Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
MCPA-d3 is a deuterated form of the phenoxyacetic acid herbicide MCPA, which primarily disrupts plant membrane integrity and energy metabolism by decreasing ATP levels. This compound is capable of enhancing hepatic cytochrome P-450 levels and stimulating the activities of enzymes such as aniline hydroxylase and 7-ethoxycoumarin O-deethylase. MCPA-d3 is utilized in research applications focusing on herbicide mechanisms, plant biochemistry, and environmental impact studies involving broadleaf weed control. -
Stable Isotope
Diosmetin-d3 is a deuterium-labeled derivative of Diosmetin, a natural flavonoid. This compound targets the human CYP1A enzyme, exhibiting inhibitory activity with an IC50 value of 40 μM in HepG2 cells. Diosmetin-d3 is primarily utilized in metabolic studies and pharmacokinetic research, allowing for the tracing of bioavailability and metabolic pathways of Diosmetin in various biological systems. -
Stable Isotope
7-Ethoxycoumarin-d5 is a deuterium-labeled analog of 7-Ethoxycoumarin, targeting cytochrome P450 (CYP450) enzymes. This stable isotope serves as a valuable substrate in the functional characterization and kinetic studies of various CYP450 isoforms. It is particularly useful in drug metabolism research and toxicology studies, allowing for precise measurement and analysis of enzyme activity in biological systems. -
Stable Isotope
Topiroxostat-d4 is a deuterium-labeled derivative of Topiroxostat, a potent inhibitor of xanthine oxidoreductase (XOR) with an IC50 of 5.3 nM and a Ki of 5.7 nM. This compound exhibits weak inhibitory activity on CYP3A4 (18.6%), making it suitable for in-depth metabolic studies. Topiroxostat is primarily utilized for research related to hyperuricemia, targeting pathways involved in uric acid production and metabolism. -
Stable Isotope
Clobetasol 17-Propionate-d5 is a deuterium-labeled derivative of Clobetasol propionate, a potent and selective inhibitor of CYP3A5, exhibiting an IC50 of 0.206 μM. This compound specifically targets CYP3A5 while showing no inhibition on CYP3A4 or other major cytochrome P450 enzymes. With its corticosteroid properties, Clobetasol 17-Propionate-d5 is suitable for research applications related to psoriasis and other dermatoses, providing a valuable tool for studying the pharmacokinetics and metabolism of corticosteroids in biological systems. -
Stable Isotope
Ethylvanillin-d5 is a deuterium-labeled derivative of ethylvanillin, designed as a stable isotope for use in biochemical research. This compound retains the aromatic properties of its parent molecule while providing a unique label for tracing and quantifying ethylvanillin in metabolic studies. It is particularly useful in experiments involving flavor compounds, sensory analysis, and isotopic labeling in food chemistry and fragrance research. -
Stable Isotope
Abiraterone acetate-d4 is the deuterium-labeled form of Abiraterone acetate, a potent and selective irreversible inhibitor of CYP17A1 with notable antiandrogen activity. This stable isotope is utilized in various biological research applications, including pharmacokinetic studies and metabolic profiling, allowing for precise tracking of the compound's fate in biological systems. As a proagent of Abiraterone, it provides valuable insights into androgen receptor signaling pathways and related therapeutic interventions. -
Stable Isotope
Methoxsalen-13C,d3 (8-Methoxypsoralen-13C,d3) is a stable isotope-labeled form of Methoxsalen, a furanocoumarin compound that acts as a P450 inhibitor. This compound is primarily utilized in research related to dermatological conditions such as psoriasis, eczema, and vitiligo, as well as in the study of certain sun-exposed cutaneous lymphomas. The incorporation of deuterium and carbon-13 labels allows for advanced analytical techniques in metabolic and pharmacokinetic studies. -
Stable Isotope
Veratrole-d6 is a deuterium-labeled derivative of Veratrole (1,2-Dimethoxybenzene), which serves as a stable isotope standard in research applications. This compound is prevalent in various plant species where it is involved in pollinator attraction and exhibits a circadian rhythm that influences plant reproductive processes and species differentiation. Additionally, Veratrole is known to undergo demethylation by cytochrome P-450 enzymes in Streptomyces setonii, making it valuable for studies in plant biochemistry and microbial metabolism. -
Stable Isotope
Proadifen-d2 is a deuterium-labeled derivative of Proadifen, functioning as a stable isotope. This reagent serves as an important tool for metabolic studies and pharmacokinetic investigations, enabling precise tracking of drug metabolism pathways and interactions. Its applications are valuable in both biochemical research and drug development, providing insights into the pharmacological profile of Proadifen and its derivatives. -
Stable Isotope
Dihydrolanosterol-d7 is a deuterium-labeled derivative of Dihydrolanosterol, primarily serving as a stable isotope for research applications. This compound acts as a substrate for CYP51 and functions as an inhibitor of cholesterol biosynthesis. It is valuable for studies involving lipid metabolism, sterol biosynthesis pathways, and the role of cholesterol in cellular processes. -
Stable Isotope
Chlorzoxazone-13C is a stable isotope-labeled derivative of Chlorzoxazone, a centrally acting muscle relaxant that alleviates muscle spasms and associated pain. This compound is utilized in pharmacokinetic studies and metabolic research, providing insights into the drug's mechanism of action and its effects within biological systems. The incorporation of the 13C label enables precise tracking and analysis in various experimental settings. -
Stable Isotope
Stiripentol-d9 is a deuterium-labeled variant of the anticonvulsant Stiripentol. This compound acts primarily by noncompetitively inhibiting N-demethylation of clonazepam (CLB) to its active form, N-desmethylclonazepam (NCLB), via CYP3A4 and competitively via CYP2C19, with measured inhibition constants (Kis) of 1.59±0.07 μM and 0.516±0.065 μM, respectively. With an IC50 of 1.58 μM for CYP3A4 and 3.29 μM for CYP2C19, Stiripentol-d9 is valuable for studying metabolic pathways and the pharmacokinetics of antiepileptic drugs. -
Stable Isotope
Ticlopidine hydrochloride-d6 is a deuterium-labeled derivative of Ticlopidine hydrochloride, functioning primarily as a stable isotope for research applications. Ticlopidine is recognized as an antithrombotic agent and acts as an allosteric, noncompetitive inhibitor of CD39, demonstrating an IC50 of 81.7 μM. Furthermore, it inhibits various NTPDase isoenzymes, with IC50 values of 170 μM for NTPDase2 and 149 μM for NTPDase3, in addition to its role as an inhibitor of CYP2C19, CYP2C9, and CYP3A4, with IC50s of 26.0 and 32.3 μM, respectively. This reagent is valuable for studies involving purinergic signaling and drug metabolism. -
Stable Isotope
Veratrole-d2 is a deuterium-labeled analogue of Veratrole (1,2-Dimethoxybenzene), a compound crucial for plant reproductive processes and interactions with pollinators. This stable isotope enables studies of plant circadian rhythms and the ecological impacts of Veratrole on species differentiation. Additionally, Veratrole-d2 can be utilized to investigate the demethylation activity of cytochrome P-450 enzymes in Streptomyces setonii, providing valuable insights into metabolic pathways and enzyme function in various biological systems. -
Stable Isotope
Veratrole-d10 is a deuterium-labeled derivative of Veratrole (1,2-Dimethoxybenzene), serving as a stable isotope for analytical applications. This compound is integral to various plant processes, including pollinator attraction and reproductive timing, exhibiting a release pattern governed by circadian rhythms. Additionally, Veratrole is involved in biochemical pathways, notably undergoing demethylation through cytochrome P-450 activity in Streptomyces setonii, making it valuable for studies in plant biology and microbial biochemistry. -
Stable Isotope
Rufinamide-d2 is a stable isotope-labeled derivative of Rufinamide, which primarily targets sodium channels to inhibit Na+ current activation. This compound exhibits notable anticonvulsant activity and is effective in reducing neuronal hyperexcitability. Rufinamide-d2 is particularly valuable in research related to Lennox-Gastaut syndrome, providing a tool for investigating the pharmacological mechanisms underlying this condition. -
Stable Isotope
Rufinamide-15N,d2-1 is a stable isotope-labeled derivative of Rufinamide, which serves as an orally active antiepileptic agent. This compound exerts its primary action by inhibiting sodium current activation, thereby reducing neuronal hyperexcitability and exhibiting anticonvulsant properties. Rufinamide-15N,d2-1 is valuable for research applications related to Lennox-Gastaut syndrome and the study of sodium channel modulation in epilepsy. -
Stable Isotope
Cyfluthrin-d6 is a deuterated form of Cyfluthrin, a type II pyrethroid known for its insecticidal properties. This compound primarily targets Nav1.8 sodium channels, modulating their activity through repetitive stimulation. Cyfluthrin-d6 is valuable in research applications pertaining to insect behavior, agricultural pest management, and the study of pyrethroid mechanisms of action. Its stable isotope labeling is instrumental for tracking and quantifying Cyfluthrin in various biological and environmental studies. -
Stable Isotope
Rufinamide-15N,d2 is a stable isotope-labeled variant of Rufinamide, an orally active antiepileptic agent that primarily targets sodium channels to inhibit current activation. This compound exhibits significant anticonvulsant properties, effectively reducing neuronal hyperexcitability. Rufinamide-15N,d2 is ideal for research applications focused on understanding the pharmacokinetics and mechanisms of action of Rufinamide, particularly in the context of Lennox-Gastaut syndrome studies. -
Stable Isotope
Mepivacaine-d3 is a deuterium-labeled analogue of Mepivacaine, an amide-type local anesthetic. It selectively binds to voltage-gated sodium ion channels in neuronal cell membranes, effectively inhibiting sodium influx and membrane depolarization. This stable isotope is useful in pharmacokinetic studies and isotope-labeling experiments, providing a valuable tool for understanding the mechanism of action and metabolism of local anesthetics. -
Stable Isotope
Flecainide-d4 acetate is a deuterium-labeled form of Flecainide acetate, a class 1C antiarrhythmic agent. It primarily targets the Nav1.5 sodium channel in cardiac tissue, effectively inhibiting sodium ion influx and prolonging the cardiac action potential. This reagent is utilized in research related to cardiac arrhythmias and the pharmacokinetics of antiarrhythmic drugs. Its stable isotope labeling aids in studies involving drug metabolism and distribution. -
Stable Isotope
Methocarbamol-13C,d3 is a stable isotope-labeled variant of Methocarbamol, a central muscle relaxant. It primarily targets the voltage-gated Nav1.4 sodium channel, modulating its inactivation kinetics. This compound is valuable for studying muscle spasms and pain syndromes, enabling researchers to explore its pharmacokinetics and physiological effects in various experimental contexts. -
Stable Isotope
Eslicarbazepine Acetate-d3 is a deuterated form of Eslicarbazepine acetate, a potent antiepileptic agent. This compound functions as a dual inhibitor of β-Secretase and voltage-gated sodium channels, contributing to its neurological activity. Eslicarbazepine Acetate-d3 is primarily used in research applications involving metabolic studies and pharmacokinetic profiling of antiepileptic drugs, providing insights into their mechanisms and effectiveness. -
Stable Isotope
Propafenone-(phenyl-dd5) hydrochloride is a deuterium-labeled derivative of the anti-arrhythmic agent Propafenone hydrochloride. This reagent is utilized primarily in stable isotope tracing studies to investigate metabolic pathways and drug interactions. Its application extends to understanding the pharmacokinetics of anti-arrhythmic therapies in models of atrial and ventricular arrhythmias. -
Stable Isotope
Benzocaine-d4 is a deuterium-labeled analog of Benzocaine, functioning as a stable isotope. This compound targets voltage-gated sodium channels and exhibits biological activity with an IC50 of 0.8 mM at +30 mV. Benzocaine-d4 is valuable for research applications involving pharmacokinetics, drug metabolism studies, and the investigation of local anesthetic mechanisms. -
Stable Isotope
Bupivacaine-d9 hydrochloride is a deuterium-labeled analog of Bupivacaine hydrochloride, primarily known for its role as an NMDA receptor inhibitor. This compound effectively blocks sodium, L-calcium, and potassium channels, demonstrating potent inhibition of SCN5A channels with an IC50 value of 69.5 μM. Bupivacaine-d9 hydrochloride is valuable for research focused on chronic pain modulation and neuronal signaling studies. -
Stable Isotope
Dibucaine-d9 hydrochloride is a deuterium-labeled derivative of Dibucaine hydrochloride, primarily functioning as a sodium channel inhibitor. This compound exhibits strong inhibition of serum cholinesterase (SChE) activity, making it valuable in pharmacological studies related to analgesia and local anesthesia. Its stable isotope labeling facilitates advanced metabolic research and provides insights into drug metabolism and distribution. -
Stable Isotope
Licarbazepine-d4-1 is a deuterium-labeled derivative of Licarbazepine, a known voltage-gated sodium channel blocker. This compound exhibits significant anticonvulsant and mood-stabilizing properties, making it valuable for research in neurological disorders and mood regulation. Licarbazepine-d4-1 is useful in studies requiring isotopic tracing, such as pharmacokinetic and metabolic investigations. -
Stable Isotope
Licarbazepine-d8 is a deuterium-labeled derivative of Licarbazepine, a potent voltage-gated sodium channel blocker known for its anticonvulsant and mood-stabilizing properties. The stable isotope labeling enhances research applications in pharmacokinetic studies and metabolic investigations of Licarbazepine. This compound is valuable for elucidating the mechanisms of action and efficacy of sodium channel modulation in neurological disorders. -
Stable Isotope
Propafenone-d5 Ethyl hydrochloride is a deuterium-labeled derivative of Propafenone hydrochloride, an anti-arrhythmic medication classified as a Class 1C agent. It primarily targets sodium channels to inhibit cardiac arrhythmias, making it effective in managing conditions such as atrial and ventricular arrhythmias. This stable isotope is valuable for pharmacokinetic studies and metabolic investigations in cardiovascular research applications. -
Stable Isotope
Methocarbamol-d3 is a deuterium-labeled analog of Methocarbamol, a centrally acting muscle relaxant that targets the Nav1.4 sodium channel. This stable isotope aids in studies related to muscle spasms and pain syndromes by providing insights into the voltage-dependent inactivation mechanisms of the Nav1.4 channel. Its unique labeling facilitates enhanced tracking and analysis in pharmacokinetic and metabolic studies. -
Stable Isotope
Atomoxetine-d7 is a stable isotope-labeled form of Atomoxetine, a selective norepinephrine reuptake inhibitor. With Ki values of 5, 77, and 1451 nM for norepinephrine, serotonin, and dopamine transporters, respectively, it is known to enhance catecholaminergic neurotransmission and elevate dopamine and norepinephrine levels in the prefrontal cortex. Additionally, Atomoxetine functions as a potent blocker of voltage-gated sodium channels. This reagent is applicable in research focused on attention-deficit hyperactivity disorder (ADHD) and related neural mechanisms. -
Stable Isotope
Propafenone-d5 hydrochloride is a deuterated form of the anti-arrhythmic agent Propafenone, targeting cardiac ion channels to regulate heart rhythm. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace the pharmacodynamics and pharmacokinetics of Propafenone and its metabolites. Its application extends to both clinical and preclinical investigations of cardiac health and therapeutic efficacy. -
Stable Isotope
Mexiletine-d6 is a deuterated form of Mexiletine, an orally bioavailable antiarrhythmic compound known for its ability to alleviate myotonia and neuropathic pain. This reagent functions primarily by blocking sodium channels, demonstrating an IC50 of 75±8 μM for tonic block and 23.6±2.8 μM for use-dependent block. Its unique isotopic labeling makes Mexiletine-d6 suitable for applications in cardiovascular and neurological research, allowing for enhanced tracing and understanding of molecular interactions in biological systems. -
Stable Isotope
Resolvin D2-d5 is a deuterium-labeled derivative of Resolvin D2, a metabolite of docosahexaenoic acid (DHA). This compound exhibits significant anti-inflammatory and anti-infective properties, primarily by regulating leukocyte activity and modulating responses to microbial sepsis. Additionally, Resolvin D2 serves as a potent inhibitor of TRPV1 and TRPA1 channels in primary sensory neurons, with IC50 values of 0.1 nM and 2 nM, respectively. It is valuable for research applications focusing on inflammatory responses and pain pathways. -
Stable Isotope
(E)-4-Oxo-2-nonenal-d3 is a deuterium-labeled derivative of (E)-4-Oxo-2-nonenal, a reactive aldehyde known for its role in various biological processes. This stable isotope can serve as an internal standard in analytical chemistry, particularly in mass spectrometry and NMR spectroscopy. It is valuable for tracking oxidative stress and lipid peroxidation in cellular systems, facilitating the study of mechanisms related to cell signaling and disease progression. -
Stable Isotope
Oleoyl Serotonin-d17 is a deuterium-labeled derivative of Oleoyl Serotonin, serving as a stable isotope. This compound is valuable for various biological research applications, including pharmacokinetic studies and metabolic tracking. The incorporation of deuterium facilitates enhanced study of lipid signaling pathways and neurotransmitter dynamics in a variety of biological systems. -
Stable Isotope
N-Vanillylnonanamide-d3 is a deuterium-labeled analog of Nonivamide, known for its role as a stable isotope in research. This compound serves as a valuable tool for tracing studies and quantifying bioactive lipids in biological systems. It is particularly useful in toxicological assessments and metabolic pathway investigations, facilitating enhanced understanding of the pharmacokinetics and biological activity of capsaicin-like compounds. -
Stable Isotope
4-Methyl-2-(1-piperidinyl)-quinoline-d10 is a deuterated analogue of ML204, functioning as a selective inhibitor of the TRPC4 and TRPC5 ion channels. This compound exhibits a significant 19-fold selectivity over TRPC6 and has minimal impact on other TRP channels, as well as voltage-gated sodium, potassium, and calcium channels. It is a valuable tool for investigating TRPC channel functions and their roles in various biological processes. -
Stable Isotope
(-)-Menthol-d4 is a deuterium-labeled derivative of (-)-Menthol, a significant constituent of peppermint oil. It acts as an agonist for the transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, leading to an increase in intracellular calcium levels. This compound is utilized in research to explore its biological activity, particularly its potential antitumor effects and mechanisms of action involving sensory signaling pathways. -
Stable Isotope
Butibufen-d5 is a deuterated analog of Butibufen, a non-steroidal compound known for its analgesic and antipyretic effects. This stable isotope can be utilized in pharmacokinetic studies and metabolic research to trace the compound's behavior in biological systems. It is particularly valuable in inflammation research, providing insights into the mechanisms of action and efficacy of non-steroidal anti-inflammatory drugs. -
Stable Isotope
11-Beta-hydroxyandrostenedione-d7 is a deuterium-labeled form of 11-Beta-hydroxyandrostenedione, a steroid primarily produced in the adrenal glands. This compound serves as an inhibitor of the 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes, making it valuable for studies involving steroid metabolism and hormone regulation. Its stable isotope labeling enables precise measurements in biological samples, supporting research on endocrine function and related disorders. -
Stable Isotope
11-Beta-hydroxyandrostenedione-d4 is the deuterium-labeled form of 11-beta-hydroxyandrostenedione, which is a steroid primarily derived from the adrenal gland. This compound acts as an inhibitor of 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes, playing a crucial role in steroid metabolism. It is particularly useful in studies related to adrenal steroidogenesis and hormone regulation, enabling accurate tracking of metabolic pathways in various biological research applications. -
Stable Isotope
Alpha-Estradiol-d2 is a deuterium-labeled variant of Alpha-Estradiol, exhibiting stable isotope properties. As a weak estrogen and a 5α-reductase inhibitor, it is primarily utilized in the study of androgenic alopecia and related treatments. This reagent is valuable for research applications involving hormone metabolism, endocrine signaling, and the exploration of therapeutic strategies targeting hair loss. -
Stable Isotope
Finasteride-d9 is a deuterium-labeled derivative of Finasteride, a potent competitive inhibitor of 5α-reductase, exhibiting an IC50 of 4.2 nM for the type II isoform. This compound demonstrates significantly greater affinity for type II 5α-reductase, being approximately 100 times more selective than for type I. Finasteride-d9 is valuable in research applications focused on benign prostatic hyperplasia (BPH) and androgenic alopecia, facilitating studies on the pharmacokinetics and metabolism of its parent compound. -
Stable Isotope
Terbuthylazine-d5 is a deuterium-labeled derivative of terbuthylazine, functioning primarily as an inhibitor of acetolactate synthase (ALS). As a selective herbicide, it exhibits significant biological activity in disrupting the growth of certain plants by interfering with the synthesis of branched-chain amino acids. This stable isotope compound is valuable for research applications in agronomy and environmental studies, particularly in the analysis of herbicide metabolism and distribution in biological systems. -
Stable Isotope
Nicosulfuron-d6 is a deuterium-labeled analog of Nicosulfuron, a selective herbicide from the sulfonylurea class. This compound exhibits inhibition of the acetolactate synthase (ALS) enzyme, which plays a crucial role in amino acid biosynthesis. Nicosulfuron-d6 is primarily utilized in research applications demanding stable isotopic labeling, facilitating the study of herbicide mechanisms and their interactions in agricultural settings. -
Stable Isotope
Terbuthylazine-d9 is a deuterium-labeled derivative of Terbuthylazine, functioning primarily as an inhibitor of acetolactate synthase (ALS). This stable isotope is utilized in biochemical research to study the mechanisms of herbicide action and plant physiology. Its specific activity as a selective herbicide makes it valuable for investigating herbicide resistance and environmental fate in agricultural studies. -
Stable Isotope
2-Furoic acid-d3 is a deuterated stable isotope of 2-Furoic acid, an organic compound with the formula C5H4O3. This compound is recognized for its hypolipidemic effects, effectively reducing serum cholesterol and triglyceride levels in animal models. It is used in metabolic studies and tracer experiments to understand lipid metabolism and related biological pathways.
