Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
L-Tryptophan-d5 is a deuterium-labeled form of the essential amino acid L-Tryptophan, which serves as a key precursor for the neurotransmitter serotonin, the hormone melatonin, and vitamin B3. This stable isotope is valuable for metabolic studies, tracer experiments, and research in neurochemistry. Its unique labeling allows for precise tracking of L-Tryptophan pathways and metabolism in biological systems. -
Stable Isotope
L-Leucine-d3 is a deuterium-labeled form of the essential branched-chain amino acid (BCAA) L-Leucine. This stable isotope is primarily utilized in metabolic studies to trace amino acid metabolism and protein synthesis. L-Leucine plays a crucial role in activating the mTOR signaling pathway, making L-Leucine-d3 valuable for research applications in nutrition, muscle physiology, and metabolic disorders. -
Stable Isotope
Cholic acid-d4 is a deuterium-labeled derivative of cholic acid, a principal primary bile acid synthesized in the liver. This stable isotope is crucial for metabolic studies involving bile acids, particularly in tracing pathways of fat absorption and cholesterol excretion. It serves as a valuable tool in biochemical research to investigate the roles of bile acids in digestion and lipid metabolism. -
Stable Isotope
Cholesterol-d7 is a deuterium-labeled form of cholesterol, a vital sterol in mammalian biology. It constitutes 20-25% of the plasma membrane's structural components, influencing membrane fluidity, permeability, and the functioning of transporters and signaling proteins. Additionally, cholesterol serves as an endogenous agonist for estrogen-related receptor α (ERRα). Cholesterol-d7 is particularly useful in metabolic studies, lipid trafficking investigations, and the exploration of cholesterol's role in cellular signaling pathways. -
Stable Isotope
2-Ketoglutaric acid-13C5 is a stable isotope-labeled form of 2-Ketoglutaric acid, an essential intermediate in the Krebs cycle responsible for ATP and GTP synthesis. This compound plays a vital role in nitrogen assimilation, serving as a key carbon skeleton in related biochemical processes. Additionally, 2-Ketoglutaric acid functions as a reversible inhibitor of tyrosinase, demonstrating potential applications in metabolic studies and enzyme inhibition research. -
Stable Isotope
Creatine-d3 is a deuterated form of creatine, which serves as a stable isotope. Creatine is an endogenous compound that plays a crucial role in cellular energy metabolism, particularly in muscle and brain tissues. This reagent is widely utilized in metabolic studies, tracing energy pathways, and understanding creatine's role in physiological processes. -
Stable Isotope
3-Indoleacetic acid-d5 is a deuterium-labeled variant of 3-Indoleacetic acid, serving as a stable isotope internal standard. This reagent is utilized to accurately measure indole-3-acetic acid (IAA) release from ester and amide conjugates via alkaline hydrolysis. It is particularly valuable in studies assessing plant hormone dynamics and metabolism. -
Stable Isotope
L-Tryptophan-13C11 is a stable isotope of the essential amino acid L-Tryptophan, which serves as a precursor for key biomolecules, including serotonin, melatonin, and vitamin B3. This isotope-labeled compound is valuable for metabolic studies and tracking biological processes involving Tryptophan metabolism. Its use in research contributes to understanding neurological functions, sleep regulation, and nutritional biochemistry. -
Stable Isotope
Creatinine-d3 is a deuterium-labeled stable isotope of creatinine. This compound serves as a valuable tracer in metabolic studies and is utilized in various biochemical assays to measure renal function. Its unique isotopic signature allows for precise quantification of creatinine levels in biological samples, facilitating research in fields such as nephrology and exercise physiology. -
Stable Isotope
L-Serine-13C3 is a stable isotope-labeled form of L-Serine, a non-essential amino acid critical for cellular proliferation. This compound is utilized in metabolic studies to trace amino acid pathways, investigate protein synthesis, and analyze metabolic flux. Its incorporation in research provides insights into various biological processes, including growth, development, and neurological functions. -
Stable Isotope
Myristic acid-d27 is a deuterium-labeled derivative of myristic acid, a saturated 14-carbon fatty acid found abundantly in various animal and plant fats, including butterfat and oils from coconut, palm, and nutmeg. This stable isotope is primarily used in metabolic studies and tracer experiments, providing insights into fatty acid metabolism and distribution in biological systems. Its incorporation into biological samples aids in the analysis of lipid metabolism pathways and the evaluation of fatty acid profiles in research applications. -
Stable Isotope
L-Leucine-13C is a stable isotope-labeled form of L-Leucine, an essential branched-chain amino acid (BCAA) that plays a critical role in protein synthesis and metabolism. This compound activates the mTOR signaling pathway, which is pivotal for cell growth and proliferation. L-Leucine-13C is valuable in metabolic studies, particularly in understanding amino acid metabolism and protein turnover in various biological systems. -
Stable Isotope
DL-Homocysteine-d4 is a deuterium-labeled analog of DL-Homocysteine, primarily utilized as a stable isotope for quantitative analyses. As a weak neurotoxin, DL-Homocysteine influences the synthesis of kynurenic acid in the central nervous system. This compound is essential for research focused on neurotoxicity, metabolic pathways, and the study of neurological disorders where kynurenine metabolism is implicated. -
Stable Isotope
D-Fructose-13C6 is a stable isotope-labeled form of D-Fructose, a naturally occurring monosaccharide present in numerous plants. This isotopically enriched compound serves as a valuable tool in metabolic and nutritional studies, allowing researchers to trace fructose metabolism and its incorporation into various biochemical pathways. D-Fructose-13C6 can be utilized in diverse applications, including isotopic labeling, tracer studies, and the investigation of carbohydrate metabolism. -
Stable Isotope
Linoleic acid-13C18 is a stable isotope-labeled form of linoleic acid, a polyunsaturated fatty acid (PUFA) prevalent in various plant-based oils, nuts, and seeds. It plays a crucial role as a structural component of membrane phospholipids, contributing to membrane fluidity in cellular barriers, particularly within the epidermis. This compound is invaluable for research involving metabolic studies, biomarker analysis, and oxidative stress responses, as it also exhibits the capacity to induce oxidative damage in red blood cells and hemoglobin. -
Stable Isotope
L-Methionine-13C5 is a stable isotope-labeled form of L-Methionine, the L-isomer of the essential amino acid methionine. This compound functions as a hepatoprotectant and is crucial for human development and metabolism. L-Methionine-13C5 is commonly utilized in metabolic studies and tracing experiments, providing insights into amino acid metabolism and cellular function. -
Stable Isotope
L-Cysteine-13C3,15N is a stable isotope-labeled form of the conditionally essential amino acid L-Cysteine, incorporating carbon-13 and nitrogen-15 isotopes. This compound serves as a precursor for several biologically active molecules, including hydrogen sulfide (H2S), glutathione, and taurine. L-Cysteine is also involved in metabolic studies related to appetite regulation, having shown the ability to suppress ghrelin levels and reduce appetite in both rodent and human models, making it valuable for research in nutrition and metabolic disorders. -
Stable Isotope
Succinic acid-13C4 is a stable isotope-labeled form of succinic acid, serving as a key intermediate in the tricarboxylic acid cycle. It is utilized in various research applications, including metabolic studies and tracing pathways within biochemical processes. Furthermore, succinic acid has demonstrated anxiolytic properties and can act as a precursor for the synthesis of numerous chemicals in the food, chemical, and pharmaceutical sectors. -
Stable Isotope
L-Alanine-d4 is a deuterated form of the non-essential amino acid L-Alanine. This stable isotope is utilized in metabolic studies, providing insights into amino acid metabolism and its role in energy production, immunity enhancement, and support of muscle and central nervous system function. L-Alanine-d4 serves as a valuable tool in tracer studies and various biochemical applications. -
Stable Isotope
Succinic acid-d4 is a deuterated form of succinic acid, serving as a valuable stable isotope for research applications. As an intermediate in the tricarboxylic acid cycle and a product of anaerobic metabolism, succinic acid plays a vital role in cellular respiration and metabolic pathways. This isotope-labeled reagent is useful for studies involving metabolic tracing and isotope labeling, enabling enhanced analysis of metabolic processes in various biological systems. -
Stable Isotope
L-Methionine-d3 is the deuterated form of the essential amino acid L-Methionine. This stable isotope serves as a valuable tool in metabolic studies, allowing researchers to trace amino acid metabolism and protein turnover in biological systems. L-Methionine plays a critical role in cellular functions, including acting as a hepatoprotectant, making this reagent particularly useful in investigations of liver health and oxidative stress responses. Applications include tracer studies in nutrition, biochemistry, and pharmacology research. -
Stable Isotope
Phenylacetylglutamine-d5 is a stable isotope-labeled derivative of Phenylacetylglutamine, a metabolite produced from the fermentation of amino acids by colonic microbiota. This compound serves as a valuable tracer in metabolic studies and offers insights into gut microbiome interactions and metabolic pathways. The deuterium labeling enhances detection and quantification in various analytical techniques, facilitating research in microbiome-related diseases and nutrient absorption. -
Stable Isotope
Arachidonic acid-d8 is a deuterium-labeled form of arachidonic acid, a crucial polyunsaturated fatty acid that plays a key role in cellular membranes and signaling. This stable isotope is widely used in metabolic studies and lipid research to trace fatty acid metabolism and elucidate biological pathways. Its incorporation in experimental designs can enhance the understanding of lipid biochemistry and related physiological processes. -
Stable Isotope
SDMA-d6 is a deuterium-labeled form of symmetric dimethylarginine (SDMA), a recognized endogenous inhibitor of nitric oxide (NO) synthase. This stable isotope reagent is instrumental in research investigating nitric oxide signaling pathways and the role of SDMA in various physiological and pathological conditions. Its use facilitates precise quantification in metabolic studies and helps unravel the complexities of nitric oxide-related mechanisms. -
Stable Isotope
L-Ornithine-d7 hydrochloride is a deuterium-labeled derivative of L-Ornithine hydrochloride. This stable isotope serves as a valuable tracer in metabolic studies and is crucial in the urea cycle, facilitating the excretion of excess nitrogen. Its unique isotopic composition enables precise quantification in various biological and biochemical research applications. -
Stable Isotope
D-Glucose-13C is a stable isotope-labeled form of D-Glucose, a key monosaccharide in biological systems. It plays a vital role in metabolism, serving as an energy source and a critical component in various biochemical pathways. D-Glucose also functions as a signaling molecule, influencing cellular responses to metabolic changes and environmental stressors. This reagent is commonly used in metabolic studies and isotopic labeling experiments to trace carbon flow in biological systems. -
Stable Isotope
MeIQx-13C, a stable isotope of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, serves as a valuable tool for investigating the metabolic pathways and biological effects of MeIQx. This mutagenic compound, commonly found in fried beef and beef extracts, has been shown to covalently bind to hemoglobin and is implicated in the induction of liver tumors. MeIQx-13C is particularly useful for studying the mechanisms of mutagenesis and carcinogenesis in dietary substances. -
Stable Isotope
Mephenytoin-13C,d3 is a stable isotope labeled form of Mephenytoin, an anticonvulsant agent that primarily acts as a substrate for the cytochrome P450 enzymes CYP2C19 and CYP2B6. This deuterated compound is essential for pharmacokinetic studies, metabolic profiling, and research investigating drug interactions. Its incorporation into experiments aids in the elucidation of drug metabolism and therapeutic efficacy in neurological disorders. -
Stable Isotope
Mephenytoin-d3 is a stable isotope-labeled form of racemic Mephenytoin, an anticonvulsant agent. As a substrate of cytochrome P450 enzymes CYP2C19 and CYP2B6, it serves as an essential tool for pharmacokinetic studies and metabolic profiling in drug metabolism research. This compound is particularly useful for studying drug interactions and enzyme activity in various biological systems. -
Stable Isotope
Veratrole-d2-1 is a deuterium-labeled derivative of Veratrole (1,2-Dimethoxybenzene), a naturally occurring compound found in various plant species. It demonstrates key biological activities related to plant reproduction, species differentiation, and pollinator attraction, exhibiting a circadian release pattern. This compound is also relevant for research into metabolic processes, as Veratrole can undergo demethylation by cytochrome P-450 enzymes in Streptomyces setonii, making it useful in studies of enzymatic activity and plant-pollinator interactions. -
Stable Isotope
MCPA-d3 is a deuterated derivative of MCPA, a phenoxyacetic acid herbicide that exhibits activity through the disruption of membrane integrity, reduction of ATP levels, and imbalance of redox status in plant cells. This stable isotope can enhance studies on herbicide effects by providing a means to trace metabolic pathways involving MCPA. Additionally, MCPA has been shown to elevate hepatic cytochrome P-450 levels, thereby increasing the activity of enzymes such as aniline hydroxylase and 7-ethoxycoumarin O-deethylase. It is widely utilized in research focused on weed control mechanisms and herbicide impact assessments. -
Stable Isotope
Abiraterone acetate-d3 is a deuterium-labeled derivative of the potent, selective, and irreversible CYP17A1 inhibitor, Abiraterone acetate. This stable isotope is utilized in biological research to study metabolism and pharmacokinetics of Abiraterone in various cellular contexts. Its ability to inhibit androgen synthesis makes it particularly relevant in the investigation of hormone-dependent cancers, such as prostate cancer. -
Stable Isotope
Teriflunomide-d4 is a deuterated form of Teriflunomide, a therapeutic agent primarily targeting the enzyme dihydroorotate dehydrogenase (DHODH). This stable isotope-labeled compound is utilized in metabolic studies and pharmacokinetic investigations to trace the bioactivity of Teriflunomide in biological systems. Its incorporation of deuterium facilitates enhanced tracking and quantification in research applications, contributing valuable insight into its pharmacological effects. -
Stable Isotope
Leflunomide-d4 is a deuterium-labeled form of Leflunomide, a potent inhibitor of dihydroorotate dehydrogenase (DHODH). This stable isotope variant facilitates accurate metabolic studies and pharmacokinetic analyses of Leflunomide’s action. Utilized primarily in research on autoimmune disorders, Leflunomide-d4 aids in elucidating the compound's mechanisms as a disease-modifying antirheumatic agent. -
Stable Isotope
4'-Hydroxy diclofenac-d4 is a stable isotope-labeled derivative of 4'-Hydroxy diclofenac, an active metabolite of Diclofenac primarily formed by cytochrome P450 2C9 (CYP2C9) metabolism. This compound retains the anti-inflammatory and analgesic properties of its parent drug, making it suitable for research into drug metabolism and pharmacokinetics. It is a valuable tool for studies involving drug interaction and effectiveness, particularly in the development of therapeutic applications targeting inflammation and pain relief. -
Stable Isotope
4-Hydroxymephenytoin-d3 is a deuterated form of 4-Hydroxymephenytoin, a hydroxylated metabolite of the antiepileptic drug mephenytoin. This stable isotope serves as a valuable internal standard for studies involving cytochrome P450 2C19 (CYP2C19) metabolism. It is particularly useful in pharmacokinetic research and in the development of assays to evaluate drug interactions and metabolic pathways. -
Stable Isotope
3-Methoxytyramine-d4 hydrochloride is a deuterated derivative of 3-Methoxytyramine hydrochloride, serving as a stable isotope for various analytical applications. While 3-Methoxytyramine itself is an inactive metabolite of dopamine, it has been shown to activate trace amine associated receptor 1 (TAAR1). This reagent is useful in studies related to neurotransmitter signaling and metabolic pathways, allowing for precise quantification and tracing in biological samples. -
Stable Isotope
N-Desmethyl imatinib-d8 is a deuterated metabolite of Imatinib, acting primarily as a selective inhibitor of the c-Abl tyrosine kinase. This compound effectively binds to the c-Abl catalytic domain, inhibiting substrate phosphorylation and thereby modulating c-Abl-mediated α-synuclein activation and related inflammatory signaling pathways. N-Desmethyl imatinib has been shown to induce apoptosis in K562 human leukemia cells and may demonstrate altered pharmacokinetics in gastrointestinal stromal tumor settings following viral infection. It is valuable for research applications in Parkinson’s disease, gastrointestinal stromal tumors, and chronic myeloid leukemia. -
Stable Isotope
1'-Hydroxy bufuralol-d9 is a deuterium-labeled analog of 1'-Hydroxy bufuralol, serving as a stable isotope for research applications. As the primary metabolite of bufuralol, it is produced by the action of cytochrome P450 isoenzymes CYP2D1 and CYP2D2. This reagent is invaluable for studying CYP2D1/2 enzyme activity and can aid in pharmacokinetic studies and metabolite profiling. -
Stable Isotope
3-Amino-2-oxazolidinone-d4 is a deuterium-labeled analog of 3-Amino-2-oxazolidinone, serving as a stable isotope for research applications. This compound is identified as a metabolite of Furazolidone and is commonly utilized to detect furazolidone residues in biological samples. Its oral bioactivity enhances its relevance in pharmacokinetic studies and residue analysis in both environmental and clinical research. -
Stable Isotope
2-Hydroxy Atorvastatin-d5 disodium is a deuterium-labeled form of 2-Hydroxy Atorvastatin, a hydroxy metabolite of Atorvastatin. This compound functions as a potent inhibitor of HMG-CoA reductase, exhibiting an IC50 value of 8 nM. It is primarily utilized in stable isotope labeling studies and pharmacokinetic research, offering insights into atorvastatin metabolism and therapeutic efficacy. -
Stable Isotope
5-Hydroxy Omeprazole-d3 is a stable isotope labeled derivative of 5-Hydroxyomeprazole. It serves as a valuable tool for the quantitative analysis of omeprazole metabolism in pharmacokinetic studies. This reagent enables precise tracking of drug metabolism and disposition, enhancing the understanding of therapeutic efficacy and safety profiles in clinical research. -
Stable Isotope
N-Acetyl mesalazine-d3 is a deuterium-labeled derivative of N-Acetyl-5-aminosalicylic acid, serving as a stable isotope. It functions as a biomarker for assessing the efficacy of 5-Aminosalicylic Acid and exhibits biological activities including free radical scavenging, reduction of DNA base hydroxylation, and mitigation of mucosal inflammation. This compound is particularly relevant in the research of gastrointestinal diseases, including colitis and colon cancer, providing valuable insight into therapeutic mechanisms and outcomes. -
Stable Isotope
N-Desethyl Sunitinib-d5 is a deuterium-labeled metabolite of Sunitinib, known for its potent inhibition of vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptor beta (PDGFRβ), as well as the receptor tyrosine kinase KIT. With Ki values of 2 nM for VEGFR-1, 9 nM for VEGFR-2, 17 nM for VEGFR-3, 8 nM for PDGFRβ, and 4 nM for KIT, this compound serves as a valuable tool in pharmacokinetic studies and metabolic profiling. Its stable isotope labeling allows for enhanced tracking in biochemical and cellular assays, facilitating research into targeted therapies for cancer. -
Stable Isotope
Omeprazole sulfide-d3 is a deuterated form of Omeprazole sulfide, a key metabolite of the proton pump inhibitor Omeprazole. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace the biological pathways and interactions of Omeprazole in various biological systems. It serves as a valuable tool for understanding drug metabolism and the pharmacodynamics of proton pump inhibitors. -
Stable Isotope
Leukotriene D4-d5 is a deuterated form of Leukotriene D4, a cysteinyl leukotriene derived from the metabolism of Leukotriene C4 by γ-glutamyl transpeptidase. This compound plays a critical role in mediating bronchoconstriction and increasing vascular permeability, which are key factors in the pathophysiology of asthma and acute hypersensitivity reactions. Leukotriene D4-d5 serves as a valuable stable isotope for biochemical assays and research applications, enabling the study of leukotriene signaling pathways and their effects on inflammatory diseases. -
Isotope-Labeled Compound
Nordoxepin-d3 hydrochloride is an isotope-labeled compound derived from Nordoxepin hydrochloride, an active metabolite of the tricyclic antidepressant Doxepin hydrochloride. This labeled form is utilized in pharmacokinetic studies to trace the metabolic pathways and systemic exposure of Nordoxepin. Its application in research is crucial for understanding the biological activity and pharmacodynamics of tricyclic antidepressants in clinical settings. -
Stable Isotope
2-Oxo-3-hydroxy-LSD-d10 is a deuterium-labeled analogue of the metabolite 2-Oxo-3-hydroxy-LSD. It serves as a stable isotope for applications in pharmacokinetic studies and metabolic profiling of Lysergic acid diethylamide (LSD). This compound aids in the precise quantification of LSD metabolites in biological samples, enhancing the understanding of their pharmacological effects and metabolism. -
Stable Isotope
(rac)-N,O-Didesmethyl Tramadol-d3 is a deuterated form of (rac)-N,O-Didesmethyl Tramadol, the primary metabolite of the analgesic drug Tramadol. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace and quantify drug metabolism and distribution. Its incorporation into research allows for enhanced sensitivity and specificity in mass spectrometry applications. -
Stable Isotope
Melamine-15N3,13C3 is a stable isotope-labeled compound featuring both 15N and 13C isotopes. As a metabolite of cyromazine, melamine serves as an important intermediate in the synthesis of melamine resins and various plastic materials. Its unique isotopic labeling facilitates applications in scientific research, particularly in tracing metabolic pathways and studying nitrogen and carbon dynamics in biological systems.
