Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
D-Mannose-13C6 is a stable isotope-labeled carbohydrate essential for metabolic studies. It plays a significant role in human metabolism, particularly in the glycosylation of proteins. This reagent is valuable for research applications involving metabolic flux analysis and tracing pathways in glycoprotein synthesis. -
Stable Isotope
L-Isoleucine-d10 is a stable isotope-labeled form of the essential nonpolar amino acid L-isoleucine, incorporating ten deuterium atoms. This compound is valuable in metabolic studies, tracer experiments, and protein labeling applications, allowing for enhanced tracking and quantification in biological systems. L-Isoleucine plays a crucial role in protein synthesis and energy production, making it significant for research in nutrition, cellular metabolism, and muscle physiology. -
Stable Isotope
Glycodeoxycholic acid-d4 is a deuterium-labeled derivative of Glycodeoxycholic Acid, an important endogenous metabolite. This stable isotope is utilized in various metabolic studies and tracer experiments, enhancing the understanding of bile acid dynamics and their roles in gastrointestinal physiology. Its applications extend to research pertaining to liver function, cholesterol metabolism, and disorders associated with bile acid dysregulation. -
Stable Isotope
Lignoceric acid-d4-1 is the deuterated form of lignoceric acid, a 24-carbon saturated fatty acid (Tetracosanoic acid) primarily synthesized in the developing brain. This stable isotope serves as a valuable tool in metabolic studies, particularly relating to Zellweger cerebro-hepato-renal syndrome and adrenoleukodystrophy. Its unique labeling enables researchers to track metabolic pathways and study lipid metabolism in various biological contexts. -
Stable Isotope
Estrone sulfate-d4 sodium is a deuterium-labeled derivative of Estrone sulfate, primarily utilized as a stable isotope in research. It serves as a precursor to bioactive estrogens, Estrone and Estradiol, through enzymatic conversion in various biological systems. This compound is important for studying estrogen metabolism and signaling pathways, particularly in breast cancer research, where it has been shown to promote the proliferation of mammary tumor cells and influence tumor growth in experimental models. Its role as a substrate for the OATP1B3 transporter also highlights its relevance in pharmacokinetic studies. -
Stable Isotope
Stearic acid-d3 is a stable isotope-labeled form of stearic acid, a long-chain saturated fatty acid commonly found in various animal and vegetable fats and oils. This compound is utilized in metabolic studies and lipid research to trace fatty acid metabolism and distribution in biological systems. Its deuterated form enables precise quantification and tracking in mass spectrometry applications, aiding in understanding fatty acid synthesis and metabolism pathways. -
Stable Isotope
Bisphenol A-d16 is the deuterated version of Bisphenol A, a key phenolic compound utilized in the synthesis of polycarbonate plastics and epoxy resins. This stable isotope is valuable for research applications related to environmental monitoring and toxicology, given Bisphenol A's classification as an endocrine-disrupting compound (EDC) and its associations with various health issues, including reproductive disorders and metabolic diseases. The use of Bisphenol A-d16 aids in tracking and quantifying the compound's presence and effects in biological systems. -
Stable Isotope
Pentadecanoic acid-d29 is a stable isotope-labeled form of pentadecanoic acid, a saturated fatty acid characterized by a 15-carbon backbone. This compound serves as a valuable tool in metabolic studies and tracer applications due to its unique isotopic signature. It is particularly useful in investigating fatty acid metabolism and lipid biochemistry in various biological systems. -
Stable Isotope
L-Tryptophan-15N2 is a stable isotope-labeled form of the essential amino acid L-Tryptophan. As a precursor to key biomolecules such as serotonin, melatonin, and vitamin B3, this compound is essential in studies related to neurotransmitter function and metabolic pathways. L-Tryptophan-15N2 is valuable in metabolic tracing experiments and isotopic labeling studies in various biological systems. -
Stable Isotope
Ethynyl Estradiol-d4 is a deuterium-labeled derivative of Ethynyl Estradiol, a synthetic estrogen primarily employed in oral contraceptive formulations. This compound serves as a stable isotope standard for mass spectrometry and other analytical techniques. Additionally, Ethynyl Estradiol-d4 contains an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC). Its applications extend to click chemistry, facilitating the study of biological processes and drug development. -
Stable Isotope
D-Glutamic acid-d5 is a deuterium-labeled analog of D-glutamic acid, serving as a stable isotope. This compound is typically employed in metabolic studies and tracer experiments to investigate D-glutamic acid's biological functions and pathways. Its applications extend to the pharmaceutical and food industries, where it can contribute to research in neurochemistry and sensory analysis. -
Stable Isotope
N-Methylnicotinamide-d4 is a deuterium-labeled derivative of N-Methylnicotinamide, serving as a stable isotope for metabolic studies. This compound is an endogenous metabolite known for its antithrombotic properties, acting primarily through the production and release of prostacyclin, which inhibits arterial thrombosis formation. Its role as the N-methylation product of nicotinamide, catalyzed by N-methyltransferase, positions it as a valuable tool in the analysis of nicotinate and nicotinamide metabolic pathways. -
Stable Isotope
Indolelactic acid-d5 is a stable isotope-labeled derivative of Indolelactic acid. This compound serves as a tryptophan catabolite and is particularly relevant in the study of metabolic pathways in Azotobacter vinelandii. It is utilized in various research applications, including tracing metabolic processes and investigating tryptophan degradation pathways. -
Stable Isotope
L-Leucine-d10 is a deuterium-labeled form of the essential branched-chain amino acid L-Leucine. It activates the mTOR signaling pathway, which is crucial for regulating cellular growth, metabolism, and protein synthesis. This stable isotope is particularly valuable in metabolic studies, allowing researchers to trace pathways and quantify amino acid metabolism in various biological systems. -
Stable Isotope
Succinic acid-d6 is a deuterium-labeled form of succinic acid, a key intermediate in the tricarboxylic acid cycle. This stable isotope is widely used in metabolic studies and tracer experiments, providing insights into metabolic pathways and cellular metabolism. It serves as a valuable tool in research applications involving metabolic flux analysis and isotopic labeling studies. -
Stable Isotope
Cholesterol-d6-1 is a deuterated form of cholesterol, a key sterol in mammalian biology. This stable isotope plays a critical role in cellular membranes, comprising 20-25% of their structural components, and influencing membrane fluidity and permeability characteristics. Additionally, cholesterol modulates the function of transporters and signaling proteins, and acts as an endogenous agonist for estrogen-related receptor α (ERRα). Cholesterol-d6-1 is valuable for studies in lipid metabolism, membrane dynamics, and receptor signaling pathways. -
Stable Isotope
Glycocyamine-d2 is a deuterium-labeled stable isotope of glycocyamine, a crucial precursor in creatine synthesis. This compound plays a significant role in energy metabolism regulation and promotes myogenic differentiation by activating the Akt/mTOR/S6K signaling pathway through the modulation of miR-133a-3p and miR-1a-3p. Glycocyamine-d2 enhances the expression of muscle-specific factors such as MyoD and MyoG, increases muscle creatine levels, and supports ATP homeostasis via the creatine phosphate/creatine kinase system. Its applications extend to research involving feed additives in poultry farming and muscle physiology studies. -
Stable Isotope
Urea-d4 is a deuterium-labeled isotope of urea, commonly utilized in stable isotope labeling studies. Urea serves as a potent protein denaturant through both direct and indirect pathways, and it also functions as an effective emollient and keratolytic agent. In research, it aids in the assessment of renal function by measuring blood urea nitrogen (BUN) levels. Additionally, urea's nitrogen content makes it a valuable compound in fertilizers and a key raw material in various chemical processes. -
Stable Isotope
Glycocyamine-15N,13C2 is a stable isotope-labeled form of Glycocyamine, featuring both 13C and 15N stable isotopes. As a direct precursor of creatine, it serves as an effective regulator of energy metabolism and a promoter of myogenic differentiation. Glycocyamine activates the Akt/mTOR/S6K signaling pathway through miR-133a-3p and miR-1a-3p, enhancing the expression of myogenic differentiation factors such as MyoD and MyoG. Its role in increasing muscle creatine concentration and maintaining ATP homeostasis makes it an important reagent for research applications, particularly in studies related to feed additives in poultry farming. -
Stable Isotope
Trimethylammonium chloride-d9 is a deuterium-labeled derivative of trimethylammonium chloride, a stable isotope that serves as a valuable internal standard in quantitative mass spectrometry. This compound is an endogenous metabolite involved in various biological processes and lipid metabolism. Its unique isotopic labeling enables sensitive tracking and quantification of metabolites in biological samples, facilitating research in metabolism and cellular biochemistry. -
Stable Isotope
3-Indoleacetic acid-13C6 is a stable isotope-labeled form of 3-Indoleacetic acid, a naturally occurring plant growth hormone classified as an auxin. This compound plays a crucial role in promoting cell elongation and division in plant tissues. Researchers utilize 3-Indoleacetic acid-13C6 in metabolic studies and isotopic tracing experiments to investigate auxin biosynthesis, transport, and signaling pathways in plant development. -
Stable Isotope
D-Alanine-d3 is a deuterium-labeled derivative of D-Alanine, primarily utilized as a stable isotope in biochemical research. This compound acts as a weak agonist for glycine receptors (GlyR), exhibiting an EC50 value of 9 mM. D-Alanine-d3 is valuable for studies investigating neurotransmission and receptor pharmacology, as well as in metabolic labeling applications. -
Stable Isotope
(R)-3-Hydroxybutanoic acid-13C4 sodium is a stable isotope-labeled variant of (R)-3-Hydroxybutanoic acid, which serves as a key metabolite derived from acetoacetic acid through the action of 3-hydroxybutyrate dehydrogenase. This compound plays a crucial role as an energy source and is involved in the biosynthesis of essential metabolites, including vitamins, antibiotics, and pheromones. It is valuable for metabolic studies, tracer experiments, and investigations into lipid metabolism and cellular energy pathways. -
Stable Isotope
Glycoursodeoxycholic acid-d4 is a stable isotope-labeled derivative of glycoursodeoxycholic acid, specifically deuterated at four positions. This compound acts as a bile acid-glycine conjugate, linked to metabolic pathways of ursodeoxycholic acid. It is commonly utilized in biochemical research to study bile acid metabolism and transport mechanisms, providing valuable insights into liver function and gastrointestinal physiology. -
Stable Isotope
Octanoic acid-13C4 is a stable isotope-labeled form of octanoic acid, also known as caprylic acid. This compound serves as a valuable internal standard in mass spectrometry applications, facilitating the quantification of fatty acids in biological samples. Its unique isotopic signature allows for precise tracking of metabolic processes, making it an essential tool in lipid metabolism studies and related biochemical research. -
Stable Isotope
L-Serine-1-13C is a stable isotope-labeled form of the non-essential amino acid L-Serine. It plays a crucial role in cellular metabolism and proliferation, making it an important compound in various biological research applications. This isotope is particularly valuable in studies involving metabolic tracing and quantitative analysis of amino acid metabolism. -
Stable Isotope
L-Ornithine-d6 hydrochloride is a deuterium-labeled form of L-Ornithine, an essential free amino acid involved in the urea cycle. It plays a critical role in nitrogen metabolism and is utilized in various biochemical research applications, including metabolic studies and isotopic tracing. This stable isotope enhances the sensitivity and accuracy of analytical techniques in research focusing on amino acid metabolism and related pathways. -
Stable Isotope
Glutaric acid-d4 is a stable isotope of glutaric acid, a dicarboxylic acid involved in the metabolic pathways of lysine and tryptophan. Its biological activity includes modulation of pericyte contractility and migration, contributing to investigations in cellular dynamics. Glutaric acid-d4 serves as a valuable tool in research focusing on metabolic disorders, particularly as an indicator of glutaric aciduria type I. -
Stable Isotope
Triolein-13C3 is a stable isotope-labeled form of triolein, a symmetrical triacylglycerol. It is known to reduce the upregulation of MMP-1 and exhibits significant antioxidant and anti-inflammatory properties. This compound is valuable for research applications in metabolic studies and lipid metabolism, providing insights into the effects of dietary triglycerides on cellular processes. -
Stable Isotope
Creatinine-13C is a stable isotope-labeled form of creatinine, a breakdown product of creatine phosphate in muscle tissue. This compound is typically produced at a consistent rate in the human body, making it valuable for research applications in metabolic studies and kidney function assessment. Its use in isotopic labeling enhances the precision of analytical techniques, allowing for improved tracking of metabolic processes in various biological systems. -
Stable Isotope
β-Alanine-d4 is a stable isotope-labeled form of β-Alanine, a non-essential amino acid involved in the synthesis of carnosine. Carnosine acts as an important intracellular buffer, contributing to pH homeostasis in muscle cells. This reagent is valuable for metabolic studies, particularly in researching amino acid metabolism and carnosine's role in physiological processes. -
Stable Isotope
L-Serine-15N is a stable isotope-labeled form of L-Serine. As a non-essential amino acid, L-Serine is crucial in various biological processes, including cellular proliferation and metabolism. This isotopically labeled version is valuable for research applications in metabolic studies, tracer experiments, and protein labeling in proteomics. -
Stable Isotope
Linoleic acid-d4 is a deuterium-labeled derivative of linoleic acid, a polyunsaturated fatty acid commonly found in plant oils, nuts, and seeds. It serves as a crucial component of membrane phospholipids, contributing to the maintenance of membrane fluidity essential for the integrity of the transdermal water barrier in the epidermis. In research applications, linoleic acid-d4 can be used to investigate oxidative stress mechanisms, particularly its effects on red blood cells and hemoglobin. This stable isotope is valuable for studies involving metabolic pathways and lipid dynamics. -
Stable Isotope
L-Tryptophan-1-13C is a stable isotope-labeled form of the essential amino acid L-Tryptophan. It serves as a precursor for key biomolecules, including serotonin, melatonin, and vitamin B3, making it valuable in metabolic studies. This compound is useful in research applications such as probing metabolic pathways, isotopic labeling, and tracing the biosynthesis of neurotransmitters and hormones. -
Stable Isotope
DPPC-d62 is a deuterium-labeled derivative of dipalmitoylphosphatidylcholine (DPPC), a zwitterionic phosphoglyceride. This stable isotope is instrumental in the preparation of liposomal monolayers, serving as a delivery vehicle in immunological studies. Research applications include the induction of immune responses against glycosphingolipid (GSL) antigens in murine models, facilitating enhanced understanding of lipid-mediated immune mechanisms. -
Stable Isotope
4β-Hydroxycholesterol-d4 is a deuterium-labeled derivative of 4β-Hydroxycholesterol, a significant metabolite of cholesterol. This compound serves as a precursor in bile acid synthesis and is present in human circulation. It is primarily utilized in research applications involving lipid metabolism, cholesterol homeostasis, and the assessment of cholesterol-derived signaling pathways. This stable isotope enables accurate quantitative analysis in mass spectrometry studies. -
Stable Isotope
Triolein-d5 is a deuterium-labeled form of triolein, a symmetrical triacylglycerol. This compound exhibits significant antioxidant and anti-inflammatory properties, while also being noted for its ability to reduce the upregulation of matrix metalloproteinase-1 (MMP-1). Triolein-d5 is primarily used as a stable isotope in metabolic studies and tracers in lipid metabolism research. -
Stable Isotope
Azelaic acid-d14 is a stable isotope-labeled derivative of azelaic acid, an organic compound derived from the ozonolysis of oleic acid. This reagent serves as a valuable tool for metabolic studies and tracer experiments, allowing for precise quantification and tracking of azelaic acid's biological processes in research. Azelaic acid has demonstrated antimicrobial properties and is commonly utilized in dermatological applications, making this labeled form highly relevant for pharmacokinetic and pharmacodynamic investigations. -
Stable Isotope
Deoxycorticosterone-d8 is a deuterated form of deoxycorticosterone, a steroid hormone that serves as a mineralocorticoid and precursor to aldosterone. This stable isotope is primarily used in research applications requiring precise quantification of steroid hormones in biological samples. Its incorporation of deuterium facilitates studies in metabolic pathways, hormone profiling, and pharmacokinetics of steroid-related compounds. -
Stable Isotope
3-Methoxy-4-hydroxyphenylglycol-d3 is a stable isotope-labeled derivative of 3-Methoxy-4-hydroxyphenylglycol, specifically incorporating deuterium atoms. This compound serves as a valuable internal standard in quantitative mass spectrometry and biochemical assays, facilitating the accurate measurement of biological samples. It is widely utilized in pharmacokinetic studies and metabolic research to track and analyze various metabolic pathways involving phenolic compounds. -
Stable Isotope
D-(+)-Trehalose-d14 is a deuterium-labeled derivative of D-(+)-Trehalose, serving as a stable isotope for research applications. Isolated from Saccharomyces cerevisiae, D-(+)-Trehalose plays a significant role as a protective sugar against cellular stress and is utilized in various biochemical studies. This compound is valuable for tracing metabolic pathways, enhancing understanding of cellular processes, and can be applied in formulations for food and pharmaceutical research. -
Stable Isotope
Arachidic acid-d39 is a deuterium-labeled derivative of arachidic acid, a long-chain saturated fatty acid. This stable isotope is utilized in metabolic studies and tracer experiments to investigate lipid metabolism and the dynamics of fatty acid incorporation in biological systems. Arachidic acid has been identified in human plasma phospholipids and various plant oils, and it interacts with chitosan oligosaccharides for potential applications in targeted anti-cancer drug delivery research. -
Stable Isotope
25-Hydroxycholesterol-d6 is a deuterium-labeled form of 25-Hydroxycholesterol, a metabolite of cholesterol synthesized and released by macrophages upon Toll-like receptor (TLR) activation. This compound serves as a selective and potent inhibitor of immunoglobulin A (IgA) production in B cells, with an effective concentration (EC50) of approximately 65 nM. Its unique labeling makes it a valuable tool for tracing cholesterol metabolism and studying immune response mechanisms in various research applications. -
Stable Isotope
Calcifediol-d3 is a deuterium-labeled form of Calcifediol, serving as an effective ligand for the Vitamin D Receptor (VDR) and a viable Vitamin D supplement. As a prohormone within the vitamin D endocrine system (VDES), it undergoes hepatic hydroxylation to form calcitriol, the bioactive variant of vitamin D. Calcifediol-d3 can effectively elevate serum vitamin D levels, making it useful in research focused on vitamin D metabolism and VDR signaling pathways. -
Stable Isotope
Vanillylmandelic acid-d3 is a deuterium-labeled derivative of vanillylmandelic acid, which serves as a stable isotope in research applications. As the final metabolite of epinephrine and norepinephrine, it serves as a biomarker for assessing disorders in neurotransmitter metabolism. Additionally, vanillylmandelic acid exhibits antioxidant properties, displaying activity against the DPPH radical with an IC50 value of 33 μM, making it useful in studies of oxidative stress and related pathways. -
Stable Isotope
Normetanephrine-d3 hydrochloride is a stable isotope-labeled form of Normetanephrine hydrochloride, which serves as the O-methylated metabolite of norepinephrine (NE). This compound is utilized in various research applications, particularly in metabolic studies and pharmacokinetics, providing insights into phenolic compound metabolism. Its deuterium labeling enhances the sensitivity and accuracy of analytical techniques, making it a valuable tool for scientists studying catecholamine pathways and their physiological implications. -
Stable Isotope
D-Glucose-d2 is a deuterium-labeled form of D-Glucose, a key monosaccharide involved in various metabolic processes. This stable isotope is essential for metabolic research and can be used to trace metabolic pathways, providing insights into cellular energy metabolism and signaling mechanisms in response to environmental stresses. Its incorporation into biological systems allows for precise analysis of glucose utilization and metabolism in different conditions. -
Stable Isotope
L-Tyrosine-d5 is a deuterated form of the non-essential amino acid L-Tyrosine, used as a stable isotope in metabolic studies. This reagent is utilized to trace metabolic pathways and analyze amino acid metabolism in various biological systems. Its application extends to research in neurobiology, as it can influence the activity of enzymes such as citrate synthase in the central nervous system. -
Stable Isotope
Paraxanthine-d6 is a deuterium-labeled derivative of Paraxanthine, a significant caffeine metabolite. This stable isotope can be utilized in metabolic studies and tracer experiments to investigate the pharmacokinetics of caffeine and its metabolites. Paraxanthine has been shown to offer neuroprotective effects against dopaminergic cell death through the modulation of Ryanodine Receptor Channels, highlighting its relevance in neurobiology and toxicology research. -
Stable Isotope
NNK-d4 is a deuterium-labeled analog of NNK, a potent tobacco-specific nitrosamine. This stable isotope is utilized in pharmacokinetic studies to trace the metabolism and distribution of NNK in biological systems. Research applications include understanding the mechanisms of carcinogenesis and evaluating the effects of tobacco-related compounds on cellular processes.
