Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Arachidonic acid-d11 is a deuterium-labeled form of arachidonic acid, an essential fatty acid integral to cell membrane structure and function. This stable isotope is widely utilized in biochemical research to study complex lipid signaling pathways, including those involved in inflammation and cellular signaling. Its application in mass spectrometry enables precise quantification of arachidonic acid metabolism in various biological systems. -
Stable Isotope
Hypoxanthine-13C5 is a stable isotope-labeled form of hypoxanthine, a purine derivative. It serves as a potential free radical generator and can be utilized as an indicator of hypoxic conditions in biological research. This reagent is valuable for studies investigating cellular metabolism, hypoxia-related pathways, and the effects of reactive oxygen species in various physiological contexts. -
Stable Isotope
Cytosine-d2 is a stable isotope-labeled form of cytosine, one of the four principal nucleobases in DNA and RNA. The deuterium substitution enhances its utility in various analytical techniques, especially in studies of epigenetic modifications. This reagent is particularly valuable for investigating circadian oscillations of cytosine modifications, contributing to the understanding of epigenetic diversity and aging processes. -
Stable Isotope
D-Leucine-d10 is a deuterium-labeled variant of D-Leucine, known for its enhanced potency as an anti-seizure compound compared to its L-leucine counterpart. This stable isotope effectively terminates seizure activity even after it has commenced and is recognized for its ability to reduce long-term potentiation without affecting basal synaptic transmission in vitro. D-Leucine-d10 is valuable for research applications involving seizure mechanisms and synaptic plasticity studies. -
Stable Isotope
Lignoceric acid-d47 is a deuterium-labeled derivative of Lignoceric acid, a saturated fatty acid with a chain length of 24 carbons (24:0). This stable isotope is primarily utilized for tracer studies in metabolic research. Lignoceric acid plays a crucial role in neurodevelopment and is implicated in disorders such as Zellweger syndrome and adrenoleukodystrophy, making this labeled form valuable for studying these conditions at a molecular level. -
Stable Isotope
5-Hydroxyindole-3-acetic acid-d5 is a deuterium-labeled form of 5-Hydroxyindole-3-acetic acid, primarily used as a stable isotope. As a significant metabolite of serotonin, it serves as an important biomarker for neuroendocrine tumors. This reagent is essential for analytical studies involving metabolic pathways and biomarker identification in various research applications. -
Stable Isotope
3-Hydroxybutyric acid-13C4 sodium is a stable isotope-labeled form of 3-Hydroxybutyric acid, a key metabolite involved in lipid metabolism. This compound is particularly relevant in the study of type I diabetes, where its levels are often elevated, and it has the potential to influence the properties of membrane lipids. Research applications include metabolic studies and investigations into the biochemical pathways associated with diabetes and lipid metabolism. -
Stable Isotope
L-Ornithine-15N2 hydrochloride is a stable isotope-labeled form of the amino acid L-Ornithine, which is crucial in the urea cycle and nitrogen metabolism. This reagent is primarily used in metabolic studies and tracer experiments to investigate nitrogen sources and amino acid dynamics in biological systems. Its isotopic labeling allows for precise tracking of L-Ornithine in various research applications, including nutrition and biochemical pathways. -
Stable Isotope
2-Ketoglutaric acid-d6 is a stable isotope-labeled form of 2-Ketoglutaric acid, a key intermediate in the Krebs cycle responsible for ATP and GTP production. This compound plays a vital role in nitrogen assimilation processes and serves as a substrate for various biosynthetic pathways. Additionally, 2-Ketoglutaric acid-d6 exhibits properties as a reversible inhibitor of tyrosinase, making it useful for studies related to enzymatic regulation and metabolic pathways. This reagent is ideal for use in metabolic labeling experiments and kinetic studies in biochemical research. -
Stable Isotope
DL-Aspartic acid-d3 is a deuterated form of L-Aspartic acid, an amino acid known for its ability to traverse the blood-brain barrier. This stable isotope serves as a valuable tool in metabolic studies and is particularly beneficial in researching inflammatory conditions and preparing prodrugs aimed at colon and cecal tissues. Its unique labeling allows for precise tracking and quantification in biological systems, enhancing its application in biochemical research. -
Stable Isotope
L-Threonine-13C4,15N is a stable isotope-labeled form of the natural amino acid L-Threonine, incorporating four carbon-13 atoms and one nitrogen-15 atom. This compound is valuable for metabolic studies and isotopic tracing in biochemical research. Its applications include investigating protein synthesis, metabolic pathways, and amino acid utilization in various biological systems. L-Threonine-13C4,15N is suitable for enhancing the precision of analyses in food, pharmaceutical, and nutritional studies. -
Stable Isotope
Hypoxanthine-d2 is a deuterium-labeled derivative of hypoxanthine, serving as a stable isotope for research applications. As a purine metabolite, hypoxanthine-d2 can act as a potential free radical generator, making it useful for studies related to oxidative stress and hypoxia. Its incorporation in metabolic research allows for the tracing of pathways in cellular metabolism and the evaluation of hypoxic conditions in biological systems. -
Stable Isotope
(R)-3-Hydroxybutanoic acid-13C2 sodium is a stable isotope-labeled form of (R)-3-hydroxybutanoic acid sodium, a metabolite derived from acetoacetic acid through the action of 3-hydroxybutyrate dehydrogenase. This compound serves as an important nutritional source and acts as a precursor for various biological molecules, including vitamins, antibiotics, and pheromones. It is widely used in metabolic studies and tracing experiments to understand metabolic pathways and compound utilization in biological systems. -
Stable Isotope
L-Alanine-d7 is a deuterium-labeled stable isotope of L-Alanine, a non-essential amino acid. This compound plays a crucial role in sugar and acid metabolism and is known to enhance immune function while supplying energy to muscle tissue, the brain, and the central nervous system. L-Alanine-d7 is valuable in metabolic research, tracer studies, and isotopic labeling applications, enabling precise analysis of biochemical pathways. -
Stable Isotope
Suberic acid-d4 is a deuterium-labeled derivative of suberic acid (octanedioic acid), a dicarboxylic acid that plays a role in metabolic pathways. It is utilized as a stable isotope for isotopic tracing studies in metabolic research. Suberic acid is associated with carnitine-acylcarnitine translocase deficiency and malonyl-CoA decarboxylase deficiency, making this reagent valuable for studying these metabolic disorders and related biochemical processes. -
Stable Isotope
Stearic acid-d7 is the deuterium-labeled form of stearic acid, a saturated long-chain fatty acid commonly found in various animal and vegetable fats and oils. As a stable isotope, Stearic acid-d7 serves as a valuable tool in metabolic studies, aiding in the investigation of lipid metabolism and pathways. Its precise labeling allows for enhanced tracking in biological systems, making it suitable for applications in pharmacokinetics and metabolic flux analysis. -
Stable Isotope
L-Alanine-13C3 is a stable isotope-labeled form of the non-essential amino acid L-Alanine. This compound plays a crucial role in metabolic pathways, particularly in glucose and organic acid metabolism, and is essential for supporting immune function and energy production in muscle, brain, and central nervous systems. L-Alanine-13C3 is commonly utilized in metabolic studies and tracer experiments to investigate amino acid metabolism and related physiological processes. -
Stable Isotope
Fumaric acid-d4 is a stable isotope-labeled form of fumaric acid, a key intermediate in the tricarboxylic acid (TCA) cycle. This compound is associated with fumarase deficiency and has been identified as an oncometabolite involved in cancer metabolism. Fumaric acid-d4 can be utilized in metabolic studies, tracer experiments, and research into the biochemical pathways related to cancer and metabolic disorders. -
Stable Isotope
L-Alanine-13C3,15N is a stable isotope-labeled form of the non-essential amino acid L-Alanine, featuring three carbon-13 isotopes and one nitrogen-15 isotope. L-Alanine plays a critical role in amino acid metabolism, enhances immune function, and serves as an energy source for muscle tissue, the brain, and the central nervous system. This reagent is widely applicable in metabolic flux studies, tracer experiments, and isotope labeling investigations in biochemical and clinical research. -
Stable Isotope
N-Deshydroxyethyl Dasatinib-d8 is a deuterium-labeled derivative of N-Deshydroxyethyl Dasatinib, designed for use as a stable isotope tracer in biological studies. This compound acts by binding to IAP ligands through a linker, facilitating the degradation of Abl proteins via the SNIPER technique. Its unique isotopic labeling allows for precise tracking in pharmacokinetic and metabolic research, enhancing the understanding of drug mechanisms and interactions in cell signaling pathways. -
Stable Isotope
9-Amino-1,2,3,4-tetrahydroacridin-1-ol-d3 Maleate is a deuterated variant of CRBN ligand-74, functioning as a CRBN-type E3 ubiquitin ligase ligand. This stable isotope can be utilized in the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation studies. Its unique deuterated structure enhances analytical applications and facilitates tracing in various biological research protocols. -
Stable Isotope
Benzoin-d10 is a deuterium-labeled derivative of Benzoin, functioning as a stable isotope. It serves as a valuable tool in pharmacokinetic studies and metabolic research. The native compound exhibits anti-cancer properties, specifically acting as a PI3Kα inhibitor and demonstrating growth inhibition in colon cancer cell lines such as HCT-116. Benzoin-d10 can also be utilized in food additive applications, providing insights into food chemistry and safety assessments. -
Stable Isotope
Safinamide-d4-1 is a deuterium-labeled derivative of Safinamide, a selective and reversible inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 0.098 μM, demonstrating significantly lower inhibition of MAO-A (IC50=580 μM). In addition to its MAO-B inhibitory activity, Safinamide also interacts with sodium channels and modulates glutamate release, exhibiting a greater affinity at depolarized potentials (IC50=8 μM) compared to resting potentials (IC50=262 μM). This reagent is valuable for research applications related to neurobiology, particularly in the investigation of Parkinson's disease and ischemic stroke mechanisms. -
Stable Isotope
Hydroxylamine-15N hydrochloride is a stable isotope-labeled variant of Hydroxylamine hydrochloride, primarily recognized for its role as a selective inhibitor of Monoamine oxidase (MAO). This compound is employed in the study of platelet aggregation and serves as an important intermediate in the nitrogen cycle, particularly in aerobic ammonium-oxidizing microorganisms, including ammonium-oxidizing bacteria (AOB), ammonium-oxidizing archaea (AOA), and complete ammonium oxidizing bacteria (comammox). Additionally, it plays a critical role in research focused on nitrogen oxide (NO) and nitrous oxide (N2O) emissions while inhibiting the activity of nitrite-oxidizing bacteria (NOB). -
Stable Isotope
Moclobemide-d8 is a deuterated form of Moclobemide, a reversible inhibitor of monoamine oxidase A (MAO-A) with an IC50 of 6.061 μM for human MAO-A. This compound effectively penetrates the blood-brain barrier and has been shown to promote the proliferation of hippocampal progenitor cells in models of chronic stress. Moclobemide-d8 is particularly useful in pharmacokinetic studies and metabolic research involving MAO-A modulation. -
Stable Isotope
Selegiline-d5 is a deuterium-labeled derivative of Selegiline, targeting the selective and irreversible inhibition of monoamine oxidase B (MAO-B) with an IC50 of 51 nM. This compound demonstrates a 450-fold selectivity for MAO-B over MAO-A (IC50=23 µM). Selegiline-d5 is valuable for research into neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, as well as in the investigation of major depressive disorder. -
Stable Isotope
Selegiline-d5 hydrochloride is a deuterium-labeled form of the irreversible monoamine oxidase B (MAO-B) inhibitor, Selegiline. This compound exhibits a high selectivity for MAO-B with an IC50 of 51 nM, demonstrating 450-fold preference over MAO-A (IC50 = 23 μM). Selegiline-d5 hydrochloride is utilized in research related to neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, and major depressive disorder, providing valuable insights into the biochemical pathways involved in these conditions. -
Stable Isotope
Fluoxetine-d5 hydrochloride is a deuterated analog of Fluoxetine hydrochloride, serving as a stable isotope. It is primarily utilized in pharmacokinetic studies and metabolic tracing, allowing for the investigation of drug metabolism and pharmacodynamics in biological systems. This reagent is critical for research exploring the biochemical pathways and therapeutic effects associated with selective serotonin reuptake inhibitors (SSRIs). -
Stable Isotope
Venlafaxine-d6 is a deuterium-labeled derivative of Venlafaxine, a potent dual inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake. This stable isotope is utilized in pharmacokinetic studies to trace the metabolism and distribution of Venlafaxine in biological systems. Its applications extend to evaluating the pharmacological profile of this antidepressant in research settings. -
Stable Isotope
(±)-cis-Sertraline-d3 hydrochloride is a deuterated form of Sertraline hydrochloride, acting as a selective serotonin reuptake inhibitor (SSRI). This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research involving antidepressants. Its applications extend to investigations of major depressive disorder and obsessive-compulsive disorder, providing insights into the drug's mechanism of action and therapeutic effectiveness. -
Stable Isotope
Venlafaxine-d6 hydrochloride is a stable isotope-labeled form of the antidepressant Venlafaxine hydrochloride, functioning as a potent dual inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake. This reagent is primarily used in pharmacokinetic studies and metabolic research to trace the pharmacological behavior of Venlafaxine in biological systems. Its deuterium labeling aids in enhancing the sensitivity and specificity of analytical methods, providing valuable insights into drug metabolism and biochemical pathways. -
Stable Isotope
rel-Sertraline-d3 hydrochloride is a deuterated form of Sertraline hydrochloride, targeting the selective serotonin reuptake inhibitor (SSRI) mechanism. This stable isotope is utilized in pharmacokinetic studies to trace metabolic pathways and quantify drug concentrations in biological samples. Research applications include investigations into major depressive disorder, obsessive-compulsive disorder, and other serotonin-related disorders. -
Stable Isotope
Duloxetine-d7 is the deuterated form of Duloxetine, a potent serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM. This labeled compound is utilized in pharmacokinetic studies and metabolic research related to major depressive disorder and generalized anxiety disorder (GAD). Its stable isotope labeling provides valuable insights into the drug's metabolic pathways and pharmacological mechanisms. -
Stable Isotope
Clomipramine-d6 hydrochloride is a deuterated form of Clomipramine hydrochloride, primarily acting as a potent inhibitor of serotonin (5-HT) reuptake, with an IC50 value of 1.5 nM. This stable isotope is valuable for research applications in depression and obsessive-compulsive disorder (OCD). Its deuterated nature enables precise quantification and tracing in metabolic studies, facilitating a better understanding of these psychiatric conditions and the pharmacodynamics of tricyclic antidepressants. -
Stable Isotope
Dapoxetine-d6 is a deuterium-labeled form of Dapoxetine, a selective serotonin reuptake inhibitor (SSRI). This stable isotope is utilized in pharmacokinetic studies and metabolic research. Dapoxetine is primarily researched for its effectiveness in treating premature ejaculation (PE), making Dapoxetine-d6 an essential tool for understanding its biological mechanisms and enhancing drug development in this area. -
Stable Isotope
Dapoxetine-d7 is a deuterated form of the selective serotonin reuptake inhibitor (SSRI) Dapoxetine. Its primary mechanism involves the inhibition of serotonin reuptake, which enhances serotonergic signaling. This stable isotope-labeled compound is utilized in pharmacokinetic studies and metabolic research related to premature ejaculation (PE), providing insights into the drug's pharmacological properties and behaviors in biological systems. -
Stable Isotope
Dextromilnacipran-d6 is a deuterium-labeled analog of Dextromilnacipran, a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor. This compound also acts as a human alpha-adrenergic receptor antagonist, exhibiting an IC50 of 3.4 μM. Dextromilnacipran-d6 is a valuable tool for metabolic and pharmacokinetic studies, providing insights into the behavior and efficacy of 5-HT/NE reuptake inhibitors in various research contexts. -
Stable Isotope
Dapoxetine-d6 hydrochloride is a stable isotope-labeled form of Dapoxetine hydrochloride, a short-acting selective serotonin reuptake inhibitor (SSRI). This deuterated compound is primarily used in pharmacokinetic studies to trace the metabolic pathways of Dapoxetine. Its applications include drug metabolism research and studies assessing serotonin modulation in various biological systems. -
Stable Isotope
Venlafaxine-d6-1 is a deuterium-labeled derivative of Venlafaxine, a potent dual inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace and quantify the drug's behavior in biological systems. Venlafaxine is primarily used as an antidepressant, making this labeled compound valuable for investigating its mechanism of action and therapeutic effects. -
Stable Isotope
Desvenlafaxine-d10 is a deuterated version of Desvenlafaxine, which is the active metabolite of Venlafaxine. It functions primarily as a selective inhibitor of the serotonin and norepinephrine transporters (5-HT and NET), demonstrating IC50 values of 47.3 nM and 531.3 nM, respectively. This compound is utilized in pharmacokinetic studies and research involving neurotransmitter systems, given its ability to penetrate the blood-brain barrier and its limited interaction with the dopamine transporter, where it exhibits only weak inhibitory activity. -
Stable Isotope
Desvenlafaxine-d6 is a deuterium-labeled derivative of Desvenlafaxine, which acts as a selective serotonin (5-HT) and norepinephrine reuptake inhibitor. It exhibits significant potency with IC50 values of 47.3 nM for the human serotonin transporter (hSERT) and 531.3 nM for the human norepinephrine transporter (hNET). Additionally, Desvenlafaxine shows minimal binding affinity at the human dopamine transporter, indicating its focused mechanism of action. This stable isotope is valuable for pharmacokinetic studies and metabolic profiling in neuropharmacology research. -
Stable Isotope
Venlafaxine-d9 is a deuterated analog of Venlafaxine, functioning primarily as a stable isotope. This compound acts as a potent dual inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake, making it relevant for antidepressant research. Venlafaxine-d9 is employed in pharmacokinetic studies and metabolite tracking, enhancing our understanding of the pharmacodynamics and pharmacokinetics of its parent compound. -
Stable Isotope
(E)-Fluvoxamine-d4 maleate is a deuterated analog of (E)-Fluvoxamine maleate, serving as a stable isotope tracer in pharmacokinetic studies. This compound is primarily utilized in research to investigate the pharmacological effects and metabolic pathways of (E)-Fluvoxamine. Its stable isotope labeling allows for enhanced detection and quantification in various biological assays, facilitating a deeper understanding of its biological activity and therapeutic potential. -
Stable Isotope
Venlafaxine-d10 is a deuterium-labeled analog of the antidepressant venlafaxine, which functions as a potent dual inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake. This stable isotope is valuable for pharmacokinetic studies, enabling researchers to investigate the metabolism and biological activity of venlafaxine in various biological systems. Its applications are critical for understanding the pharmacological mechanisms underlying antidepressant effects and for developing improved therapeutic strategies. -
Stable Isotope
Imipramine-d6 is the deuterium-labeled form of Imipramine hydrochloride, a tricyclic antidepressant that primarily acts as a serotonin transporter inhibitor with an IC50 value of 32 nM. It exhibits notable antitumor activity as a Fascin1 inhibitor, promoting autophagy in U-87MG glioma cells and inducing apoptosis in HL-60 cells. Additionally, Imipramine-d6 demonstrates neuroprotective and immunomodulatory effects, making it valuable for research into depression, cancer, and neurodegenerative disorders. -
Stable Isotope
Citalopram-d4 hydrobromide is a deuterated form of the selective serotonin reuptake inhibitor (SSRI) Citalopram hydrobromide. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic profiling to provide detailed information on drug metabolism and distribution. Its incorporation into research can enhance the understanding of serotonin-related pathways and support the development of therapeutic strategies for mood disorders. -
Stable Isotope
Escitalopram-d6 oxalate is a deuterium-labeled derivative of the selective serotonin reuptake inhibitor (SSRI) escitalopram, specifically the S-enantiomer of racemic citalopram. It demonstrates a binding affinity of 0.89 nM, approximately 30 times higher than its R(-)-enantiomer, while maintaining selectivity for serotonin transporters over dopamine (DAT) and norepinephrine (NET) transporters. This reagent is utilized in research focused on the mechanisms of major depression and the pharmacokinetics of SSRIs. -
Stable Isotope
Duloxetine-d5 oxalate is a deuterium-labeled derivative of Duloxetine, primarily acting as a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM. This stable isotope is useful in pharmacokinetic studies and investigations of drug metabolism. Its unique isotopic labeling enables precise tracking and quantification in biological assays, making it valuable for research in psychiatric disorders such as major depressive disorder and generalized anxiety disorder. -
Stable Isotope
Venlafaxine-d10 hydrochloride is a deuterium-labeled derivative of Venlafaxine hydrochloride, acting as a potent dual inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake. This stable isotope is utilized in pharmacokinetic studies to better understand the metabolism and distribution of Venlafaxine in biological samples. Its application extends to research involving antidepressant efficacy and neurochemical dynamics in the treatment of mood disorders. -
Stable Isotope
Opipramol-d4 is a deuterium-labeled analog of Opipramol, serving as a stable isotope for biochemical applications. This isotopic modification enhances the study of Opipramol's pharmacokinetics and metabolic pathways. Opipramol-d4 is primarily used in research involving its antidepressant and anxiolytic properties, facilitating more precise tracking in experiments involving liquid chromatography and mass spectrometry.
