2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate is a deuterium-labeled derivative of Octinoxate, functioning primarily as a thyroid hormone receptor agonist. This compound has been shown to decrease levels of triiodothyronine (T3) and thyroxine (T4), along with transcription levels of genes associated with type II deiodinase (deio2) in Japanese Medaka, supporting its role in endocrine research. Additionally, it is utilized as a UV filter in aquatic environments and exhibits inhibitory effects on CYP1A1 and CYP1B1, influencing hyaluronan metabolism through the PI3K pathway in human keratinocytes. Its anti-estrogenic and anti-androgenic properties have been demonstrated in both in vitro and in vivo studies, making it valuable for hormonal modulation research.
2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate is a deuterium-labeled derivative of Octinoxate, functioning primarily as a thyroid hormone receptor agonist. This compound has been shown to decrease levels of triiodothyronine (T3) and thyroxine (T4), along with transcription levels of genes associated with type II deiodinase (deio2) in Japanese Medaka, supporting its role in endocrine research. Additionally, it is utilized as a UV filter in aquatic environments and exhibits inhibitory effects on CYP1A1 and CYP1B1, influencing hyaluronan metabolism through the PI3K pathway in human keratinocytes. Its anti-estrogenic and anti-androgenic properties have been demonstrated in both in vitro and in vivo studies, making it valuable for hormonal modulation research.
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