Propiconazole-d3 nitrate is a deuterium-labeled analog of propiconazole, acting primarily as a triazole fungicide. It targets the enzymatic conversion of lanosterol to ergosterol, crucial for fungal cell membrane integrity. This compound exhibits inhibitory effects on Saccharomyces cerevisiae, while showing significantly lower impact on rat liver microsomal cytochrome P450, with reported IC50 values of 0.04 µM and >200 µM, respectively. Propiconazole-d3 nitrate has demonstrated efficacy against Trichophyton deformans and Rhizopus stolonifer, with ED50 values of 0.073 µg/mL and 4.6 µg/mL, respectively, and is known to enhance the production of reactive oxygen species (ROS), making it a valuable tool in fungal research and studies related to oxidative stress.
Propiconazole-d3 nitrate is a deuterium-labeled analog of propiconazole, acting primarily as a triazole fungicide. It targets the enzymatic conversion of lanosterol to ergosterol, crucial for fungal cell membrane integrity. This compound exhibits inhibitory effects on Saccharomyces cerevisiae, while showing significantly lower impact on rat liver microsomal cytochrome P450, with reported IC50 values of 0.04 µM and >200 µM, respectively. Propiconazole-d3 nitrate has demonstrated efficacy against Trichophyton deformans and Rhizopus stolonifer, with ED50 values of 0.073 µg/mL and 4.6 µg/mL, respectively, and is known to enhance the production of reactive oxygen species (ROS), making it a valuable tool in fungal research and studies related to oxidative stress.
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