Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Amodiaquine-d10 is a deuterium-labeled analog of Amodiaquine, a 4-aminoquinoline antimalarial agent. This compound functions primarily as a histamine N-methyltransferase inhibitor and demonstrates activity as a Nurr1 agonist, selectively binding to the Nurr1 ligand-binding domain with an EC50 of approximately 20 μM. Amodiaquine-d10 is valuable for research applications in studying malaria mechanisms, anti-inflammatory pathways, and the role of Nurr1 in cellular processes. -
Stable Isotope
Vildagliptin-d3 is the deuterium-labeled analog of Vildagliptin, a highly selective dipeptidyl peptidase IV (DPP-IV) inhibitor that exhibits an IC50 of 3.5 nM in human Caco-2 cells. This stable isotope is ideal for tracer studies in metabolic research, particularly in exploring glucose metabolism and the pharmacokinetics of DPP-IV inhibitors. Vildagliptin-d3 offers exceptional oral bioavailability and retains significant antihyperglycemic activity, making it valuable in diabetes research applications. -
Stable Isotope
Lapatinib-d7 is a deuterated analog of Lapatinib, primarily targeting the ErbB-2 and EGFR tyrosine kinase domains. It exhibits potent inhibition with IC50 values of 10.2 nM and 9.8 nM for EGFR and ErbB-2, respectively. This stable isotope-labeled compound is ideal for pharmacokinetic studies and metabolic profiling in research applications related to cancer therapeutics and drug metabolism. -
Stable Isotope
Deferasirox-13C6 is a stable isotope-labeled form of Deferasirox, which functions as an oral iron chelator. It primarily targets excess iron in patients with transfusion-related iron overload. This reagent is beneficial for research applications involving the study of iron metabolism and chelation therapy. Its isotopic labeling facilitates advanced analytical techniques, enhancing the understanding of pharmacokinetics and dynamic iron homeostasis in biological systems. -
Stable Isotope
Butylated hydroxytoluene-d24 is a deuterium-labeled form of butylated hydroxytoluene, primarily used as a stable isotope in research. As a well-known antioxidant, butylated hydroxytoluene is commonly applied in food preservation and various food-related products. Additionally, it serves as a ferroptosis inhibitor, making it valuable in studies of oxidative stress, cell death mechanisms, and potential therapeutic applications. -
Stable Isotope
Cerivastatin-d3 sodium is a deuterated form of Cerivastatin, an effective HMG-CoA reductase inhibitor with a Ki of 1.3 nM. This compound functions primarily as a lipid-lowering agent by reducing low-density lipoprotein (LDL) cholesterol levels. Additionally, Cerivastatin exhibits anti-cancer activity by inhibiting the proliferation and invasiveness of MDA-MB-231 cells through RhoA pathway modulation. Its stable isotope labeling makes it valuable for metabolic studies and pharmacokinetic research. -
Stable Isotope
Rosiglitazone-d4-1 is a deuterated analog of Rosiglitazone, serving as a stable isotope for tracer studies. This compound is utilized primarily in pharmacokinetic research and metabolic studies to track the disposition of Rosiglitazone in biological systems without interfering with its activity. Researchers may use Rosiglitazone-d4-1 to enhance the understanding of its mechanisms of action and to investigate its influence on glucose metabolism and insulin sensitivity in various experimental models. -
Stable Isotope
L-Glutamine-2-13C is a stable isotope-labeled form of L-Glutamine, a non-essential amino acid integral to various metabolic processes. This compound serves as a key carbon source for cellular oxidation, making it valuable for studies involving metabolic pathways and nutrient utilization. L-Glutamine-2-13C is widely used in isotopic labeling experiments, enabling researchers to trace metabolic fluxes in both in vitro and in vivo systems. -
Stable Isotope
2-ambo-Vitamin E-13C3 is a stable isotope-labeled form of α-Vitamin E (13C-labeled α-Tocopherol). As a naturally occurring form of vitamin E, it functions primarily as a potent antioxidant, effectively scavenging free radicals and protecting cellular components from oxidative stress. This reagent is valuable for metabolic studies, tracing vitamin E metabolism and bioavailability, and for examining its role in various biological processes. -
Isotope-Labeled Compounds
Linagliptin-d3-1 is a deuterium-labeled analog of Linagliptin, a highly potent and selective inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 of 1 nM. This isotope-labeled compound is primarily utilized in pharmacokinetic studies and metabolic research to trace the pharmacological pathways of DPP-4 inhibitors in various biological systems. Its unique isotopic signature allows for enhanced detection and quantification in analytical applications, facilitating insights into drug metabolism and efficacy. -
Stable Isotope
Zileuton-d4 is a deuterium-labeled version of Zileuton, a selective inhibitor of 5-lipoxygenase. This compound exhibits significant antiasthmatic properties, making it valuable for research in respiratory diseases and inflammation. Zileuton-d4 serves as a stable isotope tracer in pharmacokinetic studies, aiding in the investigation of metabolic pathways and drug interactions related to leukotriene synthesis. -
Stable Isotope
L-Glutamine-5-13C is a stable isotope-labeled form of the non-essential amino acid L-Glutamine, involved in various metabolic processes within the body. This compound serves as a crucial carbon source for cellular oxidation and energy production. It is widely utilized in metabolic studies, tracer experiments, and research focused on amino acid metabolism and cellular physiology. -
Stable Isotope
Lapatinib-d4 tosylate is a deuterated form of Lapatinib, a highly effective inhibitor targeting the tyrosine kinase domains of ErbB-2 and EGFR. It demonstrates potent biological activity with IC50 values of 10.2 nM and 9.8 nM against purified EGFR and ErbB-2, respectively. This stable isotope-labeled compound is valuable in pharmacokinetic studies and can facilitate research in cancer biology, particularly in the context of targeted therapies for breast cancer. -
Stable Isotope
Epi Lovastatin-d3 is a deuterium-labeled variant of Lovastatin, a potent inhibitor of HMG-CoA reductase. This stable isotope is utilized in chemical research to study metabolic pathways and cholesterol biosynthesis. Its application is vital in pharmacokinetic studies and tracer experiments, providing insight into the pharmacodynamics of cholesterol-lowering therapies. -
Isotope-Labeled Compound
α-Vitamin E-d11 is a deuterium-labeled form of α-Vitamin E ((+)-α-Tocopherol), primarily utilized in isotope labeling studies. This compound acts as a potent antioxidant, involved in protecting cellular components from oxidative damage. It is valuable for research applications focused on lipid metabolism, oxidative stress, and vitamin E bioactivity in biological systems. -
Stable Isotope
Dopamine-13C,15N hydrochloride is a stable isotope-labeled form of dopamine, incorporating carbon-13 and nitrogen-15. This reagent is primarily utilized in metabolic studies and tracer applications, enabling researchers to elucidate dopamine metabolism and signaling pathways. Its unique isotopic composition allows for precise quantification and differentiation in various analytical techniques, including NMR and mass spectrometry. -
Stable Isotope
Vildagliptin-13C5,15N is a stable isotope-labeled form of Vildagliptin, a selective dipeptidyl peptidase IV (DPP-IV) inhibitor, which exhibits an IC50 of 3.5 nM in human Caco-2 cells. This compound demonstrates potent antihyperglycemic activity and possesses excellent oral bioavailability. It is primarily utilized in metabolic research and studies aimed at understanding glucose homeostasis and diabetes treatment mechanisms. -
Stable Isotope
Rosiglitazone-d3 is a deuterium-labeled derivative of Rosiglitazone, a selective and orally active agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It exhibits EC50 values of 30 nM, 100 nM, and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, with a binding affinity (Kd) of approximately 40 nM. In addition to its PPARγ activity, Rosiglitazone also activates TRPC5 with an EC50 of around 30 μM and inhibits TRPM3, making it a valuable tool for investigating metabolic and cardiovascular diseases. -
Stable Isotope
L-Glutamic acid-13C2 is a stable isotope-labeled form of L-Glutamic acid, acting primarily as an excitatory neurotransmitter. It serves as an agonist at all subtypes of glutamate receptors, including metabotropic, kainate, NMDA, and AMPA receptors. This compound plays a significant role in neurotransmission and is utilized in research related to neuronal signaling, neurotransmitter release, and metabolic studies involving dopamine release from dopaminergic terminals. -
Stable Isotope
Deferiprone-d3 is a deuterated form of Deferiprone, an orally active iron-chelating agent. It primarily targets iron overload conditions, particularly in patients undergoing chronic blood transfusions. Its stable isotope label allows for advanced pharmacokinetic studies and tracing experiments, facilitating research into iron metabolism and related disorders. Deferiprone-d3 is essential for in vivo and in vitro studies focusing on iron regulation and its therapeutic applications. -
Stable Isotope
Rosiglitazone-d4 is a deuterated form of Rosiglitazone, a selective agonist of PPARγ with an EC50 of 60 nM and a Kd of 40 nM. In addition to its role as a PPARγ activator, Rosiglitazone also functions as a TRPC5 activator (EC50: 30 μM) and a TRPM3 inhibitor. This compound is valuable for research into obesity, diabetes, cellular senescence, and ovarian cancer. Its stable isotope labeling allows for precise tracking and quantification in various biological studies. -
Stable Isotope
2-Ambo-Vitamin E-13C6 is a stable isotope-labeled form of α-Vitamin E (also known as (+)-α-Tocopherol). This compound exhibits significant antioxidant activity, neutralizing free radicals and protecting cellular components from oxidative stress. It is widely used in research applications studying lipid metabolism, oxidative damage, and the physiological roles of vitamin E in biological systems. -
Stable Isotope
Lapatinib-d4-1 is a deuterium-labeled derivative of Lapatinib, which primarily targets the ErbB-2 and EGFR tyrosine kinase domains. It exhibits strong inhibition with IC50 values of 10.2 nM for EGFR and 9.8 nM for ErbB-2. This stable isotope-labeled compound is valuable for pharmacokinetic studies and provides insights into drug metabolism, distribution, and bioavailability in chemical research applications. -
Stable Isotope
Lapatinib-d5 is a deuterium-labeled analogue of Lapatinib, a potent inhibitor targeting the ErbB-2 and EGFR tyrosine kinase domains. This compound exhibits strong inhibitory activity with IC50 values of 10.2 nM for EGFR and 9.8 nM for ErbB-2. Lapatinib-d5 is primarily utilized in pharmacokinetic studies and metabolic research to trace drug absorption, distribution, metabolism, and excretion pathways. -
Stable Isotope
(±)-Epicatechin-13C3 is a stable isotope-labeled form of (±)-Epicatechin, which primarily interacts with cyclooxygenase-1 (COX-1). This compound exhibits significant inhibition of COX-1 activity, with an IC50 value of 3.2 μM. Additionally, (±)-Epicatechin is known to suppress the IL-1β-induced expression of inducible nitric oxide synthase (iNOS) by preventing the nuclear translocation of the p65 subunit of NF-κB. These properties make (±)-Epicatechin-13C3 valuable for studies focused on inflammation and signal transduction pathways. -
Stable Isotope
DL-alpha-Tocopherol-d9 is a deuterium-labeled form of DL-alpha-Tocopherol, a synthetic variant of vitamin E. This compound exhibits significant antioxidant properties, providing protection to human skin fibroblasts from UVB-induced cytotoxicity. It is commonly utilized in research applications focused on skin health, oxidative stress, and the study of vitamin E metabolism. -
Stable Isotope
Vildagliptin-d7 is a deuterium-labeled derivative of Vildagliptin, a selective dipeptidyl peptidase IV (DPP-IV) inhibitor with notable potency, exhibiting an IC50 of 3.5 nM in human Caco-2 cells. This stable isotope can be utilized in studies focusing on pharmacokinetics and metabolic profiling of DPP-IV inhibitors, providing insight into their antihyperglycemic effects and oral bioavailability. Vildagliptin-d7 serves as a valuable tool for researchers investigating diabetes therapeutics and related metabolic disorders. -
Stable Isotope
Sorafenib-d3 tosylate is a deuterium-labeled derivative of Sorafenib, a potent multikinase inhibitor primarily targeting Raf, VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit with respective IC50 values of 6 nM, 20 nM, 90 nM, 15 nM, 57 nM, and 58 nM. It exhibits notable biological activities, including the induction of autophagy and apoptosis, contributing to its anti-tumor efficacy. Sorafenib-d3 tosylate serves as a valuable tool for research applications focusing on cancer biology, signaling pathways, and ferroptosis mechanisms. -
Stable Isotope
Simvastatin-d11 is a deuterium-labeled analog of Simvastatin, which acts as a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. This stable isotope is utilized in pharmacokinetic studies to trace drug metabolism and distribution in biological systems. Simvastatin-d11 not only aids in the investigation of cholesterol synthesis but also supports research on the therapeutic effects of statins in lipid regulation and cardiovascular disease. -
Stable Isotope
Bisdemethoxycurcumin-d8 is a deuterium-labeled derivative of Bisdemethoxycurcumin, a curcuminoid compound that primarily inhibits P-glycoprotein and ferroptosis. This compound demonstrates significant biological activities, including antioxidant, anti-inflammatory, and anti-tumor effects. Bisdemethoxycurcumin-d8 serves as a valuable tool for research related to tumor biology and inflammatory disease mechanisms. -
Stable Isotope
Linagliptin-13C,d3 is a stable isotope-labeled form of Linagliptin, a highly selective DPP-4 inhibitor with an IC50 of 1 nM. This compound serves as a valuable tool in metabolic studies and pharmacokinetic research, allowing for precise tracking and analysis of Linagliptin in biological systems. Additionally, Linagliptin-13C,d3 features an alkyne group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, facilitating various bioorthogonal labeling applications. -
Stable Isotope
Lapatinib-13C215N is a stable isotope-labeled variant of Lapatinib, specifically featuring 13C and 15N isotopes. This compound acts as a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains, displaying IC50 values of 10.2 nM and 9.8 nM, respectively, against purified targets. It is valuable for research applications in understanding signaling pathways involved in cancer and for quantitative analysis in pharmacokinetic studies. -
Stable Isotope
Artesunate-d3 is a deuterium-labeled derivative of Artesunate, primarily functioning as a stable isotope. This compound exhibits inhibitory activity against STAT-3 and exported protein 1 (EXP1), making it valuable for studies investigating the modulation of these pathways. Its application spans various areas of research, including cancer biology, infectious diseases, and the mechanisms of drug resistance. -
Stable Isotope
Lovastatin-d3 is a deuterium-labeled derivative of Lovastatin, targeting HMG-CoA reductase. This stable isotope serves as a valuable tool in metabolic studies, particularly in the investigation of cholesterol biosynthesis and lipid metabolism. Its application extends to pharmacokinetic research, enabling precise quantification and tracing of Lovastatin's effects within biological systems. -
Stable Isotope
Artesunate-d4 is a deuterium-labeled derivative of Artesunate, functioning primarily as an inhibitor of Signal Transducer and Activator of Transcription 3 (STAT-3) and Exported Protein 1 (EXP1). This stable isotope is valuable for various research applications, including pharmacokinetics studies and metabolic profiling of Artesunate in biological systems. Its unique labeling enables precise tracking and quantification of the compound in complex biological matrices. -
Stable Isotope
Troglitazone-d4 is a deuterated form of Troglitazone, which serves as a potent agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). With EC50 values of 550 nM and 780 nM for human and murine PPARγ receptors, respectively, Troglitazone-d4 is valuable for stabilizing isotopic labeling in metabolic studies. This reagent is particularly useful in research applications involving insulin sensitization and adipocyte differentiation. -
Stable Isotope
Roxadustat-d5 is a deuterated form of Roxadustat, an oral inhibitor of hypoxia-inducible factor prolyl-hydroxylase (HIF-PHI). This compound enhances erythropoiesis by increasing endogenous erythropoietin levels, regulating iron metabolism, and decreasing hepcidin production. Roxadustat-d5 is valuable in research applications focused on erythropoiesis modulation, anemia management, and the exploration of hypoxia-related pathways. -
Stable Isotope
Butylated hydroxytoluene-d21 is a deuterium-labeled form of butylated hydroxytoluene, a well-known antioxidant. This compound is primarily utilized in food and food-related products to prevent oxidative degradation. Additionally, butylated hydroxytoluene has been identified as a ferroptosis inhibitor, making it useful in research applications focusing on cell death mechanisms and oxidative stress. -
Stable Isotope
Curcumin-d6, a deuterium-labeled derivative of curcumin (Diferuloylmethane-d6), serves as a stable isotope for research applications. This natural phenolic compound functions as a selective inhibitor of p300/CREB-binding protein acetyltransferase, thereby influencing histone acetylation and chromatin transcription. Curcumin exhibits significant biological activities, including anti-inflammatory, antioxidant, antiproliferative, and antiangiogenic properties, while also acting as a photosensitizer against microorganisms. Additionally, it promotes the stabilization of Nrf2 protein through modification of Keap1 cysteine. -
Stable Isotope
Sulfasalazine-d4 is a deuterium-labeled derivative of the anti-rheumatic agent Sulfasalazine, primarily used in the investigation of rheumatoid arthritis and ulcerative colitis. This compound is known to inhibit NF-κB activity and serves as a type 1 ferroptosis inducer. Its stable isotope labeling enhances analytical techniques, aiding in the study of pharmacokinetics and metabolic pathways associated with Sulfasalazine's biological effects. -
Stable Isotope
Eugenol-d3 is a deuterium-labeled derivative of Eugenol, which primarily targets various biological pathways through its antioxidant properties. This compound exhibits antibacterial and anthelmintic activities, making it significant in studies related to microbial resistance and parasitic infections. Additionally, Eugenol has been demonstrated to inhibit lipid peroxidation, providing insights into oxidative stress research. Its isotopic labeling enhances tracking and quantification in metabolic studies. -
Stable Isotope
L-Glutamic acid-1-13C is a stable isotope-labeled form of L-Glutamic acid, a key excitatory neurotransmitter that acts as an agonist at all glutamate receptor subtypes, including metabotropic, kainate, NMDA, and AMPA receptors. This compound is crucial for investigating neurotransmission processes and metabolic pathways in research studies. Additionally, L-Glutamic acid has been shown to promote dopamine release from dopaminergic terminals, making it valuable for studies related to neurobiology and psychiatric disorders. -
Stable Isotope
Acetylcysteine-d3 is a deuterium-labeled derivative of Acetylcysteine, functioning primarily as a stable isotope for research applications. As a mucolytic agent, Acetylcysteine reduces mucus viscosity, while also acting as a reactive oxygen species (ROS) inhibitor. This compound serves as a precursor to cysteine and plays a critical role in preventing hemin-induced ferroptosis by neutralizing lipid peroxidation products from 5-lipoxygenase activity. Furthermore, Acetylcysteine has demonstrated properties in inducing cell apoptosis and antiviral activity against influenza, making it valuable for studies in drug delivery and disulfidptosis investigations. -
Stable Isotope
L-Cystine-3,3'-13C2 is a stable isotope-labeled form of the amino acid L-Cystine, specifically containing two carbon-13 atoms at the 3 and 3' positions. As an important intracellular thiol, L-Cystine is essential for the regulation of various cellular processes, including redox homeostasis and protein synthesis. This isotope-labeled reagent is valuable for applications in metabolic studies, tracer experiments, and proteomics, providing insights into cystine metabolism and its role in physiological and pathological conditions. -
Stable Isotope
Butylated hydroxytoluene-d3 is a deuterium-labeled derivative of butylated hydroxytoluene, an established antioxidant utilized predominantly in food and food products. This compound exhibits significant inhibitory effects on ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation. Butylated hydroxytoluene-d3 serves as a valuable tool in research focused on oxidative stress and cell death pathways, facilitating studies in cellular biology and pharmacology. -
Stable Isotope
L-Cystine-15N2 is a stable isotope-labeled form of L-Cystine, an amino acid that serves as a key intracellular thiol. It is essential in the regulation of various cellular processes, including redox balance and protein synthesis. This reagent is widely used in metabolic studies, tracing experiments, and studies involving cystine metabolism, offering insights into cellular thiol dynamics and related biochemical pathways. -
Stable Isotope
L-Glutamic acid-5-13C is a stable isotope-labeled form of L-Glutamic acid, which serves as an excitatory neurotransmitter and agonist for all glutamate receptor subtypes, including metabotropic, kainate, NMDA, and AMPA receptors. This compound is significant in studying neurophysiology and synaptic transmission, as it influences dopamine release from dopaminergic terminals. L-Glutamic acid-5-13C is valuable in metabolic tracing and isotopic labeling experiments in research applications involving neurotransmitter dynamics and neuronal signaling pathways. -
Stable Isotope
Linagliptin-d4 is a deuterium-labeled analog of Linagliptin, a highly potent and selective inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 1 nM. This stable isotope serves as a valuable tool in click chemistry applications, featuring an alkyne functional group capable of engaging in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. Linagliptin-d4 is useful in biological research for tracking and quantifying DPP-4 activity and dynamics in various systems. -
Stable Isotope
L-Glutamine-13C5,15N2,d5 is a stable isotope-labeled form of the non-essential amino acid L-Glutamine, featuring deuterium and isotopes of carbon and nitrogen. This compound plays a critical role in cellular metabolism, serving as a key nitrogen donor and a carbon source for energy production. It is widely utilized in metabolic studies, isotopic labeling experiments, and research involving amino acid transport and metabolism pathways. -
Stable Isotope
L-Glutamine-5-13C is a stable isotope-labeled form of the non-essential amino acid L-Glutamine, which plays a crucial role in various metabolic pathways. This labeled compound serves as a source of carbon for cellular energy production, particularly in tissues with high metabolic activity. L-Glutamine-5-13C is commonly used in metabolic research, tracer studies, and studies investigating amino acid metabolism.
