Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Octanoic acid-13C is a stable isotope-labeled form of octanoic acid, also known as caprylic acid. This compound serves as an important tracer in metabolic studies and isotope-labeling experiments due to its unique carbon-13 signature. Octanoic acid is widely utilized in the production of esters for perfumery and in dye manufacturing, making it a valuable reagent for various chemical research applications. -
Stable Isotope
DL-Tryptophan-d8 is a deuterium-labeled analogue of DL-Tryptophan, an endogenous metabolite that serves as a precursor for neurotransmitters such as serotonin. This stable isotope is valuable in metabolic studies and tracer experiments, allowing for precise tracking of tryptophan metabolism and its derivatives in biological systems. DL-Tryptophan-d8 is essential for research applications involving isotopic labeling, providing insights into metabolic pathways and biochemical mechanisms. -
Stable Isotope
N-Acetyl-D-glucosamine-13C2,15N is a stable isotope-labeled analogue of N-Acetyl-D-glucosamine, incorporating two carbon-13 atoms and one nitrogen-15 atom. This compound serves as a valuable tool for metabolic studies and tracer applications in carbohydrate metabolism. Its use in biochemistry and molecular biology can provide insights into glycosylation processes and cellular function, making it essential for research involving glycosaminoglycans and related biomolecules. -
Stable Isotope
2-Methylcitric acid-d3 trisodium is a deuterium-labeled form of 2-Methylcitric acid, serving as a stable isotope for analytical applications. This compound is utilized in metabolic studies and tracer experiments to investigate metabolic pathways involving citric acid metabolism. Its stable isotopic nature provides enhanced sensitivity and accuracy in detecting metabolic products in biological samples. -
Stable Isotope
2'-Deoxycytidine-13C9,15N3 is a stable isotope-labeled form of the nucleoside 2'-deoxycytidine, featuring carbon-13 and nitrogen-15 isotopes. It serves as a valuable tool in metabolic studies and tracing experiments due to its ability to participate in nucleic acid metabolism. This reagent can also inhibit the biological effects of bromodeoxyuridine (BrdU), making it useful in studies pertaining to DNA synthesis and cellular proliferation. Researchers can employ 2'-Deoxycytidine-13C9,15N3 in various biological assays to explore cellular processes involving nucleotides and their derivatives. -
Stable Isotope
L-Leucine-18O2 is the stable isotope-labeled form of L-Leucine, an essential branched-chain amino acid (BCAA) known to activate the mTOR signaling pathway. This compound is utilized in metabolic studies and tracer experiments to investigate amino acid metabolism and protein synthesis. Its stable isotope labeling enables precise quantification and tracking of L-Leucine in biological systems, making it valuable for research in nutrition, exercise physiology, and cellular signaling. -
Stable Isotope
N-Acetylglycine-d2 is a deuterated isotope of N-Acetylglycine, primarily utilized as a stable isotope for scientific research. This compound serves as a flavor enhancer and demonstrates sensory properties similar to monosodium glutamate (MSG), making it valuable in food science studies. Its applications extend to metabolic studies, tracing synthesis pathways, and flavor profile analysis in nutritional research. -
Stable Isotope
Homogentisic acid-13C6 is a stable isotope-labeled form of homogentisic acid, a phenolic acid metabolite. This compound is significant in the diagnosis of alkaptonuria, a rare metabolic disorder characterized by the accumulation of homogentisic acid in urine and serum. Homogentisic acid-13C6 can be utilized in research applications involving metabolic tracking and the study of enzymatic pathways related to phenolic acid metabolism. -
Stable Isotope
1-Dodecanol-d25 is a deuterium-labeled form of 1-Dodecanol, a long-chain alcohol that serves as an endogenous metabolite. This stable isotope is primarily utilized in metabolic studies and tracer experiments, allowing for precise tracking of metabolic pathways and interactions in biological systems. Its incorporation into research can enhance the understanding of lipid metabolism and biological processes involving fatty alcohols. -
Stable Isotope
DPPC-13C2 is a stable isotope-labeled form of dipalmitoylphosphatidylcholine (DPPC), a phospholipid that serves as a primary component of pulmonary surfactant. This compound can be utilized to prepare lipid monolayers, bilayers, and liposomes, facilitating various biophysical studies. Additionally, DPPC-liposomes have demonstrated efficacy as a delivery vector, eliciting immune responses against glycosphingolipid antigens in murine models, making it a valuable reagent for research in lipid biochemistry and immunology. -
Stable Isotope
DPPC-d71 is a deuterated form of dimyristoylphosphatidylcholine (DPPC) known for its stable isotope properties. This zwitterionic phosphoglyceride is primarily utilized in the formation of liposomal monolayers, serving as an effective delivery system for targeting glycospingolipid (GSL) antigens. Researchers employ DPPC-d71 in studies involving immunological responses and lipid-based drug delivery mechanisms, enhancing the understanding of membrane interactions and immune activation pathways. -
Stable Isotope
H-HoArg-OH-d4 is a deuterium-labeled form of H-HoArg-OH, which serves as a potent inhibitor of human bone and liver alkaline phosphatase. This stable isotope is valuable for research applications involving enzyme kinetics, metabolic studies, and pharmacokinetic analyses. Its isotopic labeling facilitates precise tracking and quantification in various biological systems. -
Stable Isotope
D-Panthenol-d6 is a deuterium-labeled derivative of D-Panthenol, which serves as a stable isotope. It acts as a biologically active form of pantothenic acid, promoting increased levels of coenzyme A within cells. This reagent is valuable for research applications involving metabolic studies, tracer studies, and quantification of cellular coenzyme A levels. -
Stable Isotope
Adrenosterone-d10 is a deuterium-labeled derivative of Adrenosterone, specifically designed as a stable isotope for advanced research applications. As a competitive inhibitor of 11-beta hydroxysteroid dehydrogenase 1 (HSD11β1), Adrenosterone demonstrates key biological activity by modulating steroid metabolism. This compound exhibits weak androgenic effects and has been studied for its potential in inhibiting metastatic progression in human cancer cells, as well as its role in influencing body composition through fat reduction and muscle mass increase. -
Stable Isotope
Cholestenone-13C is a stable isotope-labeled form of Cholestenone (4-Cholesten-3-one), an intermediate oxidation product of cholesterol primarily metabolized in the liver. This compound exhibits significant mobility within cellular membranes, affecting cholesterol flip-flop dynamics and efflux processes. Cholestenone-13C is valuable for research applications involving lipid metabolism and the role of cholesterol derivatives in cellular functions, providing insights into potential long-term functional defects associated with cholesterol metabolism. -
Stable Isotope
DL-Mevalonolactone-d7 is a deuterium-labeled stable isotope derivative of DL-Mevalonolactone, a key intermediate in the mevalonate pathway. This compound has been shown to decrease mitochondrial membrane potential, reduce NAD(P)H levels, and impair calcium retention in neuronal tissues, ultimately leading to mitochondrial swelling. It is useful for studies involving mitochondrial function, metabolic pathways, and isotopic tracing in biochemical research. -
Stable Isotope
Pyruvic acid-13C2 is a stable isotope-labeled form of pyruvic acid, a crucial intermediate in the metabolic pathways of carbohydrates, proteins, and fats. This reagent facilitates precise metabolic studies and tracer experiments, providing insight into cellular respiration and energy production. It is valuable in biochemical research, particularly in flux analysis and metabolic profiling. -
Stable Isotope
L-Proline-13C5 is a stable isotope-labeled form of the amino acid L-Proline, where five carbon atoms are labeled with carbon-13. L-Proline plays a critical role as a building block of proteins and is involved in collagen synthesis and cellular metabolism. This reagent is essential for isotopic labeling studies, metabolic flux analysis, and tracking biochemical pathways, providing valuable insights into protein synthesis and metabolic activities in various biological systems. -
Stable Isotope
L-Methionine-13C is the stable isotope-labeled form of the essential amino acid L-Methionine. Important for human development, Methionine serves as a crucial building block for protein synthesis and exhibits hepatoprotective properties. This reagent is valuable for metabolic studies, tracing amino acid pathways, and examining the role of Methionine in various biological processes. -
Stable Isotope
3-Hydroxybutyric acid-d4 sodium is a stable isotope-labeled form of 3-Hydroxybutyric acid. This metabolite, known for its elevation in type I diabetes, plays a crucial role in metabolic processes and can influence the properties of membrane lipids. Research applications include metabolic studies, isotope tracing in biochemical pathways, and investigations into the physiological effects of β-Hydroxybutyric acid. -
Stable Isotope
Urea-13C,15N2 is a stable isotope-labeled compound featuring both 13C and 15N isotopes. Urea serves as an effective protein denaturant through direct and indirect mechanisms, demonstrating key biological activity and therapeutic properties, including its role as an emollient and keratolytic agent. It is commonly utilized in research applications, such as evaluating renal function via blood urea nitrogen (BUN) measurements. Additionally, Urea-13C,15N2 is significant in agricultural and chemical industries as a nitrogen source. -
Stable Isotope
Saflufenacil-d7 is a deuterium-labeled variant of Saflufenacil, a herbicide belonging to the pyrimidinedione class. This compound acts as a potent inhibitor of protoporphyrinogen IX oxidase (PPO), providing effective preplant burndown and selective preemergence control of dicot weeds in various crops, including corn. Saflufenacil-d7 is primarily utilized in chemical research for tracking and understanding the behavior of Saflufenacil in biological systems and environmental studies. -
Stable Isotope
AGN 193109-d7 is a deuterated variant of AGN 193109, a retinoid analog that serves as a potent and selective antagonist of retinoic acid receptors (RARs). It exhibits strong binding affinities with Kd values of 2 nM for RARα, 2 nM for RARβ, and 3 nM for RARγ. This stable isotope is valuable for research applications involving the investigation of RAR-mediated pathways and the effects of retinoid signaling in various biological contexts. -
Stable Isotope
L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride is a stable isotope-labeled variant of L-Azidohomoalanine, featuring both 13C and 15N isotopes. This reagent acts as a versatile PROTAC linker, facilitating the synthesis of protein-targeting chimeras. It serves as a click chemistry tool, incorporating an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne, DBCO, or BCN-containing molecules, expanding its utility in biological research applications. -
Stable Isotope
N-Deshydroxyethyl Dasatinib-d8 is a deuterium-labeled derivative of N-Deshydroxyethyl Dasatinib, designed for use as a stable isotope tracer in biological studies. This compound acts by binding to IAP ligands through a linker, facilitating the degradation of Abl proteins via the SNIPER technique. Its unique isotopic labeling allows for precise tracking in pharmacokinetic and metabolic research, enhancing the understanding of drug mechanisms and interactions in cell signaling pathways. -
Stable Isotope
5-Ethynyl-2'-deoxyuridine-13C is a stable isotope-labeled analogue of 5-Ethynyl-2'-deoxyuridine (EdU), targeting cellular DNA during replication. This compound is incorporated into DNA and allows for visualization through a copper-catalyzed azide-alkyne cycloaddition (CuAAc) in Click chemistry applications. EdU-13C serves as a sensitive and efficient probe for assessing cell proliferation, making it invaluable for research in cell biology and drug development. Additionally, it can function as a linker in the synthesis of PROTACs, facilitating studies in targeted protein degradation. -
Stable Isotope
NH2-C2-NH-Boc-d4 is a deuterium-labeled variant of the PROTAC linker NH2-C2-NH-Boc. This alkyl chain-based linker facilitates the development of proteolysis-targeting chimeras (PROTACs) by enhancing the stability and efficacy of the resultant compounds. Its incorporation in PROTAC synthesis enables precise investigation of protein degradation mechanisms and aids in the advancement of targeted protein modulation research. -
Stable Isotope
5-Ethynyl-2'-deoxyuridine-13C2 is a stable isotope-labeled analogue of 5-Ethynyl-2'-deoxyuridine, specifically incorporating two carbon-13 atoms. This compound functions primarily in studying DNA replication, as it is incorporated into cellular DNA and subsequently detected through a fluorescent azide in a "Click" reaction. Key applications include cell proliferation assays and the synthesis of PROTACs, leveraging its alkyne functionality for copper-catalyzed azide-alkyne cycloaddition. Its use in research facilitates advanced studies in nucleic acid dynamics and targeted protein degradation. -
Stable Isotope
Dabigatran-d3 is a deuterium-labeled form of Dabigatran, a potent and reversible direct thrombin inhibitor with a Ki of 4.5 nM. This isotope-labeled reagent retains the pharmacological properties of its non-labeled counterpart, effectively inhibiting thrombin-induced platelet aggregation with an IC50 of 10 nM. Dabigatran-d3 is primarily utilized in pharmacokinetic studies and metabolic research, facilitating the investigation of the drug's behavior in biological systems. -
Stable Isotope
Dabigatran-d4 is a deuterated form of Dabigatran, a potent and reversible direct thrombin inhibitor with a Ki of 4.5 nM. This oral anticoagulant is effective in preventing thrombin-induced platelet aggregation, exhibiting an IC50 value of 10 nM. Dabigatran-d4 can be utilized in pharmacokinetic studies and metabolic research, providing a valuable tool for understanding thrombin inhibition in various biological contexts. -
Stable Isotope
Dabigatran etexilate-d13 is a deuterium-labeled form of Dabigatran etexilate, an orally active prodrug of Dabigatran. This compound exhibits anticoagulant properties and is utilized in the prevention of venous thromboembolism and strokes associated with atrial fibrillation. The stable isotope labeling facilitates pharmacokinetic and metabolic studies, enhancing research applications in drug development and safety assessment. -
Stable Isotope
Argatroban-d3 is a deuterium-labeled analog of Argatroban, a direct and selective inhibitor of thrombin. This stable isotope-labeled compound enables precise tracking and quantification in pharmacokinetic studies. It is particularly valuable for research applications involving anticoagulation therapy and thrombus formation, allowing for improved insights into the pharmacodynamics of thrombin inhibition. -
Stable Isotope
Dabigatran etexilate-d11 is a stable isotope-labeled form of Dabigatran etexilate, a prodrug that acts as a direct inhibitor of thrombin. This compound exhibits potent anticoagulant properties and is primarily utilized in research involving venous thromboembolism and stroke prevention in patients with atrial fibrillation. The deuterium labeling facilitates advanced metabolic studies and pharmacokinetic assessments. -
Stable Isotope
Dabigatran-d7 is a deuterium-labeled analog of Dabigatran, a potent, reversible direct thrombin inhibitor with a Ki of 4.5 nM. This compound effectively inhibits thrombin-induced platelet aggregation, demonstrating an IC50 of 10 nM. Dabigatran-d7 is utilized in pharmacokinetic studies and tracer applications to investigate metabolism and drug interactions in anticoagulation research. -
Stable Isotope
Metolazone-d7 is a deuterium-labeled derivative of Metolazone, primarily utilized in pharmacokinetic studies and tracer experiments. Metolazone functions as a thiazide-like diuretic, effectively lowering blood pressure and managing fluid retention in conditions such as congestive heart failure. The stable isotope labeling enables precise quantification and metabolic tracking in biological assays, facilitating research into drug metabolism and efficacy. -
Stable Isotope
Dabigatran-13C6 is a stable isotope-labeled form of Dabigatran, a potent oral anticoagulant that functions as a reversible, competitive direct thrombin inhibitor with a Ki of 4.5 nM. It effectively inhibits thrombin-induced platelet aggregation, demonstrating an IC50 of 10 nM. This reagent is valuable for pharmacokinetic studies and metabolic profiling in anticoagulant research, enabling precise tracking of drug dynamics in biological systems. -
Stable Isotope
D-Tyrosine-d7 is a deuterium-labeled derivative of D-Tyrosine, primarily utilized as a stable isotope in scientific research. This compound serves to negatively regulate melanin synthesis through the inhibition of tyrosinase activity. Additionally, D-Tyrosine has demonstrated efficacy in inhibiting biofilm formation and promoting the self-dispersal of established biofilms, all while maintaining bacterial growth levels. Its applications are valuable in studies related to melanin production and biofilm dynamics. -
Stable Isotope
D-Tyrosine-d4 is a deuterium-labeled derivative of D-Tyrosine, functioning primarily as a stable isotope. This compound plays a crucial role in biological research by negatively regulating melanin synthesis through the inhibition of tyrosinase activity. Additionally, D-Tyrosine has been shown to inhibit biofilm formation and induce self-dispersal of biofilms, while not affecting bacterial growth. These properties make it valuable for studies in skin pigmentation and microbial behavior. -
Stable Isotope
D-Tyrosine-d2 is the deuterium-labeled form of D-Tyrosine, an important stable isotope used in chemical research. D-Tyrosine serves as a negative regulator of melanin synthesis by inhibiting the enzymatic activity of tyrosinase. Additionally, it has been shown to inhibit biofilm formation and induce self-dispersal of existing biofilms without adversely affecting bacterial growth. This compound is useful for investigations in biochemical pathways and microbial studies. -
Stable Isotope
β-Tocopherol-d3 is a deuterated analogue of β-Tocopherol, which functions as a stable isotope. This compound exhibits notable antioxidant properties and has been shown to inhibit tyrosinase activity, thereby affecting melanin synthesis. Additionally, β-Tocopherol can counteract the suppression of cell growth and protein kinase C (PKC) activity induced by d-alpha-tocopherol, making it valuable for research in cellular signaling and pigmentation studies. -
Stable Isotope
Febuxostat-d7 is a deuterated analog of Febuxostat, a selective xanthine oxidase inhibitor with a Ki of 0.6 nM. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research to trace drug metabolism and evaluate chemical reactions involving Febuxostat. Its application in labeling studies enhances the understanding of drug metabolism and its interactions in biological systems. -
Stable Isotope
Allopurinol-d2 is a deuterium-labeled derivative of Allopurinol, primarily functioning as a xanthine oxidase inhibitor, with reported IC50 values ranging from 0.2 to 50 μM. This reagent is widely utilized in research on hyperuricemia and gout, facilitating studies on uric acid metabolism. Additionally, Allopurinol has demonstrated antileishmanial properties, making it relevant for investigations into leishmaniasis treatment strategies. -
Stable Isotope
Oxypurinol-13C,15N2-1 is a stable isotope-labeled form of Oxypurinol, the primary active metabolite of Allopurinol, functioning as an effective inhibitor of xanthine oxidase. This compound plays a critical role in regulating blood urate levels, making it valuable for the treatment of gout. Its isotopic labeling allows for advanced research applications, including metabolic studies and drug metabolism investigations. -
Stable Isotope
Tramiprosate-d6 is a deuterium-labeled derivative of Tramiprosate, a naturally occurring amino acid with notable brain-penetrant properties. This compound primarily targets soluble amyloid-beta (Aβ) peptides, effectively maintaining them in a non-fibrillar configuration. Tramiprosate shows significant biological activities, including neuroprotection, anticonvulsant, and antihypertensive effects, making it valuable for research on neurodegenerative diseases and neurological disorders. -
Stable Isotope
Glimepiride-d5 is a deuterated derivative of Glimepiride, a medium-to-long acting sulfonylurea antidiabetic agent. This stable isotope is primarily used in pharmacokinetic studies to trace the compound's metabolic pathways and evaluate its biological efficacy. With an ED50 of 182 μg/kg, Glimepiride effectively stimulates insulin secretion from pancreatic beta cells, making it relevant for diabetes research and therapeutic investigations. -
Stable Isotope
Protriptyline-d3 is a deuterated analog of the tricyclic antidepressant Protriptyline, serving as a stable isotope for research applications. It exerts potent inhibition of acetylcholinesterase (AChE) with an IC50 value of 0.06 mM and effectively inhibits amyloid beta (Aβ) self-assembly. This compound is valuable for studying the mechanisms underlying depression and Alzheimer's disease. -
Stable Isotope
Sacubitril-d4 is a deuterated form of Sacubitril, a selective neprilysin (NEP) inhibitor with an IC50 value of 5 nM. This stable isotope is utilized in analytical studies to trace metabolic pathways and pharmacokinetics related to heart failure therapies, particularly those involving the combination treatment LCZ696. Researchers can employ Sacubitril-d4 to investigate its biochemical profiles and interaction dynamics in various biological systems. -
Stable Isotope
Racecadotril-d5 is a deuterated form of Racecadotril, a neutral endopeptidase (NEP) inhibitor. It exhibits significant inhibition of NEP activity in mouse brain tissues, with reported inhibition constants (Kis) of 4500 nM for Racecadotril and 6.1 nM for its active metabolite, Thiorphan. Racecadotril-d5 serves as a valuable tool for research applications involving pain modulation and gastrointestinal studies, further contributing to the understanding of NEP's role in various biological processes. -
Stable Isotope
Thiorphan-d7 is a deuterium-labeled derivative of Thiorphan, a selective inhibitor of neprilysin (NEP) with an IC50 value of 6.9 nM. This stable isotope-labeled compound enables advanced metabolic studies and tracking of NEP-related pathways in various biological contexts. Thiorphan-d7 is valuable for research applications involving the modulation of neuropeptide levels and the investigation of neurodegenerative diseases. -
Stable Isotope
Thiorphan-d5 is a deuterated form of Thiorphan, a well-known inhibitor of the enkephalin-degrading enzyme, neprilysin. This stable isotope-labeled compound is utilized in pharmacokinetic studies and metabolic profiling, providing valuable insights into drug metabolism and efficacy. It serves as an essential tool for researchers investigating neuropeptide regulation and pain modulation in biochemical assays.
