Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Dopamine-13C,15N hydrochloride is a stable isotope-labeled form of dopamine, incorporating carbon-13 and nitrogen-15. This reagent is primarily utilized in metabolic studies and tracer applications, enabling researchers to elucidate dopamine metabolism and signaling pathways. Its unique isotopic composition allows for precise quantification and differentiation in various analytical techniques, including NMR and mass spectrometry. -
Stable Isotope
Vildagliptin-13C5,15N is a stable isotope-labeled form of Vildagliptin, a selective dipeptidyl peptidase IV (DPP-IV) inhibitor, which exhibits an IC50 of 3.5 nM in human Caco-2 cells. This compound demonstrates potent antihyperglycemic activity and possesses excellent oral bioavailability. It is primarily utilized in metabolic research and studies aimed at understanding glucose homeostasis and diabetes treatment mechanisms. -
Stable Isotope
Rosiglitazone-d3 is a deuterium-labeled derivative of Rosiglitazone, a selective and orally active agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It exhibits EC50 values of 30 nM, 100 nM, and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, with a binding affinity (Kd) of approximately 40 nM. In addition to its PPARγ activity, Rosiglitazone also activates TRPC5 with an EC50 of around 30 μM and inhibits TRPM3, making it a valuable tool for investigating metabolic and cardiovascular diseases. -
Stable Isotope
L-Glutamic acid-13C2 is a stable isotope-labeled form of L-Glutamic acid, acting primarily as an excitatory neurotransmitter. It serves as an agonist at all subtypes of glutamate receptors, including metabotropic, kainate, NMDA, and AMPA receptors. This compound plays a significant role in neurotransmission and is utilized in research related to neuronal signaling, neurotransmitter release, and metabolic studies involving dopamine release from dopaminergic terminals. -
Stable Isotope
Deferiprone-d3 is a deuterated form of Deferiprone, an orally active iron-chelating agent. It primarily targets iron overload conditions, particularly in patients undergoing chronic blood transfusions. Its stable isotope label allows for advanced pharmacokinetic studies and tracing experiments, facilitating research into iron metabolism and related disorders. Deferiprone-d3 is essential for in vivo and in vitro studies focusing on iron regulation and its therapeutic applications. -
Stable Isotope
Rosiglitazone-d4 is a deuterated form of Rosiglitazone, a selective agonist of PPARγ with an EC50 of 60 nM and a Kd of 40 nM. In addition to its role as a PPARγ activator, Rosiglitazone also functions as a TRPC5 activator (EC50: 30 μM) and a TRPM3 inhibitor. This compound is valuable for research into obesity, diabetes, cellular senescence, and ovarian cancer. Its stable isotope labeling allows for precise tracking and quantification in various biological studies. -
Stable Isotope
2-Ambo-Vitamin E-13C6 is a stable isotope-labeled form of α-Vitamin E (also known as (+)-α-Tocopherol). This compound exhibits significant antioxidant activity, neutralizing free radicals and protecting cellular components from oxidative stress. It is widely used in research applications studying lipid metabolism, oxidative damage, and the physiological roles of vitamin E in biological systems. -
Stable Isotope
Lapatinib-d4-1 is a deuterium-labeled derivative of Lapatinib, which primarily targets the ErbB-2 and EGFR tyrosine kinase domains. It exhibits strong inhibition with IC50 values of 10.2 nM for EGFR and 9.8 nM for ErbB-2. This stable isotope-labeled compound is valuable for pharmacokinetic studies and provides insights into drug metabolism, distribution, and bioavailability in chemical research applications. -
Stable Isotope
Lapatinib-d5 is a deuterium-labeled analogue of Lapatinib, a potent inhibitor targeting the ErbB-2 and EGFR tyrosine kinase domains. This compound exhibits strong inhibitory activity with IC50 values of 10.2 nM for EGFR and 9.8 nM for ErbB-2. Lapatinib-d5 is primarily utilized in pharmacokinetic studies and metabolic research to trace drug absorption, distribution, metabolism, and excretion pathways. -
Stable Isotope
(±)-Epicatechin-13C3 is a stable isotope-labeled form of (±)-Epicatechin, which primarily interacts with cyclooxygenase-1 (COX-1). This compound exhibits significant inhibition of COX-1 activity, with an IC50 value of 3.2 μM. Additionally, (±)-Epicatechin is known to suppress the IL-1β-induced expression of inducible nitric oxide synthase (iNOS) by preventing the nuclear translocation of the p65 subunit of NF-κB. These properties make (±)-Epicatechin-13C3 valuable for studies focused on inflammation and signal transduction pathways. -
Stable Isotope
DL-alpha-Tocopherol-d9 is a deuterium-labeled form of DL-alpha-Tocopherol, a synthetic variant of vitamin E. This compound exhibits significant antioxidant properties, providing protection to human skin fibroblasts from UVB-induced cytotoxicity. It is commonly utilized in research applications focused on skin health, oxidative stress, and the study of vitamin E metabolism. -
Stable Isotope
Vildagliptin-d7 is a deuterium-labeled derivative of Vildagliptin, a selective dipeptidyl peptidase IV (DPP-IV) inhibitor with notable potency, exhibiting an IC50 of 3.5 nM in human Caco-2 cells. This stable isotope can be utilized in studies focusing on pharmacokinetics and metabolic profiling of DPP-IV inhibitors, providing insight into their antihyperglycemic effects and oral bioavailability. Vildagliptin-d7 serves as a valuable tool for researchers investigating diabetes therapeutics and related metabolic disorders. -
Stable Isotope
Sorafenib-d3 tosylate is a deuterium-labeled derivative of Sorafenib, a potent multikinase inhibitor primarily targeting Raf, VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit with respective IC50 values of 6 nM, 20 nM, 90 nM, 15 nM, 57 nM, and 58 nM. It exhibits notable biological activities, including the induction of autophagy and apoptosis, contributing to its anti-tumor efficacy. Sorafenib-d3 tosylate serves as a valuable tool for research applications focusing on cancer biology, signaling pathways, and ferroptosis mechanisms. -
Stable Isotope
Simvastatin-d11 is a deuterium-labeled analog of Simvastatin, which acts as a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. This stable isotope is utilized in pharmacokinetic studies to trace drug metabolism and distribution in biological systems. Simvastatin-d11 not only aids in the investigation of cholesterol synthesis but also supports research on the therapeutic effects of statins in lipid regulation and cardiovascular disease. -
Stable Isotope
Bisdemethoxycurcumin-d8 is a deuterium-labeled derivative of Bisdemethoxycurcumin, a curcuminoid compound that primarily inhibits P-glycoprotein and ferroptosis. This compound demonstrates significant biological activities, including antioxidant, anti-inflammatory, and anti-tumor effects. Bisdemethoxycurcumin-d8 serves as a valuable tool for research related to tumor biology and inflammatory disease mechanisms. -
Stable Isotope
Linagliptin-13C,d3 is a stable isotope-labeled form of Linagliptin, a highly selective DPP-4 inhibitor with an IC50 of 1 nM. This compound serves as a valuable tool in metabolic studies and pharmacokinetic research, allowing for precise tracking and analysis of Linagliptin in biological systems. Additionally, Linagliptin-13C,d3 features an alkyne group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, facilitating various bioorthogonal labeling applications. -
Stable Isotope
Lapatinib-13C215N is a stable isotope-labeled variant of Lapatinib, specifically featuring 13C and 15N isotopes. This compound acts as a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains, displaying IC50 values of 10.2 nM and 9.8 nM, respectively, against purified targets. It is valuable for research applications in understanding signaling pathways involved in cancer and for quantitative analysis in pharmacokinetic studies. -
Stable Isotope
Artesunate-d3 is a deuterium-labeled derivative of Artesunate, primarily functioning as a stable isotope. This compound exhibits inhibitory activity against STAT-3 and exported protein 1 (EXP1), making it valuable for studies investigating the modulation of these pathways. Its application spans various areas of research, including cancer biology, infectious diseases, and the mechanisms of drug resistance. -
Stable Isotope
Lovastatin-d3 is a deuterium-labeled derivative of Lovastatin, targeting HMG-CoA reductase. This stable isotope serves as a valuable tool in metabolic studies, particularly in the investigation of cholesterol biosynthesis and lipid metabolism. Its application extends to pharmacokinetic research, enabling precise quantification and tracing of Lovastatin's effects within biological systems. -
Stable Isotope
Artesunate-d4 is a deuterium-labeled derivative of Artesunate, functioning primarily as an inhibitor of Signal Transducer and Activator of Transcription 3 (STAT-3) and Exported Protein 1 (EXP1). This stable isotope is valuable for various research applications, including pharmacokinetics studies and metabolic profiling of Artesunate in biological systems. Its unique labeling enables precise tracking and quantification of the compound in complex biological matrices. -
Stable Isotope
Troglitazone-d4 is a deuterated form of Troglitazone, which serves as a potent agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). With EC50 values of 550 nM and 780 nM for human and murine PPARγ receptors, respectively, Troglitazone-d4 is valuable for stabilizing isotopic labeling in metabolic studies. This reagent is particularly useful in research applications involving insulin sensitization and adipocyte differentiation. -
Stable Isotope
Roxadustat-d5 is a deuterated form of Roxadustat, an oral inhibitor of hypoxia-inducible factor prolyl-hydroxylase (HIF-PHI). This compound enhances erythropoiesis by increasing endogenous erythropoietin levels, regulating iron metabolism, and decreasing hepcidin production. Roxadustat-d5 is valuable in research applications focused on erythropoiesis modulation, anemia management, and the exploration of hypoxia-related pathways. -
Stable Isotope
Butylated hydroxytoluene-d21 is a deuterium-labeled form of butylated hydroxytoluene, a well-known antioxidant. This compound is primarily utilized in food and food-related products to prevent oxidative degradation. Additionally, butylated hydroxytoluene has been identified as a ferroptosis inhibitor, making it useful in research applications focusing on cell death mechanisms and oxidative stress. -
Stable Isotope
Curcumin-d6, a deuterium-labeled derivative of curcumin (Diferuloylmethane-d6), serves as a stable isotope for research applications. This natural phenolic compound functions as a selective inhibitor of p300/CREB-binding protein acetyltransferase, thereby influencing histone acetylation and chromatin transcription. Curcumin exhibits significant biological activities, including anti-inflammatory, antioxidant, antiproliferative, and antiangiogenic properties, while also acting as a photosensitizer against microorganisms. Additionally, it promotes the stabilization of Nrf2 protein through modification of Keap1 cysteine. -
Stable Isotope
Sulfasalazine-d4 is a deuterium-labeled derivative of the anti-rheumatic agent Sulfasalazine, primarily used in the investigation of rheumatoid arthritis and ulcerative colitis. This compound is known to inhibit NF-κB activity and serves as a type 1 ferroptosis inducer. Its stable isotope labeling enhances analytical techniques, aiding in the study of pharmacokinetics and metabolic pathways associated with Sulfasalazine's biological effects. -
Stable Isotope
Eugenol-d3 is a deuterium-labeled derivative of Eugenol, which primarily targets various biological pathways through its antioxidant properties. This compound exhibits antibacterial and anthelmintic activities, making it significant in studies related to microbial resistance and parasitic infections. Additionally, Eugenol has been demonstrated to inhibit lipid peroxidation, providing insights into oxidative stress research. Its isotopic labeling enhances tracking and quantification in metabolic studies. -
Stable Isotope
L-Glutamic acid-1-13C is a stable isotope-labeled form of L-Glutamic acid, a key excitatory neurotransmitter that acts as an agonist at all glutamate receptor subtypes, including metabotropic, kainate, NMDA, and AMPA receptors. This compound is crucial for investigating neurotransmission processes and metabolic pathways in research studies. Additionally, L-Glutamic acid has been shown to promote dopamine release from dopaminergic terminals, making it valuable for studies related to neurobiology and psychiatric disorders. -
Stable Isotope
Acetylcysteine-d3 is a deuterium-labeled derivative of Acetylcysteine, functioning primarily as a stable isotope for research applications. As a mucolytic agent, Acetylcysteine reduces mucus viscosity, while also acting as a reactive oxygen species (ROS) inhibitor. This compound serves as a precursor to cysteine and plays a critical role in preventing hemin-induced ferroptosis by neutralizing lipid peroxidation products from 5-lipoxygenase activity. Furthermore, Acetylcysteine has demonstrated properties in inducing cell apoptosis and antiviral activity against influenza, making it valuable for studies in drug delivery and disulfidptosis investigations. -
Stable Isotope
L-Cystine-3,3'-13C2 is a stable isotope-labeled form of the amino acid L-Cystine, specifically containing two carbon-13 atoms at the 3 and 3' positions. As an important intracellular thiol, L-Cystine is essential for the regulation of various cellular processes, including redox homeostasis and protein synthesis. This isotope-labeled reagent is valuable for applications in metabolic studies, tracer experiments, and proteomics, providing insights into cystine metabolism and its role in physiological and pathological conditions. -
Stable Isotope
Butylated hydroxytoluene-d3 is a deuterium-labeled derivative of butylated hydroxytoluene, an established antioxidant utilized predominantly in food and food products. This compound exhibits significant inhibitory effects on ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation. Butylated hydroxytoluene-d3 serves as a valuable tool in research focused on oxidative stress and cell death pathways, facilitating studies in cellular biology and pharmacology. -
Stable Isotope
L-Cystine-15N2 is a stable isotope-labeled form of L-Cystine, an amino acid that serves as a key intracellular thiol. It is essential in the regulation of various cellular processes, including redox balance and protein synthesis. This reagent is widely used in metabolic studies, tracing experiments, and studies involving cystine metabolism, offering insights into cellular thiol dynamics and related biochemical pathways. -
Stable Isotope
L-Glutamic acid-5-13C is a stable isotope-labeled form of L-Glutamic acid, which serves as an excitatory neurotransmitter and agonist for all glutamate receptor subtypes, including metabotropic, kainate, NMDA, and AMPA receptors. This compound is significant in studying neurophysiology and synaptic transmission, as it influences dopamine release from dopaminergic terminals. L-Glutamic acid-5-13C is valuable in metabolic tracing and isotopic labeling experiments in research applications involving neurotransmitter dynamics and neuronal signaling pathways. -
Stable Isotope
Linagliptin-d4 is a deuterium-labeled analog of Linagliptin, a highly potent and selective inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 1 nM. This stable isotope serves as a valuable tool in click chemistry applications, featuring an alkyne functional group capable of engaging in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. Linagliptin-d4 is useful in biological research for tracking and quantifying DPP-4 activity and dynamics in various systems. -
Stable Isotope
L-Glutamine-13C5,15N2,d5 is a stable isotope-labeled form of the non-essential amino acid L-Glutamine, featuring deuterium and isotopes of carbon and nitrogen. This compound plays a critical role in cellular metabolism, serving as a key nitrogen donor and a carbon source for energy production. It is widely utilized in metabolic studies, isotopic labeling experiments, and research involving amino acid transport and metabolism pathways. -
Stable Isotope
L-Glutamine-5-13C is a stable isotope-labeled form of the non-essential amino acid L-Glutamine, which plays a crucial role in various metabolic pathways. This labeled compound serves as a source of carbon for cellular energy production, particularly in tissues with high metabolic activity. L-Glutamine-5-13C is commonly used in metabolic research, tracer studies, and studies investigating amino acid metabolism. -
Stable Isotope
L-Glutamic acid-13C is a stable isotope-labeled form of L-Glutamic acid, primarily utilized in metabolic studies and tracer experiments. As an excitatory neurotransmitter, L-Glutamic acid functions as an agonist at various glutamate receptor subtypes, including metabotropic, kainate, NMDA, and AMPA receptors. This compound is valuable in research exploring neurotransmission and the modulation of dopamine release from dopaminergic terminals, providing insight into neurochemical pathways and their implications in neurological disorders. -
Stable Isotope
Sorafenib-13C,d3 is a stable isotope-labeled derivative of Sorafenib, a potent and orally bioavailable inhibitor of the mitogen-activated protein kinase (MAPK) pathway. Sorafenib exhibits strong biological activity, with IC50 values of 6 nM and 20 nM for Raf-1 and B-Raf, respectively, in addition to notable inhibition of multiple kinases such as VEGFR2 and PDGFRβ. This compound promotes autophagy and apoptosis and is recognized for its anti-tumor properties, serving as a valuable tool in cancer research and therapeutic studies exploring ferroptosis mechanisms. -
Stable Isotope
Simvastatin-d6 is a deuterated form of Simvastatin, a competitive inhibitor of HMG-CoA reductase, exhibiting a Ki of 0.2 nM. The stable isotope labeling enables precise metabolic studies and pharmacokinetic analyses in research applications. This reagent is essential for investigating lipid metabolism, cholesterol regulation, and the effects of statin therapy in various biological models. -
Stable Isotope
Lapatinib-d4 is a deuterium-labeled derivative of Lapatinib, a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains. It exhibits IC50 values of 10.2 nM for EGFR and 9.8 nM for ErbB-2, demonstrating its superior efficacy in inhibiting these targets. This stable isotope compound is primarily utilized in pharmacokinetic and metabolic studies to trace the absorption and distribution of Lapatinib in biological systems. -
Stable Isotope
L-Glutamic acid-13C5,15N,d5 is a stable isotope-labeled form of L-Glutamic acid, incorporating deuterium, carbon-13, and nitrogen-15 isotopes. This compound serves as an excitatory neurotransmitter and functions as an agonist for all glutamate receptor subtypes, including metabotropic, kainate, NMDA, and AMPA receptors. Its unique labeling permits advanced studies on neurotransmission and metabolic pathways, making it valuable for research in neurobiology, pharmacology, and metabolic profiling. -
Stable Isotope
2-Acetamidophenol-d3 is a deuterium-labeled derivative of 2-Acetamidophenol, primarily utilized as a stable isotope. This compound influences ferroptosis and glutathione metabolism pathways, demonstrating anti-atherosclerotic properties. In zebrafish models of hyperlipidemia, it effectively reduces total cholesterol and triglyceride levels with IC50 values of 30 μM and 40 μM, respectively. Additionally, 2-Acetamidophenol-d3 enhances the expression of glutathione synthesis-related genes and mitigates the accumulation of reactive oxygen species, ultimately inhibiting the formation of foam cells through reduced macrophage uptake of oxidized low-density lipoprotein. -
Stable Isotope
Coenzyme Q10-d6 is a deuterium-labeled derivative of Coenzyme Q10, an essential cofactor in the electron transport chain. This stable isotope plays a critical role in mitochondrial energy production and acts as a potent antioxidant. Coenzyme Q10-d6 is valuable for metabolic studies, tracer studies, and the investigation of oxidative stress in various biological systems. -
Stable Isotope
Pioglitazone-d4 (alkyl) is a deuterated form of Pioglitazone, a selective agonist of PPARγ (peroxisome proliferator-activated receptor gamma). This compound exhibits high-affinity binding to the PPARγ ligand-binding domain, with EC50 values of 0.93 μM for human PPARγ and 0.99 μM for mouse PPARγ. Pioglitazone-d4 (alkyl) is useful in pharmacokinetic studies, metabolic research, and tracing PPARγ-mediated biological effects in various cellular contexts. -
Stable Isotope
Simvastatin-d3 is a deuterated analog of Simvastatin, which acts as a competitive inhibitor of HMG-CoA reductase, exhibiting a Ki of 0.2 nM. This stable isotope is useful for pharmacokinetic studies and metabolic tracing in lipid regulation research. Its specificity towards HMG-CoA reductase makes it an important tool for investigating cholesterol biosynthesis and the effects of statins on cellular metabolism. -
Stable Isotope
Alogliptin-d3 is a deuterated form of Alogliptin, a selective DPP-4 inhibitor that demonstrates high potency with an IC50 of less than 10 nM and outstanding selectivity over DPP-8 and DPP-9. This stable isotope variant is particularly valuable in metabolic research and can aid in the investigation of type 2 diabetes mechanisms. It serves as a useful tool for examining pharmacokinetic behavior and metabolic pathways in biochemical studies. -
Stable Isotope
Coenzyme Q10-d9 is a deuterium-labeled derivative of Coenzyme Q10, a crucial cofactor involved in the electron transport chain. It exhibits significant antioxidant activity, making it valuable for research into cellular respiration and oxidative stress. This stable isotope is ideal for metabolic studies and tracer applications in biochemical research. -
Stable Isotope
L-Glutamine-15N2 is a stable isotope-labeled form of L-Glutamine, often utilized in metabolic and tracer studies. This non-essential amino acid plays a crucial role in various metabolic processes, serving as a source of nitrogen and carbon for cellular function. Its applications extend to research in nitrogen metabolism, protein turnover, and cellular energy production, making it a valuable tool in both basic and clinical research settings. -
Stable Isotope
L-Glutamine-d5 is a deuterium-labeled derivative of L-Glutamine, a non-essential amino acid integral to various metabolic pathways. This stable isotope serves as a valuable tracer in metabolic studies, allowing for precise tracking of nitrogen and carbon flow in biological systems. L-Glutamine-d5 is utilized in research applications involving cellular metabolism, protein synthesis, and nitrogen metabolism, contributing to insights in nutritional and physiological studies. -
Stable Isotope
L-Glutamine-15N is a stable isotope-labeled form of the non-essential amino acid L-Glutamine. It plays a crucial role in various metabolic processes and serves as a key source of carbon for cellular oxidation in certain tissues. L-Glutamine-15N is commonly utilized in metabolic studies, tracer experiments, and isotopic labeling applications, enabling researchers to investigate amino acid metabolism and nitrogen flux in biological systems. -
Stable Isotope
L-Glutamine-15N-1 is a stable isotope-labeled form of L-Glutamine, a non-essential amino acid integral to numerous metabolic processes. It serves as a carbon source for oxidation in various cells, making it valuable for studying metabolic pathways and amino acid metabolism. This reagent is particularly useful in tracer studies, metabolic flux analysis, and isotopic labeling experiments within biochemical research.
