Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Cinnamyl acetate-13C2 is a stable isotope-labeled form of cinnamyl acetate. This compound exhibits broad-spectrum antibacterial activity and is widely utilized in the flavor and fragrance industry. Its stable isotope labeling makes it an essential tool for research applications in metabolic studies and tracing pathways in biochemical research. -
Stable Isotope
Rimonabant-d10 hydrochloride is a deuterium-labeled derivative of Rimonabant hydrochloride, a selective antagonist of the central cannabinoid receptor (CB1) with a Ki of 1.8 nM. This compound is utilized in studies investigating the role of CB1 receptors in various physiological processes and the development of obesity therapies. Additionally, Rimonabant hydrochloride is known to inhibit Mycobacterial membrane protein Large 3 (MMPL3), making it relevant for research in tuberculosis and related infectious diseases. -
Stable Isotope
Isopropyl 4-hydroxybenzoate-d7 is a deuterium-labeled derivative of Isopropyl 4-hydroxybenzoate, commonly known as Isopropylparaben. This stable isotope exhibits antimicrobial and antioxidant properties, making it a valuable tool in research involving the study of parabens and their biological effects. It is particularly useful in pharmacokinetic studies and metabolic research, allowing for enhanced tracking of compound behavior in biological systems. -
Stable Isotope
Hypoxanthine-13C,15N2 is a stable isotope-labeled form of hypoxanthine that incorporates both 13C and 15N isotopes. As a purine derivative, hypoxanthine serves as a potential free radical generator and may be utilized as a biomarker for hypoxic conditions. This reagent is valuable for research applications in metabolic studies, hypoxia-related investigations, and isotopic tracing in cellular and molecular biology. -
Stable Isotope
Isoeugenol-d3 is a deuterated form of Isoeugenol, a compound derived from various essential oils such as nutmeg, clove, and cinnamon. It serves as a stable isotope for use in research applications, particularly in studies involving the antimicrobial properties of isoeugenol. This compound demonstrates inhibitory effects on Escherichia coli and Listeria innocua, with minimum inhibitory concentrations (MICs) of 0.6 mg/mL and 1 mg/mL, respectively, making it valuable for microbiological studies. -
Stable Isotope
Itopride-d6 is a deuterated form of Itopride, a potent dopamine D2 receptor antagonist and acetylcholinesterase (AChE) inhibitor. Its unique stable isotope labeling allows for advanced metabolic and pharmacokinetic studies. Itopride enhances gastric motility through its combined antidopaminergic and anti-AChE actions, making it valuable in research applications focused on gastrointestinal prokinetics and conditions such as gastro-esophageal reflux disease (GERD). -
Stable Isotope
Probenecid-d7 is a stable isotope-labeled derivative of Probenecid, featuring seven deuterium atoms. This compound is primarily utilized in pharmacokinetic studies and drug metabolism research, enabling precise tracking of Probenecid in biological systems. Its unique isotopic labeling enhances analytical sensitivity and specificity in mass spectrometry applications, facilitating the investigation of metabolic pathways and drug interactions. -
Stable Isotope
Hexadecane-1,2-13C2 is a stable isotope-labeled form of hexadecane, a saturated hydrocarbon belonging to the alkane family. This compound serves as an effective organic solvent and is commonly utilized in research to study the microbial degradation of hydrophobic substrates. Its application in metabolic studies allows for the tracing of carbon flows in biochemical pathways, enhancing understanding of environmental processes and microbial dynamics. -
Stable Isotope
p-Anisic acid-13C6 is a stable isotope-labeled variant of p-Anisic acid (4-Methoxybenzoic acid), which is known for its antibacterial and antiseptic properties. This compound is utilized as a tracer in metabolic studies and is important for research involving the analysis of metabolic pathways and compound interactions. Its isotopic labeling allows for precise quantification in various biochemical investigations, enhancing the understanding of its biological activities. -
Stable Isotope
2,6-Dichlorodiphenylamine-13C6 serves as a stable isotope labeled analog of 2,6-Dichlorodiphenylamine. This compound demonstrates significant anti-Candida albicans activity, contributing to its potential utility in antifungal research. It is structurally related to Diclofenac Sodium, a well-known COX inhibitor with IC50 values of 4 and 1.3 nM for human COX-1 and COX-2, making 2,6-Dichlorodiphenylamine-13C6 valuable for studies in inflammation and enzyme inhibition mechanisms. -
Stable Isotope
Veratryl alcohol-13C (3,4-Dimethoxybenzyl alcohol-13C) is a stable isotope-labeled analog of Veratryl alcohol, a secondary metabolite produced by lignin-degrading fungi. This compound serves as a substrate for lignin peroxidase (LiP), enabling the assessment of lignin degradation activity. Additionally, Veratryl alcohol-13C protects LiP from inactivation by hydrogen peroxide and stabilizes manganese-dependent peroxidases (MnP). The compound also functions as a quorum-sensing inhibitor, demonstrating antibacterial properties, making it valuable for various biochemical and microbiological research applications. -
Stable Isotope
L-Tryptophan-d5 is a deuterium-labeled form of the essential amino acid L-Tryptophan, which serves as a key precursor for the neurotransmitter serotonin, the hormone melatonin, and vitamin B3. This stable isotope is valuable for metabolic studies, tracer experiments, and research in neurochemistry. Its unique labeling allows for precise tracking of L-Tryptophan pathways and metabolism in biological systems. -
Stable Isotope
L-Leucine-d3 is a deuterium-labeled form of the essential branched-chain amino acid (BCAA) L-Leucine. This stable isotope is primarily utilized in metabolic studies to trace amino acid metabolism and protein synthesis. L-Leucine plays a crucial role in activating the mTOR signaling pathway, making L-Leucine-d3 valuable for research applications in nutrition, muscle physiology, and metabolic disorders. -
Stable Isotope
Cholic acid-d4 is a deuterium-labeled derivative of cholic acid, a principal primary bile acid synthesized in the liver. This stable isotope is crucial for metabolic studies involving bile acids, particularly in tracing pathways of fat absorption and cholesterol excretion. It serves as a valuable tool in biochemical research to investigate the roles of bile acids in digestion and lipid metabolism. -
Stable Isotope
Cholesterol-d7 is a deuterium-labeled form of cholesterol, a vital sterol in mammalian biology. It constitutes 20-25% of the plasma membrane's structural components, influencing membrane fluidity, permeability, and the functioning of transporters and signaling proteins. Additionally, cholesterol serves as an endogenous agonist for estrogen-related receptor α (ERRα). Cholesterol-d7 is particularly useful in metabolic studies, lipid trafficking investigations, and the exploration of cholesterol's role in cellular signaling pathways. -
Stable Isotope
2-Ketoglutaric acid-13C5 is a stable isotope-labeled form of 2-Ketoglutaric acid, an essential intermediate in the Krebs cycle responsible for ATP and GTP synthesis. This compound plays a vital role in nitrogen assimilation, serving as a key carbon skeleton in related biochemical processes. Additionally, 2-Ketoglutaric acid functions as a reversible inhibitor of tyrosinase, demonstrating potential applications in metabolic studies and enzyme inhibition research. -
Stable Isotope
Creatine-d3 is a deuterated form of creatine, which serves as a stable isotope. Creatine is an endogenous compound that plays a crucial role in cellular energy metabolism, particularly in muscle and brain tissues. This reagent is widely utilized in metabolic studies, tracing energy pathways, and understanding creatine's role in physiological processes. -
Stable Isotope
3-Indoleacetic acid-d5 is a deuterium-labeled variant of 3-Indoleacetic acid, serving as a stable isotope internal standard. This reagent is utilized to accurately measure indole-3-acetic acid (IAA) release from ester and amide conjugates via alkaline hydrolysis. It is particularly valuable in studies assessing plant hormone dynamics and metabolism. -
Stable Isotope
L-Tryptophan-13C11 is a stable isotope of the essential amino acid L-Tryptophan, which serves as a precursor for key biomolecules, including serotonin, melatonin, and vitamin B3. This isotope-labeled compound is valuable for metabolic studies and tracking biological processes involving Tryptophan metabolism. Its use in research contributes to understanding neurological functions, sleep regulation, and nutritional biochemistry. -
Stable Isotope
Creatinine-d3 is a deuterium-labeled stable isotope of creatinine. This compound serves as a valuable tracer in metabolic studies and is utilized in various biochemical assays to measure renal function. Its unique isotopic signature allows for precise quantification of creatinine levels in biological samples, facilitating research in fields such as nephrology and exercise physiology. -
Stable Isotope
L-Serine-13C3 is a stable isotope-labeled form of L-Serine, a non-essential amino acid critical for cellular proliferation. This compound is utilized in metabolic studies to trace amino acid pathways, investigate protein synthesis, and analyze metabolic flux. Its incorporation in research provides insights into various biological processes, including growth, development, and neurological functions. -
Stable Isotope
Myristic acid-d27 is a deuterium-labeled derivative of myristic acid, a saturated 14-carbon fatty acid found abundantly in various animal and plant fats, including butterfat and oils from coconut, palm, and nutmeg. This stable isotope is primarily used in metabolic studies and tracer experiments, providing insights into fatty acid metabolism and distribution in biological systems. Its incorporation into biological samples aids in the analysis of lipid metabolism pathways and the evaluation of fatty acid profiles in research applications. -
Stable Isotope
L-Leucine-13C is a stable isotope-labeled form of L-Leucine, an essential branched-chain amino acid (BCAA) that plays a critical role in protein synthesis and metabolism. This compound activates the mTOR signaling pathway, which is pivotal for cell growth and proliferation. L-Leucine-13C is valuable in metabolic studies, particularly in understanding amino acid metabolism and protein turnover in various biological systems. -
Stable Isotope
DL-Homocysteine-d4 is a deuterium-labeled analog of DL-Homocysteine, primarily utilized as a stable isotope for quantitative analyses. As a weak neurotoxin, DL-Homocysteine influences the synthesis of kynurenic acid in the central nervous system. This compound is essential for research focused on neurotoxicity, metabolic pathways, and the study of neurological disorders where kynurenine metabolism is implicated. -
Stable Isotope
D-Fructose-13C6 is a stable isotope-labeled form of D-Fructose, a naturally occurring monosaccharide present in numerous plants. This isotopically enriched compound serves as a valuable tool in metabolic and nutritional studies, allowing researchers to trace fructose metabolism and its incorporation into various biochemical pathways. D-Fructose-13C6 can be utilized in diverse applications, including isotopic labeling, tracer studies, and the investigation of carbohydrate metabolism. -
Stable Isotope
Linoleic acid-13C18 is a stable isotope-labeled form of linoleic acid, a polyunsaturated fatty acid (PUFA) prevalent in various plant-based oils, nuts, and seeds. It plays a crucial role as a structural component of membrane phospholipids, contributing to membrane fluidity in cellular barriers, particularly within the epidermis. This compound is invaluable for research involving metabolic studies, biomarker analysis, and oxidative stress responses, as it also exhibits the capacity to induce oxidative damage in red blood cells and hemoglobin. -
Stable Isotope
L-Methionine-13C5 is a stable isotope-labeled form of L-Methionine, the L-isomer of the essential amino acid methionine. This compound functions as a hepatoprotectant and is crucial for human development and metabolism. L-Methionine-13C5 is commonly utilized in metabolic studies and tracing experiments, providing insights into amino acid metabolism and cellular function. -
Stable Isotope
L-Cysteine-13C3,15N is a stable isotope-labeled form of the conditionally essential amino acid L-Cysteine, incorporating carbon-13 and nitrogen-15 isotopes. This compound serves as a precursor for several biologically active molecules, including hydrogen sulfide (H2S), glutathione, and taurine. L-Cysteine is also involved in metabolic studies related to appetite regulation, having shown the ability to suppress ghrelin levels and reduce appetite in both rodent and human models, making it valuable for research in nutrition and metabolic disorders. -
Stable Isotope
Succinic acid-13C4 is a stable isotope-labeled form of succinic acid, serving as a key intermediate in the tricarboxylic acid cycle. It is utilized in various research applications, including metabolic studies and tracing pathways within biochemical processes. Furthermore, succinic acid has demonstrated anxiolytic properties and can act as a precursor for the synthesis of numerous chemicals in the food, chemical, and pharmaceutical sectors. -
Stable Isotope
L-Alanine-d4 is a deuterated form of the non-essential amino acid L-Alanine. This stable isotope is utilized in metabolic studies, providing insights into amino acid metabolism and its role in energy production, immunity enhancement, and support of muscle and central nervous system function. L-Alanine-d4 serves as a valuable tool in tracer studies and various biochemical applications. -
Stable Isotope
Succinic acid-d4 is a deuterated form of succinic acid, serving as a valuable stable isotope for research applications. As an intermediate in the tricarboxylic acid cycle and a product of anaerobic metabolism, succinic acid plays a vital role in cellular respiration and metabolic pathways. This isotope-labeled reagent is useful for studies involving metabolic tracing and isotope labeling, enabling enhanced analysis of metabolic processes in various biological systems. -
Stable Isotope
L-Methionine-d3 is the deuterated form of the essential amino acid L-Methionine. This stable isotope serves as a valuable tool in metabolic studies, allowing researchers to trace amino acid metabolism and protein turnover in biological systems. L-Methionine plays a critical role in cellular functions, including acting as a hepatoprotectant, making this reagent particularly useful in investigations of liver health and oxidative stress responses. Applications include tracer studies in nutrition, biochemistry, and pharmacology research. -
Stable Isotope
Phenylacetylglutamine-d5 is a stable isotope-labeled derivative of Phenylacetylglutamine, a metabolite produced from the fermentation of amino acids by colonic microbiota. This compound serves as a valuable tracer in metabolic studies and offers insights into gut microbiome interactions and metabolic pathways. The deuterium labeling enhances detection and quantification in various analytical techniques, facilitating research in microbiome-related diseases and nutrient absorption. -
Stable Isotope
Arachidonic acid-d8 is a deuterium-labeled form of arachidonic acid, a crucial polyunsaturated fatty acid that plays a key role in cellular membranes and signaling. This stable isotope is widely used in metabolic studies and lipid research to trace fatty acid metabolism and elucidate biological pathways. Its incorporation in experimental designs can enhance the understanding of lipid biochemistry and related physiological processes. -
Stable Isotope
SDMA-d6 is a deuterium-labeled form of symmetric dimethylarginine (SDMA), a recognized endogenous inhibitor of nitric oxide (NO) synthase. This stable isotope reagent is instrumental in research investigating nitric oxide signaling pathways and the role of SDMA in various physiological and pathological conditions. Its use facilitates precise quantification in metabolic studies and helps unravel the complexities of nitric oxide-related mechanisms. -
Stable Isotope
L-Ornithine-d7 hydrochloride is a deuterium-labeled derivative of L-Ornithine hydrochloride. This stable isotope serves as a valuable tracer in metabolic studies and is crucial in the urea cycle, facilitating the excretion of excess nitrogen. Its unique isotopic composition enables precise quantification in various biological and biochemical research applications. -
Stable Isotope
D-Glucose-13C is a stable isotope-labeled form of D-Glucose, a key monosaccharide in biological systems. It plays a vital role in metabolism, serving as an energy source and a critical component in various biochemical pathways. D-Glucose also functions as a signaling molecule, influencing cellular responses to metabolic changes and environmental stressors. This reagent is commonly used in metabolic studies and isotopic labeling experiments to trace carbon flow in biological systems. -
Stable Isotope
MeIQx-13C, a stable isotope of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, serves as a valuable tool for investigating the metabolic pathways and biological effects of MeIQx. This mutagenic compound, commonly found in fried beef and beef extracts, has been shown to covalently bind to hemoglobin and is implicated in the induction of liver tumors. MeIQx-13C is particularly useful for studying the mechanisms of mutagenesis and carcinogenesis in dietary substances. -
Stable Isotope
Mephenytoin-13C,d3 is a stable isotope labeled form of Mephenytoin, an anticonvulsant agent that primarily acts as a substrate for the cytochrome P450 enzymes CYP2C19 and CYP2B6. This deuterated compound is essential for pharmacokinetic studies, metabolic profiling, and research investigating drug interactions. Its incorporation into experiments aids in the elucidation of drug metabolism and therapeutic efficacy in neurological disorders. -
Stable Isotope
Mephenytoin-d3 is a stable isotope-labeled form of racemic Mephenytoin, an anticonvulsant agent. As a substrate of cytochrome P450 enzymes CYP2C19 and CYP2B6, it serves as an essential tool for pharmacokinetic studies and metabolic profiling in drug metabolism research. This compound is particularly useful for studying drug interactions and enzyme activity in various biological systems. -
Stable Isotope
Veratrole-d2-1 is a deuterium-labeled derivative of Veratrole (1,2-Dimethoxybenzene), a naturally occurring compound found in various plant species. It demonstrates key biological activities related to plant reproduction, species differentiation, and pollinator attraction, exhibiting a circadian release pattern. This compound is also relevant for research into metabolic processes, as Veratrole can undergo demethylation by cytochrome P-450 enzymes in Streptomyces setonii, making it useful in studies of enzymatic activity and plant-pollinator interactions. -
Stable Isotope
MCPA-d3 is a deuterated derivative of MCPA, a phenoxyacetic acid herbicide that exhibits activity through the disruption of membrane integrity, reduction of ATP levels, and imbalance of redox status in plant cells. This stable isotope can enhance studies on herbicide effects by providing a means to trace metabolic pathways involving MCPA. Additionally, MCPA has been shown to elevate hepatic cytochrome P-450 levels, thereby increasing the activity of enzymes such as aniline hydroxylase and 7-ethoxycoumarin O-deethylase. It is widely utilized in research focused on weed control mechanisms and herbicide impact assessments. -
Stable Isotope
Abiraterone acetate-d3 is a deuterium-labeled derivative of the potent, selective, and irreversible CYP17A1 inhibitor, Abiraterone acetate. This stable isotope is utilized in biological research to study metabolism and pharmacokinetics of Abiraterone in various cellular contexts. Its ability to inhibit androgen synthesis makes it particularly relevant in the investigation of hormone-dependent cancers, such as prostate cancer. -
Stable Isotope
Teriflunomide-d4 is a deuterated form of Teriflunomide, a therapeutic agent primarily targeting the enzyme dihydroorotate dehydrogenase (DHODH). This stable isotope-labeled compound is utilized in metabolic studies and pharmacokinetic investigations to trace the bioactivity of Teriflunomide in biological systems. Its incorporation of deuterium facilitates enhanced tracking and quantification in research applications, contributing valuable insight into its pharmacological effects. -
Stable Isotope
Leflunomide-d4 is a deuterium-labeled form of Leflunomide, a potent inhibitor of dihydroorotate dehydrogenase (DHODH). This stable isotope variant facilitates accurate metabolic studies and pharmacokinetic analyses of Leflunomide’s action. Utilized primarily in research on autoimmune disorders, Leflunomide-d4 aids in elucidating the compound's mechanisms as a disease-modifying antirheumatic agent. -
Stable Isotope
4'-Hydroxy diclofenac-d4 is a stable isotope-labeled derivative of 4'-Hydroxy diclofenac, an active metabolite of Diclofenac primarily formed by cytochrome P450 2C9 (CYP2C9) metabolism. This compound retains the anti-inflammatory and analgesic properties of its parent drug, making it suitable for research into drug metabolism and pharmacokinetics. It is a valuable tool for studies involving drug interaction and effectiveness, particularly in the development of therapeutic applications targeting inflammation and pain relief. -
Stable Isotope
4-Hydroxymephenytoin-d3 is a deuterated form of 4-Hydroxymephenytoin, a hydroxylated metabolite of the antiepileptic drug mephenytoin. This stable isotope serves as a valuable internal standard for studies involving cytochrome P450 2C19 (CYP2C19) metabolism. It is particularly useful in pharmacokinetic research and in the development of assays to evaluate drug interactions and metabolic pathways. -
Stable Isotope
3-Methoxytyramine-d4 hydrochloride is a deuterated derivative of 3-Methoxytyramine hydrochloride, serving as a stable isotope for various analytical applications. While 3-Methoxytyramine itself is an inactive metabolite of dopamine, it has been shown to activate trace amine associated receptor 1 (TAAR1). This reagent is useful in studies related to neurotransmitter signaling and metabolic pathways, allowing for precise quantification and tracing in biological samples. -
Stable Isotope
N-Desmethyl imatinib-d8 is a deuterated metabolite of Imatinib, acting primarily as a selective inhibitor of the c-Abl tyrosine kinase. This compound effectively binds to the c-Abl catalytic domain, inhibiting substrate phosphorylation and thereby modulating c-Abl-mediated α-synuclein activation and related inflammatory signaling pathways. N-Desmethyl imatinib has been shown to induce apoptosis in K562 human leukemia cells and may demonstrate altered pharmacokinetics in gastrointestinal stromal tumor settings following viral infection. It is valuable for research applications in Parkinson’s disease, gastrointestinal stromal tumors, and chronic myeloid leukemia. -
Stable Isotope
1'-Hydroxy bufuralol-d9 is a deuterium-labeled analog of 1'-Hydroxy bufuralol, serving as a stable isotope for research applications. As the primary metabolite of bufuralol, it is produced by the action of cytochrome P450 isoenzymes CYP2D1 and CYP2D2. This reagent is invaluable for studying CYP2D1/2 enzyme activity and can aid in pharmacokinetic studies and metabolite profiling.
