Catalog No.
Product Name
Application
Product Information
Citations
-
Stable Isotope
Stiripentol-d9 is a deuterium-labeled variant of the anticonvulsant Stiripentol. This compound acts primarily by noncompetitively inhibiting N-demethylation of clonazepam (CLB) to its active form, N-desmethylclonazepam (NCLB), via CYP3A4 and competitively via CYP2C19, with measured inhibition constants (Kis) of 1.59±0.07 μM and 0.516±0.065 μM, respectively. With an IC50 of 1.58 μM for CYP3A4 and 3.29 μM for CYP2C19, Stiripentol-d9 is valuable for studying metabolic pathways and the pharmacokinetics of antiepileptic drugs. -
Stable Isotope
Ticlopidine hydrochloride-d6 is a deuterium-labeled derivative of Ticlopidine hydrochloride, functioning primarily as a stable isotope for research applications. Ticlopidine is recognized as an antithrombotic agent and acts as an allosteric, noncompetitive inhibitor of CD39, demonstrating an IC50 of 81.7 μM. Furthermore, it inhibits various NTPDase isoenzymes, with IC50 values of 170 μM for NTPDase2 and 149 μM for NTPDase3, in addition to its role as an inhibitor of CYP2C19, CYP2C9, and CYP3A4, with IC50s of 26.0 and 32.3 μM, respectively. This reagent is valuable for studies involving purinergic signaling and drug metabolism. -
Stable Isotope
Veratrole-d2 is a deuterium-labeled analogue of Veratrole (1,2-Dimethoxybenzene), a compound crucial for plant reproductive processes and interactions with pollinators. This stable isotope enables studies of plant circadian rhythms and the ecological impacts of Veratrole on species differentiation. Additionally, Veratrole-d2 can be utilized to investigate the demethylation activity of cytochrome P-450 enzymes in Streptomyces setonii, providing valuable insights into metabolic pathways and enzyme function in various biological systems. -
Stable Isotope
Veratrole-d10 is a deuterium-labeled derivative of Veratrole (1,2-Dimethoxybenzene), serving as a stable isotope for analytical applications. This compound is integral to various plant processes, including pollinator attraction and reproductive timing, exhibiting a release pattern governed by circadian rhythms. Additionally, Veratrole is involved in biochemical pathways, notably undergoing demethylation through cytochrome P-450 activity in Streptomyces setonii, making it valuable for studies in plant biology and microbial biochemistry. -
Stable Isotope
Rufinamide-d2 is a stable isotope-labeled derivative of Rufinamide, which primarily targets sodium channels to inhibit Na+ current activation. This compound exhibits notable anticonvulsant activity and is effective in reducing neuronal hyperexcitability. Rufinamide-d2 is particularly valuable in research related to Lennox-Gastaut syndrome, providing a tool for investigating the pharmacological mechanisms underlying this condition. -
Stable Isotope
Rufinamide-15N,d2-1 is a stable isotope-labeled derivative of Rufinamide, which serves as an orally active antiepileptic agent. This compound exerts its primary action by inhibiting sodium current activation, thereby reducing neuronal hyperexcitability and exhibiting anticonvulsant properties. Rufinamide-15N,d2-1 is valuable for research applications related to Lennox-Gastaut syndrome and the study of sodium channel modulation in epilepsy. -
Stable Isotope
Cyfluthrin-d6 is a deuterated form of Cyfluthrin, a type II pyrethroid known for its insecticidal properties. This compound primarily targets Nav1.8 sodium channels, modulating their activity through repetitive stimulation. Cyfluthrin-d6 is valuable in research applications pertaining to insect behavior, agricultural pest management, and the study of pyrethroid mechanisms of action. Its stable isotope labeling is instrumental for tracking and quantifying Cyfluthrin in various biological and environmental studies. -
Stable Isotope
Rufinamide-15N,d2 is a stable isotope-labeled variant of Rufinamide, an orally active antiepileptic agent that primarily targets sodium channels to inhibit current activation. This compound exhibits significant anticonvulsant properties, effectively reducing neuronal hyperexcitability. Rufinamide-15N,d2 is ideal for research applications focused on understanding the pharmacokinetics and mechanisms of action of Rufinamide, particularly in the context of Lennox-Gastaut syndrome studies. -
Stable Isotope
Mepivacaine-d3 is a deuterium-labeled analogue of Mepivacaine, an amide-type local anesthetic. It selectively binds to voltage-gated sodium ion channels in neuronal cell membranes, effectively inhibiting sodium influx and membrane depolarization. This stable isotope is useful in pharmacokinetic studies and isotope-labeling experiments, providing a valuable tool for understanding the mechanism of action and metabolism of local anesthetics. -
Stable Isotope
Flecainide-d4 acetate is a deuterium-labeled form of Flecainide acetate, a class 1C antiarrhythmic agent. It primarily targets the Nav1.5 sodium channel in cardiac tissue, effectively inhibiting sodium ion influx and prolonging the cardiac action potential. This reagent is utilized in research related to cardiac arrhythmias and the pharmacokinetics of antiarrhythmic drugs. Its stable isotope labeling aids in studies involving drug metabolism and distribution. -
Stable Isotope
Methocarbamol-13C,d3 is a stable isotope-labeled variant of Methocarbamol, a central muscle relaxant. It primarily targets the voltage-gated Nav1.4 sodium channel, modulating its inactivation kinetics. This compound is valuable for studying muscle spasms and pain syndromes, enabling researchers to explore its pharmacokinetics and physiological effects in various experimental contexts. -
Stable Isotope
Eslicarbazepine Acetate-d3 is a deuterated form of Eslicarbazepine acetate, a potent antiepileptic agent. This compound functions as a dual inhibitor of β-Secretase and voltage-gated sodium channels, contributing to its neurological activity. Eslicarbazepine Acetate-d3 is primarily used in research applications involving metabolic studies and pharmacokinetic profiling of antiepileptic drugs, providing insights into their mechanisms and effectiveness. -
Stable Isotope
Propafenone-(phenyl-dd5) hydrochloride is a deuterium-labeled derivative of the anti-arrhythmic agent Propafenone hydrochloride. This reagent is utilized primarily in stable isotope tracing studies to investigate metabolic pathways and drug interactions. Its application extends to understanding the pharmacokinetics of anti-arrhythmic therapies in models of atrial and ventricular arrhythmias. -
Stable Isotope
Benzocaine-d4 is a deuterium-labeled analog of Benzocaine, functioning as a stable isotope. This compound targets voltage-gated sodium channels and exhibits biological activity with an IC50 of 0.8 mM at +30 mV. Benzocaine-d4 is valuable for research applications involving pharmacokinetics, drug metabolism studies, and the investigation of local anesthetic mechanisms. -
Stable Isotope
Bupivacaine-d9 hydrochloride is a deuterium-labeled analog of Bupivacaine hydrochloride, primarily known for its role as an NMDA receptor inhibitor. This compound effectively blocks sodium, L-calcium, and potassium channels, demonstrating potent inhibition of SCN5A channels with an IC50 value of 69.5 μM. Bupivacaine-d9 hydrochloride is valuable for research focused on chronic pain modulation and neuronal signaling studies. -
Stable Isotope
Dibucaine-d9 hydrochloride is a deuterium-labeled derivative of Dibucaine hydrochloride, primarily functioning as a sodium channel inhibitor. This compound exhibits strong inhibition of serum cholinesterase (SChE) activity, making it valuable in pharmacological studies related to analgesia and local anesthesia. Its stable isotope labeling facilitates advanced metabolic research and provides insights into drug metabolism and distribution. -
Stable Isotope
Licarbazepine-d4-1 is a deuterium-labeled derivative of Licarbazepine, a known voltage-gated sodium channel blocker. This compound exhibits significant anticonvulsant and mood-stabilizing properties, making it valuable for research in neurological disorders and mood regulation. Licarbazepine-d4-1 is useful in studies requiring isotopic tracing, such as pharmacokinetic and metabolic investigations. -
Stable Isotope
Licarbazepine-d8 is a deuterium-labeled derivative of Licarbazepine, a potent voltage-gated sodium channel blocker known for its anticonvulsant and mood-stabilizing properties. The stable isotope labeling enhances research applications in pharmacokinetic studies and metabolic investigations of Licarbazepine. This compound is valuable for elucidating the mechanisms of action and efficacy of sodium channel modulation in neurological disorders. -
Stable Isotope
Propafenone-d5 Ethyl hydrochloride is a deuterium-labeled derivative of Propafenone hydrochloride, an anti-arrhythmic medication classified as a Class 1C agent. It primarily targets sodium channels to inhibit cardiac arrhythmias, making it effective in managing conditions such as atrial and ventricular arrhythmias. This stable isotope is valuable for pharmacokinetic studies and metabolic investigations in cardiovascular research applications. -
Stable Isotope
Methocarbamol-d3 is a deuterium-labeled analog of Methocarbamol, a centrally acting muscle relaxant that targets the Nav1.4 sodium channel. This stable isotope aids in studies related to muscle spasms and pain syndromes by providing insights into the voltage-dependent inactivation mechanisms of the Nav1.4 channel. Its unique labeling facilitates enhanced tracking and analysis in pharmacokinetic and metabolic studies. -
Stable Isotope
Atomoxetine-d7 is a stable isotope-labeled form of Atomoxetine, a selective norepinephrine reuptake inhibitor. With Ki values of 5, 77, and 1451 nM for norepinephrine, serotonin, and dopamine transporters, respectively, it is known to enhance catecholaminergic neurotransmission and elevate dopamine and norepinephrine levels in the prefrontal cortex. Additionally, Atomoxetine functions as a potent blocker of voltage-gated sodium channels. This reagent is applicable in research focused on attention-deficit hyperactivity disorder (ADHD) and related neural mechanisms. -
Stable Isotope
Propafenone-d5 hydrochloride is a deuterated form of the anti-arrhythmic agent Propafenone, targeting cardiac ion channels to regulate heart rhythm. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace the pharmacodynamics and pharmacokinetics of Propafenone and its metabolites. Its application extends to both clinical and preclinical investigations of cardiac health and therapeutic efficacy. -
Stable Isotope
Mexiletine-d6 is a deuterated form of Mexiletine, an orally bioavailable antiarrhythmic compound known for its ability to alleviate myotonia and neuropathic pain. This reagent functions primarily by blocking sodium channels, demonstrating an IC50 of 75±8 μM for tonic block and 23.6±2.8 μM for use-dependent block. Its unique isotopic labeling makes Mexiletine-d6 suitable for applications in cardiovascular and neurological research, allowing for enhanced tracing and understanding of molecular interactions in biological systems. -
Stable Isotope
Resolvin D2-d5 is a deuterium-labeled derivative of Resolvin D2, a metabolite of docosahexaenoic acid (DHA). This compound exhibits significant anti-inflammatory and anti-infective properties, primarily by regulating leukocyte activity and modulating responses to microbial sepsis. Additionally, Resolvin D2 serves as a potent inhibitor of TRPV1 and TRPA1 channels in primary sensory neurons, with IC50 values of 0.1 nM and 2 nM, respectively. It is valuable for research applications focusing on inflammatory responses and pain pathways. -
Stable Isotope
(E)-4-Oxo-2-nonenal-d3 is a deuterium-labeled derivative of (E)-4-Oxo-2-nonenal, a reactive aldehyde known for its role in various biological processes. This stable isotope can serve as an internal standard in analytical chemistry, particularly in mass spectrometry and NMR spectroscopy. It is valuable for tracking oxidative stress and lipid peroxidation in cellular systems, facilitating the study of mechanisms related to cell signaling and disease progression. -
Stable Isotope
Oleoyl Serotonin-d17 is a deuterium-labeled derivative of Oleoyl Serotonin, serving as a stable isotope. This compound is valuable for various biological research applications, including pharmacokinetic studies and metabolic tracking. The incorporation of deuterium facilitates enhanced study of lipid signaling pathways and neurotransmitter dynamics in a variety of biological systems. -
Stable Isotope
N-Vanillylnonanamide-d3 is a deuterium-labeled analog of Nonivamide, known for its role as a stable isotope in research. This compound serves as a valuable tool for tracing studies and quantifying bioactive lipids in biological systems. It is particularly useful in toxicological assessments and metabolic pathway investigations, facilitating enhanced understanding of the pharmacokinetics and biological activity of capsaicin-like compounds. -
Stable Isotope
4-Methyl-2-(1-piperidinyl)-quinoline-d10 is a deuterated analogue of ML204, functioning as a selective inhibitor of the TRPC4 and TRPC5 ion channels. This compound exhibits a significant 19-fold selectivity over TRPC6 and has minimal impact on other TRP channels, as well as voltage-gated sodium, potassium, and calcium channels. It is a valuable tool for investigating TRPC channel functions and their roles in various biological processes. -
Stable Isotope
(-)-Menthol-d4 is a deuterium-labeled derivative of (-)-Menthol, a significant constituent of peppermint oil. It acts as an agonist for the transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, leading to an increase in intracellular calcium levels. This compound is utilized in research to explore its biological activity, particularly its potential antitumor effects and mechanisms of action involving sensory signaling pathways. -
Isotope-Labeled Compounds
Verapamil-d7 is a deuterium-labeled derivative of Verapamil, a calcium channel blocker and a potent inhibitor of the P-glycoprotein (P-gp) transporter. This isotope-labeled compound is utilized in pharmacokinetic studies and metabolic research, providing insights into drug interactions and transport mechanisms. Its applications extend to investigating conditions such as hypertension, cardiac arrhythmias, and angina, making it a valuable tool in cardiovascular research. -
Stable Isotope
Ethosuximide-d5 is a stable isotopically labeled form of Ethosuximide, an established anti-epileptic agent. This compound acts primarily as a blocker of low voltage activated T-type calcium channels, contributing to its therapeutic effects. Ethosuximide-d5 is valuable for research applications involving neurodegenerative disease models and mechanisms of epilepsy, enabling precise metabolic studies and tracking within biological systems. -
Stable Isotope
Diltiazem-(acetoxy-d3) hydrochloride is a deuterium-labeled derivative of Diltiazem hydrochloride, a calcium channel antagonist. As a stable isotope compound, it serves as a valuable tool for pharmacokinetic studies and metabolic research, allowing for precise tracking of Diltiazem's biological fate. This reagent can facilitate investigations into calcium signaling pathways and cardiovascular pharmacology. -
Stable Isotope
Levamlodipine-d4 is the deuterium-labeled form of Levamlodipine, a selective dihydropyridine calcium channel blocker. This compound exhibits significant vasodilatory activity and is commonly utilized in the management of hypertension and angina. As a stable isotope, Levamlodipine-d4 is a valuable tool for pharmacokinetic studies and related research applications. -
Stable Isotope
Menthol-d2 is a deuterated derivative of menthol, serving as a stable isotope. It acts as an analgesic and modulates the TRPM8 ion channel, which is responsible for sensing cold temperatures. By regulating TRPM8, Menthol-d2 exerts analgesic and anti-irritation effects. Additionally, it stimulates cold receptors, inducing a cooling sensation through the inhibition of Ca++ currents in neuronal cell membranes, making it valuable for research in pain relief and sensory modulation. -
Stable Isotope
Amlodipine-1,1,2,2-d4 maleate is a deuterium-labeled derivative of Amlodipine, a dihydropyridine calcium channel blocker. Its primary mechanism involves the inhibition of voltage-dependent L-type calcium channels, which reduces calcium influx. This reagent is valuable for studies related to hypertension and cancer research, offering insights into calcium signaling pathways and their implications in various pathological conditions. -
Stable Isotope
Diltiazem-d5 hydrochloride is a deuterated isotopic form of Diltiazem, a calcium channel blocker that inhibits L-type calcium channels. Its primary mechanism involves modulation of calcium ion influx, leading to reduced myocardial contractility and vasodilation. This stable isotope is valuable for pharmacokinetic studies, metabolic pathway analysis, and isotopic labeling techniques in chemical research and drug development. -
Stable Isotope
Farnesyl pyrophosphate-d6 is a deuterium-labeled stable isotope derivative of farnesyl pyrophosphate, an important metabolic intermediate in the mevalonate pathway. It acts as an agonist for TRP channel TRPM2, facilitating calcium influx and promoting cell death. Farnesyl pyrophosphate plays a crucial role in cholesterol and ubiquinone synthesis, as well as in protein farnesylation and geranylgeranyl pyrophosphate synthesis. This reagent is utilized in research exploring cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune disorders. -
Stable Isotope
Diltiazem-d4 is a deuterated form of Diltiazem, which acts as a selective L-type calcium channel blocker. It exhibits significant antihypertensive and antiarrhythmic properties, making it useful in the study of cardiac arrhythmias, hypertension, and angina pectoris. This stable isotope is ideal for research applications requiring isotopic tracing and elucidation of pharmacokinetic pathways involved in calcium channel modulation. -
Stable Isotope
Ranolazine-d8 is a deuterated form of Ranolazine, which primarily targets the late phase of inward sodium current (INa) and potassium current (IKr) with IC50 values of 6 μM and 12 μM, respectively. This compound functions as an anti-anginal agent, alleviating symptoms without influencing heart rate or blood pressure. Additionally, Ranolazine acts as a partial fatty acid oxidation inhibitor, making it valuable for research related to cardiac ischemia and metabolic modulation in heart diseases. -
Stable Isotope
Verapamil-d3 is a deuterium-labeled form of Verapamil, a calcium channel blocker that serves as a potent, orally active first-generation inhibitor of P-glycoprotein (P-gp) and CYP3A4. This stable isotope variant is utilized in pharmacokinetic studies and metabolic research, aiding in the investigation of cardiovascular diseases such as hypertension, arrhythmias, and angina. Verapamil-d3's unique properties make it an invaluable tool for studying drug interactions and bioavailability in various biological systems. -
Stable Isotope
1-Octanol-d2-1 is a deuterated form of 1-Octanol, serving as a stable isotope for various research applications. As a saturated fatty alcohol, 1-Octanol acts as an inhibitor of T-type calcium channels with an IC50 value of 4 μM for native T-currents, making it valuable for studies in neurobiology and pharmacology. Additionally, its characteristics as a biofuel with diesel-like properties position it for investigation in energy research and sustainable technologies. -
Stable Isotope
Norverapamil-d6 hydrochloride is a stable isotope-labeled version of Norverapamil, an N-demethylated metabolite of Verapamil. This compound acts as a blocker of L-type calcium channels and inhibits P-glycoprotein (P-gp) function. It is primarily utilized in pharmacokinetic studies, drug metabolism research, and for tracing metabolic pathways in biological systems. -
Stable Isotope
Diltiazem-d6 hydrochloride is a deuterium-labeled derivative of Diltiazem, functioning as a calcium antagonist that inhibits Ca2+ influx. This stable isotope is primarily utilized in research applications involving pharmacokinetics, metabolic studies, and the optimization of drug formulations. Its deuterated form enhances analytical sensitivity and specificity in various biochemical analyses. -
Stable Isotope
Teludipine-d6 is a deuterium-labeled analog of Teludipine hydrochloride, a potent lipophilic calcium channel blocker. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace the metabolic pathways of Teludipine without altering its pharmacological properties. It is well-suited for investigations requiring precise quantification of drug concentrations in biological systems. -
Stable Isotope
O-Desmethyl carvedilol-d5 is a deuterium-labeled derivative of O-Desmethylcarvedilol, a potent active metabolite of the non-selective β-adrenergic receptor antagonist Carvedilol. This compound exhibits inhibitory effects on store-overload-induced calcium release in HEK293 cells expressing the RyR2 R4496C mutation, with an IC50 of 7.62 μM. Additionally, O-Desmethyl carvedilol-d5 contributes to cardiovascular research by attenuating heart rate increases and stabilizing diastolic blood pressure in response to Isoproterenol in conscious rabbit models, demonstrating ED50 values of 32 and 5 μg/kg, respectively. -
Stable Isotope
Taurolithocholic Acid-d5 sodium is a deuterium-labeled derivative of Taurolithocholic acid, serving as a stable isotope for analytical studies. This compound exhibits potent cholestatic activity and functions as a significant Ca2+ agonist, making it valuable for research in liver function and bile acid metabolism. Taurolithocholic Acid-d5 sodium can be utilized in pharmacokinetic studies and tracer experiments to elucidate the biological pathways of bile acids and their physiological effects. -
Stable Isotope
DSPC-d9 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9) is a deuterium-labeled form of DSPC, a cylindrical-shaped phospholipid. This reagent is primarily utilized in the preparation of liposomes and serves as a critical component in lipid nanoparticle (LNP) formulations. Its stable isotope labeling enables enhanced tracking and characterization of lipid interactions and dynamics in biological research and drug delivery applications. -
Stable Isotope
DSPC-d13, a deuterated form of 1,2-Distearoyl-sn-glycero-3-phosphorylcholine, serves as a stable isotope for various biological studies. This cylindrical-shaped lipid is integral for the synthesis of liposomes and functions as a key component in lipid nanoparticle (LNP) systems. Its unique labeling with deuterium facilitates advanced research applications in drug delivery and lipid metabolism studies, enabling enhanced tracking and analysis in complex biological environments. -
Stable Isotope
DSPC-d79 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d79) is a deuterium-labeled analog of DSPC, a cylindrical-shaped phospholipid. This compound is crucial for the synthesis of liposomes and serves as a key lipid component in lipid nanoparticle (LNP) formulations. DSPC-d79 can be utilized in studies involving drug delivery systems, membrane biology, and biophysical characterization of lipid structures, enabling enhanced tracking and analysis in various biomedical research applications. -
Stable Isotope
1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-d70 sodium is a deuterium-labeled form of 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol. This stable isotope serves as a vital component in the formulation of liposomes, enhancing the precision of drug delivery systems. Its application extends to various biochemical and biological research, facilitating the study of lipid dynamics and membrane interactions in a wide range of experimental settings.
