research applications. -
Stable Isotope
Phenylbutazone-13C12 is a stable isotope-labeled form of the nonsteroidal anti-inflammatory drug (NSAID) phenylbutazone, which acts primarily as a reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). This compound exhibits significant biological activity by inducing expression of muscleblind-like protein 1 (MBNL1) and has potential applications in research related to ankylosing spondylitis. Its stable isotope labeling facilitates tracking and quantification in metabolic studies and pharmacokinetic analysis. -
Stable Isotope
Diflunisal-d3 is a deuterium-labeled derivative of Diflunisal, a salicylate compound recognized for its nonsteroidal anti-inflammatory and uricosuric properties. Its primary mechanism of action involves the inhibition of Cyclooxygenase (COX), making it effective as an analgesic and a treatment option for patients with rheumatoid arthritis. This stable isotope labeled reagent is utilized in pharmacokinetic studies and metabolic research to track and quantify the metabolism of Diflunisal in biological systems. -
Stable Isotope
Apafant-d8 is a deuterium-labeled derivative of Apafant, a potent antagonist of platelet-activating factor (PAF). It effectively inhibits PAF binding to human PAF receptors with an IC50 value of 9.9 nM. Apafant-d8 enhances the expression of PAF receptor, α-globin, and β-globin genes while reducing c-myb gene expression. This compound also demonstrates protective effects against alkyl-PAF-mediated cytotoxicity, making it valuable for research in cellular protection and receptor signaling. -
Stable Isotope
Prostaglandin E2-d4 is a deuterium-labeled analog of Prostaglandin E2 (PGE2), which serves as a significant mediator in various physiological processes. PGE2 is involved in smooth muscle contraction and relaxation, vascular dilation and constriction, blood pressure regulation, and the modulation of inflammatory responses. This stable isotope is commonly utilized in pharmacokinetic studies, metabolic research, and as an internal standard in mass spectrometry assays to accurately quantify PGE2 levels in biological samples. -
Stable Isotope
Prostaglandin D2-d4 is a deuterium-labeled form of Prostaglandin D2 (PGD2), a key lipid mediator. PGD2 is recognized for its potent role in promoting sleep and plays a protective function by reducing inflammation in the central nervous system. This stable isotope is valuable in research applications involving sleep regulation, neuroinflammation, and the broader mechanisms of prostaglandin signaling pathways. -
Stable Isotope
Prostaglandin E2-d9 is a deuterated analog of Prostaglandin E2, a potent bioactive lipid mediator involved in numerous physiological processes. PGE2 plays a critical role in regulating smooth muscle contraction, vascular tone, blood pressure, and inflammation. This stable isotope is particularly useful in analytical studies, allowing for precise quantification and tracing of PGE2 in biological samples and facilitating research in pharmacology, toxicology, and metabolic pathways. -
Stable Isotope
Prostaglandin D2-d9 is a deuterated form of Prostaglandin D2, a key signaling molecule in the central nervous system. This stable isotope is known for its prominent role in promoting sleep and regulating various physiological processes. Prostaglandin D2 exhibits anti-inflammatory properties and is essential in research settings focused on sleep regulation, neurobiology, and inflammation pathways. Its deuterated form aids in quantitative analysis and tracking within biological systems. -
Stable Isotope
Selexipag-d7 is a deuterium-labeled derivative of Selexipag, a highly potent and orally bioavailable agonist of the prostacyclin (PGI2) receptor, also known as the IP receptor. This stable isotope-labeled form is valuable for pharmacokinetic studies and metabolic profiling, enhancing the understanding of drug metabolism and dynamics in biological systems. Selexipag-d7 is particularly relevant in research focused on pulmonary arterial hypertension and cardiovascular diseases, supporting the development of targeted therapies. -
Stable Isotope
Iloprost-d4 is a deuterium-labeled analog of Iloprost, a synthetic derivative of prostacyclin (PGI2) that primarily targets the prostacyclin receptor (IP). This stable isotope is utilized in various biochemical research applications, including pharmacokinetic studies and metabolic profiling. Its unique isotopic labeling facilitates advanced analytical techniques and enhances the understanding of prostacyclin's role in vascular biology and therapeutic interventions. -
Stable Isotope
Prostaglandin E1-d9 is a deuterium-labeled derivative of Prostaglandin E1, functioning as a potent ligand for prostanoid receptors. It exhibits high affinity with inhibitory constants of 1.1 nM, 2.1 nM, 10 nM, 33 nM, and 36 nM for mouse EP3, EP4, EP2, IP, and EP1 receptors, respectively. As a stable isotope, Prostaglandin E1-d9 is valuable in metabolic studies and pharmacokinetic research, facilitating the investigation of prostanoid signaling pathways and their physiological effects, including vasodilation. -
Stable Isotope
Selexipag-d6 is a deuterium-labeled derivative of Selexipag, a potent and orally bioavailable agonist of the prostacyclin (PGI2) receptor. This stable isotope-labeled compound serves as a valuable tool in pharmacokinetic and metabolic studies, enabling researchers to trace metabolic pathways and evaluate the pharmacodynamics of prostacyclin receptor modulation. Selexipag-d6 is particularly useful in elucidating the pharmacological profiles and therapeutic potentials of compounds targeting PGI2 receptors in cardiovascular research. -
Stable Isotope
trans-Isoferulic acid-d3 is a deuterium-labeled derivative of trans-Isoferulic acid, a naturally occurring aromatic acid derived from Clematis florida var. plena. This compound possesses notable anti-inflammatory properties, primarily through its ability to suppress nitric oxide (NO) and prostaglandin E2 (PGE2) production. Its mechanism of action involves the induction of Nrf2-dependent heme oxygenase-1 (HO-1), making it valuable for research into cellular stress responses and inflammation pathways. -
Isotope-Labeled Compound
Misoprostol acid-d5 is a deuterium-labeled analog of Misoprostol acid, the active metabolite of Misoprostol. This compound is a synthetic analog of prostaglandin E1 (PGE1) and is rapidly absorbed, undergoing de-esterification in the gastrointestinal tract post oral administration. Misoprostol acid-d5 is instrumental in studying NSAID-induced gastric ulcers and is utilized in research related to labor induction. This isotope-labeled compound facilitates the investigation of metabolic pathways and pharmacokinetics in various biological systems. -
Stable Isotope
MRE-269-d6 is a deuterium-labeled derivative of MRE-269, which is a selective agonist of the IP receptor and an active metabolite of selexipag. This stable isotope is valuable for metabolic studies, pharmacokinetic research, and tracer studies in vivo due to its unique mass properties. MRE-269-d6 facilitates enhanced detection and quantification in various biological assays, contributing to a deeper understanding of IP receptor-mediated pathways. -
Stable Isotope
13,14-Dihydro-15-keto Prostaglandin F2α-d4 is a deuterated analog of 13,14-Dihydro-15-keto Prostaglandin F2α, functioning as a stable isotope. This compound is an endogenous metabolite found in blood, making it a valuable tool for investigating biological processes related to pregnancy. It can facilitate quantitative assays and metabolic studies in reproductive biology, enhancing research on prostaglandin metabolism and its implications in gestational health. -
Stable Isotope
Prostaglandin E1-d4 is the deuterium-labeled derivative of Prostaglandin E1, a potent prostanoid receptor ligand. It demonstrates affinity for various prostaglandin receptors, including EP3 and EP4, with inhibition constants of 1.1 nM and 2.1 nM, respectively. This compound plays a critical role in inducing vasodilation and inhibiting platelet aggregation, making it a valuable tool for research applications in cardiovascular health and peripheral vascular diseases. Prostaglandin E1-d4 can facilitate advanced studies of prostanoid signaling pathways and therapeutic interventions. -
Stable Isotope
MRE-269-d7 sodium is a deuterium-labeled analog of MRE-269, serving as a stable isotope for research. This reagent retains the biological activity of MRE-269, which modulates specific signaling pathways. It is primarily utilized in pharmacokinetic studies and metabolic research to track and quantify metabolites, facilitating understanding of drug metabolism and disposition. -
Stable Isotope
Tetranor-PGDM-d6 is a deuterium-labeled analog of Tetranor-PGDM, serving as a stable isotope tracer. This compound is pivotal for metabolic studies and analytical applications in biological research. Its incorporation into various assays enhances the understanding of cellular pathways and lipid metabolism, facilitating detailed investigations into physiological processes.
