N-Desethyl Sunitinib-d5 is a deuterium-labeled metabolite of Sunitinib, known for its potent inhibition of vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptor beta (PDGFRβ), as well as the receptor tyrosine kinase KIT. With Ki values of 2 nM for VEGFR-1, 9 nM for VEGFR-2, 17 nM for VEGFR-3, 8 nM for PDGFRβ, and 4 nM for KIT, this compound serves as a valuable tool in pharmacokinetic studies and metabolic profiling. Its stable isotope labeling allows for enhanced tracking in biochemical and cellular assays, facilitating research into targeted therapies for cancer.
N-Desethyl Sunitinib-d5 is a deuterium-labeled metabolite of Sunitinib, known for its potent inhibition of vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptor beta (PDGFRβ), as well as the receptor tyrosine kinase KIT. With Ki values of 2 nM for VEGFR-1, 9 nM for VEGFR-2, 17 nM for VEGFR-3, 8 nM for PDGFRβ, and 4 nM for KIT, this compound serves as a valuable tool in pharmacokinetic studies and metabolic profiling. Its stable isotope labeling allows for enhanced tracking in biochemical and cellular assays, facilitating research into targeted therapies for cancer.
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