Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
α-Vitamin E-d6 is the deuterium-labeled form of α-Vitamin E, serving as a stable isotope for isotopic labeling studies. This compound is utilized in research applications focusing on metabolic pathways, pharmacokinetics, and the bioavailability of vitamin E. Its unique isotopic signature allows for precise tracking and quantification in complex biological systems, enhancing the understanding of vitamin E’s role in health and disease. -
Stable Isotope
Guaiacol-d3 is a deuterated form of guaiacol, a phenolic compound known for its ability to inhibit lipopolysaccharide (LPS)-induced cyclooxygenase-2 (COX-2) expression and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. This reagent exhibits significant anti-inflammatory properties and is employed in research applications studying inflammatory pathways and the modulation of COX-2 expression. Its stable isotope labeling facilitates tracing studies and enhances the understanding of metabolic processes in biological systems. -
Stable Isotope
Phenacetin-d5 is a deuterium-labeled derivative of Phenacetin, functioning primarily as a stable isotope. As a non-opioid analgesic and antipyretic agent, Phenacetin selectively inhibits COX-3. This compound serves as a valuable probe for studying cytochrome P450 enzymes, particularly CYP1A2, in human liver microsomes and rat models, facilitating research in drug metabolism and pharmacokinetics. -
Stable Isotope
Alvimopan-d7 is a deuterium-labeled variant of Alvimopan, a potent and selective oral μ-opioid receptor antagonist. With an IC50 of 1.7 nM, Alvimopan exhibits significant selectivity for the μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors, with Kis of 100 nM and 12 nM, respectively. This stable isotope-labeled compound is valuable for research applications focused on postoperative ileus and opioid receptor pharmacology. -
Isotope-Labeled Compound
O,O-Diethyl dithiophosphate-13C4 ammonium is a stable isotope-labeled compound used primarily in chemical and biological research. It serves as a useful tool for tracing and quantifying metabolic pathways in various biological systems due to its incorporation of the carbon-13 isotope. This compound aids in the study of organophosphate interactions and can enhance the understanding of biochemical mechanisms and environmental fate of similar thiophosphate agents. -
Stable Isotope
O-Desmethyltramadol-d6 hydrochloride is a deuterated stable isotope of O-Desmethyltramadol hydrochloride, the principal active metabolite of tramadol. This compound is capable of traversing the blood-brain barrier and primarily exerts its analgesic effects through activation of the µ-opioid receptor (µ-OR). O-Desmethyltramadol-d6 hydrochloride is valuable in pharmacokinetic studies and tracer research due to its isotopic labeling, offering precise tracking in biological systems. -
Stable Isotope
Ticagrelor-d7 is a deuterium-labeled derivative of Ticagrelor, a reversible P2Y12 receptor antagonist. This stable isotope is utilized in research for studying platelet aggregation and related cardiovascular processes. Its unique labeling enables precise tracking and quantification in various biochemical assays, enhancing the understanding of antiplatelet therapies in clinical and experimental settings. -
Stable Isotope
Prasugrel-d3 is a deuterium-labeled form of Prasugrel, a thienopyridine prodrug that selectively antagonizes the P2Y12 receptor. This compound effectively inhibits ADP-induced platelet aggregation, thereby demonstrating significant platelet-inhibitory activity. Prasugrel-d3 is valuable for studying platelet function and the pharmacokinetics of Prasugrel in various biological research applications. -
Stable Isotope
Uridine 5′-diphosphoglucose-13C6 disodium is a stable isotope-labeled form of Uridine 5′-diphosphoglucose. It functions primarily as a potent agonist of the proinflammatory P2Y14 receptor, playing a crucial role in modulating inflammation and neutrophil polarization. This compound is significant for research applications in understanding cellular responses to ischemia and reperfusion, particularly in myocardial infarction models. Additionally, it serves as a precursor for glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids, making it valuable for various biochemical studies. -
Stable Isotope
Prasugrel-13C6 is a stable isotope-labeled form of Prasugrel, a thienopyridine compound classified as a prodrug. It functions as a potent P2Y12 receptor antagonist, effectively inhibiting ADP-induced platelet aggregation, thereby reducing platelet activation and aggregation in cardiovascular settings. This reagent is valuable for research applications involving pharmacokinetics, metabolism studies, and mechanisms of platelet inhibition. -
Stable Isotope
Clopidogrel-13C,d3 sulfate is a stable isotope-labeled version of (±)-Clopidogrel bisulfate, primarily functioning as a platelet P2Y12 receptor inhibitor and ADP receptor antagonist. It inhibits the binding of adenosine diphosphate (ADP) to its receptors on platelet membranes, thereby blocking ADP-mediated activation of the GPIIb/IIIa complex. This compound demonstrates significant potential in reducing vascular inflammation and attenuating progression of angiotensin II-induced abdominal aortic aneurysms, in addition to exhibiting anti-inflammatory properties. It is utilized in various research applications focused on platelet aggregation and cardiovascular health. -
Stable Isotope
(±)-Clopidogrel-d4 is a deuterium-labeled derivative of (±)-Clopidogrel, a selective platelet P2Y12 receptor inhibitor and adenosine diphosphate (ADP) receptor antagonist. This compound effectively prevents ADP binding to platelet receptors, thereby inhibiting ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel-d4 is utilized in research related to vascular inflammation and the progression of conditions such as angiotensin II-induced abdominal aortic aneurysms, and it also exhibits notable anti-inflammatory properties. -
Stable Isotope
Prasugrel-d4 is a deuterated analog of Prasugrel, a thienopyridine compound that acts as a potent P2Y12 receptor antagonist. By inhibiting ADP-induced platelet aggregation, Prasugrel is utilized in various research applications related to cardiovascular diseases and thrombosis studies. The stable isotope labeling allows for advanced pharmacokinetic and metabolic investigations, facilitating deeper insights into the drug's mechanism of action and its effects on platelet function. -
Stable Isotope
Prasugrel-d5 is a deuterium-labeled variant of Prasugrel, a thienopyridine prodrug that functions as a potent inhibitor of platelet aggregation. By acting as an antagonist of the P2Y12 receptor, Prasugrel-d5 effectively inhibits ADP-induced platelet activation. This stable isotope can be used in pharmacokinetic studies and metabolic profiling to enhance understanding of drug metabolism and therapeutic effects in cardiovascular research. -
Stable Isotope
Clopidogrel-d3 hydrogen sulfate is a deuterated form of Clopidogrel hydrogen sulfate, primarily designed as a stable isotope for pharmacokinetic studies. This compound functions as a potent antiplatelet agent, preventing blood clot formation by inhibiting platelet aggregation induced by ADP. Clopidogrel-d3 hydrogen sulfate also selectively inhibits cytochrome P450 isoforms CYP2B6 and CYP2C19, with IC50 values of 18.2 nM and 524 nM, respectively. Its usage is instrumental in research involving antithrombotic therapies and drug metabolism. -
Stable Isotope
Uridine 5′-diphosphoglucose-13C disodium is a stable isotope-labeled form of Uridine 5′-diphosphoglucose (UDP-glucose). This compound functions as a potent agonist for the proinflammatory P2Y14 receptor, playing a critical role in modulating inflammation and the polarization of neutrophils. Additionally, UDP-glucose is a key precursor for the synthesis of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in both animal tissues and select microorganisms. It holds potential for research applications focused on mitigating inflammation associated with myocardial infarction and reperfusion injury in cardiac tissue. -
Stable Isotope
Ticagrelor-d4 is a deuterium-labeled derivative of Ticagrelor, functioning as a reversible oral P2Y12 receptor antagonist. This stable isotope is primarily utilized in pharmacokinetic and metabolic studies, providing a valuable tool for investigating pharmacodynamics and the pharmacological effects of Ticagrelor. Its application in research facilitates a deeper understanding of platelet aggregation mechanisms and the drug's therapeutic efficacy. -
Stable Isotope
(±)-Clopidogrel-d7 sulfate is a stable isotope-labeled derivative of (±)-Clopidogrel sulfate, featuring deuterium substitution. This compound serves as an important tool in pharmacokinetic studies and drug metabolism research, facilitating the investigation of clopidogrel's biotransformation and biological activity. Its isotopic labeling enables detailed analysis in mass spectrometry applications, providing insights into drug interactions and therapeutic efficacy. -
Stable Isotope
Rac-Fesoterodine-d14 fumarate is a stable isotope-labeled version of the racemic muscarinic receptor antagonist Fesoterodine. It exhibits competitive inhibition across multiple mAChR subtypes, with pKivalues of 8.0, 7.7, 7.4, 7.3, and 7.5 for M1, M2, M3, M4, and M5 receptors, respectively. This compound is primarily utilized in research applications focusing on the pharmacological characterization and monitoring of overactive bladder treatments. -
Stable Isotope
(R)-Oxybutynin-d10 is a deuterium-labeled derivative of (R)-Oxybutynin, a racemic isomer known for its role as a muscarinic receptor antagonist. This compound exhibits antispasmodic, antimuscarinic, and anticholinergic properties, effectively competing with carbachol-induced contractions. (R)-Oxybutynin-d10 is utilized in research related to urinary incontinence and neurogenic bladder dysfunction, facilitating the study of mechanisms underlying these conditions. -
Stable Isotope
Biperiden-d5 is a deuterium-labeled analog of Biperiden, a non-selective muscarinic receptor antagonist that primarily targets M1 muscarinic receptors. By competitively binding to these receptors, Biperiden-d5 inhibits acetylcholine signaling, which can enhance dopaminergic activity within the central nervous system. This stable isotope is valuable for research applications related to Parkinson's disease and associated neuropsychiatric disorders, providing insights into receptor interactions and signaling pathways. -
Stable Isotope
(1R,3S-)Solifenacin-d5 hydrochloride is a deuterated form of Solifenacin hydrochloride, a potent muscarinic receptor antagonist. It exhibits significant binding affinity with pKis of 7.6, 6.9, and 8.0 for M1, M2, and M3 receptors, respectively. This stable isotope is valuable for use in pharmacokinetic studies and metabolic research, facilitating the investigation of drug metabolism and receptor interactions. -
Stable Isotope
Flavoxate-d4 hydrochloride is a deuterated form of Flavoxate hydrochloride, acting as a muscarinic acetylcholine receptor antagonist. It is utilized in the study of urinary disorders and exhibits antispasmodic properties. This stable isotope is particularly useful in pharmacokinetic studies and metabolic research, enabling precise tracking and quantification of the compound in various biological systems. -
Stable Isotope
(R)-Hydroxytolterodine-d14 is a deuterated form of Desfesoterodine, a selective antagonist of muscarinic acetylcholine receptors (mAChRs). This compound exhibits high potency, with a KB value of 0.84 nM and a pA2 of 9.14. As a significant metabolite of Tolterodine and Fesoterodine, it has demonstrated efficacy in models of cerebral infarction-induced detrusor overactivity in rats, making it valuable for research in urology and neurology. -
Stable Isotope
Ethyl linolenate-d5 is the deuterium-labeled form of Ethyl linolenate, a fatty acid ethyl ester. This compound is known for its ability to inhibit melanin production, demonstrating an IC50 value of 70 μM. It is primarily utilized in research applications focused on melanogenesis and can serve as a valuable tool in studying pigmentation processes and related disorders. -
Stable Isotope
Ramelteon metabolite M-II-d3 is a deuterium-labeled derivative of the major metabolite M-II of Ramelteon, a selective agonist of melatonin receptors (MT1 and MT2). This reagent exhibits significant biological activity, with IC50 values of 208 pM and 1470 pM for human MT1 and MT2 receptors, respectively. It is primarily used in pharmacological studies and metabolic research involving melatonin signaling pathways. -
Stable Isotope
Ramelteon-d5 is a deuterated form of Ramelteon, a highly selective and potent agonist of the MT1 and MT2 melatonin receptors, exhibiting Ki values of 14 pM and 112 pM, respectively. This stable isotope is valuable for research studies focusing on insomnia and sleep disorders, as Ramelteon has demonstrated efficacy in reducing sleep onset during long-term treatment without leading to next-morning residual effects or withdrawal symptoms upon discontinuation. Researchers can utilize Ramelteon-d5 in pharmacokinetic and metabolic studies to gain insights into the compound's mechanism and therapeutic potential. -
Stable Isotope
Tasimelteon-d5 is a deuterium-labeled derivative of Tasimelteon, a selective dual melatonin receptor agonist targeting MT1 and MT2 receptors. This compound exhibits significantly higher affinity for the MT2 receptor, with an affinity range of 2.1-4.4 times greater than that for the MT1 receptor. Tasimelteon serves as a circadian regulator and is being investigated for its potential therapeutic applications in managing Non-24-Hour Sleep-Wake Disorder (Non-24). -
Stable Isotope
Ramelteon-d3 is a deuterium-labeled derivative of Ramelteon, a highly selective and orally active agonist of melatonin receptors MT1 and MT2, exhibiting Ki values of 14 pM and 112 pM, respectively. This stable isotope is utilized in pharmacokinetic studies and research applications focused on insomnia, providing insight into sleep modulation mechanisms. Ramelteon is known for its efficacy in reducing sleep onset without causing residual effects, rebound insomnia, or withdrawal symptoms with long-term use. -
Stable Isotope
O-Phospho-L-serine-13C3,15N is a stable isotope-labeled form of O-Phospho-L-serine, which serves as the immediate precursor to L-serine in the serine biosynthesis pathway. This compound functions as an agonist at group III metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7, and mGluR8) and exhibits weak antagonistic properties at mGluR1 while acting as a potent antagonist at mGluR2. Its unique isotopic labeling makes it valuable for metabolic and neurobiological research, particularly in studies involving neurotransmitter signaling and cellular metabolism. -
Stable Isotope
O-Phospho-L-serine-13C3 is a stable isotope-labeled form of O-Phospho-L-serine, serving as a valuable tool in metabolic studies. As an immediate precursor to L-cysteine in the serine synthesis pathway, it plays a critical role in amino acid metabolism. This compound also acts as an agonist for group III metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7, and mGluR8) while exhibiting weak antagonistic properties at mGluR1 and potent antagonism at mGluR2. Its isotopic labeling makes it suitable for tracing and quantifying metabolic pathways in research applications. -
Stable Isotope
Netupitant-d6 is a deuterated derivative of Netupitant, a highly potent and selective neurokinin-1 (NK1) receptor antagonist. This stable isotope is utilized in various biochemical and pharmacological studies to investigate the mechanisms of action and metabolic pathways of NK1 receptor inhibitors. Its application in research facilitates the analysis of drug behavior, distributions, and interactions within biological systems. -
Stable Isotope
Maropitant-d3 is a deuterium-labeled derivative of Maropitant, a selective neurokinin (NK1) receptor antagonist. This compound functions by inhibiting the binding of substance P in the emetic center and the chemoreceptor trigger zone (CRTZ), showcasing significant efficacy in the prevention of vomiting. Maropitant-d3 is valuable in chemical research requiring stable isotopes for the study of pharmacokinetics and metabolism of NK1 receptor antagonists. -
Stable Isotope
L-Tyrosine-13C,15N is a stable isotope-labeled version of L-Tyrosine, incorporating both carbon-13 and nitrogen-15 isotopes. L-Tyrosine is a non-essential amino acid that plays a critical role in protein synthesis and neurotransmitter production. This isotopic labeling is valuable for metabolic research and tracer studies, enabling the tracking of metabolic pathways and the investigation of amino acid dynamics in various biological systems. -
Stable Isotope
Hippuric acid-15N is a stable isotope-labeled form of hippuric acid, which is 2-benzamidoacetic acid. This compound is produced through the conjugation of benzoic acid and glycine and serves as a primary metabolite of aromatic compounds derived from dietary intake. Hippuric acid-15N is utilized in research applications such as metabolic profiling, tracer studies, and studies investigating the metabolism and excretion of aromatic substances. -
Stable Isotope
Tetradecanoylcarnitine-d9 is a deuterium-labeled derivative of Tetradecanoylcarnitine, a critical human metabolite that participates in the β-oxidation of long-chain fatty acids. This stable isotope is valuable for metabolic studies, allowing for precise tracing of lipid metabolism and fatty acid utilization in biological systems. Its application spans various research areas, including metabolic disorders and energy homeostasis. -
Stable Isotope
Methoxyacetic acid-d3 is a deuterated derivative of Methoxyacetic acid, primarily utilized as a stable isotope label in chemical research. It serves as a metabolite of ethylene glycol monomethyl ether and exhibits the capacity to inhibit respiratory functions in hepatic and testicular mitochondria at elevated concentrations. Its use in studies of mitochondrial dynamics, toxicology, and metabolic pathways provides valuable insights into cellular function and potential toxicity mechanisms. -
Stable Isotope
Glutaric acid-d2 is a stable isotope-labeled form of glutaric acid, a C5 dicarboxylic acid involved in the catabolism of lysine and tryptophan. This compound plays a significant role in biological processes, influencing pericyte contractility and migration. Glutaric acid-d2 serves as a valuable tool for research applications in metabolic studies and diagnostic assessments related to glutaric aciduria type I. -
Stable Isotope
Decanedioic acid-d16 is a deuterium-labeled derivative of decanedioic acid, a straight-chain dicarboxylic acid. This compound exhibits significant biological activity, particularly in the context of metabolic regulation, and has been shown to prevent and reverse metabolic-associated liver disease and obesity. Research applications include studies on metabolic inflexibility in type 2 diabetes, as well as investigations into conditions related to carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency. -
Stable Isotope
Estrone sulfate-d5 sodium is a deuterium-labeled derivative of estrone sulfate, serving as a stable isotope for metabolic studies. As an inactive endogenous estrogen, it can be converted into active forms, estrone and estradiol, through various biological processes. Estrone sulfate-d5 sodium acts as a substrate for the OATP1B3 transporter and is involved in mammary tumor growth in models of breast cancer. This compound is valuable for research into estrogen metabolism and its role in breast cancer pathophysiology. -
Stable Isotope
3-Hydroxybutyric acid-13C2 sodium is a stable isotope-labeled derivative of 3-Hydroxybutyric acid sodium. This metabolite has been shown to be elevated in type I diabetes and plays a crucial role in modulating the properties of membrane lipids. It is valuable for metabolic research, particularly in studies investigating diabetes mechanisms and lipid metabolism. -
Stable Isotope
Dodecanedioic Acid-13C12 is a stable isotope-labeled version of dodecanedioic acid, functioning as an alternative energy substrate in metabolic studies. This straight-chain dicarboxylic acid is known for its ability to enhance oxidation during physical exertion, thereby mitigating muscle fatigue without causing insulin secretion. Moreover, it demonstrates potential in lowering blood glucose levels in models of non-insulin-dependent diabetes mellitus, making it a valuable reagent for metabolic and diabetes research. -
Stable Isotope
N-Palmitoyl-D-sphingomyelin-13C is a stable isotope-labeled form of N-Palmitoyl-D-sphingomyelin. This compound plays a critical role in lipid nanoparticle synthesis, making it vital for research in drug delivery systems and nanomedicine. The incorporation of the deuterated label allows for precise tracking and analysis of sphingolipid dynamics in biological studies. -
Stable Isotope
1,4-Dimethoxybenzene-d10 is the deuterated form of 1,4-Dimethoxybenzene, a compound recognized as an endogenous metabolite. This stable isotope is utilized in various research applications, including metabolic studies and tracer experiments. It serves as a valuable tool for investigating metabolic pathways and enhancing the accuracy of analytical techniques in chemical research. -
Stable Isotope
D-Lyxose-13C-4 is a stable isotopically labeled form of D-Lyxose, an endogenous metabolite that serves as a rare pentose sugar. This compound plays a crucial role in the synthesis of various pharmaceutical agents, including anti-tumor drugs like alpha-galactose ceramide immunostimulants, and L-nucleoside analogs used for antiviral drug development. Furthermore, D-Lyxose can be employed as a synthetic intermediate for producing other rare sugars, such as L-ribose, enhancing its utility in chemical and biological research applications. -
Stable Isotope
Arabinose-d-1 is a deuterium-labeled form of arabinose, a naturally occurring sugar in metabolic pathways. This stable isotope is useful for tracer studies and metabolic research, allowing for precise tracking of metabolic processes in various biological systems. Its applications extend to investigating carbohydrate metabolism and the role of arabinose in cellular functions. -
Stable Isotope
Lignoceric acid-d9 is a deuterated derivative of lignoceric acid, a long-chain saturated fatty acid (Tetracosanoic acid) comprised of 24 carbon atoms. This stable isotope is prevalent in the developing brain and serves as a by-product of lignin metabolism. Lignoceric acid-d9 is primarily utilized in research focused on Zellweger cerebro-hepato-renal syndrome and adrenoleukodystrophy, aiding in the investigation of metabolic pathways and disease mechanisms associated with these conditions. -
Stable Isotope
1-Arachidoyl-sn-glycero-3-phosphocholine-d4 is a deuterium-labeled lysophospholipid, specifically 1-Arachidoyl-sn-glycero-3-phosphocholine. This stable isotope is utilized in various biochemical research applications, particularly in mass spectrometry and metabolic studies. Due to its labeled nature, it serves as an effective internal standard for analyzing lipid metabolism and profiling in complex biological samples. -
Stable Isotope
1,5-Anhydrosorbitol-13C is a stable isotope-labeled form of 1,5-Anhydrosorbitol, which serves as a short-term biomarker for glycemic control. This compound is utilized in metabolic studies and provides insight into carbohydrate metabolism and insulin sensitivity. Its isotopic labeling facilitates precise quantification and tracking in various biological research applications. -
Stable Isotope
Stearoylcarnitine-d3-1 hydrochloride is a deuterium-labeled derivative of stearoylcarnitine, a naturally occurring fatty ester lipid metabolite in humans. This compound is utilized as a stable isotope in metabolomics research, particularly as a biomarker for early-onset and late-onset preeclampsia. Its application in metabolic studies supports the understanding of lipid metabolism and related pathophysiological conditions.
