Catalog No.
Product Name
Application
Product Information
Citations
-
Stable Isotope
(S)-(+)-Ketoprofen-13C,d3 is a deuterium and carbon-13 labeled derivative of the nonsteroidal anti-inflammatory drug (NSAID) S-(+)-Ketoprofen. Primarily, it acts as a dual inhibitor of cyclooxygenase enzymes COX-1 and COX-2, demonstrating potent inhibitory activity with IC50 values of 1.9 nM and 27 nM, respectively. This stable isotope-labeled compound is valuable for pharmacokinetic studies, metabolic research, and tracing experiments in biological systems. -
Stable Isotope
(±)-Naproxen-13C,d3 is a stable isotope-labeled version of (±)-Naproxen, featuring deuterium and carbon-13 isotopes. As a nonsteroidal anti-inflammatory drug (NSAID), (±)-Naproxen functions as an inhibitor of cyclooxygenase enzymes COX-1 and COX-2, with IC50 values of 8.72 μM and 5.15 μM, respectively. This compound is valuable for studies investigating drug metabolism, pharmacokinetics, and the mechanistic pathways of inflammation. -
Stable Isotope
Benoxaprofen-13C,d3 is a deuterium and carbon-13 labeled derivative of Benoxaprofen, a nonsteroidal anti-inflammatory drug (NSAID) with notable anti-inflammatory and antipyretic properties. This compound exhibits weak inhibition of cyclooxygenase and inhibits lipoxygenase, in addition to reducing monocyte migration in certain in vivo inflammation models. Benoxaprofen-13C,d3 is valuable in pharmacokinetic studies and metabolic research applications, offering insights into the compound's behavior and interactions in biological systems. -
Stable Isotope
Tolfenamic acid-13C6 is a stable isotope-labeled derivative of Tolfenamic acid, a non-steroidal anti-inflammatory and anti-cancer agent. It selectively inhibits COX-2 with an IC50 of 13.49 μM in LPS-treated canine DH82 monocyte/macrophage cells, while exhibiting no inhibitory effect on COX-1. This reagent is valuable for studying COX-2-related pathways and assessing the pharmacokinetics and metabolism of Tolfenamic acid in various biological contexts. -
Stable Isotope
Rofecoxib-d5 is a deuterium-labeled derivative of Rofecoxib, a potent and selective inhibitor of cyclooxygenase-2 (COX-2). This compound exhibits inhibitory activity with IC50 values of 26 nM in human osteosarcoma cells and 18 nM in Chinese hamster ovary cells, demonstrating over 1000-fold selectivity for COX-2 compared to COX-1. Rofecoxib-d5 is suitable for use in pharmacokinetic studies, metabolic labeling, and other research applications involving COX-2 inhibition. -
Stable Isotope
Etofenamate-d4 is a deuterium-labeled form of Etofenamate, a non-steroidal anti-inflammatory drug (NSAID) that acts as a non-selective inhibitor of cyclooxygenases (COX). This compound exhibits notable analgesic, anti-rheumatic, antipyretic, and anti-inflammatory properties, making it valuable in researching conditions such as osteoarthritis, arthritis, and other inflammatory diseases. Its stable isotope nature allows for precise quantification and tracking in metabolic studies and pharmacokinetic investigations. -
Stable Isotope
4-Acetylaminoantipyrine-d3 is a deuterium-labeled derivative of 4-Acetylaminoantipyrine, primarily known for its role as a stable isotope in chemical research. This compound acts as a selective reversible inhibitor of cyclooxygenase (COX) and a PGE2-dependent blocker, contributing to studies on prostaglandin synthesis and inflammation. Additionally, it exhibits the ability to inhibit copper/zinc superoxide dismutase (Cu/ZnSOD) and shows potential for binding to bovine serum albumin (BSA), leading to conformational changes that may be relevant for pharmacokinetic studies. -
Stable Isotope
4-Methylamino antipyrine-d3-1 is a deuterium-labeled derivative of 4-Methylamino antipyrine. This compound serves as a stable isotope for tracing and analytical applications. As an active metabolite of Metamizole, it exhibits analgesic and antipyretic properties, making it valuable for studying pain relief and fever reduction. The compound is essential in pharmacokinetic studies and metabolic research involving non-steroidal anti-inflammatory drugs (NSAIDs). -
Stable Isotope
Mefenamic acid-13C6 is a stable isotope-labeled derivative of Mefenamic acid, a non-steroidal anti-inflammatory drug (NSAID) that penetrates the blood-brain barrier. It functions as a competitive inhibitor of human cyclooxygenase-1 (hCOX-1) and human cyclooxygenase-2 (hCOX-2), with reported IC50 values of 40 nM and 3 μM, respectively. This reagent is valuable for metabolic studies and pharmacokinetic research involving the behavior of Mefenamic acid in biological systems. -
Stable Isotope
Propyphenazone-d3 is a deuterium-labeled derivative of Propyphenazone, a pyrazolone compound known for its anti-inflammatory, analgesic, and antipyretic properties. This stable isotope is utilized in research to study metabolic pathways and drug interactions involving Propyphenazone and its analogues, particularly as proagents and selective inhibitors of cyclooxygenase-2 (COX-2). Its labeling facilitates precise tracking and characterization in biological assays and pharmacokinetic studies. -
Stable Isotope
Guaiacol-d4 is a deuterium-labeled derivative of guaiacol, a phenolic compound recognized for its role in modulating inflammatory pathways. It inhibits lipopolysaccharide (LPS)-stimulated cyclooxygenase-2 (COX-2) expression and the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). This compound is valuable for research in inflammation, offering insights into anti-inflammatory mechanisms and potential therapeutic applications. -
Stable Isotope
Tenidap-d3 is a deuterated form of Tenidap, a non-steroidal anti-inflammatory drug that selectively inhibits COX-1 with an IC50 of 0.03 μM, while showing weaker inhibition of COX-2 at 1.2 μM. This compound exhibits notable anti-inflammatory and antirheumatic effects, making it a valuable reagent in studies of inflammatory pathways. Additionally, Tenidap is identified as a specific inhibitor of SLC26A3, facilitating research into its role in ion transport and related physiological processes. -
Stable Isotope
Metamizole-d3 sodium is a deuterium-labeled derivative of Metamizole sodium, a potent non-opioid analgesic and antipyretic agent. It primarily acts as a cyclooxygenase-3 (COX-3) inhibitor, providing insight into the pharmacological mechanisms of pain relief and fever reduction. This stable isotope is valuable for research applications involving drug metabolism and pharmacokinetics, enabling the study of metabolic pathways and the effects of deuteration on drug efficacy. -
Stable Isotope
Bromfenac-d4 sodium is a deuterated form of Bromfenac, which functions as a potent inhibitor of cyclooxygenases (COX-1 and COX-2), displaying IC50 values of 5.56 nM and 7.45 nM, respectively. This non-steroidal anti-inflammatory drug (NSAID) is primarily utilized in research focused on post-operative inflammation and pain management following cataract surgery, as well as studies related to pseudophakic cystoid macular edema. The incorporation of deuterium enhances its stability and may facilitate metabolic studies. -
Stable Isotope
N-(4-Ethoxyphenyl)acetamide-2,2,2-d3 is a deuterium-labeled derivative of Phenacetin, primarily serving as a stable isotope. This compound exhibits non-opioid analgesic and antipyretic properties, functioning as a selective COX-3 inhibitor. It is commonly utilized in research to investigate the activity of cytochrome P450 enzymes, specifically CYP1A2, in human liver microsomes and rat models, providing valuable insights into metabolic pathways and drug interactions. -
Stable Isotope
Flunixin-d3 is a deuterium-labeled derivative of Flunixin, serving as a stable isotope reagent. It acts as a potent inhibitor of cyclooxygenase (COX), exhibiting significant analgesic, anti-inflammatory, and antipyretic properties. This compound is primarily utilized in pharmacokinetic studies and metabolic research to trace the distribution and metabolism of Flunixin in biological systems. -
Stable Isotope
Ketorolac-d4 is a deuterated form of Ketorolac, a non-steroidal anti-inflammatory drug that functions as a nonselective cyclooxygenase (COX) inhibitor, exhibiting IC50 values of 20 nM for COX-1 and 120 nM for COX-2. This stable isotope-labeled compound is primarily utilized in pharmacokinetic studies and metabolic profiling to track drug metabolism in biological systems. Its unique properties make it an essential tool in therapeutic research and drug development. -
Stable Isotope
Ketoprofen-13C6 is a stable isotope-labeled form of the non-steroidal anti-inflammatory drug Ketoprofen. This compound functions primarily by inhibiting cyclooxygenase enzymes, demonstrating IC50 values of 2 nM for COX-1 and 26 nM for COX-2. Ketoprofen-13C6 is valuable for investigating inflammation, immunology, and metabolic diseases, including obesity, by providing insights into drug metabolism and pharmacokinetics in biological research. -
Stable Isotope
Firocoxib-d4 is a deuterium-labeled derivative of Firocoxib, acting primarily as a selective inhibitor of cyclooxygenase-2 (COX-2). With an IC50 value of 0.13 μM, Firocoxib demonstrates a notable selectivity, being 58-fold more potent against COX-2 compared to COX-1 (IC50 of 7.5 μM). This compound is primarily utilized in research to investigate COX-2's role in inflammation and associated therapeutic targets. Its stable isotope labeling allows for advanced studies in pharmacokinetics and metabolism in biological systems. -
Stable Isotope
Tolmetin-d3 is a deuterium-labeled analog of Tolmetin, a potent non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase (COX) enzymes. With IC50 values of 0.35 μM for human COX-1 and 0.82 μM for COX-2, Tolmetin effectively modulates inflammatory pathways. This stable isotope variant is ideal for research applications involving pharmacokinetics, metabolic studies, and the assessment of drug interactions. -
Stable Isotope
Vedaprofen-d3 is a deuterium-labeled derivative of Vedaprofen, a nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-1. This compound demonstrates significant biological activity by reducing serum TxB2 and exudate PGE2 levels. Additionally, it acts as an inhibitor of the Escherichia coli sliding clamp, with an IC50 value of 222 μM, making it useful for various biochemical and pharmacological research applications. -
Stable Isotope
Mefenamic Acid-d3 is a deuterium-labeled derivative of Mefenamic acid, a non-steroidal anti-inflammatory compound. It functions primarily as a competitive inhibitor of human cyclooxygenase enzymes hCOX-1 and hCOX-2, exhibiting IC50 values of 40 nM and 3 μM, respectively. This reagent is valuable in pharmacokinetic studies and metabolic research, particularly for tracing metabolic pathways and evaluating the bioavailability of Mefenamic acid in various biological systems. -
Stable Isotope
S-(+)-Ketoprofen-d3 is a deuterium-labeled analog of S-(+)-Ketoprofen, a selective inhibitor of cyclooxygenase enzymes COX-1 and COX-2. It exhibits high potency with IC50 values of 1.9 nM for COX-1 and 27 nM for COX-2. This stable isotope-labeled compound is invaluable for pharmacokinetic studies and metabolic research in drug development, allowing for precise tracking of S-(+)-Ketoprofen in biological systems. -
Stable Isotope
(rac)-Etodolac-d3 is a stable isotope-labeled analogue of Etodolac, a racemic non-steroidal anti-inflammatory drug. Its primary mechanism involves the non-selective inhibition of cyclooxygenase (COX) enzymes, with an IC50 value of 53.5 nM. This reagent is valuable for research applications requiring the tracking of Etodolac in biochemical assays or pharmacokinetic studies involving COX inhibition and inflammation pathways. -
Stable Isotope
Corticosterone-d8 is a deuterium-labeled derivative of corticosterone, primarily utilized as a stable isotope. This compound serves as a crucial tool in research applications involving hormone metabolism, signaling pathways, and stress response mechanisms. Its dual activity as both a mineralocorticoid and glucocorticoid enables detailed studies on the physiological effects and interactions of steroid hormones in biological systems. -
Stable Isotope
Hydrocortisone-d4 is a deuterium-labeled form of hydrocortisone, a steroid hormone produced in the adrenal cortex. This stable isotope is utilized in scientific research to analyze metabolic pathways and pharmacokinetics of glucocorticoids. Its unique labeling enables precise quantification and tracking in biological samples, facilitating advancements in studies involving stress response and inflammation regulation. -
Stable Isotope
Cortisone-d8 is a deuterium-labeled derivative of cortisone, a biologically active metabolite of cortisol and a member of the glucocorticoid class. This stable isotope is utilized in metabolic studies and has applications in pharmacokinetic research and the characterization of glucocorticoid receptor interactions. Cortisone exhibits immunosuppressive and anti-inflammatory properties, contributing to its role in a variety of therapeutic applications. -
Stable Isotope
Corticosterone-d4 is a deuterated form of corticosterone, functioning as a stable isotope tracer. It exhibits biological activity as both a mineralocorticoid and glucocorticoid, playing a crucial role in stress response and metabolism regulation. This reagent is primarily utilized in research applications involving hormone quantification, metabolic studies, and tracer experiments in biological assays. -
Stable Isotope
Triamcinolone acetonide-d6 is a deuterium-labeled derivative of the glucocorticoid triamcinolone acetonide. This stable isotope can be utilized in pharmacokinetic studies, allowing for the investigation of drug metabolism and distribution. Its incorporation in tracer studies facilitates the analysis of biological pathways and therapeutic monitoring in research applications related to inflammation and immune responses. -
Stable Isotope
Budesonide-d8 is a deuterium-labeled analog of Budesonide, which acts primarily as a glucocorticoid receptor agonist. This compound exhibits anti-inflammatory properties essential for the management of asthma and has been shown to reduce lung tumor size, reverse DNA hypomethylation, and modulate mRNA expression of various genes. Budesonide-d8 serves as a valuable tool in pharmacokinetic and metabolic research, providing insights into the pharmacological effects and mechanisms of Budesonide in vivo. -
Stable Isotope
Hydrocortisone-d2 is a deuterated form of Hydrocortisone, a naturally occurring glucocorticoid hormone produced by the adrenal cortex. This stable isotope is essential for studies requiring precise tracking and quantification in metabolic and pharmacokinetic research. It is widely utilized in experiments investigating adrenal function, stress response, and corticosteroid therapies. -
Stable Isotope
Hydrocortisone-d3 is a deuterium-labeled derivative of hydrocortisone, a glucocorticoid hormone produced in the adrenal cortex. This stable isotope is primarily utilized in metabolic studies and pharmacokinetic research to trace and quantify the pathways of hydrocortisone in biological systems. Its application aids in understanding the mechanistic roles of glucocorticoids in various physiological and pathological processes. -
Stable Isotope
Cortodoxone-d5 is a deuterium-labeled derivative of Cortodoxone, utilized primarily as a stable isotope internal standard in analytical chemistry. This reagent enables precise quantification of Cortodoxone in various biological samples, enhancing the accuracy of pharmacokinetic studies. Its application is crucial for researchers analyzing steroid metabolism and distribution in physiological contexts. -
Stable Isotope
Cortodoxone-d2 is a deuterium-labeled derivative of Cortodoxone, a glucocorticoid steroid hormone. This stable isotope enables precise tracking and quantification in metabolic studies, particularly in the investigation of cortisol (Hydrocortisone) production and regulation. It serves as a valuable tool in various research applications, including endocrine and pharmacological studies involving steroid hormone dynamics. -
Stable Isotope
Ciclesonide-d7 is a deuterium-labeled derivative of Ciclesonide, a potent glucocorticoid with significant anti-inflammatory properties. This stable isotope is particularly useful in pharmacokinetic studies and metabolic research, allowing for the detailed investigation of Ciclesonide's biological activity and effectiveness in asthma treatment. Its unique isotopic signature facilitates the tracking and quantification of the compound in biological systems, making it an indispensable tool for researchers studying glucocorticoid mechanisms and therapeutic applications. -
Stable Isotope
Betamethasone dipropionate-d10 is a deuterium-labeled derivative of Betamethasone dipropionate, a synthetic glucocorticoid steroid. This compound exhibits significant anti-inflammatory and immunosuppressive properties, making it valuable in various research applications. Betamethasone dipropionate-d10 is utilized in studies that require stable isotope labeling for pharmacokinetic and metabolic investigations. -
Stable Isotope
Beclomethasone-d5 is a deuterium-labeled analogue of Beclometasone, a potent glucocorticoid receptor agonist. This stable isotope is utilized in quantitative analysis of glucocorticoid metabolism and pharmacokinetics. Beclomethasone-d5 serves as an effective tool in research applications focused on inflammatory responses and hormonal regulation. -
Stable Isotope
(22R)-Budesonide-d8 is the deuterium-labeled form of the glucocorticoid (22R)-Budesonide, exhibiting high local anti-inflammatory activity. As a stable isotope, (22R)-Budesonide-d8 serves as an essential tool for pharmacokinetic and metabolic studies, allowing for precise tracking of (22R)-Budesonide in biological systems. This compound is especially valuable in research focused on the mechanisms of inflammation and therapeutic interventions in related conditions. -
Stable Isotope
Cortisone-13C3 is a stable isotope-labeled form of cortisone, specifically 13C-labeled at three sites. Cortisone, an oxidized metabolite of cortisol, exhibits anti-inflammatory and immunosuppressive properties through its interaction with the glucocorticoid receptor. This reagent is valuable for research applications in metabolic studies, pharmacokinetics, and the investigation of glucocorticoid signaling pathways in various biological contexts. -
Stable Isotope
Cortisone-d2 is a deuterium-labeled form of cortisone, an oxidized metabolite of cortisol, and a glucocorticoid. This stable isotope serves as a valuable tool for research applications, including metabolic studies and pharmacokinetic analysis. Cortisone exhibits notable immunosuppressive and anti-inflammatory properties, and its interactions with the glucocorticoid receptor can be examined through labeling to enhance the understanding of glucocorticoid dynamics in biological systems. -
Stable Isotope
2'-Deoxy-2'-fluorouridine-d2 is a deuterated nucleoside analog that targets viral RNA replication. As a derivative of uridine, it inhibits the replication of wild-type viruses by binding to their RNA. This compound is particularly relevant in research focusing on Hepatitis C and respiratory syncytial virus (RSV), as it can be utilized in the synthesis of RSV polymerase inhibitors. Additionally, 2'-Deoxy-2'-fluorouridine-d2 incorporates into DNA and RNA in animal models, making it a valuable tool for anti-viral research. -
Stable Isotope
3-Iodothyronamine hydrochloride-13C6 is a stable isotope-labeled derivative of the endogenous thyroid hormone, 3-Iodothyronamine hydrochloride. It acts as a potent activator of the orphan G protein-coupled receptor TAAR1, demonstrating significant biological activity through the induction of hypothermia in vivo. This compound is valuable for research applications related to thyroid hormone signaling and can contribute to studies on congestive heart failure. -
Stable Isotope
Mozavaptan-d6 is a deuterium-labeled variant of Mozavaptan, a selective competitive antagonist of the vasopressin V2 receptor, with an IC50 of 14 nM. This compound exhibits approximately 85-fold selectivity for the V2 receptor compared to the V1 receptor, which has an IC50 of 1.2 μM. Mozavaptan-d6 is utilized in research studying the modulation of fluid balance and potential therapies for hyponatremia, syndrome of inappropriate antidiuretic hormone secretion (SIADH), and congestive heart failure. Its stable isotope labeling enables advanced pharmacokinetic studies and metabolic profiling. -
Stable Isotope
L-Kynurenine-d4 is the deuterium-labeled form of L-Kynurenine, a metabolite derived from the amino acid L-tryptophan. This compound acts as an agonist of the aryl hydrocarbon receptor, playing a significant role in various biological pathways, including immune responses and neurodegenerative diseases. L-Kynurenine-d4 is primarily used in research applications involving metabolic studies and the investigation of aryl hydrocarbon receptor signaling. -
Stable Isotope
Benzyl butyl phthalate-d4 is a deuterium-labeled derivative of Benzyl butyl phthalate, classified as a phthalic acid ester (PAE). This compound has demonstrated the ability to induce migration and invasion in hemangioma (HA) cells through the upregulation of Zeb1. Additionally, it activates the aryl hydrocarbon receptor (AhR) in breast cancer cells, thereby stimulating the SPHK1/S1P/S1PR3 signaling pathway and promoting the formation of metastasis-initiating breast cancer stem cells (BCSCs). This reagent is valuable for studies involving cellular signaling, cancer biology, and environmental health research. -
Stable Isotope
Carbidopa-d3 monohydrate is a deuterium-labeled derivative of Carbidopa, acting as a peripheral decarboxylase inhibitor. This compound is primarily utilized in Parkinson's disease research due to its ability to modify dopaminergic signaling. Additionally, Carbidopa-d3 monohydrate serves as a selective aryl hydrocarbon receptor modulator and has demonstrated inhibitory effects on pancreatic cancer cell proliferation and tumor growth. -
Stable Isotope
Dibenzothiophene-d8 is a deuterium-labeled analogue of dibenzothiophene, serving as a stable isotope for research applications. This compound acts as a noncompetitive inhibitor of cytochrome P450 1A (CYP1A), demonstrating an inhibition of CYP1A-mediated EROD activity with a Km value of 0.592 μM. Additionally, dibenzothiophene-d8 interacts with the aryl hydrocarbon receptor (AHR) pathway and has been shown to enhance the embryotoxic effects of β-naphthoflavone. Its unique properties make it valuable for investigating the mechanisms of developmental toxicity in various organisms. -
Stable Isotope
L-Kynurenine-d4-1 is a deuterated form of L-Kynurenine, a metabolite derived from the amino acid L-tryptophan. It acts as an agonist of the aryl hydrocarbon receptor, playing a critical role in various biological processes. This stable isotope is valuable for research applications, particularly in isotope labeling studies and metabolic pathway analyses involving tryptophan metabolism and its downstream effects. -
Stable Isotope
Tapinarof-d5 is a deuterium-labeled derivative of Tapinarof, serving as a stable isotope for research applications. Tapinarof functions as an agonist of the aryl hydrocarbon receptor (AhR) with an EC50 of 13 nM. This compound has demonstrated efficacy in resolving skin inflammation in murine models, making it a valuable tool for studies related to dermatological conditions and AhR signaling pathways. -
Stable Isotope
Sudan IV-d6 is a deuterium-labeled analog of Sudan IV, acting as an agonist of the aryl hydrocarbon receptor (AhR). It activates downstream signaling pathways, leading to the induction of CYP1A1 expression, which plays a crucial role in drug metabolism. This reagent is valuable for investigating the toxicity mechanisms of industrial dyes and understanding their interactions with serum proteins, such as bovine serum albumin (BSA). Additionally, Sudan IV-d6 functions as a fat-soluble diazo dye, suitable for lipid, triglyceride, and lipoprotein staining in frozen tissue sections.
