Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Clozapine-d4 is a deuterated derivative of Clozapine, an atypical antipsychotic primarily utilized in schizophrenia research. This stable isotope allows for advanced pharmacokinetic studies and the evaluation of metabolic pathways. Clozapine exhibits a high affinity for multiple neuroreceptors, making Clozapine-d4 valuable for investigating receptor interactions and drug metabolism in preclinical studies. -
Stable Isotope
Chlorpromazine-d6 hydrochloride is a deuterated derivative of Chlorpromazine, primarily functioning as a dopamine receptor antagonist. This stable isotope is utilized in biochemical and pharmacological research to explore the interactions and mechanisms of action of antipsychotic agents. Its ability to inhibit serotonin receptors, potassium channels, and sodium channels makes it valuable for studying neuropharmacology and drug metabolism. -
Stable Isotope
Brexpiprazole-d8 is a deuterium-labeled derivative of Brexpiprazole, an atypical antipsychotic agent. Acting primarily as a partial agonist at the human 5-HT1A and dopamine D2L receptors, it exhibits Ki values of 0.12 nM and 0.3 nM, respectively. Additionally, Brexpiprazole functions as a 5-HT2A receptor antagonist with a Ki of 0.47 nM and exhibits significant antagonistic activity at noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM). This reagent is suitable for various research applications including pharmacological studies and mechanism of action investigations. -
Stable Isotope
Ondansetron-d5 is a deuterium-labeled analog of Ondansetron, a highly selective antagonist of the 5-HT3 receptor with an IC50 value of 103 pM. It functions by blocking 5-HT3 receptors in neurons within both the peripheral and central nervous systems, thereby effectively reducing nausea and vomiting associated with chemotherapy and radiotherapy. Ondansetron-d5 is valuable for research involving pharmacokinetic studies and metabolic profiling of Ondansetron. -
Stable Isotope
Brexpiprazole-d8-1 is a stable isotope-labeled form of Brexpiprazole, an atypical antipsychotic agent. It functions as a partial agonist at the human 5-HT1A and dopamine D2L receptors, exhibiting affinities (Ki values) of 0.12 nM and 0.3 nM, respectively. Additionally, it acts as an antagonist at the 5-HT2A receptor with a Ki of 0.47 nM, and demonstrates potent antagonistic activity at noradrenergic α1B and α2C receptors with Ki values of 0.17 nM and 0.59 nM, respectively. This compound is suited for studies involving neuropharmacology and receptor interaction analysis. -
Stable Isotope
Trazodone-d6 hydrochloride is a deuterated form of Trazodone hydrochloride, serving as a stable isotope reagent. This compound is utilized in pharmacokinetic studies, particularly for the quantification of Trazodone in biological samples through mass spectrometry. It aids in understanding the metabolic pathways and pharmacological profiles of Trazodone in clinical research settings. -
Stable Isotope
Risperidone-d4 is a deuterated analog of Risperidone, functioning primarily as a serotonin 5-HT2 receptor antagonist and dopamine D2 receptor antagonist. It is characterized by its inhibitory effects on P-Glycoprotein, with binding affinities (Kis) of 4.8 nM for the 5-HT2A receptor and 5.9 nM for the dopamine D2 receptor. This stable isotope is valuable for pharmacokinetic studies, metabolic profiling, and tracing mechanisms in neurological research applications. -
Stable Isotope
Brexpiprazole S-oxide-d8 is a deuterium-labeled analog of Brexpiprazole S-oxide, the primary metabolite of the atypical antipsychotic Brexpiprazole. This compound acts as a partial agonist at human 5-HT1A and dopamine receptors, with inhibition constants (Kis) of 0.12 nM and 0.3 nM, respectively. Additionally, it functions as an antagonist at the 5-HT2A receptor, exhibiting a Ki of 0.47 nM. Brexpiprazole S-oxide-d8 is valuable for pharmacokinetic studies and metabolic profiling in research applications focused on psychiatric disorders. -
Stable Isotope
Ondansetron-d3 hydrochloride is a deuterium-labeled analog of Ondansetron hydrochloride, a potent antagonist of the serotonin 5-HT3 receptor. This stable isotope is primarily utilized in research applications involving pharmacokinetics and metabolic studies of Ondansetron. Its unique labeling enables precise tracking in biological systems, facilitating the investigation of its antiemetic properties, particularly in the context of chemotherapy-induced nausea and vomiting. -
Stable Isotope
Volinanserin-d4 hydrochloride is a deuterated analog of Volinanserin, a potent and selective antagonist of the 5-HT2 receptor, exhibiting a Ki value of 0.36 nM. This compound demonstrates significant selectivity, being 300-fold more potent at the 5-HT2 receptor compared to 5-HT1c, alpha-1, and DA D2 receptors. Volinanserin is primarily utilized in research focused on antipsychotic activity and the modulation of serotonergic signaling pathways. -
Stable Isotope
Clozapine-d8 is a stable isotope-labeled analog of Clozapine, an antipsychotic agent primarily utilized in schizophrenia research. This compound exhibits a high affinity for various neuroreceptors, making it valuable for studies investigating the pharmacodynamics and pharmacokinetics of antipsychotic therapies. Its deuterium labeling enables more precise analytical techniques in metabolic and binding studies. -
Stable Isotope
Aripiprazole-d8 is the deuterium-labeled variant of Aripiprazole, primarily known for its activity as a partial agonist at the human 5-HT1A receptor with a Ki of 4.2 nM. This stable isotope is utilized in research applications requiring precise quantification and tracing of Aripiprazole in biological systems. It facilitates studies on the pharmacokinetics, metabolism, and biological interactions of the compound. -
Stable Isotope
Norfluoxetine-d5 hydrochloride is a deuterated derivative of 3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine. This stable isotope-labeled compound serves as a valuable tool for pharmacokinetic studies and metabolic research, enabling precise tracking and analysis of drug interactions and dynamics. Its incorporation in experimental designs aids in the elucidation of the mechanisms underlying fluoxetine metabolism and pharmacology. -
Stable Isotope
Urapidil-d3 is a deuterium-labeled derivative of Urapidil, functioning primarily as an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist. This stable isotope is valuable in studying drug metabolism, distribution, and pharmacokinetics, providing insights into the bioactivity of Urapidil in various biological systems. Researchers can utilize Urapidil-d3 to enhance the understanding of cardiovascular and neuropharmacological effects associated with this compound. -
Stable Isotope
Agomelatine-d3 is a deuterium-labeled derivative of Agomelatine, which primarily targets MT1 and MT2 melatonin receptors, demonstrating high affinity with Ki values of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2 cells, respectively. Additionally, Agomelatine acts as a selective antagonist of the 5-HT2C receptor with pKi values of 6.4 and 6.2 for native porcine and cloned human receptors, respectively. This stable isotope compound is valuable for pharmacokinetic studies and metabolic research involving melatonergic modulation and serotonin receptor interactions. -
Stable Isotope
Sumatriptan-d6 succinate is a deuterated form of Sumatriptan succinate, functioning as an orally active agonist of the 5-HT1 receptor family. With inhibition constants (Kis) of 17 nM, 27 nM, and 100 nM for the 5-HT1D, 5-HT1B, and 5-HT1A receptors, respectively, this compound is primarily utilized in research focused on migraine headaches. Its stable isotope labeling enables advanced studies in pharmacokinetics and metabolism. -
Isotope-Labeled Compounds
5-Methoxytryptamine-d4 is a deuterium-labeled derivative of 5-Methoxytryptamine, functioning as a nonselective agonist of 5-HT receptors while showing no affinity for the 5-HT3 receptor. This compound exhibits significant antioxidant properties and offers radioprotective effects. It is valuable for research applications in neurotransmitter signaling, oxidative stress studies, and the exploration of melatonin metabolism. -
Stable Isotope
Quetiapine hemifumarate-d8 is a deuterated form of Quetiapine hemifumarate, primarily acting as an antagonist at dopamine D2 receptors and an agonist at 5-HT1A receptors. It exhibits moderate to high affinity for multiple serotonin receptors, including 5-HT2A and 5-HT2C, making it a valuable tool for studying neurochemical pathways involved in mood regulation. This stable isotope is useful in pharmacokinetic studies, aiding in the understanding of Quetiapine's pharmacodynamics and therapeutic effects related to its antidepressant and anxiolytic properties. -
Stable Isotope
Psychosine-d5 is a deuterium-labeled analog of Psychosine, a substrate for the galactocerebrosidase (GALC) enzyme. This stable isotope serves as a potential biomarker for Krabbe disease and is utilized in research to study the disease's pathophysiology. As a highly cytotoxic lipid, Psychosine can induce cell death across various cell types, making Psychosine-d5 valuable for investigations into cell toxicity and lipid metabolism. -
Stable Isotope
Ruboxistaurin-d6 hydrochloride is a deuterated form of Ruboxistaurin hydrochloride, a selective inhibitor of protein kinase C (PKC) beta. Exhibiting ATP-dependent competitive inhibition, it demonstrates significant potency with a Ki of 2 nM and an IC50 of 4.7 nM for PKC beta I and 5.9 nM for PKC beta II. This stable isotope is valuable for research applications involving metabolic tracing, pharmacokinetics, and the study of PKC-related cellular signaling pathways. -
Stable Isotope
1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol is a deuterium-labeled derivative of 1-Stearoyl-2-arachidonoyl-sn-glycerol, a diacylglycerol (DAG) that includes polyunsaturated fatty acids. This compound is known to activate protein kinase C (PKC) and enhance the activity of nonselective cation channels (NSCC). It serves as a valuable tool for studying lipid signaling pathways and the regulation of cellular processes in various research applications. -
Stable Isotope
Psychosine-d7 is a deuterium-labeled analog of psychosine, serving as a stable isotope for research applications. Psychosine acts as a substrate for the galactocerebrosidase (GALC) enzyme and is identified as a potential biomarker for Krabbe disease. This lipid is known for its high cytotoxicity, inducing apoptosis across various cell types, making it valuable for studies related to neurodegenerative disorders and cellular stress responses. -
Stable Isotope
Stearoyl-L-carnitine-d9 chloride is a deuterated analogue of Stearoyl-L-carnitine chloride, classified as a stable isotope. It serves as a valuable tool in metabolic studies, particularly in understanding lipid metabolism and energy deficiency in type 2 diabetes models. This compound is known to inhibit protein kinase C (PKC) and lecithin cholesterol acyltransferase (LCAT), while also acting as a metabolomic biomarker for Parkinson's disease. Additionally, it demonstrates reduced potency as an inhibitor of GlyT2, providing insights into neurotransmitter dynamics. -
Stable Isotope
Stearoyl-L-carnitine-d3 is a deuterated form of Stearoylcarnitine, functioning primarily as a stable isotope for research applications. This fatty ester lipid is an endogenous metabolite, known to inhibit protein kinase C (PKC) and accumulate in pancreatic β cells, resulting in impaired insulin synthesis and energy deficiency in type 2 diabetes models. Additionally, Stearoyl-L-carnitine-d3 inhibits lecithin cholesterol acyltransferase (LCAT) in animal plasma and serves as a potential metabolomics biomarker for Parkinson’s disease, further expanding its utility in metabolic research. -
Stable Isotope
(±)-1,2-Diolein-CC3 is a stable isotope-labeled derivative of (±)-1,2-Diolein, also known as 1,2-Dioleoyl-rac-glycerol-13C3. This compound acts as an activator of protein kinase C (PKC) and is known to enhance calcium ion influx in myotubes. It is particularly useful in research applications studying lipid signaling pathways, cell proliferation, and muscle physiology. -
Stable Isotope
2-Deoxyuridine-1,2,3,4,5-13C5 is a stable isotope-labeled form of 2'-Deoxyuridine, a naturally occurring pyrimidine nucleotide. This compound plays a crucial role in nucleotide metabolism and is linked to various neurological disorders. Notably, 2'-Deoxyuridine has been shown to enhance chromosome breakage and reduce thymidylate synthase activity. It also demonstrates neuroprotective effects by decreasing microglial activation and alleviating oxidative stress in models of Alzheimer's disease, making it a valuable tool for research in neurodegeneration and related fields. -
Stable Isotope
Methotrexate metabolite-d3 is a deuterium-labeled form of the active Methotrexate metabolite known as DAMPA. This compound serves as a folic acid antagonist, playing a crucial role in inhibiting dihydrofolate reductase, which is critical for nucleotide synthesis. Methotrexate metabolite-d3 is utilized in various research applications, including pharmacokinetic studies and metabolic profiling, to better understand the dynamics of Methotrexate metabolism and its therapeutic effects. -
Stable Isotope
Gartisertib-d8 is a deuterated analog of Gartisertib, serving as a stable isotope labeled compound. As an ATP-competitive and selective inhibitor of ATR, Gartisertib exhibits a high binding affinity with a Ki of less than 150 pM. It effectively inhibits ATR-mediated phosphorylation of checkpoint kinase 1 (Chk1) with an IC50 of 8 nM, demonstrating significant antitumor activity. This reagent is suitable for research applications in cancer biology, particularly in studies focusing on DNA damage response and checkpoint regulation. -
Stable Isotope
Abemaciclib-d8 is a deuterium-labeled version of Abemaciclib, a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). It exhibits potent inhibition with IC50 values of 2 nM for CDK4 and 10 nM for CDK6. This stable isotope is useful in pharmacokinetic studies and metabolic research, allowing for detailed analysis of drug behavior in biological systems. -
Stable Isotope
Palbociclib-d8 is a deuterated form of Palbociclib, a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4 and CDK6), showing IC50 values of 11 nM and 16 nM, respectively. This isotopically labeled compound allows for detailed pharmacokinetic studies and metabolic profiling. Palbociclib-d8 is particularly relevant in research on ER-positive and HER2-negative breast cancer, facilitating investigations into its mechanisms of action and therapeutic efficacy. -
Stable Isotope
Ribociclib-d8 is a deuterated form of Ribociclib, a selective inhibitor of CDK4 and CDK6. It demonstrates potent inhibitory activity with IC50 values of 10 nM for CDK4 and 39 nM for CDK6, while exhibiting over a 1,000-fold reduced potency against the cyclin B/CDK1 complex. This stable isotope-labeled compound is ideal for applications in pharmacokinetic studies, drug metabolism research, and metabolic profiling. -
Stable Isotope
Ribociclib-d6 is a deuterium-labeled derivative of Ribociclib, a highly selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). It exhibits potent inhibitory activity with IC50 values of 10 nM and 39 nM for CDK4 and CDK6, respectively, while demonstrating over 1,000-fold reduced potency against the cyclin B/CDK1 complex. Ribociclib-d6 serves as a valuable tool for studying CDK4/6 dynamics and evaluating the pharmacokinetics of Ribociclib in chemical biology research and therapeutic applications in cancer treatment. -
Stable Isotope
CDK2-IN-14-d3 is a stable isotope-labeled inhibitor targeting Cyclin-Dependent Kinase 2 (CDK2). This compound exhibits potent and selective inhibition of CDK2, making it a valuable tool in cancer research. It is suitable for studies investigating cell cycle regulation and therapeutic strategies for CDK2-related malignancies. -
Stable Isotope
Palbociclib-d4 is a stable isotope-labeled form of Palbociclib, a selective inhibitor of CDK4 and CDK6, demonstrating IC50 values of 11 and 16 nM respectively. This compound exhibits strong anti-proliferative effects and effectively induces cell cycle arrest in cancer cells. Palbociclib-d4 is primarily utilized in research related to hormone receptor-positive and HER2-negative breast cancer, as well as hepatocellular carcinoma studies. -
Stable Isotope
EthD-d5 bromide is a deuterium-labeled variant of Ethidium bromide, serving as a stable isotope. It acts as an intercalating agent and is widely utilized as a fluorescent nucleic acid stain in molecular biology applications, including agarose gel electrophoresis. This reagent facilitates the visualization and analysis of nucleic acids, enhancing the accuracy of molecular assays. -
Stable Isotope
Fluphenazine-d8 is a deuterium-labeled derivative of fluphenazine, functioning primarily as a dopamine receptor antagonist. It effectively inhibits postsynaptic dopamine-2 receptors in key neural pathways, including the mesolimbic, nigrostriatal, and tuberoinfundibular systems. This reagent is valuable in research areas such as psychosis and diabetic peripheral neuropathy, and it has shown potential in studies related to SARS-CoV-2 inhibition. Fluphenazine-d8 serves as a useful tool for elucidating the pharmacodynamics of dopaminergic activity and its downstream effects. -
Stable Isotope
FOY 251-d4 is a deuterium-labeled derivative of FOY 251, a potent proteinase inhibitor and active metabolite of Camostate. It effectively inhibits SARS-CoV-2 infection in cellular assays, making it a valuable tool for studying viral entry and proteolytic processes. FOY 251-d4 serves as a stable isotope research reagent for exploring protein interactions and mechanisms within virology and pharmacology. -
Stable Isotope
Nirmatrelvir-d6 is a deuterated form of Nirmatrelvir, a potent inhibitor of the SARS-CoV 3C-like protease (3CLPRO). This stable isotope is designed for use in research applications related to COVID-19, allowing researchers to study the pharmacokinetics and metabolic pathways of the original compound. By utilizing Nirmatrelvir-d6, scientists can gain insights into the effects of 3CLPRO inhibition on SARS-CoV-2, contributing to the development of therapeutic strategies against this virus. -
Stable Isotope
DL-Serine-2,3,3-d3 is a stable isotope-labeled form of DL-Serine, a crucial metabolite consisting of both D-Serine and L-Serine. This compound serves as a valuable tool for metabolic and pharmacological studies, particularly in understanding serine metabolism. Additionally, DL-Serine exhibits antiviral activity against the replication of tobacco mosaic virus (TMV), making it relevant for virology research. -
Stable Isotope
L-Lysine-13C6,15N2 hydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine. This compound serves as a valuable tool in metabolic research and tracer studies, allowing for the examination of amino acid metabolism and kinetics in biological systems. Its applications extend to understanding lysine's role in physiological processes, including calcium absorption and gut health. -
Stable Isotope
L-Lysine-d4 hydrochloride is a deuterium-labeled analog of the essential amino acid L-Lysine, which plays a crucial role in protein synthesis and metabolic functions. As a stable isotope, it serves as a valuable tracer in metabolic studies, particularly in amino acid metabolism and kinetics. Research applications include studying the pharmacokinetics of lysine-related compounds and its implications in health conditions such as herpes treatment and calcium absorption enhancement. -
Stable Isotope
Phenytoin-d10 is a deuterium-labeled derivative of Phenytoin, primarily targeting voltage-gated sodium channels (VGSCs). This compound exhibits significant antiepileptic activity and has been shown to inhibit breast tumor growth and metastasis in murine models. Phenytoin-d10 serves as a valuable tool for research involving drug metabolism, pharmacokinetics, and the investigation of sodium channel function in various biological contexts. -
Stable Isotope
L-Lysine-13C6 dihydrochloride is a stable isotope-labeled derivative of the essential amino acid L-Lysine. This compound plays a crucial role in various biological processes, including the synthesis of connective tissues and carnitine, as well as energy production and immune function. Its applications extend to metabolic studies, isotopic labeling experiments, and research focusing on amino acid metabolism and physiological functions in both human and animal systems. -
Stable Isotope
L-Lysine-13C6 hydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine, targeting metabolic and biological research applications. This compound plays a critical role in protein synthesis, cellular function, and is involved in various physiological processes. Its isotopic labeling allows for precise tracing in metabolic studies, making it a valuable tool for researchers investigating amino acid utilization, metabolism, and related health effects. -
Stable Isotope
L-Lysine-15N2 hydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine, which plays a crucial role in protein synthesis and metabolic processes. This reagent is valuable in biochemical research, particularly in the study of amino acid metabolism, nutritional biochemistry, and the tracking of metabolic pathways using stable isotope labeling techniques. Its applications extend to research on nutritional deficiencies, disease states, and the physiological impacts of lysine supplementation. -
Stable Isotope
L-Lysine-d8 hydrochloride is a stable isotope of the essential amino acid L-lysine. This compound serves as a valuable tool in biochemical and metabolic research applications, particularly in studies involving protein metabolism and amino acid tracking. The deuterium labeling facilitates precise quantification and tracing in various experimental settings, enhancing understanding of metabolic pathways and physiological effects associated with L-lysine supplementation. -
Stable Isotope
L-Lysine-d9 hydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine. This compound serves as a valuable tool in metabolic studies and isotopic tracing applications. Its role in various biological processes makes it relevant for research related to amino acid metabolism, dietary interventions, and the physiological effects of lysine supplementation in health and disease contexts. -
Stable Isotope
L-Lysine-d3 hydrochloride is a deuterated form of the essential amino acid L-Lysine, which primarily functions as a stable isotope. This compound plays a crucial role in various biological processes, including the synthesis of connective tissues and carnitine, energy metabolism, and supporting immune functions. It is widely utilized in metabolic studies and tracer experiments, facilitating research in nutrition, developmental biology, and related fields. -
Stable Isotope
L-Lysine-13C dihydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine. This compound serves as a valuable tracer in metabolic studies and is significant for research involving amino acid metabolism, cellular transport, and protein synthesis. Its applications include investigating lysine's role in various biological processes and exploring therapeutic potentials for conditions such as herpes, calcium absorption, and diabetes-related disorders. -
Stable Isotope
N-Desmethylclozapine-d8 is a deuterium-labeled analogue of N-Desmethylclozapine, a significant active metabolite of the atypical antipsychotic clozapine. This compound serves as a potent partial agonist at M1 receptors (EC50 = 115 nM), effectively enhancing hippocampal NMDA receptor currents through M1 receptor activation. Additionally, it functions as a δ-opioid agonist, making it a valuable tool for research into neuropharmacology and the mechanisms underlying psychiatric disorders.
