Catalog No.
Product Name
Application
Product Information
Citations
-
Stable Isotope
11-Beta-hydroxyandrostenedione-d7 is a deuterium-labeled form of 11-Beta-hydroxyandrostenedione, a steroid primarily produced in the adrenal glands. This compound serves as an inhibitor of the 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes, making it valuable for studies involving steroid metabolism and hormone regulation. Its stable isotope labeling enables precise measurements in biological samples, supporting research on endocrine function and related disorders. -
Stable Isotope
11-Beta-hydroxyandrostenedione-d4 is the deuterium-labeled form of 11-beta-hydroxyandrostenedione, which is a steroid primarily derived from the adrenal gland. This compound acts as an inhibitor of 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes, playing a crucial role in steroid metabolism. It is particularly useful in studies related to adrenal steroidogenesis and hormone regulation, enabling accurate tracking of metabolic pathways in various biological research applications. -
Stable Isotope
Alpha-Estradiol-d2 is a deuterium-labeled variant of Alpha-Estradiol, exhibiting stable isotope properties. As a weak estrogen and a 5α-reductase inhibitor, it is primarily utilized in the study of androgenic alopecia and related treatments. This reagent is valuable for research applications involving hormone metabolism, endocrine signaling, and the exploration of therapeutic strategies targeting hair loss. -
Stable Isotope
Finasteride-d9 is a deuterium-labeled derivative of Finasteride, a potent competitive inhibitor of 5α-reductase, exhibiting an IC50 of 4.2 nM for the type II isoform. This compound demonstrates significantly greater affinity for type II 5α-reductase, being approximately 100 times more selective than for type I. Finasteride-d9 is valuable in research applications focused on benign prostatic hyperplasia (BPH) and androgenic alopecia, facilitating studies on the pharmacokinetics and metabolism of its parent compound. -
Stable Isotope
Terbuthylazine-d5 is a deuterium-labeled derivative of terbuthylazine, functioning primarily as an inhibitor of acetolactate synthase (ALS). As a selective herbicide, it exhibits significant biological activity in disrupting the growth of certain plants by interfering with the synthesis of branched-chain amino acids. This stable isotope compound is valuable for research applications in agronomy and environmental studies, particularly in the analysis of herbicide metabolism and distribution in biological systems. -
Stable Isotope
Nicosulfuron-d6 is a deuterium-labeled analog of Nicosulfuron, a selective herbicide from the sulfonylurea class. This compound exhibits inhibition of the acetolactate synthase (ALS) enzyme, which plays a crucial role in amino acid biosynthesis. Nicosulfuron-d6 is primarily utilized in research applications demanding stable isotopic labeling, facilitating the study of herbicide mechanisms and their interactions in agricultural settings. -
Stable Isotope
Terbuthylazine-d9 is a deuterium-labeled derivative of Terbuthylazine, functioning primarily as an inhibitor of acetolactate synthase (ALS). This stable isotope is utilized in biochemical research to study the mechanisms of herbicide action and plant physiology. Its specific activity as a selective herbicide makes it valuable for investigating herbicide resistance and environmental fate in agricultural studies. -
Stable Isotope
2-Furoic acid-d3 is a deuterated stable isotope of 2-Furoic acid, an organic compound with the formula C5H4O3. This compound is recognized for its hypolipidemic effects, effectively reducing serum cholesterol and triglyceride levels in animal models. It is used in metabolic studies and tracer experiments to understand lipid metabolism and related biological pathways. -
Stable Isotope
L-Palmitoylcarnitine-d3 hydrochloride is the deuterium-labeled form of L-Palmitoylcarnitine hydrochloride, which serves as a stable isotope in research applications. This long-chain acylcarnitine plays a crucial role in fatty acid metabolism and is known to accumulate in the sarcolemma, disrupting membrane lipid composition during ischemic conditions. Additionally, L-Palmitoylcarnitine hydrochloride inhibits KATP channel activity via interaction with the Kir6.2 subunit, providing valuable insights for studies on cardiac health and metabolic disorders. -
Stable Isotope
Ropivacaine-d7 is a deuterium-labeled derivative of Ropivacaine, a potent sodium channel blocker. It works by reversibly inhibiting sodium ion influx, thereby blocking impulse conduction in nerve fibers. Additionally, Ropivacaine acts as an inhibitor of the K2P (two-pore domain potassium channel) TREK-1, exhibiting an IC50 of 402.7 μM in COS-7 cell membranes. This reagent is primarily used in studies focused on the management of neuropathic pain. -
Stable Isotope
Minoxidil-d10 is a deuterium-labeled analogue of Minoxidil, primarily functioning as an ATP-sensitive potassium (KATP) channel opener. This compound exhibits potent antihypertensive properties and functions as a peripheral vasodilator, enhancing vasodilation and influencing hair growth. Additionally, Minoxidil-d10 serves as a significant inhibitor of soybean lipoxygenase, with an IC50 of 20 μM, making it valuable for research applications in cardiovascular science and dermatology. -
Stable Isotope
L-Methionine-13C,d3 is a stable isotope-labeled form of the essential amino acid L-Methionine, featuring both carbon-13 and deuterium labeling. L-Methionine plays a crucial role in human development and functions as a hepatoprotectant, supporting liver health. This reagent is valuable for metabolic studies, isotopic tracing experiments, and research into amino acid metabolism. -
Stable Isotope
Hippuric acid-d5 is a deuterated form of hippuric acid, a metabolite resulting from the conjugation of benzoic acid and glycine. This stable isotope serves as a valuable tool for tracking metabolic pathways and understanding the excretion of aromatic compounds from dietary sources. Its applications include pharmacokinetic studies and metabolic profiling in various biochemical research settings. -
Stable Isotope
Estradiol-d4 is a deuterated form of the steroid hormone estradiol, functioning as a stable isotope. It plays a critical role in regulating fertility and the development of secondary sexual characteristics in females. Estradiol-d4 is utilized in research to study estrogen signaling, particularly its influence on interleukin-6 (IL-6) expression via the estrogen receptor β (ERβ) pathway, enabling precise quantification and analysis in various biological studies. -
Stable Isotope
L-Leucine-13C6,15N is a stable isotope-labeled form of L-Leucine, incorporating both carbon-13 and nitrogen-15 isotopes. This essential branched-chain amino acid (BCAA) plays a crucial role in activating the mTOR signaling pathway, which is important for regulating cell growth and metabolism. L-Leucine-13C6,15N is widely utilized in metabolic studies and tracer experiments to investigate protein synthesis and amino acid metabolism in various biological systems. -
Stable Isotope
L-Aspartic acid-d3 is a deuterium-labeled analog of L-Aspartic acid, known for its ability to penetrate the blood-brain barrier. This amino acid plays a significant role in various metabolic pathways and is utilized in synthesizing prodrugs aimed at colon and cecal tissues. Additionally, L-Aspartic acid-d3 is valuable in research on inflammatory conditions, enabling precise tracking and assessment of metabolic processes. -
Stable Isotope
L-Cysteine-d3 is a deuterium-labeled derivative of L-Cysteine, a conditionally essential amino acid. This compound serves as a precursor for key biological molecules, including hydrogen sulfide (H2S), glutathione, and taurine. L-Cysteine-d3 is valuable for research applications investigating metabolic pathways, appetite regulation, and the synthesis of reactive sulfur species. Its stable isotope labeling facilitates the study of L-Cysteine's roles in various physiological processes. -
Stable Isotope
L-Aspartic acid-13C4 is a stable isotope-labeled variant of L-Aspartic acid, an amino acid capable of crossing the blood-brain barrier. This compound is utilized in research focusing on prodrug formulation to effectively target colon and cecal tissues. Additionally, L-Aspartic acid-13C4 serves as a valuable tool in studying various inflammatory conditions, enhancing the understanding of metabolic and pathological processes. -
Stable Isotope
L-Proline-d3 is a deuterium-labeled derivative of L-Proline, an essential amino acid integral to protein synthesis in living organisms. This stable isotope serves as a valuable tool in biochemical research, particularly in studies involving metabolic pathways, protein folding, and structure-function relationships of proteins. Its unique labeling facilitates advanced analytical techniques, including NMR and mass spectrometry, enabling precise tracking of metabolic processes and biomolecular interactions. -
Stable Isotope
Benzyl alcohol-d1 is a deuterium-labeled derivative of benzyl alcohol, serving as a stable isotope. It is primarily utilized in research applications such as mass spectrometry and metabolic studies, enabling the tracing of biological pathways and the quantitation of metabolites. Its distinct isotopic signature allows for enhanced specificity in chemical analysis and improved detection limits in various experimental setups. -
Stable Isotope
Fumaric acid-13C4 is a stable isotope-labeled form of fumaric acid, primarily utilized in metabolic studies and tracer experiments. Fumaric acid is recognized as an oncometabolite, implicated in fumarase deficiency and various cancer-related processes. The incorporation of the 13C label facilitates advanced research applications, including metabolic flux analysis and the investigation of biochemical pathways associated with cancer metabolism. -
Stable Isotope
3-Indoleacetic acid-d7 is a deuterium-labeled derivative of 3-Indoleacetic acid, a pivotal auxin and plant growth hormone. This stable isotope is employed in various research applications, particularly in studies investigating the mechanisms of plant growth and development. By incorporating 3-Indoleacetic acid-d7 into cell culture mediums, researchers can effectively explore the dynamics of cell elongation and division in plant systems. -
Stable Isotope
Glycolic acid-d2 is a deuterium-labeled variant of glycolic acid, functioning as a stable isotope. It acts as a selective inhibitor of tyrosinase, effectively suppressing melanin production, which can lead to skin lightening effects. This reagent is valuable for studies in skin biology, cosmetic research, and investigations into pigmentation processes. -
Stable Isotope
Glycerol-13C3 is a stable isotope-labeled form of glycerol, featuring three carbon-13 atoms. It serves as a valuable tool in sample preparation and is commonly employed in polyacrylamide gel electrophoresis to enhance the sensitivity of detection methods. The incorporation of Glycerol-13C3 allows for precise quantification and tracking of metabolic pathways in various biological studies. -
Stable Isotope
Hypoxanthine-d4 is a deuterium-labeled derivative of hypoxanthine, which serves as a stable isotope. It exhibits potential as a free radical generator and can be utilized as an indicator of hypoxic conditions. This compound is suitable for research applications focused on metabolism, hypoxia-related studies, and oxidative stress investigations, providing a valuable tool for analyzing purine metabolism and its implications in various biological processes. -
Stable Isotope
Cholesterol-13C2 is a stable isotope-labeled form of cholesterol, a critical sterol in mammalian biology. It constitutes 20-25% of the plasma membrane's structural components and is essential for regulating the fluidity and permeability of the membrane, influencing the behavior of transporters and signaling proteins. This compound also acts as an endogenous agonist for estrogen-related receptor α (ERRα), making it valuable for studies in cell membrane dynamics and receptor signaling in various biological contexts. -
Stable Isotope
3,4-Dihydroxybenzeneacetic acid-d5 is a deuterated stable isotope of 3,4-Dihydroxybenzeneacetic acid, which serves as a primary neuronal metabolite of dopamine. This labeled compound is essential for studying dopamine metabolism and its related pathways in neurological research. It provides valuable insights into the dynamics of neurotransmitter activity and can be utilized in various analytical techniques, including mass spectrometry and nuclear magnetic resonance spectroscopy. -
Stable Isotope
L-Alanine-d3 is a stable isotope of the non-essential amino acid L-Alanine, distinguished by the presence of deuterium. This compound plays a vital role in metabolic processes, particularly in sugar and acid metabolism. L-Alanine-d3 is utilized in various research applications, including studies of metabolic pathways, amino acid transport, and the tracing of metabolic processes in biological systems. Its incorporation into research provides enhanced analytical accuracy in understanding amino acid dynamics and energy production in tissues. -
Stable Isotope
Indole-d7 is a deuterium-labeled derivative of indole, serving as a stable isotope in chemical research. As an endogenous metabolite, indole plays a crucial role in various biological processes, including neurotransmitter synthesis and tryptophan metabolism. Indole-d7 is primarily utilized in mass spectrometry and other analytical techniques for metabolic tracing and studying metabolic pathways. Its isotopic labeling aids in quantifying concentrations and analyzing the kinetics of indole-related biological effects. -
Stable Isotope
p-Cresol sulfate-d7 potassium is a deuterium-labeled derivative of p-Cresyl sulfate, a known protein-bound uremic toxin. This stable isotope is utilized in metabolic studies and pharmacokinetic research to trace the behavior of p-Cresyl sulfate in biological systems. Its incorporation into research enables enhanced understanding of protein binding and uremic toxicity in clinical settings. -
Stable Isotope
Taurocholic acid-d4 sodium is a deuterium-labeled derivative of taurocholic acid, a bile acid primarily involved in the emulsification of dietary fats. This stable isotope is valuable for research applications, particularly in metabolic studies and tracer experiments that investigate lipid digestion and absorption. It can be utilized in mass spectrometry and other analytical techniques to trace metabolic pathways and quantify bile acid levels in biological samples. -
Stable Isotope
p-Coumaric acid-d6 is a deuterium-labeled derivative of p-Coumaric acid, a prominent isomer of cinnamic acid. This compound exhibits notable antitumor and anti-mutagenic properties, making it valuable for cancer research and mutagenesis studies. Its stable isotope labeling facilitates quantitative analysis and metabolic tracking in biochemical research applications. -
Stable Isotope
L-Threonine-13C4 is a stable isotope-labeled form of the amino acid L-Threonine. As a naturally occurring amino acid, L-Threonine plays a critical role in protein synthesis and is utilized widely in biochemical research. This stable isotope can be employed in metabolic studies, tracer experiments, and quantitative analyses to track metabolic pathways and protein dynamics in various biological systems. -
Stable Isotope
L-Tryptophan-d8 is a deuterium-labeled form of the essential amino acid L-Tryptophan, serving as a stable isotope for various research applications. It is a precursor to important biomolecules such as serotonin, melatonin, and vitamin B3. This reagent is valuable in metabolic studies, isotopic labeling experiments, and investigations of amino acid metabolism, aiding in the understanding of biological processes and drug development. -
Stable Isotope
L-Serine-d3 is a deuterium-labeled form of the non-essential amino acid L-Serine, which plays a crucial role in cellular proliferation and metabolic processes. This stable isotope is useful in research applications involving metabolic tracing and NMR spectroscopy. L-Serine-d3 allows for enhanced detection and quantification in various biochemical studies, thereby aiding in the understanding of amino acid metabolism and related pathways. -
Stable Isotope
i-Inositol-d6 is a deuterium-labeled form of i-Inositol, a naturally occurring compound involved in various biological processes. It serves as an important precursor for inositol phosphates and plays a critical role in cell signaling and membrane formation. This stable isotope is widely used in metabolic studies and tracer experiments to investigate cellular pathways and lipid metabolism. -
Stable Isotope
Estradiol-d5 is a deuterium-labeled derivative of estradiol, a steroid sex hormone essential for female fertility and the development of secondary sexual characteristics. This stable isotope serves as a valuable tool in research applications, particularly in metabolic studies and hormone tracking. Estradiol-d5 activates the estrogen receptor β (ERβ) pathway, leading to the upregulation of IL-6 expression, making it useful for investigating estrogen-related biological processes. -
Stable Isotope
Glutaric acid-d6 is a stable isotope-labeled form of glutaric acid, an important intermediate in the catabolic pathways of lysine and tryptophan. It plays a significant role in modulating pericyte contractility and migration, making it relevant for studies in cellular dynamics and pathology. Additionally, glutaric acid is an important biomarker for diagnosing glutaric aciduria type I, facilitating research in metabolic disorders. -
Stable Isotope
1-Methyl-L-histidine-d3 is a deuterium-labeled form of 1-Methyl-L-histidine, utilized as a stable isotope in metabolic studies. This compound serves as a valuable biomarker for quantifying meat consumption and the intake of exogenous 3-methylhistidine (3MH). Researchers can apply this reagent in dietary assessments and metabolic tracing to better understand protein turnover and the physiological effects of meat-derived amino acids. -
Stable Isotope
Hippuric acid-d2 is the deuterium-labeled form of hippuric acid, a stable isotope used in various analytical applications. As a metabolite of aromatic compounds, it plays a key role in studies involving metabolic pathways and biochemistry. Its incorporation in research can enhance the accuracy of metabolic profiling and pharmacokinetic studies, providing insights into the metabolism of aromatic substances in biological systems. -
Stable Isotope
L-Citrulline-d4 is the deuterium-labeled analog of the amino acid L-Citrulline, which plays a critical role in the urea cycle and the production of nitric oxide. This stable isotope is utilized in metabolic studies and pharmacokinetic research to trace metabolic pathways involving citrulline. Its applications include investigating amino acid metabolism and exploring nitric oxide-mediated physiological processes. -
Stable Isotope
L-Serine-13C is a stable isotope-labeled form of L-Serine, an amino acid fundamental to various biological processes. It plays a critical role in cellular proliferation and is involved in the synthesis of proteins and neurotransmitters. This reagent is particularly useful for metabolic studies, isotopic tracing experiments, and research related to amino acid metabolism. -
Stable Isotope
DEHP-d4 is a deuterated form of bis(2-ethylhexyl) phthalate (DEHP), serving as a stable isotope. This compound is utilized in biological studies to trace and quantify metabolic pathways involving DEHP, an endogenous metabolite. Its incorporation into research allows for enhanced accuracy in the analysis of phthalate exposure and its effects on biological systems. -
Stable Isotope
p-Tyramine-d4 hydrochloride is a deuterium-labeled variant of tyramine hydrochloride, which serves as a stable isotope for analytical applications. This compound is involved in the regulation of blood pressure and is naturally occurring in various foods and biological systems. It can be utilized in metabolic studies and tracing experiments to elucidate the role of tyramine in physiological processes. -
Stable Isotope
L-Aspartic acid-15N is a stable isotope-labeled form of the amino acid L-Aspartic acid. This compound plays a crucial role in various metabolic processes and is known for its ability to penetrate the blood-brain barrier. L-Aspartic acid-15N is primarily applied in the development of prodrugs targeting colon and cecal tissues and is also utilized in research related to inflammatory conditions. Its isotopic labeling allows for advanced studies in metabolic tracking and related biochemical pathways. -
Stable Isotope
Cinnamic acid-d6 is a deuterium-labeled derivative of cinnamic acid, serving as a stable isotope for analytical studies. Cinnamic acid is recognized for its potential anti-cancer properties, exhibiting IC50 values between 1-4.5 mM in various cancer cell lines, including glioblastoma, melanoma, prostate, and lung carcinoma. This compound is valuable for research applications that require tracking metabolic pathways, studying drug interactions, and understanding the mechanisms of action in cancer biology. -
Stable Isotope
L-Serine-d7 is a deuterated form of the non-essential amino acid L-Serine, serving as a stable isotope labeled compound. L-Serine is vital for cellular processes, including proliferation and metabolism. This reagent is primarily utilized in metabolic studies, tracer experiments, and proteomic analyses, enhancing the understanding of amino acid metabolism and biological pathways. -
Stable Isotope
L-Cysteine-13C3 is a stable isotope-labeled form of the conditionally essential amino acid L-Cysteine. This compound serves as a crucial precursor for biologically active molecules, including hydrogen sulfide (H2S), glutathione, and taurine, which are integral to various metabolic pathways. L-Cysteine is also noted for its role in appetite regulation, as it has been shown to suppress ghrelin levels in both rodent models and human studies. This reagent is valuable for metabolic studies and investigations into amino acid metabolism. -
Stable Isotope
L-Isoleucine-13C6 is a stable isotope-labeled form of the essential amino acid L-Isoleucine, which exhibits hydrophobic properties. As a nonpolar amino acid, L-Isoleucine plays a critical role in protein synthesis and energy production. This reagent is primarily utilized in metabolic studies, isotopic labeling experiments, and protein tracking to elucidate metabolic pathways and cellular processes. -
Stable Isotope
L-Ornithine-1,2,3,4,5-13C5 hydrochloride is a stable isotope-labeled form of the amino acid L-Ornithine. This compound is integral to the urea cycle, facilitating the excretion of excess nitrogen in the body. Its unique isotopic labeling makes it a valuable tool for metabolic studies and tracer experiments in biochemical research.
