Atovaquone-d5 is a deuterium-labeled derivative of Atovaquone, a selective and orally active inhibitor targeting the mitochondrial cytochrome bc1 complex in parasites. It exhibits significant inhibitory activity against human cytochrome bc1 with an IC50 of 460 nM and against Plasmodium falciparum with an IC50 of 2.0 nM. This reagent is essential for studying the mechanisms of action in antimalarial therapies and has applications in investigating conditions such as pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.
Atovaquone-d5 is a deuterium-labeled derivative of Atovaquone, a selective and orally active inhibitor targeting the mitochondrial cytochrome bc1 complex in parasites. It exhibits significant inhibitory activity against human cytochrome bc1 with an IC50 of 460 nM and against Plasmodium falciparum with an IC50 of 2.0 nM. This reagent is essential for studying the mechanisms of action in antimalarial therapies and has applications in investigating conditions such as pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.
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