Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Benzoic acid-d5 is a stable isotope-labeled form of benzoic acid, serving as a valuable internal standard in analytical chemistry. This compound is widely used in various applications, including metabolic studies and tracer experiments, enabling the investigation of benzoic acid's metabolic pathways and interactions in biological systems. Its deuterium labeling facilitates precise detection in mass spectrometry and other analytical techniques, enhancing the study of benzoic acid's role in different matrices such as food and beverages. -
Stable Isotope
Pelitinib-d6 is a stable isotope-labeled variant of Pelitinib, an irreversible inhibitor of the epidermal growth factor receptor (EGFR). Pelitinib demonstrates potent biological activity with an IC50 of 38.5 nM against EGFR and also exhibits moderate inhibition of Src, MEK/ERK, and ErbB2 with IC50 values of 282, 800, and 1255 nM, respectively. This deuterium-labeled compound is valuable for studies requiring precise tracking of drug metabolism and pharmacokinetics, as well as kinetic and mechanistic investigations in cancer research. -
Stable Isotope
Neratinib-d6 is a deuterium-labeled derivative of Neratinib, an irreversible tyrosine kinase inhibitor primarily targeting HER2 and EGFR. With IC50 values of 59 nM for HER2 and 92 nM for EGFR, it demonstrates significant inhibitory activity. This stable isotope form is valuable in research applications focusing on pharmacokinetics, metabolism studies, and the exploration of therapeutic strategies for cancers associated with HER2 and EGFR overexpression. -
Stable Isotope
Erlotinib-d4 is a deuterium-labeled analog of Erlotinib, a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 2 nM for human EGFR. This compound effectively reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM and is utilized in the treatment of non-small cell lung cancer. Additionally, Erlotinib-d4 serves as a valuable click chemistry reagent, featuring an alkyne group for performing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating various biochemical applications. -
Stable Isotope
N-Methyl-dosimertinib-d5 is a deuterium-labeled analog of N-Methyl-dosimertinib, designed for use as a stable isotope in biochemical research. This compound allows for accurate tracing and quantification in various biological studies, including pharmacokinetics and metabolic profiling. Its unique isotopic labeling facilitates advanced analytical techniques, making it invaluable for researchers exploring drug interactions and mechanisms of action. -
Stable Isotope
N-Desmethyl dosimertinib-d5 is a deuterated stable isotope of N-Desmethyl dosimertinib. This compound serves as a valuable tracer in pharmacokinetic studies, enabling researchers to track the metabolism and distribution of dosimertinib derivatives. Its unique isotopic labeling enhances the understanding of drug interactions and mechanisms of action in biological systems, making it a crucial tool for drug development and therapeutic research. -
Stable Isotope
Erlotinib-13C6 hydrochloride is a stable isotope-labeled derivative of Erlotinib hydrochloride, targeting the epidermal growth factor receptor (EGFR) kinase with an IC50 of 2 nM. This compound serves as a valuable tool in click chemistry applications due to its alkyne group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its isotopic labeling facilitates quantitative analysis in metabolic studies and drug metabolism research. -
Stable Isotope
Gefitinib-d6 is the deuterated form of Gefitinib, a highly selective and orally bioavailable inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 33 nM. This compound effectively inhibits EGF-mediated tumor cell proliferation (IC50 of 54 nM) and prevents EGFR autophosphorylation in cancer cells. Additionally, Gefitinib can induce autophagy, further contributing to its antitumoral effects. Gefitinib-d6 is valuable for studies involving metabolic labeling and pharmacokinetics in cancer research. -
Stable Isotope
Osimertinib-13C,d3 is a stable isotope-labeled derivative of Osimertinib, a covalent, orally active, irreversible inhibitor of mutant-selective EGFR. This compound exhibits an apparent IC50 value of 12 nM against the L858R mutation and 1 nM against the L858R/T790M mutation. Osimertinib-13C,d3 is essential for analytical studies, including pharmacokinetics and metabolic profiling, enabling researchers to investigate the drug's biological activity and mechanism of action in various cancer research applications. -
Stable Isotope
AZ-5104-d2 is a deuterium-labeled derivative of AZ-5104, acting as a selective inhibitor of the epidermal growth factor receptor (EGFR). It demonstrates potent inhibitory activity with IC50 values of 1 nM for EGFRL858R/T790M, 6 nM for EGFRL858R, 1 nM for EGFRL861Q, 25 nM for EGFR, and 7 nM for ErbB4. This stable isotope variant is valuable for applications in pharmacokinetics and metabolic studies, providing insights into EGFR-mediated signaling pathways and therapeutic interventions. -
Stable Isotope
Gefitinib-d3 is a deuterium-labeled derivative of Gefitinib, acting as a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It exhibits robust antitumor activity by inhibiting EGF-stimulated growth in tumor cells with an IC50 of 54 nM and effectively blocking EGF-induced EGFR autophosphorylation. This stable isotope variant is particularly valuable for research applications involving drug metabolism and pharmacokinetics, as well as studying the mechanisms of autophagy associated with EGFR signaling. -
Stable Isotope
Gefitinib-d8 is a deuterium-labeled analogue of Gefitinib, a potent inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. With an IC50 ranging from 2 to 37 nM in NR6wtEGFR cells, this stable isotope serves as a valuable tool in quantitative analysis and metabolic studies. It is particularly useful for research applications involving drug metabolism and pharmacokinetics, enabling detailed investigations of EGFR-targeted therapies. -
Stable Isotope
Afatinib-d6 is a deuterium-labeled derivative of Afatinib, an irreversible inhibitor of the epidermal growth factor receptor (EGFR) family. This stable isotope variant is utilized primarily in pharmacokinetic studies to trace the metabolic pathways of Afatinib and assess drug distribution and elimination in various biological systems. It offers valuable insights for researchers in oncology and drug development, enhancing the understanding of EGFR-targeted therapies. -
Stable Isotope
Benzamide-d5 is a deuterium-labeled derivative of Benzamide, serving as a stable isotope for use in chemical research. This compound acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP), demonstrating protective effects against neurotoxicity induced by glutamate and methamphetamine in vitro. Benzamide-d5 is valuable for studies assessing neuroprotective mechanisms and the modulation of dopamine metabolism in models of neurodegeneration and substance abuse. Its unique isotopic labeling allows for precise tracking and quantification in metabolic studies. -
Stable Isotope
Benzamide-15N is a stable isotope-labeled variant of Benzamide, featuring a nitrogen-15 (15N) isotope. This compound functions as a poly(ADP-ribose) polymerase (PARP) inhibitor, which is crucial in the study of DNA repair mechanisms. Benzamide-15N is applicable in research involving cellular processes impacted by PARP activity, aiding in the understanding of therapeutic approaches for cancer and other diseases related to DNA damage response. -
Stable Isotope
Olaparib-d4-1 is a deuterium-labeled derivative of Olaparib, a potent and orally active inhibitor of poly(ADP-ribose) polymerase (PARP). It exhibits IC50 values of 5 nM and 1 nM for PARP1 and PARP2, respectively, effectively inducing cellular responses associated with DNA repair inhibition. This stable isotope compound is valuable for research applications in cancer therapeutics, particularly in studies involving PARP-mediated pathways and autophagy activation. -
Stable Isotope
Nudifloramide-d6 is a deuterium-labeled analog of Nudifloramide, functioning as a stable isotope. This reagent is primarily utilized in quantitative mass spectrometry applications to study drug metabolism and pharmacokinetics. Its incorporation into research enables detailed investigations of biological pathways and the effects of Nudifloramide in various therapeutic contexts. -
Stable Isotope
Olaparib-d5 is a deuterated version of Olaparib, a potent and orally active inhibitor of the poly (ADP-ribose) polymerases PARP1 and PARP2, exhibiting IC50 values of 5 nM and 1 nM, respectively. This stable isotope is valuable for pharmacokinetic and metabolic studies, enabling precise tracking of Olaparib metabolism in biological systems. Additionally, Olaparib has been shown to activate autophagy and mitophagy, thereby contributing to its therapeutic efficacy in cancer research. -
Stable Isotope
Nudifloramide-d3 is a deuterium-labeled derivative of Nudifloramide, which is a significant end product of nicotinamide-adenine dinucleotide (NAD) degradation. This compound demonstrates potent inhibitory activity against poly(ADP-ribose) polymerase (PARP-1) in vitro, making it a valuable tool for studying PARP-1 mediated pathways. Its use in research applications includes investigating cellular responses to DNA damage and elucidating mechanisms of cellular stress response. -
Stable Isotope
Acetaminophen-13C6 is a stable isotope-labeled derivative of acetaminophen, primarily utilized for metabolic studies and tracing experiments. This compound functions as a selective inhibitor of cyclooxygenase-2 (COX-2) with an IC50 of 25.8 μM, demonstrating significant antipyretic and analgesic properties. Additionally, it acts as a potent inhibitor of hepatic N-acetyltransferase 2 (NAT2), making it valuable for pharmacokinetic research and understanding drug metabolism. -
Stable Isotope
Acetaminophen-d4 is a stable isotope-labeled variant of Acetaminophen, functioning primarily as a selective inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 25.8 μM. This compound is commonly utilized in research for its antipyretic and analgesic properties, as well as its role as a potent inhibitor of hepatic N-acetyltransferase 2 (NAT2). Its deuterium labeling enhances its utility in metabolic studies and pharmacokinetic investigations. -
Stable Isotope
Acetaminophen-d7 is a deuterium-labeled form of acetaminophen, functioning primarily as a selective inhibitor of cyclooxygenase-2 (COX-2), with an IC50 of 25.8 μM. This stable isotope variant is utilized in pharmacokinetic studies to trace the metabolic pathways of acetaminophen while minimizing interference from natural acetaminophen. Its applications include investigations into analgesic and antipyretic effects, as well as studies on hepatic N-acetyltransferase 2 (NAT2) inhibition. -
Stable Isotope
Acetaminophen-d3 is the deuterium-labeled form of Acetaminophen, a selective inhibitor of cyclooxygenase-2 (COX-2) with an IC50 of 25.8 μM. It exhibits significant antipyretic and analgesic properties, making it a widely utilized therapeutic agent. Additionally, Acetaminophen has been shown to act as a potent inhibitor of hepatic N-acetyltransferase 2 (NAT2). This stable isotope is valuable for research applications involving drug metabolism, pharmacokinetics, and the study of COX-2-related pathways. -
Stable Isotope
Acetaminophen-13C2,15N is a stable isotope-labeled version of Acetaminophen, featuring both 13C and 15N isotopes. As a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM, it serves as an effective antipyretic and analgesic. In addition, Acetaminophen exhibits strong inhibitory action on hepatic N-acetyltransferase 2 (NAT2), making it valuable for biochemical and pharmacological research applications. -
Stable Isotope
α-Hydroxyglutaric acid-13C5 disodium is a stable isotope-labeled form of α-Hydroxyglutaric acid, an α-hydroxy acid derived from glutaric acid. This compound acts as a competitive inhibitor of various α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methylcytosine hydroxylases. It is useful in research applications involving epigenetics, metabolism studies, and cellular response to metabolic changes. -
Stable Isotope
Phenelzine-d5 sulfate is a deuterium-labeled derivative of the antidepressant phenelzine sulfate, functioning primarily as an irreversible inhibitor of monoamine oxidase (MAO-A and MAO-B). It exhibits significant biological activities, including the inhibition of GABA transaminase and primary amine oxidase, and plays a role in sequestering reactive aldehydes. This compound is utilized in research related to neurological and metabolic disorders, as well as in cancer studies, particularly for conditions such as depression, anxiety, stroke, and neurodegenerative diseases. -
Stable Isotope
Belinostat-d5 is a deuterium-labeled derivative of Belinostat, a potent histone deacetylase (HDAC) inhibitor. With an IC50 of 27 nM in HeLa cell extracts, it effectively modulates gene expression through the inhibition of HDAC activity. This stable isotope-labeled compound is valuable for quantitative studies in chemical biology and drug development, allowing for precise tracking and analysis of Belinostat metabolism and pharmacokinetics in various biological systems. -
Stable Isotope
Valproic acid-d15 is a deuterium-labeled variant of Valproic acid, a known histone deacetylase (HDAC) inhibitor with an IC50 ranging from 0.5 to 2 mM. It specifically inhibits HDAC1 (IC50, 400 μM) and promotes the proteasomal degradation of HDAC2. Valproic acid-d15 activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. This stable isotope is valuable for pharmacokinetic studies, allowing researchers to trace the metabolic pathways and biological effects of Valproic acid in various therapeutic contexts. -
Stable Isotope
4-Phenylbutyric acid-d11 is the deuterated form of 4-Phenylbutyric acid, a known inhibitor of histone deacetylases (HDAC) and a modulator of endoplasmic reticulum (ER) stress. This compound exhibits significant biological activity in cancer therapy and infection studies, facilitating research on cellular stress responses and epigenetic regulation. Its stable isotope labeling enables advanced metabolic studies and applications in the fields of biochemistry and pharmacology. -
Stable Isotope
Valproic acid-d6 is a deuterium-labeled derivative of Valproic acid, primarily recognized for its role as a histone deacetylase (HDAC) inhibitor, exhibiting an IC50 range of 0.5 to 2 mM. It selectively inhibits HDAC1 (IC50, 400 μM) and promotes the proteasomal degradation of HDAC2. Valproic acid-d6 has demonstrated the ability to activate Notch1 signaling while inhibiting cell proliferation in small cell lung cancer (SCLC) models. This stable isotope is beneficial for studies requiring precise quantification in metabolic and pharmacokinetic research related to neurological disorders and cancer therapeutics. -
Stable Isotope
Valproic acid-d4 is a deuterium-labeled form of Valproic acid, a potent histone deacetylase (HDAC) inhibitor with an IC50 range of 0.5 to 2 mM. This compound specifically inhibits HDAC1 (IC50, 400 μM) and prompts proteasomal degradation of HDAC2. Valproic acid also activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. It is commonly employed in research pertaining to neurological disorders, including epilepsy and bipolar disorder, as well as in studies investigating its potential for migraine prevention. -
Stable Isotopes
Tasquinimod-d3 is a deuterated form of Tasquinimod, an oral antiangiogenic agent targeting castration-resistant prostate cancer. This compound selectively binds to the regulatory Zn2+ binding domain of HDAC4 with a Kd of 10-30 nM, thereby influencing histone deacetylation processes. Additionally, Tasquinimod-d3 acts as an inhibitor of S100A9, highlighting its potential for diverse applications in cancer research and therapeutic development. -
Stable Isotope
Deferasirox-d4 is a deuterium-labeled form of Deferasirox, an oral iron chelator that targets excess iron accumulation in patients with transfusion-related iron overload. This stable isotope compound allows for precise tracing and quantification in biological studies, facilitating research on metabolic pathways and iron homeostasis. Deferasirox-d4 is essential for studies related to iron dysregulation and its associated pathologies. -
Stable Isotope
PRMT5-MTA-IN-3-d3 is a deuterated form of the PRMT5-MTA inhibitor, designed for stable isotope applications. This compound exhibits notable antiproliferative activity against colorectal cancer cell lines, specifically showing IC50 values of 6 nM in MTAP-deficient HTC116-MTAP del cells and 961 nM in wild-type HCT-116 cells. PRMT5-MTA-IN-3-d3 is particularly relevant for research on cancers involving MTAP deficiency, including non-small cell lung cancer (NSCLC) and pancreatic cancer. -
Stable Isotope
Acedapsone-d8 is a deuterium-labeled derivative of Acedapsone, designed for use as a stable isotope in research applications. Acedapsone exhibits significant antimalarial and antimicrobial properties and is primarily employed as a long-acting inhibitor for leprosy treatment. This labeled compound is suitable for pharmacokinetic studies and metabolic investigations, offering a valuable tool for researchers studying the pharmacology and therapeutic potential of Acedapsone. -
Stable Isotope
Amodiaquine-d10 is a deuterium-labeled analog of Amodiaquine, a 4-aminoquinoline antimalarial agent. This compound functions primarily as a histamine N-methyltransferase inhibitor and demonstrates activity as a Nurr1 agonist, selectively binding to the Nurr1 ligand-binding domain with an EC50 of approximately 20 μM. Amodiaquine-d10 is valuable for research applications in studying malaria mechanisms, anti-inflammatory pathways, and the role of Nurr1 in cellular processes. -
Stable Isotope
Vildagliptin-d3 is the deuterium-labeled analog of Vildagliptin, a highly selective dipeptidyl peptidase IV (DPP-IV) inhibitor that exhibits an IC50 of 3.5 nM in human Caco-2 cells. This stable isotope is ideal for tracer studies in metabolic research, particularly in exploring glucose metabolism and the pharmacokinetics of DPP-IV inhibitors. Vildagliptin-d3 offers exceptional oral bioavailability and retains significant antihyperglycemic activity, making it valuable in diabetes research applications. -
Stable Isotope
Lapatinib-d7 is a deuterated analog of Lapatinib, primarily targeting the ErbB-2 and EGFR tyrosine kinase domains. It exhibits potent inhibition with IC50 values of 10.2 nM and 9.8 nM for EGFR and ErbB-2, respectively. This stable isotope-labeled compound is ideal for pharmacokinetic studies and metabolic profiling in research applications related to cancer therapeutics and drug metabolism. -
Stable Isotope
Deferasirox-13C6 is a stable isotope-labeled form of Deferasirox, which functions as an oral iron chelator. It primarily targets excess iron in patients with transfusion-related iron overload. This reagent is beneficial for research applications involving the study of iron metabolism and chelation therapy. Its isotopic labeling facilitates advanced analytical techniques, enhancing the understanding of pharmacokinetics and dynamic iron homeostasis in biological systems. -
Stable Isotope
Butylated hydroxytoluene-d24 is a deuterium-labeled form of butylated hydroxytoluene, primarily used as a stable isotope in research. As a well-known antioxidant, butylated hydroxytoluene is commonly applied in food preservation and various food-related products. Additionally, it serves as a ferroptosis inhibitor, making it valuable in studies of oxidative stress, cell death mechanisms, and potential therapeutic applications. -
Stable Isotope
Cerivastatin-d3 sodium is a deuterated form of Cerivastatin, an effective HMG-CoA reductase inhibitor with a Ki of 1.3 nM. This compound functions primarily as a lipid-lowering agent by reducing low-density lipoprotein (LDL) cholesterol levels. Additionally, Cerivastatin exhibits anti-cancer activity by inhibiting the proliferation and invasiveness of MDA-MB-231 cells through RhoA pathway modulation. Its stable isotope labeling makes it valuable for metabolic studies and pharmacokinetic research. -
Stable Isotope
Rosiglitazone-d4-1 is a deuterated analog of Rosiglitazone, serving as a stable isotope for tracer studies. This compound is utilized primarily in pharmacokinetic research and metabolic studies to track the disposition of Rosiglitazone in biological systems without interfering with its activity. Researchers may use Rosiglitazone-d4-1 to enhance the understanding of its mechanisms of action and to investigate its influence on glucose metabolism and insulin sensitivity in various experimental models. -
Stable Isotope
L-Glutamine-2-13C is a stable isotope-labeled form of L-Glutamine, a non-essential amino acid integral to various metabolic processes. This compound serves as a key carbon source for cellular oxidation, making it valuable for studies involving metabolic pathways and nutrient utilization. L-Glutamine-2-13C is widely used in isotopic labeling experiments, enabling researchers to trace metabolic fluxes in both in vitro and in vivo systems. -
Stable Isotope
2-ambo-Vitamin E-13C3 is a stable isotope-labeled form of α-Vitamin E (13C-labeled α-Tocopherol). As a naturally occurring form of vitamin E, it functions primarily as a potent antioxidant, effectively scavenging free radicals and protecting cellular components from oxidative stress. This reagent is valuable for metabolic studies, tracing vitamin E metabolism and bioavailability, and for examining its role in various biological processes. -
Isotope-Labeled Compounds
Linagliptin-d3-1 is a deuterium-labeled analog of Linagliptin, a highly potent and selective inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 of 1 nM. This isotope-labeled compound is primarily utilized in pharmacokinetic studies and metabolic research to trace the pharmacological pathways of DPP-4 inhibitors in various biological systems. Its unique isotopic signature allows for enhanced detection and quantification in analytical applications, facilitating insights into drug metabolism and efficacy. -
Stable Isotope
Zileuton-d4 is a deuterium-labeled version of Zileuton, a selective inhibitor of 5-lipoxygenase. This compound exhibits significant antiasthmatic properties, making it valuable for research in respiratory diseases and inflammation. Zileuton-d4 serves as a stable isotope tracer in pharmacokinetic studies, aiding in the investigation of metabolic pathways and drug interactions related to leukotriene synthesis. -
Stable Isotope
L-Glutamine-5-13C is a stable isotope-labeled form of the non-essential amino acid L-Glutamine, involved in various metabolic processes within the body. This compound serves as a crucial carbon source for cellular oxidation and energy production. It is widely utilized in metabolic studies, tracer experiments, and research focused on amino acid metabolism and cellular physiology. -
Stable Isotope
Lapatinib-d4 tosylate is a deuterated form of Lapatinib, a highly effective inhibitor targeting the tyrosine kinase domains of ErbB-2 and EGFR. It demonstrates potent biological activity with IC50 values of 10.2 nM and 9.8 nM against purified EGFR and ErbB-2, respectively. This stable isotope-labeled compound is valuable in pharmacokinetic studies and can facilitate research in cancer biology, particularly in the context of targeted therapies for breast cancer. -
Stable Isotope
Epi Lovastatin-d3 is a deuterium-labeled variant of Lovastatin, a potent inhibitor of HMG-CoA reductase. This stable isotope is utilized in chemical research to study metabolic pathways and cholesterol biosynthesis. Its application is vital in pharmacokinetic studies and tracer experiments, providing insight into the pharmacodynamics of cholesterol-lowering therapies. -
Isotope-Labeled Compound
α-Vitamin E-d11 is a deuterium-labeled form of α-Vitamin E ((+)-α-Tocopherol), primarily utilized in isotope labeling studies. This compound acts as a potent antioxidant, involved in protecting cellular components from oxidative damage. It is valuable for research applications focused on lipid metabolism, oxidative stress, and vitamin E bioactivity in biological systems.
