Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
D-Psicose-d is a deuterium-labeled form of D-Psicose, which serves as a stable isotope for research applications. This rare sugar is known for its oral bioactivity and demonstrates inhibitory effects on p38-MAPK phosphorylation and MCP-1 expression. D-Psicose also modulates the AGEs/RAGE/NF-κB signaling pathway, offering protective effects on pancreatic β-islets and improving metabolic conditions such as hyperglycemia and non-alcoholic fatty liver disease induced by high-fat diets. -
Stable Isotope
Fumaric acid-13C2 is a stable isotope-labeled version of fumaric acid, an unsaturated dicarboxylic acid involved in the citric acid cycle. This compound plays a critical role in energy metabolism by facilitating ATP production. Additionally, fumaric acid exhibits anti-inflammatory properties by inhibiting the NF-κB signaling pathway via p38 MAPK modulation. Its applications extend to the investigation of conditions such as pregnancy-induced hypertension, making it a valuable tool for metabolic and physiological research. -
Stable Isotope
(R)-STU104-d6 is a deuterium-labeled derivative of (R)-STU104, a potent inhibitor of the TAK1-MKK3 interaction, exhibiting IC50 values of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation, respectively. This compound effectively disrupts the TAK1/MKK3/p38/MnK1/MK2/eIF4E signaling pathways by binding to MKK3, thereby inhibiting its phosphorylation by TAK1. (R)-STU104-d6 is suitable for applications in research focused on ulcerative colitis and related inflammatory conditions. -
Stable Isotope
Epalrestat-d5 is a deuterium-labeled derivative of Epalrestat, which functions as an orally active aldose reductase inhibitor. This compound primarily targets the aldose reductase enzyme involved in the glucose metabolism pathway, making it relevant in the study of diabetic neuropathy. Epalrestat-d5 is useful in pharmacokinetic studies and metabolic research that require stable isotope labeling for precise analysis. -
Stable Isotope
Haloxyfop-d4 is a deuterium-labeled derivative of Haloxyfop, an aryloxyphenoxypropionic acid herbicide. Its primary mechanism involves the inhibition of acetyl coenzyme A carboxylase (EC 6.4.1.2), demonstrating an IC50 of 0.5 μM in corn seedling chloroplasts. This compound is utilized in chemical research to investigate herbicide action and metabolic pathways, particularly in studies focusing on weed control in broad-leaf crops. -
Stable Isotope
Cromolyn-d5, a deuterium-labeled derivative of Cromolyn, serves as a stable isotope for research applications. As an orally active inhibitor of GSK-3β with an IC50 of 2.0 μM, Cromolyn exhibits significant biological activity as a mast cell stabilizer, effectively inhibiting the release of mediators and regulating bronchial hyperreactivity. Its utility extends to bronchial asthma research, alongside additional effects including anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective properties. -
Stable Isotope
AR-A014418-d3 is a deuterium-labeled analogue of the selective GSK3β inhibitor AR-A014418. It exhibits potent ATP-competitive inhibition with an IC50 of 104 nM and a Ki of 38 nM. This stable isotope form is useful for tracking and quantifying GSK3β activity in biological systems, and it serves as a valuable tool in research focused on cellular signaling, metabolism, and neurodegenerative diseases. -
Stable Isotope
Fluocinolone acetonide-13C3 is a stable isotope-labeled form of Fluocinolone, a potent glucocorticoid receptor agonist. It exhibits anti-inflammatory properties and effectively inhibits lipid accumulation, making it valuable for investigating its effects on various biological processes. Fluocinolone acetonide-13C3 can be utilized in research involving the proliferation of dental pulp cells and the potential repair of injured pulp tissues, as well as in studies focused on mitigating chemotherapy-induced peripheral neuropathy, particularly in relation to drugs like Paclitaxel. -
Stable Isotope
Ornidazole-d5 is a deuterium-labeled derivative of Ornidazole, a nitroimidazole compound. This reagent exhibits anti-trichomonad properties and demonstrates in vitro activity against various anaerobic bacteria. Additionally, Ornidazole inhibits the Sonic hedgehog (Shh) signaling pathway and displays antitumor effects, making it a valuable tool for research in cancer biology and conditions such as Crohn's disease. -
Stable Isotope
Succinic anhydride-13C2 is a stable isotope-labeled form of succinic anhydride. This cyclic anhydride serves as a versatile linker for antibody-drug conjugates (ADCs), facilitating the attachment of proagents to amine or hydroxy groups on targeting polypeptides. Its application in labeling and tracing metabolic pathways makes it suitable for biochemical research, particularly in studying drug delivery systems and protein interactions. -
Stable Isotope
Succinic anhydride-d4 is a deuterium-labeled variant of succinic anhydride, a cyclic anhydride frequently utilized in chemical synthesis. This stable isotope serves as a valuable tool in the development of antibody-drug conjugates (ADCs), as it facilitates the conjugation of proagents to amine or hydroxy groups within targeting polypeptides. Its unique isotopic properties allow for enhanced tracking and characterization in various biological studies and applications. -
Stable Isotope
N-butyryl-L-Homoserine lactone-d5 is a deuterium-labeled version of N-butyrate-L-homoserine lactone, serving as a stable isotope for research applications. This compound is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs). N-butyryl-L-homoserine lactone exhibits antibacterial properties and interferes with quorum sensing, thereby inhibiting biofilm formation in Pseudomonas aeruginosa. Its ability to block bacterial communication makes it a valuable tool in studies focusing on bacterial pathogenesis and biofilm-related infections. -
Stable Isotope
Nateglinide-d5 is a deuterium-labeled derivative of Nateglinide, an insulinotropic agent that functions as a DPP IV inhibitor. This compound enhances insulin secretion by inhibiting ATP-sensitive K+ channels in pancreatic β-cells, making it an important tool for studying type 2 diabetes mellitus. Nateglinide-d5 is valuable in metabolic research and can aid in pharmacokinetic studies involving deuterated compounds. -
Stable Isotope
Trelagliptin-13C,d3 is a stable isotope-labeled derivative of Trelagliptin, a highly selective DPP-4 inhibitor with an IC50 value of 4 nM. This compound is utilized in research applications aimed at understanding the pharmacokinetics and pharmacodynamics of glycemic control in type 2 diabetes mellitus (T2DM). Its deuterated form allows for precise tracking in metabolic studies, facilitating deeper insights into the therapeutic effects of DPP-4 inhibition. -
Stable Isotope
5-Hydroxy saxagliptin-13C,d2-2 hydrochloride is a stable isotope-labeled form of 5-Hydroxy saxagliptin hydrochloride, a potent and selective DPP-4 inhibitor. This active metabolite of Saxagliptin demonstrates Ki values of 2.6 nM in human enzymes and 2.9 nM in cynomolgus monkeys, highlighting its efficacy in inhibiting DPP-4 activity. It is valuable for research applications focusing on type 2 diabetes mellitus, enabling detailed metabolic studies and pharmacokinetic assessments. -
Stable Isotope
(rel)-Saxagliptin-13C,d2 TFA is a stable isotope-labeled analogue of Saxagliptin, designed for use in metabolic studies and pharmacokinetic research. This compound serves as a valuable tool for tracing metabolic pathways and understanding the pharmacological behavior of Saxagliptin in biological systems. It facilitates the investigation of its biological effects and interactions, contributing to a more comprehensive understanding of diabetes treatment efficacy. -
Stable Isotope
Vardenafil-d4 is a deuterium-labeled variant of Vardenafil, designed for metabolic and pharmacokinetic studies. This stable isotope can be utilized as an internal standard in mass spectrometry analysis, providing accuracy in quantifying Vardenafil and its metabolites in biological samples. Its application supports research in cardiovascular pharmacology, specifically in the assessment of phosphodiesterase type 5 inhibitors. -
Stable Isotope
Cis-Tadalafil-d3 is a stable isotope-labeled form of cis-Tadalafil, designed for enhanced analytical applications. This compound retains the biological activity of its non-labeled counterpart, facilitating studies related to pharmacokinetics, metabolism, and drug interaction. By utilizing cis-Tadalafil-d3, researchers can achieve improved sensitivity and specificity in mass spectrometry and other analytical techniques. -
Stable Isotope
Doxofylline-d4 is a deuterium-labeled derivative of Doxofylline, which functions primarily as an antagonist of the adenosine A1 receptor while also inhibiting phosphodiesterase IV. This reagent is valuable for studying pharmacokinetics and metabolic pathways in research involving adenosine receptor modulation and phosphodiesterase activity. Its stable isotope labeling allows for enhanced detection and quantification in various analytical applications. -
Stable Isotope
Ibudilast-d3 is a deuterated form of Ibudilast, a cyclic AMP phosphodiesterase (PDE) inhibitor. This stable isotope contributes to research on asthma by inhibiting tracheal smooth muscle contractility and exhibiting platelet anti-aggregatory effects. Additionally, Ibudilast-d3 shows potential as a neuroprotective agent, with applications in studies related to neurotoxicity in activated microglia and anti-dementia research. -
Stable Isotope
Propentofylline-d6 is a deuterium-labeled derivative of Propentofylline, which primarily acts as an adenosine uptake inhibitor and a phosphodiesterase activity blocker. This compound exhibits neuroprotective, antiproliferative, and anti-inflammatory properties, making it valuable in research related to cognitive enhancement and the treatment of dementia, including Alzheimer's and vascular dementia. Propentofylline-d6 is a stable isotope that facilitates in vivo studies and tracer applications in metabolic and pharmacokinetic research. -
Stable Isotope
Homo Sildenafil-d5 is a deuterium-labeled analog of Homo Sildenafil, targeting phosphodiesterase enzymes. This stable isotope variant retains the biochemical properties of its parent compound, making it useful in pharmacokinetic studies and metabolic research. Its application extends to elucidating the pharmacodynamics of phosphodiesterase inhibitors and tracking drug metabolism in vivo. -
Stable Isotope
Avanafil-d4 is a deuterium-labeled analog of Avanafil, serving as a stable isotope for biomedical research. This compound can be utilized in pharmacokinetic studies, enabling precise tracking and quantification in various biological systems. Its isotopic labeling enhances the accuracy of mass spectrometry analyses and facilitates investigations into the pharmacodynamics of Avanafil and its metabolites. -
Stable Isotope
Lisinopril-d5 is the deuterated form of Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor. This stable isotope is utilized primarily in pharmacokinetic studies and metabolic research to track drug metabolism and interactions in various biological systems. Lisinopril is clinically used to manage hypertension, congestive heart failure, and to prevent further heart attack complications. -
Stable Isotope
Ramiprilat-d5 is a deuterium-labeled form of Ramiprilat, the active metabolite of Ramipril, which functions as a potent angiotensin-converting enzyme (ACE) inhibitor, exhibiting a Ki value of 7 pM. This stable isotope is useful for pharmacokinetic and metabolic studies of Ramiprilat and its mechanisms of action in regulating blood pressure and heart failure. Its unique labeling allows for enhanced tracking and differentiation in complex biological systems, facilitating research in cardiovascular pharmacology. -
Stable Isotope
Benazeprilat-d5 is a deuterated analog of Benazeprilat, serving as a stable isotope for various biochemical studies. This compound is primarily used in pharmacokinetic and metabolic research, allowing for precise tracking of drug absorption, distribution, metabolism, and excretion in biological systems. It facilitates the assessment of pharmacological interactions and the evaluation of therapeutic effects in associated studies. -
Stable Isotope
Ramiprilat-d3 (Mixture of Diastereomers) is a deuterium-labeled form of Ramiprilat, designed as a stable isotope. It functions primarily to trace metabolic pathways and pharmacokinetics in biological systems. This reagent is particularly useful in the study of angiotensin-converting enzyme (ACE) inhibition and its implications in cardiovascular research. -
Stable Isotope
Quinapril-d5 is a deuterium-labeled derivative of Quinapril, an angiotensin-converting enzyme (ACE) inhibitor. This stable isotope is utilized in pharmacokinetic studies and metabolic profiling to trace drug metabolism and dynamics in biological systems. Its incorporation into research facilitates accurate quantification and analysis of Quinapril's pharmacological effects and distribution in vivo. -
Stable Isotope
Perindoprilat-d4 is a deuterium-labeled form of Perindoprilat, a potent inhibitor of angiotensin-converting enzyme (ACE). This stable isotope enables precise pharmacokinetic studies and metabolic profiling of Perindoprilat and its derivatives. Perindoprilat-d4 is utilized in research involving cardiovascular pharmacology, hypertension, and drug metabolism to enhance analytical accuracy in tracer studies. -
Stable Isotope
Delapril-d3 hydrochloride is a deuterium-labeled derivative of Delapril hydrochloride, an angiotensin-converting enzyme (ACE) inhibitor. This stable isotope is used in metabolic studies and pharmacokinetic research to trace drug distribution and metabolism within biological systems. Its application facilitates a deeper understanding of ACE inhibition and its effects on cardiovascular health. -
Stable Isotope
Captopril-d3 is a deuterium-labeled derivative of Captopril, a well-characterized competitive angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.025 μM. This stable isotope is utilized in the study of hypertension and congestive heart failure. Additionally, Captopril has been identified as an inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), exhibiting an IC50 of 7.9 μM, making it valuable in antibiotic resistance research. -
Stable Isotope
Quinapril-d5 hydrochloride is a deuterium-labeled derivative of Quinapril hydrochloride, which acts as a prodrug targeting the angiotensin-converting enzyme (ACE). This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace drug behavior in biological systems. Its application is crucial for understanding the dynamics of ACE inhibition and evaluating therapeutic efficacy in cardiovascular diseases. -
Stable Isotope
Enalapril-d3 is a deuterium-labeled derivative of Enalapril, an angiotensin-converting enzyme (ACE) inhibitor. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research related to hypertensive diseases. Enalapril-d3 serves as a valuable tool for tracing drug metabolism and dynamics in various biological contexts. -
Stable Isotope
(S)-Lisinopril-d5 sodium is a stable isotope-labeled form of the angiotensin-converting enzyme (ACE) inhibitor, Lisinopril. This deuterium-labeled compound retains the biological activity of Lisinopril, which is utilized primarily in the management of hypertension, congestive heart failure, and post-myocardial infarction. Its application in research includes pharmacokinetic studies, metabolic profiling, and investigations into the mechanisms of ACE inhibition. -
Stable Isotope
Imidapril-d3 hydrochloride is a stable isotope-labeled form of Imidapril hydrochloride, a selective angiotensin-converting enzyme (ACE) inhibitor. This compound exhibits significant antihypertensive activity and is used to investigate the pharmacokinetics and pharmacodynamics of ACE inhibitors in biological systems. Its deuterium labeling facilitates advanced research applications, including mass spectrometry and metabolic studies. -
Stable Isotope
Temocapril-d5 is a deuterated form of Temocapril, an angiotensin-converting enzyme (ACE) inhibitor. This stable isotope can be employed in research focusing on hypertension and related cardiovascular conditions, such as congestive heart failure and acute myocardial infarction. Additionally, Temocapril-d5 is relevant for studies investigating insulin resistance and renal diseases, providing a valuable tool for understanding the pharmacokinetics and dynamics of ACE inhibition in various biological contexts. -
Stable Isotope
Quinaprilat-d5 is a deuterium-labeled derivative of Quinaprilat, a nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. Quinaprilat serves as the active diacid metabolite of Quinapril, effectively blocking the conversion of angiotensin I to angiotensin II and inhibiting the degradation of bradykinin. This compound primarily functions as a vasodilator, leading to decreased total peripheral and renal vascular resistance, making it valuable in cardiovascular research and studies on blood pressure regulation. -
Stable Isotope
Perindopril-d4 erbumine is a stable isotope of Perindopril, functioning as a long-acting angiotensin-converting enzyme (ACE) inhibitor. This reagent is primarily used in pharmacokinetic studies and metabolic profiling of Perindopril for conditions such as hypertension, heart failure, and stable coronary artery disease. Its deuterium labeling allows for enhanced tracking and quantification in research applications, facilitating investigations into drug metabolism and therapeutic efficacy. -
Stable Isotope
Imidaprilat-d3 is a deuterium-labeled form of Imidaprilate, a potent angiotensin-converting enzyme (ACE) inhibitor known for its IC50 of 2.6 nM. This stable isotope is utilized in research related to hypertensive diseases, enabling precise studies of ACE inhibition and its effects on blood pressure regulation. Imidaprilat's active metabolite properties make it a valuable tool for exploring cardiovascular pharmacology and related therapeutic applications. -
Stable Isotope
Methyl Paraben-13C6 is a stable isotope-labeled derivative of Methyl Paraben, specifically designed for use in various analytical and biological research applications. As a well-characterized antimicrobial preservative derived from p-hydroxybenzoic acid, Methyl Paraben exhibits significant biological activity, primarily by enhancing histamine release and influencing cell-mediated immune responses. This compound is particularly useful in studies investigating chemical allergenicity, antimicrobial effectiveness, and metabolic pathways in food and cosmetic formulations. -
Stable Isotope
Sudan I-d5 is a deuterated form of Sudan I, a diazo-conjugate red dye. This compound exhibits antimicrobial properties, notably inhibiting the growth of bacterial strains such as Clostridium perfringens and Lactobacillus rhamnosus. Sudan I-d5 serves as a stable isotope for applications in chemical research, including studies related to dye behavior and microbiological interaction in various formulation products. -
Stable Isotope
Physcion-d3 is a deuterated derivative of Physcion, functioning as a stable isotope and serving as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 of 38.5 μM and a Kd of 26.0 μM. This compound displays a range of biological activities including laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative, and anti-tumor effects. Its distinctive properties make Physcion-d3 suitable for research applications focusing on metabolic pathways, disease modeling, and drug development studies. -
Stable Isotope
Lansoprazole-d4 is a deuterium-labeled derivative of Lansoprazole, a proton pump inhibitor that inhibits gastric acid secretion by targeting the H+/K+ ATPase in the gastric parietal cells. The incorporation of deuterium enhances the stability and can facilitate metabolic studies and pharmacokinetic research applications. This stable isotope-labeled compound is valuable for tracing studies, improving analysis of drug metabolism, and understanding the pharmacodynamics of proton pump inhibitors. -
Stable Isotope
p-Anisic acid-d4 is a deuterium-labeled derivative of p-Anisic acid (4-Methoxybenzoic acid). This stable isotope is utilized in various research applications, particularly in pharmacokinetic studies and metabolic tracing. p-Anisic acid displays notable antibacterial and antiseptic properties, making it relevant for studies focused on microbial inhibition and therapeutic effects. Its isotopic labeling aids in elucidating metabolic pathways and quantitative analysis in biological systems. -
Stable Isotope
Tridecanoic acid-d2 is a deuterium-labeled derivative of Tridecanoic acid, a 13-carbon medium-chain saturated fatty acid. It exhibits significant biological activity as an antipersister and antibiofilm agent, specifically inhibiting the persistence and biofilm formation of Escherichia coli. This stable isotope is valuable for research applications focused on bacterial infections and biofilm-related studies, providing insights into metabolic processes and the behavior of microbial communities. -
Stable Isotope
Rimonabant-d10 is a deuterium-labeled analog of Rimonabant, a highly potent and selective antagonist of the central cannabinoid receptor (CB1) with a Ki of 1.8 nM. This compound not only exhibits strong brain penetration but also inhibits Mycobacterial membrane protein Large 3 (MMPL3). Rimonabant-d10 serves as a valuable tool for studying cannabinoid receptor signaling and the role of CB1 in various biological processes, as well as for applications in mycobacterial research. -
Stable Isotope
Sapienic acid-d19 is a deuterated derivative of sapienic acid, which is a fatty acid present in skin and mucosal tissues. This compound exhibits notable antimicrobial properties against both Gram-positive and Gram-negative bacteria, including Streptococcus sanguinis, Streptococcus mitis, and Fusobacterium nucleatum, with minimum bactericidal concentrations (MBC) of 31.3 μg/mL, 375.0 μg/mL, and 93.8 μg/mL, respectively. Sapienic acid-d19 is valuable for research applications involving microbial interactions and fatty acid metabolism. -
Stable Isotope
Triclosan-methyl-d3 is a deuterium-labeled derivative of Triclosan-methyl and serves as a stable isotope for research applications. Triclosan-methyl is a transformation product of triclosan, a widely used bactericide in personal care products, including toothpaste, shampoos, and soaps. This compound is also utilized as a stabilizing agent in various detergents and cosmetic formulations, making it valuable for studying environmental and biological interactions of triclosan-related compounds. -
Stable Isotope
Butylparaben-13C6 is a stable isotope-labeled form of Butylparaben, a widely used antimicrobial preservative in cosmetics and personal care products. Additionally, it serves as a component in medication suspensions and as a flavoring additive in food products. This compound is essential for research applications involving metabolic studies, environmental tracking, and quantitative analysis of paraben compounds in various matrices. -
Stable Isotope
N-Hexanoyl-L-homoserine lactone-d3 is a deuterium-labeled variant of N-Hexanoyl-L-homoserine lactone, a short-chain N-acyl homoserine lactone. This stable isotope serves as a valuable tracer in studies investigating cell-to-cell communication among Proteobacteria in aquatic environments, where these bacteria utilize AHLs to coordinate behavior. Its application in chemical research facilitates enhanced understanding of interspecies signaling mechanisms and the dynamics of microbial communities.
