Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
3-Amino-2-oxazolidinone-d4 is a deuterium-labeled analog of 3-Amino-2-oxazolidinone, serving as a stable isotope for research applications. This compound is identified as a metabolite of Furazolidone and is commonly utilized to detect furazolidone residues in biological samples. Its oral bioactivity enhances its relevance in pharmacokinetic studies and residue analysis in both environmental and clinical research. -
Stable Isotope
2-Hydroxy Atorvastatin-d5 disodium is a deuterium-labeled form of 2-Hydroxy Atorvastatin, a hydroxy metabolite of Atorvastatin. This compound functions as a potent inhibitor of HMG-CoA reductase, exhibiting an IC50 value of 8 nM. It is primarily utilized in stable isotope labeling studies and pharmacokinetic research, offering insights into atorvastatin metabolism and therapeutic efficacy. -
Stable Isotope
5-Hydroxy Omeprazole-d3 is a stable isotope labeled derivative of 5-Hydroxyomeprazole. It serves as a valuable tool for the quantitative analysis of omeprazole metabolism in pharmacokinetic studies. This reagent enables precise tracking of drug metabolism and disposition, enhancing the understanding of therapeutic efficacy and safety profiles in clinical research. -
Stable Isotope
N-Acetyl mesalazine-d3 is a deuterium-labeled derivative of N-Acetyl-5-aminosalicylic acid, serving as a stable isotope. It functions as a biomarker for assessing the efficacy of 5-Aminosalicylic Acid and exhibits biological activities including free radical scavenging, reduction of DNA base hydroxylation, and mitigation of mucosal inflammation. This compound is particularly relevant in the research of gastrointestinal diseases, including colitis and colon cancer, providing valuable insight into therapeutic mechanisms and outcomes. -
Stable Isotope
N-Desethyl Sunitinib-d5 is a deuterium-labeled metabolite of Sunitinib, known for its potent inhibition of vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptor beta (PDGFRβ), as well as the receptor tyrosine kinase KIT. With Ki values of 2 nM for VEGFR-1, 9 nM for VEGFR-2, 17 nM for VEGFR-3, 8 nM for PDGFRβ, and 4 nM for KIT, this compound serves as a valuable tool in pharmacokinetic studies and metabolic profiling. Its stable isotope labeling allows for enhanced tracking in biochemical and cellular assays, facilitating research into targeted therapies for cancer. -
Stable Isotope
Omeprazole sulfide-d3 is a deuterated form of Omeprazole sulfide, a key metabolite of the proton pump inhibitor Omeprazole. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace the biological pathways and interactions of Omeprazole in various biological systems. It serves as a valuable tool for understanding drug metabolism and the pharmacodynamics of proton pump inhibitors. -
Stable Isotope
Leukotriene D4-d5 is a deuterated form of Leukotriene D4, a cysteinyl leukotriene derived from the metabolism of Leukotriene C4 by γ-glutamyl transpeptidase. This compound plays a critical role in mediating bronchoconstriction and increasing vascular permeability, which are key factors in the pathophysiology of asthma and acute hypersensitivity reactions. Leukotriene D4-d5 serves as a valuable stable isotope for biochemical assays and research applications, enabling the study of leukotriene signaling pathways and their effects on inflammatory diseases. -
Isotope-Labeled Compound
Nordoxepin-d3 hydrochloride is an isotope-labeled compound derived from Nordoxepin hydrochloride, an active metabolite of the tricyclic antidepressant Doxepin hydrochloride. This labeled form is utilized in pharmacokinetic studies to trace the metabolic pathways and systemic exposure of Nordoxepin. Its application in research is crucial for understanding the biological activity and pharmacodynamics of tricyclic antidepressants in clinical settings. -
Stable Isotope
2-Oxo-3-hydroxy-LSD-d10 is a deuterium-labeled analogue of the metabolite 2-Oxo-3-hydroxy-LSD. It serves as a stable isotope for applications in pharmacokinetic studies and metabolic profiling of Lysergic acid diethylamide (LSD). This compound aids in the precise quantification of LSD metabolites in biological samples, enhancing the understanding of their pharmacological effects and metabolism. -
Stable Isotope
(rac)-N,O-Didesmethyl Tramadol-d3 is a deuterated form of (rac)-N,O-Didesmethyl Tramadol, the primary metabolite of the analgesic drug Tramadol. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace and quantify drug metabolism and distribution. Its incorporation into research allows for enhanced sensitivity and specificity in mass spectrometry applications. -
Stable Isotope
Melamine-15N3,13C3 is a stable isotope-labeled compound featuring both 15N and 13C isotopes. As a metabolite of cyromazine, melamine serves as an important intermediate in the synthesis of melamine resins and various plastic materials. Its unique isotopic labeling facilitates applications in scientific research, particularly in tracing metabolic pathways and studying nitrogen and carbon dynamics in biological systems. -
Stable Isotope
Mono(2-ethyl-5-hydroxyhexyl) phthalate-d4 (MEHHP-d4) is a deuterium-labeled derivative of Mono(2-ethyl-5-hydroxyhexyl) phthalate, which serves as an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP). This stable isotope is utilized in toxicological and pharmacokinetic studies, providing insights into the metabolic pathways of phthalates. Research has indicated that MEHHP may offer protective effects against sperm DNA damage, highlighting its relevance in reproductive toxicity investigations. It also plays a role in environmental monitoring related to plasticizers. -
Stable Isotope
Nordoxepin-d4 hydrochloride is a deuterium-labeled analogue of Nordoxepin, acting primarily as a stable isotope tracer. This compound is utilized in pharmaceutical research and metabolic studies to enhance the understanding of drug metabolism and pharmacokinetics. Its isotopic labeling allows for precise quantification and tracking of biological pathways involving Nordoxepin in various experimental settings. -
Stable Isotope
6-Hydroxy Chlorzoxazone-15N,d2 is a stable isotope-labeled variant of 6-Hydroxy Chlorzoxazone, incorporating both nitrogen-15 and deuterium isotopes. This compound is primarily used in pharmacokinetic studies, drug metabolism research, and tracer applications in biological systems. Its stable isotope labeling enhances the accuracy of quantitative analysis and molecular tracing in various biochemical assays. -
Stable Isotope
4'-Hydroxy diclofenac-13C6 is a stable isotope-labeled form of 4'-hydroxy diclofenac, a metabolite of Diclofenac formed via cytochrome P450 2C9 (CYP2C9) activity. This compound exhibits anti-inflammatory and analgesic properties, making it valuable for pharmacokinetic studies and metabolic research. The stable isotope labeling assists in tracer studies, allowing for precise quantification and tracking of drug metabolism and distribution in biological systems. -
Stable Isotope
MTIC-d3 is a deuterium-labeled derivative of MTIC, the active metabolite of Temozolomide (TMZ). Due to its altered physical properties, MTIC-d3 provides insights into the bioavailability of MITC within the central nervous system, highlighting its permeability through biological barriers and tumor cell membranes. This stable isotope is valuable for pharmacokinetic studies and investigations into the metabolic pathways of TMZ and its metabolites in cancer research. -
Stable Isotope
Omeprazole sulfone (methoxy-d3) is a deuterium-labeled metabolite of Omeprazole, a well-known proton pump inhibitor. This stable isotope is utilized to study metabolic pathways and pharmacokinetics of Omeprazole in various biological systems. Its unique labeling provides enhanced sensitivity and specificity in analytical applications, making it a valuable tool for researchers investigating drug metabolism and interactions. -
Stable Isotope
Dasatinib N-oxide-d8 is a deuterium-labeled derivative of Dasatinib N-oxide, a minor metabolite of the potent dual Src/Bcr-Abl inhibitor Dasatinib. This stable isotope can be utilized in pharmacokinetic studies and metabolic profiling to enhance the understanding of Dasatinib's metabolic pathways. With its precise isotopic labeling, Dasatinib N-oxide-d8 aids in the investigation of drug interactions and the quantification of metabolites in biological samples. -
Stable Isotope
Carboxy Gliclazide-d4 is a deuterium-labeled analog of Carboxy Gliclazide, primarily utilized as a stable isotope for research purposes. This compound is valuable for applications in pharmacokinetic studies, enabling precise tracking of drug metabolism and distribution in biological systems. Its stable isotope labeling facilitates quantitative measurements in various analytical techniques, including mass spectrometry. -
Stable Isotope
2-PADQZ-d8 is a stable isotope-labeled derivative of 2-PADQZ, incorporating deuterium atoms to enhance its stability and performance in various analytical applications. This reagent serves as a valuable internal standard in quantitative mass spectrometry, facilitating accurate measurement and analysis of target compounds in complex biological matrices. Its use is essential for metabolic tracing studies and the investigation of biochemical pathways. -
Stable Isotope
Didesethyl chloroquine-d4 is a deuterium-labeled derivative of Didesethyl chloroquine, a prominent metabolite of the antimalarial drug Chloroquine. This compound serves as a stable isotope and is valuable for metabolic studies and pharmacokinetic research. Its cardiodepressive properties make it relevant in investigations of cardiovascular effects associated with antimalarial therapy. -
Stable Isotope
4-Desmethoxy Omeprazole-d3 is a deuterium-labeled form of 4-Desmethoxy Omeprazole, the active metabolite of the proton pump inhibitor Omeprazole. This compound primarily targets the CYP2C19 enzyme, exhibiting competitive inhibition with an inhibition constant (Ki) ranging from 2 to 6 μM. It has significant biological activity, including the suppression of gastric acid secretion and the inhibition of growth in both Gram-positive and Gram-negative bacteria. This reagent is valuable for studies involving drug metabolism, pharmacokinetics, and antimicrobial activity. -
Stable Isotope
Propafenone Dimer Impurity-d10 is a stable isotope variant of Propafenone Dimer Impurity, featuring deuterium labeling. This compound serves as a valuable internal standard in analytical chemistry, particularly in pharmacokinetic studies and drug metabolism research. Its unique isotopic composition enables accurate quantification and analysis of drug-related substances in biological samples, facilitating the assessment of pharmacological activity and safety profiles. -
Stable Isotope
8-Hydroxy warfarin-d5 is a stable isotope-labeled derivative of warfarin, primarily used as an internal standard for quantifying warfarin and its metabolites in biological samples. Its incorporation in analytical methods enhances the accuracy and reliability of pharmacokinetic studies and therapeutic monitoring. This reagent is particularly valuable in research focusing on anticoagulant therapy and metabolic profiling. -
Stable Isotope
Calcitroic acid-13C is a stable isotope-labeled derivative of Calcitroic acid, serving as a vitamin D receptor (VDR) agonist. It effectively activates VDR-mediated transcription, contributing to various biological responses associated with vitamin D metabolism. As the principal metabolite of 1,25-dihydroxyvitamin D3, Calcitroic acid is predominantly found in the liver and mucosal tissues of murine models, highlighting its physiological relevance. This compound exhibits metabolic stability and possesses low toxicity, making it suitable for diverse research applications in vitamin D biology and its implications in disease. -
Stable Isotope
p,p'-DDE-d8 is a deuterated form of p,p'-DDE, a significant metabolite of the environmental contaminant dichlorodiphenyltrichloroethane (DDT). This compound acts as a potent antagonist of the androgen receptor, exhibiting an IC50 value of 5 μM and a Ki of 3.5 μM. p,p'-DDE-d8 is valuable in biological research for studying receptor interactions and the environmental impact of DDT metabolites on endocrine function. -
Stable Isotope
Desdiacetyl bisacodyl-d13 is a deuterated derivative of Desacetyl bisacodyl, known for its stable isotope properties. As the active metabolite of the laxative bisacodyl, it primarily targets chloride secretion in epithelial tissues. This compound has been shown to induce enhanced mucus and chloride secretion in the rat colon and rectum, making it a valuable tool for research in gastrointestinal physiology and pharmacology. -
Stable Isotope
N-Acetyl mesalazine-13C6 is a stable isotope-labeled form of N-Acetyl-5-aminosalicylic acid. This compound acts as an important biomarker for assessing the efficacy of 5-Aminosalicylic Acid and is known for its ability to scavenge free radicals, reduce DNA base hydroxylation, and ameliorate mucosal inflammation. Its applications are particularly relevant in studies of gastrointestinal diseases, including colitis and colon cancer. -
Stable Isotope
2-(4-Isobutylphenyl)propan-3,3,3-d3-1-ol is a deuterated form of Ibuprofen alcohol, an analogue of a nonsteroidal anti-inflammatory drug (NSAID). This stable isotope compound is primarily utilized in pharmacokinetic studies and metabolomics research to trace and quantify drug metabolism pathways. While exhibiting minimal activity on acid-sensing ion channels (ASICs), it serves as a valuable tool for understanding the pharmacological effects of ibuprofen derivatives. -
Stable Isotope
3-Methoxytyramine-d3 hydrochloride is a stable isotope of 3-Methoxytyramine hydrochloride, serving as a key metabolite of dopamine. This compound, which has been shown to activate trace amine associated receptor 1 (TAAR1), is utilized in research related to neurotransmitter metabolism and receptor interactions. Its stable isotope nature makes it particularly useful for analytical studies in pharmacology and neuroscience. -
Stable Isotope
Hydroxy Iloperidone-d3 is a stable isotope-labeled metabolite of Iloperidone, characterized by the incorporation of deuterium at specific positions. This compound serves as a tracer in pharmacokinetic studies, facilitating the investigation of Iloperidone metabolism and bioavailability. Its use is essential in drug development and clinical research to enhance the understanding of pharmacodynamic and pharmacokinetic profiles. -
Stable Isotope
Ortho-hydroxy atorvastatin lactone-d5 is a stable isotope-labeled derivative of 2-Hydroxy atorvastatin lactone, a significant metabolite of atorvastatin. As an HMG-CoA reductase inhibitor, atorvastatin is widely recognized for its efficacy in lowering blood lipid levels. This deuterium-labeled compound allows for precise studies in metabolic pathways and pharmacokinetics, making it an essential tool for researchers investigating lipid metabolism and cardiovascular diseases. -
Stable Isotope
Mono(3-carboxypropyl) phthalate-d4 is a stable isotope-labeled derivative of Mono(3-carboxypropyl) phthalate, serving as a metabolite of Di-n-octyl phthalate. This compound is utilized in analytical chemistry to trace and quantify exposure to phthalate plasticizers in environmental and biological samples. Its applications include elucidating metabolic pathways and evaluating the effects of phthalate exposure in toxicological studies. -
Stable Isotope
N-Acetyl mesalazine-d3-1 is a deuterium-labeled form of N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid), primarily functioning as a stable isotope. This compound acts as a biomarker for assessing the therapeutic effects of 5-Aminosalicylic Acid, exhibiting significant biological activities such as free radical scavenging, reduction of DNA base hydroxylation, and mitigation of mucosal inflammation. N-Acetyl mesalazine-d3-1 is applicable in research focused on gastrointestinal disorders, including colitis and colon cancer. -
Stable Isotope
Nirvanol-d5 (Ethylphenylhydantoin-d5) is a deuterium-labeled derivative of Nirvanol, a metabolite of Mephenytoin. This compound primarily targets neurological pathways to exert anticonvulsant effects, as demonstrated in the maximal electroshock (M.E.S.) seizure model in mice. Nirvanol-d5 serves as a valuable tool for research applications in epilepsy and related neurological disorders, facilitating the study of metabolic processes and drug interactions. -
Stable Isotope
Dehydro Nifedipine-13C,d3 is a deuterated derivative of Dehydro Nifedipine, a primary metabolite of Nifedipine, which is a potent calcium channel blocker. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace the pathways and effects of Nifedipine within biological systems. Its applications include exploring cardiac function and assessing drug metabolism in various experimental settings. -
Stable Isotope
3,4-Dihydroxybenzeneacetic acid-d3 is a deuterium-labeled derivative of 3,4-Dihydroxybenzeneacetic acid, serving as a stable isotope for analytical applications. This reagent is commonly utilized in metabolic studies, tracer experiments, and mass spectrometry. Its deuterated form aids in precise quantification and tracking of biological processes in various research settings. -
Stable Isotope
Mebeverine alcohol-d5 is a deuterium-labeled derivative of Mebeverine alcohol, serving as a stable isotope. This compound is primarily utilized in pharmacokinetic studies and metabolic analyses to trace the biotransformation pathways of Mebeverine. Its application in isotopic labeling facilitates enhanced quantification and detection in mass spectrometry and other analytical techniques, aiding in the understanding of drug metabolism and efficacy. -
Stable Isotope
Mono(2-ethyl-5-oxohexyl) phthalate-d4 is a deuterium-labeled analog of Mono(2-ethyl-5-oxohexyl) phthalate, serving as a stable isotope for research purposes. This compound is an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP), which is widely used as a plasticizer in polyvinyl chloride (PVC). Mono(2-ethyl-5-oxohexyl) phthalate has been implicated in protecting sperm DNA from oxidative damage. It is utilized in studies investigating the metabolic pathways and biological effects of phthalates and their metabolites in various biological systems. -
Stable Isotope
Mazindol metabolite-d4 hydrochloride is a stable isotope-labeled derivative of 2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one hydrochloride. This compound serves as a metabolite of the anorectic drug Mazindol and is utilized in pharmacokinetic studies to trace metabolic pathways and assess drug interactions. Its unique isotopic labeling facilitates accurate quantification and elucidates the pharmacodynamics of Mazindol in various biological systems. -
Stable Isotope
Modafinil EP impurity B-d5 is a deuterated analogue of the Modafinil EP impurity B. This stable isotope is utilized in quantitative analytical applications, specifically in mass spectrometry, to enhance the accuracy and precision of detection. Its biological activity and characterization make it valuable for studies related to pharmacokinetics and drug metabolism research. -
Stable Isotope
Calcifediol-d9 (25-hydroxy Vitamin D3-d9) is a deuterium-labeled analog of Calcifediol, serving as a stable isotope for research applications. This compound acts as an effective ligand for the Vitamin D receptor (VDR) and serves as a vitamin D supplement, playing a crucial role in the vitamin D endocrine system. Upon administration, Calcifediol is hydroxylated in the liver to form the biologically active metabolite, calcitriol, and is known to rapidly elevate serum vitamin D levels, thus aiding studies in vitamin D metabolism and related disorders. -
Stable Isotope
4-Hydroxyantipyrine-d3 is a deuterium-labeled derivative of 4-Hydroxyantipyrine, the primary metabolite of Antipyrine. This stable isotope is utilized in pharmacokinetic studies to enhance the biodistribution analysis of Antipyrine, particularly in assessing its concentration dynamics within the brain. Its unique labeling allows for precise tracking and quantification in various biological research applications. -
Stable Isotope
3,4,5-Trimethoxyphenylacetic acid-d2 is a deuterium-labeled derivative of 3,4,5-Trimethoxyphenylacetic acid, a metabolite of Mescaline. This stable isotope is valuable for use in pharmacokinetic studies and metabolic research, providing a means to trace and quantify biological pathways involving this compound. Its incorporation in experimental designs can enhance the understanding of the metabolic fate and biological interactions of Mescaline derivatives in various biological systems. -
Stable Isotope
Mebeverine acid-d5 is a stable isotope-labeled form of the metabolite Mebeverine acid, generated through the hydrolysis of the antispasmodic agent Mebeverine. As a key circulating metabolite, Mebeverine acid-d5 serves as an important marker for assessing the pharmacokinetics of oral Mebeverine administration. This reagent is suitable for research applications involving metabolic studies and the investigation of drug metabolism and disposition. -
Stable Isotope
1-Methylxanthine-d3 is a deuterated form of 1-Methylxanthine, a significant metabolite derived from caffeine and theophylline. This compound acts as a stable isotope, allowing for precise analytical studies in metabolic research. It has been shown to enhance the radiosensitivity of tumor cells, making it valuable for cancer research and therapeutic investigations. -
Stable Isotope
3,4-Dihydroxybenzeneacetic acid-13C,18O2 is a stable isotope-labeled form of 3,4-Dihydroxybenzeneacetic acid, featuring both 13C and 18O isotopes. This compound serves as a key neuronal metabolite of dopamine and is crucial for studies investigating dopamine metabolism and its neurological implications. It is an essential tool for applications in metabolic research, tracer studies, and analytical methods in biological samples. -
Isotope-Labeled Compounds
Tazarotenic acid-13C2,d2 is an isotope-labeled derivative of Tazarotenic acid, featuring both carbon-13 and deuterium isotopes. This compound interacts with retinoic acid receptors (RARs), which are crucial in modulating retinoid biological activity. Tazarotenic acid-13C2,d2 is valuable for studies related to warty dyskeratoma and provides insights into the metabolic pathways and pharmacodynamics of retinoids. -
Stable Isotope
N,O-Didesmethylvenlafaxine-d3 is a deuterium-labeled metabolite of Venlafaxine, functioning as a stable isotope. This compound serves as a valuable tool for pharmacokinetic studies, allowing for the quantification of Venlafaxine metabolism and its effects on serotonin and norepinephrine reuptake inhibition. It is widely employed in biological research to investigate the pharmacological profile and therapeutic implications of Venlafaxine and its metabolites. -
Stable Isotope
Tegafur-13C,15N2 is a stable isotope-labeled form of Tegafur, a chemotherapeutic prodrug of 5-fluorouracil (5-FU). This compound is utilized in cancer therapy and forms part of the tegafur-uracil combination. Its stable isotopic labels enable precise metabolic studies and pharmacokinetic research, making it a valuable tool for understanding the mechanisms of drug action and metabolism in cancer treatments.
